Core Insights - The first invasive brain-computer interface (BCI) clinical trial in China is transforming the life of its subject, allowing him to control games using his thoughts, achieving efficiency comparable to that of a typical user with a touchpad [1] - China has become the second country globally, after the United States, to conduct invasive BCI clinical trials, with several metrics surpassing those of Neuralink, founded by Elon Musk [1][2] - The research is a collaboration between the Shanghai Institute of Neuroscience and Fudan University Huashan Hospital, contributing to Shanghai's goal of becoming a global technology innovation hub [1] Technology Comparison - The Shanghai BCI technology features ultra-thin and flexible electrodes, measuring only 1/5 to 1/7 the size of those used by Neuralink, significantly reducing damage to brain tissue [2] - The implanted device is the smallest globally, with a diameter of 26mm and a thickness of less than 6mm, which is half the size of Neuralink's product [2] Surgical Procedure - The surgical procedure for the invasive BCI is less invasive than Neuralink's, requiring only a small groove in the skull rather than penetrating it, making it more patient-friendly [3] Research and Development - The BCI research is led by young scientists who have returned to China, highlighting the importance of domestic talent in advancing this technology [4][5] - The Shanghai Institute has established a micro-nano electronic processing platform, enabling precise fabrication of BCI devices and accelerating research progress [6] Future Developments - The next version of the BCI system, expected by the end of this year or early next year, will feature 256 information transmission channels, four times the current capacity, and a smaller size [7] - Future applications aim to enhance motor control for paralyzed patients and potentially restore speech for those with language impairments [7] Industry Vision - The BCI technology is seen as a foundational technology for human enhancement and human-machine integration, with aspirations for consumer-level applications in the future [8] - Shanghai's "Future Industry Cultivation Action Plan" aims to establish a global innovation hub for BCI products by 2030, reflecting a clear vision for the industry's growth [8]

Core Viewpoint - The article highlights the successful initiation of China's first invasive brain-computer interface (BCI) clinical trial, marking a significant advancement in the field and positioning China as the second country globally to enter this phase after the United States [1]. Group 1: Clinical Trial and Patient Outcomes - The clinical trial involves a male subject who lost all four limbs due to an electric shock accident. Since the implantation of the BCI device in March 2025, the system has operated stably without infections or electrode failures for over a month. The subject achieved functionalities such as playing chess and racing games within 2-3 weeks of training, demonstrating control comparable to that of a typical user with a computer touchpad [1]. - The BCI system is expected to significantly improve the quality of life for patients with complete spinal cord injuries, double upper limb amputations, and amyotrophic lateral sclerosis once it receives approval for registration and market launch [1]. Group 2: Technological Advancements - The BCI system developed by the research teams is noted for having the smallest and most flexible neural electrodes globally, with a cross-sectional area only 1/5 to 1/7 that of Neuralink's electrodes. This design minimizes damage to brain tissue and enhances compatibility with neural interfaces [2]. - The system is the only one in China to have received a registration-type inspection report and can stably collect single-neuron spike signals, providing a solid data foundation for applications [3]. Group 3: Surgical and Operational Efficiency - The implanted device has a diameter of 26mm and a thickness of less than 6mm, making it the smallest brain-controlled implant globally, only half the size of Neuralink's product. This allows for a less invasive surgical procedure, reducing risks and recovery time [3]. - The design of the BCI system is based on principles of neuroscience, allowing for similar control levels to Neuralink with fewer implanted electrodes, thus minimizing patient risk [4]. Group 4: Future Applications - Following successful trials in non-human primates, the project team aims to enable the subject to control a robotic arm for physical tasks such as grasping and holding objects. Future developments may include controlling complex physical devices like robotic dogs and intelligent agents, thereby expanding the subject's capabilities in daily life [4].

Core Viewpoint - The development of brain-computer interface (BCI) technology in China is rapidly advancing, with the country becoming the second globally to enter clinical trials for invasive BCI technology after the United States [1][5]. Group 1: Clinical Trial Progress - The first invasive BCI clinical trial in China has been successfully conducted in collaboration with the Chinese Academy of Sciences and Fudan University Huashan Hospital [1]. - The trial's participant, who lost limbs due to an electrical accident, has demonstrated the ability to control a cursor on a computer and play games within 2-3 weeks of training after the implantation surgery [3]. Group 2: Technology and Innovation - Invasive BCIs are categorized as having the highest technical challenges and barriers, with the only previous clinical trial being conducted by Neuralink [5]. - The Chinese-developed invasive BCI system is coin-sized and features ultra-flexible neural electrodes that are implanted into the brain tissue through minimally invasive surgery, with each electrode having 32 sensors to capture weak neural signals [5]. Group 3: Future Implications - The technology has the potential to significantly improve the quality of life for individuals with disabilities, such as restoring vision, speech, and mobility, as well as providing better interventions for conditions like stroke and Alzheimer's disease [6]. - Furthermore, this cutting-edge technology could revolutionize communication with the external world, enabling not only brain control but also the ability to write information directly into the brain, paving the way for a future of human-machine coexistence [6].

Core Insights - The article highlights the successful initiation of China's first invasive brain-computer interface (BCI) clinical trial, marking a significant advancement in the field, making China the second country after the United States to enter this phase [1] Group 1: Clinical Trial Details - The clinical trial was conducted by the Chinese Academy of Sciences' Brain Science and Intelligent Technology Center in collaboration with Fudan University Huashan Hospital, focusing on a male subject who lost all four limbs due to an electrical accident [1] - The implanted BCI device has shown stable operation since its implantation in March 2025, with no infections or electrode failures reported over a month [1] - The subject achieved functionalities such as playing chess and racing games within 2-3 weeks of training, demonstrating control comparable to that of a typical user with a computer touchpad [1] Group 2: Technological Advancements - The BCI system developed by the Zhao Zhengtuo and Li Xue teams features the world's smallest and most flexible neural electrodes, with a cross-sectional area only 1/5 to 1/7 that of Neuralink's electrodes, and flexibility exceeding Neuralink's by a factor of 100 [2] - This ultra-flexible electrode allows for high-density, large-area, and long-term stable neural signal acquisition, addressing key challenges in tissue compatibility and bandwidth limitations for implanted BCIs [2] Group 3: Surgical and Operational Efficiency - The BCI system is the only one in China with a registered report that can stably capture single-neuron spike signals, providing a solid data foundation for applications [3] - The device's dimensions are 26mm in diameter and less than 6mm in thickness, making it the smallest brain-controlled implant globally, requiring only a small recess in the skull for implantation, thus reducing surgical risks and recovery time [3] - The standardized operational procedures based on mature surgical techniques facilitate scalable applications in various medical institutions [3] Group 4: Future Applications - The BCI system is designed to achieve similar control levels as Neuralink with fewer implanted electrodes, minimizing patient risk while maximizing benefits [5] - Prior to human trials, the system's safety and functionality were validated in non-human primates, where it successfully controlled computer cursor movement through neural activity [5] - Future plans include enabling the subject to control robotic arms for physical tasks, expanding the potential for interaction with complex devices like robotic dogs and intelligent agents [5]

在症状出现5年后，这名男子接受了手术，在控制运动的大脑区域插入256个硅电极，每个长 1.5毫米。论文作者之一、美国加利福尼亚大学戴维斯分校的Maitreyee Wairagkar和同事训 练了深度学习算法，能够每10毫秒捕捉一次大脑中的信号。团队的系统实时解码了该男子试 图发出的声音，而不是他想要表达的具体词语或基本音素——构成单词的语音亚单位。 一名患有严重语言障碍的男子，借助大脑植入装置，能够富有表现力地说话和歌唱。 该装置 可以将他的神经活动转化为话语，不仅能实现语调变化，强调他选择的单词，还能让他以3个 音调哼唱一串音符。 该系统被称为脑机接口（BCI），使用人工智能解码参与者说话时的脑电活动。该装置是第一 个不仅能再现一个人的意图，还能复制自然语言特征的BCI。而音调、音高、重音等自然语言 特征有助于表达意思和情感。 在一项研究中，一种模仿参与者声音的合成声音，在他的神经活动发出说话意图信号的10毫 秒内就说出了他的话。这项6月11日发表于《自然》的研究成果标志着对早期BCI的重大改 进。早期BCI通常在3秒内输出语音，或者仅在用户模拟完整个句子后才能生成语音。 "这是语音BCI领域的圣杯。"荷兰 ...

Core Insights - The global market for brain-computer interfaces (BCIs) in the medical field is projected to reach between $40 billion and $145 billion from 2030 to 2040, indicating significant growth potential [1][6] - China's BCI industry is experiencing a surge in startups, with a notable increase in patent applications and funding events, as well as over a hundred products entering clinical stages [1][6] - Elon Musk's Neuralink has raised $650 million in a new funding round, with a pre-money valuation soaring to $9 billion, reflecting strong market enthusiasm [1] Industry Development - BCIs have evolved from a scientific fantasy to a promising technological innovation, with applications in medical and research fields [2] - The current BCI technology landscape includes non-invasive, semi-invasive, and invasive methods, with invasive techniques showing the most promise for medical applications [2][4] - The establishment of clinical BCI facilities, such as the first BCI clinical ward at Beijing Tiantan Hospital, marks a significant step in applying BCI technology in clinical settings [3] Clinical Advancements - The first closed-loop spinal cord nerve interface surgery in China has been successfully completed, demonstrating significant functional recovery in the patient [3][4] - Clinical trials are underway, with teams aiming to make their BCI devices the first approved implantable medical devices globally [5] Market Trends and Government Support - McKinsey forecasts a substantial market for BCIs in the medical sector, with various regions in China, including Beijing and Shanghai, implementing plans to accelerate BCI product development and clinical trials [6][7] - Policies are being introduced to support the BCI industry, aiming to establish a robust ecosystem and promote the commercialization of innovative products [6][7] Challenges and Future Outlook - The BCI industry faces challenges such as high funding requirements, lengthy clinical validation periods, and the need for improved industry standards and regulations [8][9] - Experts emphasize the importance of collaboration among researchers, clinical institutions, and government to foster innovation and overcome existing barriers [8][9]

Group 1 - The 11th China (Shanghai) International Technology Import and Export Fair focuses on "open cooperation: empowering new quality productivity and sustainable development" and covers the entire chain of the technology trading ecosystem [1] - The fair will highlight "hard technology" and future industries, showcasing nearly a hundred breakthrough achievements in fields such as brain-computer interfaces, embodied intelligence, quantum technology, and synthetic biology [3] - Brain-computer interface (BCI) technology is experiencing significant advancements, moving from laboratory research to clinical applications, marking a critical transition towards commercialization [4][9] Group 2 - The global brain-computer interface market is projected to reach $12.4 billion by 2034, with a compound annual growth rate (CAGR) of 17.4% from 2025 to 2034 [6] - In the domestic market, the BCI market is expected to exceed 3.8 billion yuan by 2025 and surpass 5.5 billion yuan by 2027, maintaining an annual growth rate of around 20% [6] - Companies like Neuralink and Meta are making significant strides in BCI technology, with Neuralink receiving FDA approval for human clinical trials and Meta unveiling a non-invasive wristband prototype [6] Group 3 - WIMI (Micro Beauty Hologram) is a leading BCI company focusing on applications that restore patients' self-care abilities, exploring the integration of BCI with quantum, optoelectronic, and AI technologies [8] - WIMI is actively establishing a long-term development strategy in the BCI field, promoting interdisciplinary collaboration and achieving several cutting-edge results [8] - The company is building a technology innovation platform to accelerate the clinical application of frontier scientific achievements [8]

Core Insights - The Shandong Provincial Science and Technology Department, along with 13 other departments, has launched the "Shandong Province Brain-Computer Interface Industry Technology Innovation Action Plan (2025-2027)" to seize opportunities in the brain-computer interface industry and foster innovation [1][2] Group 1: Action Plan Overview - The action plan aims to achieve breakthroughs in approximately 20 foundational and key core technologies in the field by 2027 [1] - The plan targets the cultivation of around 30 technology-based small and medium-sized enterprises with strong independent innovation capabilities [1] - It seeks to establish 2-3 high-level talent teams and create 1-2 specialized incubation parks in resource-rich areas [1] Group 2: Implementation Actions - The plan includes six major actions focusing on technology innovation to drive industry innovation, with an emphasis on new technologies, products, applications, and business models [1] - It will implement foundational research initiatives to strengthen basic and frontier technology research, particularly in brain science and neuroscience [2] - Key common technology breakthroughs will focus on electrode chip decoding technology to support clinical and industrial applications [2] Group 3: Infrastructure and Ecosystem Development - The action plan emphasizes the construction of innovative platforms for advanced technology research and animal experimentation [2] - It aims to strengthen the cultivation of technology-based enterprises and support the development of innovation clusters in cities like Jinan and Qingdao [2] - The plan will also enhance the industrial standard system, improve review and approval efficiency, and promote clinical trials to build a safe service system [2]

Group 1: AI Applications - The 11th China (Shanghai) International Technology Import and Export Fair showcased deep applications of artificial intelligence (AI) across various sectors, including "AI + consumption," "AI + healthcare," and "AI + commercial security" [6] - A company demonstrated XR glasses that allow users to receive navigation information while walking, integrating with wearable devices for a complete mixed-reality experience, with plans for mass production by the end of the year [6] - A smart retail system by Yunna Technology enables "frictionless payment" through 3D machine vision and AI behavior analysis, already implemented in over 1,000 stores across 30 countries [7] Group 2: Brain-Computer Interface (BCI) Market - Shanghai Shuli Intelligent Technology showcased a multi-modal BCI platform with a 95% accuracy in decoding brain signals, improving recovery outcomes for stroke patients by 30% to 50% compared to traditional methods [8] - McKinsey predicts the global BCI market in healthcare will reach $40 billion by 2030 and exceed $145 billion by 2040, indicating significant growth potential [8] - Hong Kong University displayed a non-invasive BCI technology for treating conditions like Parkinson's and insomnia, with clinical trials for insomnia treatment expected soon [8] Group 3: Medical Technology Innovations - Shanghai Jieti Medical introduced China's first high-throughput wireless invasive BCI system, designed for minimal surgical intervention, offering motor function alternatives for paralyzed patients [9] - A new blockchain vulnerability detection system based on the DeepSeek model was presented, achieving a 94% accuracy in identifying high-risk items, enhancing cybersecurity compliance [10] Group 4: Domestic Manufacturing and Innovation - A company demonstrated a single-cell sorting system that combines AI algorithms with acoustic tweezers, achieving a sorting efficiency 6 to 7 times higher than traditional methods, with a 30% cost reduction compared to foreign brands [11] - The introduction of the THT550 snow traction equipment marks a significant advancement in domestic high-end equipment, reducing reliance on imports and enhancing operational efficiency through AI and navigation systems [12]

Group 1 - The Ministry of Industry and Information Technology has decided to establish three standardization technical committees focused on the Internet of Things, brain-computer interfaces, and civilian explosives [1] - A safety emergency equipment standardization working group will also be formed to enhance safety protocols in relevant industries [1]