作者 | 哥吉拉 数据支持 | 勾股大数 据（www.gogudata.com） 5月29日，A股主要指数高开高走，截至收盘，沪指涨0.7%报3363点，深证成指涨1.24%，创业板指涨1.37%。全市场近4500股上涨，逾百 股涨停。 板块方面，金融科技、创新药、互联网、半导体等热门板块表现强势，市场情绪相比近日明显提振。 其中，创新药是涨幅最明显的板块之一，睿智医药、舒泰神、益方生物强势斩获20CM涨停，另有十多家医药股涨幅均超过10%，堪称又一轮 暴涨潮。 | 代码 | 名称 | 现价 | 1 9 mm a lond a rither more an a many 143 1994 (310 1 涨跌幅▼ | 年初至今涨跌幅 | 总市值1 | | --- | --- | --- | --- | --- | --- | | 300149 | 睿智医药 | 8.56 c | 20.06% | 33.33% | 43亿 | | 300204 | 舒泰神 | 23.04 c | 20.00% | 210.93% | 110亿 | | 688382 | 益元生物-U | 29.10 c | 20.00% | 11 ...

Core Viewpoint - The recent high-value transaction involving the innovative drug SSGJ-707 by 3SBio and Pfizer highlights the growing trend of Chinese biopharmaceutical companies expanding into international markets, despite challenges in the global pharmaceutical environment [2][4]. Group 1: Transaction Details - Pfizer has made a non-refundable upfront payment of $1.25 billion (approximately 9 billion RMB) for the rights to SSGJ-707 outside of China, with potential milestone payments totaling up to $4.8 billion (approximately 34.5 billion RMB) and an additional $100 million for equity subscription [2]. - This transaction sets a record for the upfront payment for a Chinese innovative drug going overseas, indicating a significant shift in the landscape of biopharmaceutical transactions [4]. Group 2: Company Background - 3SBio, established in 1993, is a well-established pharmaceutical company that went public on NASDAQ in 2007 and later privatized before listing on the Hong Kong Stock Exchange in 2015 [3]. - The subsidiary involved in the transaction, 3SBio Guojian, was formerly known as CITIC Guojian and is recognized as one of the earliest companies in China to engage in antibody drug research and sales [3]. Group 3: Market Trends - The trend of Chinese innovative drug companies seeking international partnerships has been growing, with a nearly 40% increase in outbound business development (BD) transactions since 2022, projected to reach around 120 deals worth approximately $63 billion in 2024 [6]. - The stock prices of 3SBio and 3SBio Guojian have surged over 200% and 130%, respectively, following the announcement of this transaction, reflecting strong market interest in innovative drug development [4]. Group 4: Strategic Implications - The increasing trend of "going overseas" is reshaping the clinical research strategies of domestic innovative drug companies, with many now considering international transactions as a key part of their development plans [4]. - The shift from a "me too" model to a focus on first-in-class (FIC) drugs is evident, as domestic companies are increasingly competing head-to-head with multinational pharmaceutical firms [4][5].

Core Viewpoint - The Chinese innovative pharmaceutical industry is transitioning from imitation to original innovation, with significant growth in outbound transactions and a promising future for internationalization [4] Group 1: Market Performance - As of May 29, 2025, the Sci-Tech Innovation Board 100 Index (000698) rose by 1.63%, with notable increases in constituent stocks such as Borui Pharmaceutical (688166) up 9.66% and Zhixiang Jintai (688443) up 6.57% [3] - The Sci-Tech 100 Index ETF (588030) increased by 1.60%, with a latest price of 0.95 yuan and a turnover rate of 1.16%, totaling 71.56 million yuan in transactions [3] - Over the past year, the average daily transaction volume of the Sci-Tech 100 Index ETF reached 424 million yuan, ranking first among comparable funds [3] Group 2: Fund Growth and Performance - The Sci-Tech 100 Index ETF saw a significant increase in scale, growing by 94.45 million yuan over the past two weeks, ranking second among comparable funds [4] - In the past week, the ETF's shares increased by 99 million, also ranking first among comparable funds [5] - The ETF has experienced a net inflow of 71.08 million yuan over the last five trading days, indicating strong investor interest [5] Group 3: Financial Metrics - As of May 28, 2025, the Sci-Tech 100 Index ETF's net value increased by 19.94% over the past year, with a maximum monthly return of 27.67% since inception [5] - The ETF's management fee is 0.15% and the custody fee is 0.05%, making it the lowest among comparable funds [5] - The tracking error for the ETF over the past six months is 0.016%, indicating high tracking precision compared to similar funds [5] Group 4: Industry Insights - From the beginning of 2025 to the present, the total outbound transaction amount for innovative drugs has reached 45.5 billion USD, with upfront payments totaling 2.2 billion USD, suggesting a record year ahead [4] - Most domestic innovative drugs currently in the U.S. are in clinical stages, with significant potential for future growth as they progress towards commercialization [4]

Core Viewpoint - The company has granted Pfizer exclusive rights to develop, produce, and commercialize a dual-targeting antibody product aimed at PD-1 and VEGF, which is expected to enhance anti-tumor effects while reducing potential side effects [1][3]. Group 1: Licensing Agreement - Sanofi Health has granted Pfizer exclusive rights for the development and commercialization of the 707 project in regions outside mainland China [1]. - The licensing agreement involves a distribution of rights based on prior R&D investments and asset ownership, with Sanofi Health receiving 30% and Shenyang Sanofi receiving 70% [2]. Group 2: Clinical Development - The efficacy and safety of the PD-1/L1 antibody combined with VEGF antibody have been validated in clinical trials for various tumors, including renal cell carcinoma and hepatocellular carcinoma [3]. - The product has multiple ongoing clinical trials, with a single-agent treatment for PD-L1 positive non-small cell lung cancer having received approval for Phase III, while combination therapies for non-small cell lung cancer, metastatic colorectal cancer, and advanced gynecological tumors are in Phase II [3]. Group 3: Financial Projections - Following the significant licensing agreement and the anticipated approval of new products, the company has adjusted its revenue forecasts for 2025-2027 to 40.2 billion, 22.4 billion, and 26.3 billion yuan, reflecting a year-on-year growth of 236.4%, -44.1%, and 17.4% respectively [4]. - The projected net profits for the same period are 28.5 billion, 11.2 billion, and 13.9 billion yuan, with year-on-year growth of 305.0%, -60.6%, and 23.4% respectively [4]. - Earnings per share (EPS) are expected to be 4.63, 1.82, and 2.25 yuan, with corresponding price-to-earnings (PE) ratios of 12, 30, and 24 times based on the closing price of 54 yuan per share on May 28, 2025 [4].

Core Viewpoint - The pharmaceutical sector, particularly innovative drugs, is performing well amid market fluctuations, with Hong Kong's innovative drug ETF significantly outperforming its A-share counterpart [1][2]. Group 1: Market Performance - The Hong Kong Innovative Drug Index has seen a one-year increase of 38.36%, outperforming the A-share Innovative Drug Industry Index, which rose by 9.58% [1]. - The Hong Kong Innovative Drug ETF (513120) has achieved a year-to-date increase of 36.36%, compared to the A-share Innovative Drug ETF (515120) which has risen by 9.76% [1]. Group 2: Index Composition and Investor Suitability - The Hong Kong Innovative Drug Index primarily consists of biotech companies, aligning well with current market trends such as AI+pharmaceuticals and internationalization, making it suitable for high-risk investors with experience in Hong Kong stocks [1]. - The A-share Innovative Drug Industry Index is weighted towards established pharmaceutical companies and CROs, offering lower volatility, thus appealing to investors seeking stable growth in the domestic innovative drug sector [1]. Group 3: Fund Management and Size - Guangfa Fund is noted for its extensive experience in index management and has launched over 100 public index products, including both Hong Kong and A-share innovative drug ETFs [2]. - The total scale of Guangfa Fund's innovative drug ETFs exceeds 13 billion yuan, with the Hong Kong ETF at 9.8 billion yuan and the A-share ETF at over 3.5 billion yuan, making it the largest in the industry [2]. Group 4: ETF Comparison - The Hong Kong Innovative Drug ETF (513120) has a latest scale of 9.8 billion yuan and an average daily trading volume exceeding 2.1 billion yuan, ranking first among similar products [3]. - The A-share Innovative Drug ETF (515120) has a scale of 3.5 billion yuan and an average daily trading volume of over 100 million yuan, also ranking first in its category on the Shanghai market [3].

Core Viewpoint - The recent surge in the stock price of Haiwang Bio is attributed to positive market sentiment following the collaboration between three pharmaceutical companies, enhancing confidence in China's innovative drug capabilities [1][8]. Company Evolution - Haiwang Bio has transformed from a regional distributor to a comprehensive biopharmaceutical platform, reflecting the industry's shift from "generic following" to "innovation leading" [3]. - Established in 1992, Haiwang Bio's growth mirrors the consolidation of China's pharmaceutical distribution sector, achieving over 10 billion yuan in revenue by 2015 [3][4]. Business Operations - The company focuses on pharmaceutical and medical device distribution, boasting a logistics network covering over 20 provinces, with significant market share in Shandong and Henan [4]. - Haiwang Bio operates 22 provincial logistics centers and 110 warehouses, with a total storage area exceeding 390,000 square meters, serving nearly 170,000 clients [4][5]. Research and Development - The company has established several innovation platforms and employs a research team of 228, focusing on major diseases and new drug development [5]. - Haiwang Bio has been recognized as a high-tech enterprise and ranks among the top in China's pharmaceutical distribution sector [5][6]. Financial Performance - Despite industry challenges, Haiwang Bio reported a revenue of 30.317 billion yuan in 2024, with a significant reduction in net losses compared to the previous year [7][8]. - The company anticipates a positive long-term growth trajectory as it completes goodwill impairment and optimizes its operations [7]. Industry Opportunities - The Chinese pharmaceutical industry is undergoing a quality upgrade, with policies favoring larger players, positioning Haiwang Bio to expand its market share [8]. - The company is transitioning to provide customized supply chain solutions, enhancing service offerings and operational efficiency [8][9]. Future Growth Potential - Haiwang Bio's NEP018 drug, targeting gastrointestinal tumors, has received clinical trial approval, potentially opening new revenue streams [9]. - The company is well-positioned to leverage its extensive logistics network and innovative service models to capitalize on industry consolidation and growth opportunities [8][9].

Core Viewpoint - The Chinese innovative pharmaceutical sector is gaining international recognition, highlighted by significant deals and promising clinical data, leading to increased interest in related ETFs [1][3][4]. Group 1: Market Performance - The innovative drug ETF (517110) has rebounded nearly 15% since early April, reflecting strong performance in the pharmaceutical sector [1]. - The biopharmaceutical ETF and vaccine ETF also showed positive movements, with respective increases of 1.17% and 0.89% [2]. Group 2: ASCO Conference Insights - At the 2025 ASCO conference, over 70 research outcomes from Chinese pharmaceutical companies were presented, showcasing advancements in ADC and bispecific antibody technologies [3]. - Notable performances include Zai Lab's ZG005 and Huahai Pharmaceutical's HB0025, which exceeded expectations in early clinical trials for cervical and endometrial cancers, respectively [3]. Group 3: Business Development Trends - Recent business development (BD) activities in the innovative drug sector have seen record-breaking upfront payments, such as the $12.5 billion upfront payment from Pfizer for a PD-1/VEGF bispecific antibody from 3SBio [4][7]. - The increase in upfront payments and total deal values indicates growing international recognition of Chinese innovative drugs [7]. Group 4: Future Outlook - The innovative drug sector is expected to benefit from ongoing BD transactions, advancements in artificial intelligence across the pharmaceutical value chain, and the implementation of new healthcare policies [7]. - The overall sentiment and valuation in the pharmaceutical sector may improve due to domestic policy optimizations and a recovery in medical equipment procurement [7].

消息面上，据中航证券、东海证券研报，2025年美国临床肿瘤学会（ASCO）年会即将于5月30日至6月 3日在美国芝加哥正式召开。研究摘要题目已于5月23日对外公布，中国药企以70余项研究成果入选。多 个具有同类首创/同类最佳潜力的国产创新药分子将有数据读出。 东海证券指出，前沿创新-商业化-反哺研发的正向循环进一步得到验证，预计"Licenseout+股权合作"将 成为出海的主流模式，而具备充裕现金流+前沿管线布局的仿创结合药企正迎来新的估值重塑。创新药 作为医药生物板块最具确定性引领性的细分板块，是核心投资主线。 中邮证券表示，2024年中国创新药Lisenceout授权总金额突破500亿美元，达519亿美元，同比增长 27.4%，占全球同类交易总额的30%。我们认为SSGJ-707授权金额创纪录有望加速中国药企出海热潮， 近年国内药企Lisenceout数量和金额呈加速趋势，未来数年或迎密集收获期。 （本文机构观点来自持牌证券机构，不构成任何投资建议，亦不代表平台观点，请投资人独立判断和决 策。） 5月27日，香港恒生指数、恒生科技指数集体低开，国证港股通创新药指数逆市高开。 热门ETF中，港股创新药ET ...

Core Viewpoint - The Hong Kong pharmaceutical sector, particularly the innovative drug segment, is experiencing a significant surge, driven by recent high-profile collaborations and a shift towards international competitiveness among Chinese pharmaceutical companies [1][11]. Group 1: Innovative Drug Collaborations - Pfizer's collaboration with 3SBio involves a record-breaking upfront payment of $1.25 billion and potential milestone payments of up to $4.8 billion, boosting confidence in the international capabilities of Chinese innovative drugs [1][5]. - Other notable collaborations include a $200 million upfront payment from United Pharmaceuticals to Novo Nordisk and a $175 million upfront payment from Hengrui Medicine to Merck, indicating a trend of increasing international partnerships [5]. - The average price-to-earnings (P/E) ratio for the Hong Kong pharmaceutical sector is currently at 15 times, significantly lower than the 24 times for both A-shares and U.S. stocks, suggesting a strong value proposition for investors [7]. Group 2: Technological Advancements - Chinese pharmaceutical companies are transitioning from "generic followers" to "innovation leaders," with R&D costs being only one-third of those in the U.S. and clinical trial durations reduced by 30% [1][2]. - Companies like Decipher Biosciences and Kintor Pharmaceutical are leveraging AI to enhance drug development efficiency, with significant improvements in response rates for clinical trials [1][2]. Group 3: Upcoming ASCO Conference - The 2025 ASCO Annual Meeting, scheduled for May 30 to June 3, will feature over 500 oral presentations and 2,700 poster presentations, with 71 original research projects from Chinese scholars, potentially leading to further stock price increases for involved companies [3][4]. Group 4: Market Dynamics and Valuation - The Hong Kong healthcare index has seen a nearly 20% increase prior to the announcement of 3SBio's contract, with a subsequent 4% rise following the news, indicating strong market interest [1]. - The current valuation levels are at historical lows, with some stocks trading below their net asset values, providing a significant safety margin for investors [7][8]. Group 5: Policy and Market Support - Recent policy changes have reduced pressures from centralized procurement, allowing innovative drugs to enter insurance coverage more rapidly, which is expected to enhance profitability for companies with genuine innovation capabilities [9]. - The government's support for biopharmaceuticals and the anticipated release of a new innovative drug directory could unlock over 300 billion yuan in market space, benefiting leading therapies like BeiGene's PD-1 inhibitors [9]. Group 6: Investment Trends - There has been a notable increase in capital inflow into the Hong Kong pharmaceutical sector, with net inflows into innovative drug ETFs exceeding 5 billion yuan since the second quarter [10]. - Active pharmaceutical funds are increasing their holdings in Hong Kong stocks, reflecting a growing confidence in the sector's potential for recovery and growth [10][11].

细分品类中，港股市场ETF净流出额居前，净流出17.7亿元。规模变化方面，宽基ETF规模下降205.15 亿元。具体到指数维度，5月23日，跟踪中证A500指数的ETF单日净流出额居前，达11.13亿元。 从单只基金看，创新药ETF单日净流出额居前，达5.87亿元。此外，上证50ETF、中证A500ETF龙头等 核心宽基指数ETF、以及港股通互联网ETF、港股创新药均遭资金净流出。 业内表示，尽管，4月受关税政策以及全球经济形势数据等因素，港股行情波动剧烈，但是，5月以来， 行情回暖显著，因此一些资金开始对港股相关指数"获利了结"。受益于政策支持与技术突破，近期A 股、港股创新药板块双双表现强势，也有一些资金选择"落袋为安"。 据中信建投证券统计，2024年医保谈判中创新药成功率超90%，国产占比达70%以上，商保政策密集出 台，为创新药支付端提供增量可能。资金面上，今年以来，创新药板块持续获得增量资金流入，上周有 较大幅度净流出，流出程度在所有指数中排名第四。 【导读】上个交易日股票ETF市场资金净流出27亿元 中国基金报记者张燕北 上周五（5月23日），A股三大股指收跌。当日，股票ETF（含跨境ETF，下 ...