12月18日早盘，A股港股市场弱势震荡，医药资产逆市活跃，彰显防御力。 A股市场上，医疗板块延续较强反弹力度，全市场最大医疗ETF（512170）盘中涨超1%上穿年线！民 营医院、AI医疗相关成份股涨幅居前，美年健康两连板，卫宁健康涨超7%。 制药板块个股涨跌分化，中药龙头片仔癀涨超1%，创新药概念股甘李药业、海思科跌1%，全市场唯一 药ETF（562050）水面附近盘整。 值得一提的是，昨日，医疗ETF（512170）日K呈现"一阳包两阴"形态，技术面释放"多空转换"信号！ 今日如能成功收于年线上方，短期趋势有望反转。资金面上，近期部分资金逢跌吸筹，512170近10日累 计吸金超9300万元。 港股医药今日一枝独秀，截至发稿恒指、恒科指均飘绿，创新药龙头多股上涨，百济神州涨超1%，石 药集团涨超3%，创新药含量100%的港股通创新药ETF（520880）盘中直线拉升翻红！ 近期资金连续押注创新药反弹，截至12月17日，520880连续8日获资金净申购，最新基金份额升至41.76 亿份，继续刷新上市以来最高份额纪录！ | | | 分野 多日 1分 5分 15分 30分 60分 · | | | | | F9 ...

Group 1 - The core viewpoint of the article highlights the impact of overseas AI bubble concerns on the Hong Kong stock market, leading to a collective decline in key indices, with the Hang Seng Technology Index dropping over 1% and the Hang Seng Biotechnology Index also experiencing a near 1% decline [1] - The medical and CXO sectors showed activity during the trading session, with companies like MicroPort Medical, MicroPort Robotics, WuXi AppTec, and WuXi Biologics leading the gains, which helped the Hang Seng Biotechnology Index turn positive [1] - Huatai Securities indicated that external disruptive factors for the CXO industry have marginally improved, and with the combination of overseas interest rate cuts, domestic recovery, and industrial upgrades, the industry has entered a new high prosperity cycle [1]

人民财讯12月18日电，华泰证券研报称，CXO行业外部扰动因素已边际改善，伴随海外降息、国内复 苏、叠加产业升级三重驱动，行业已开启新一轮高景气周期。市场部分投资者认为国内CXO企业在新 分子领域的布局优势尚不明显，区别于市场，华泰证券在报告中详细阐述了产业升级对于中国CXO行 业的重要机遇，分析得到多肽、ADC、寡核苷酸等新分子在后续商业化阶段的广阔外包潜力。外需型 CXO已于2024年下半年陆续走出困境，2025年1—3季度订单、收入同比双增，美国降息+新分子订单拉 动下有持续提速潜力；内需型CXO经历2023—2024年集中降价后目前订单端已量增价稳，收入端有望 于2026年起陆续迎来曙光。华泰证券看好CXO板块后续有望迎来业绩与估值的戴维斯双击，推荐外需 型且具备新分子布局优势的龙头。 ...

Core Insights - The report emphasizes the continuous improvement of the global competitiveness of Chinese innovative pharmaceutical companies, focusing on innovation from both "therapeutic areas" and "technology platforms" [5][6] - The growth of commercial health insurance premiums is expected to provide new payment sources for medical expenses, as the scale of commercial health insurance is projected to reach 977.4 billion yuan by 2024 [29][30] - The report identifies potential therapeutic areas such as metabolic diseases (e.g., weight loss), chronic diseases (e.g., hypertension, hyperlipidemia), and central nervous system diseases (e.g., Alzheimer's, Parkinson's) as key focus areas for innovation [5][38] - Emerging technology platforms like small nucleic acid drugs, radioactive drugs (RDC), and CAR-T therapies are highlighted as significant areas for investment [5][38] Market Review - As of November 15, 2025, the pharmaceutical sector has outperformed the market, with the pharmaceutical index rising by 22.09% compared to a 17.62% increase in the CSI 300 index, resulting in a 4.47 percentage point outperformance [11] - The chemical preparation sector showed the best performance, increasing by 40.52%, followed by medical services (+36.98%) and chemical raw materials (+25.34%) [20] - The overall PE valuation of the pharmaceutical sector is at 30.89 times, which is relatively low compared to historical averages, indicating potential for future growth [22][23] Innovative Drugs - The report notes that the growth of health expenditures in China, which reached 9.06 trillion yuan in 2023, is outpacing GDP growth, indicating a robust market for innovative drugs [26][27] - The analysis of multinational corporations (MNCs) reveals that innovation is a core competitive advantage, with companies like Eli Lilly and Novartis showing significant growth driven by innovative products in advanced technology fields such as GLP-1 and ADC [31][32] - The report highlights the strong sales performance of GLP-1 drugs, with Eli Lilly's Mounjaro generating $6.515 billion in revenue in Q3 2025, reflecting a 109% year-on-year increase [44] CXO and Upstream - The report indicates a slight increase in pharmaceutical financing, with a recovery in business development transactions and H-share IPOs, which is expected to stimulate innovation [5] - The demand for external CXO services is growing, particularly in emerging fields such as peptides and small nucleic acids, while internal CXO orders are also showing signs of recovery [5][39] Medical Devices - The domestic medical device market is currently under pressure due to policy impacts, but improvements are anticipated as companies continue to innovate and expand internationally [5] - The report suggests that the industry fundamentals are expected to improve, with a focus on companies like Mindray Medical and Microelectrophysiology [5][39]

Core Viewpoint - The biopharmaceutical sector is expected to experience significant performance divergence among its sub-sectors before the third quarter of 2025, with industry revenue and profit growth rates initially declining before rebounding, as the pressures from high baselines, centralized procurement, and anti-corruption measures have been largely absorbed [1] Group 1: Innovative Drugs - The commercial insurance innovation drug catalog is set to debut in 2025, which is anticipated to drive incremental payments for innovative drug products [2] - The domestic new drug development is accelerating, with lower costs and favorable macro policies, leading to a global leadership position in innovative drug development, contributing approximately one-third of the global innovative R&D pipeline by 2025 [2] - The overseas rights BD transactions are driving the revaluation of innovative drug assets, with a continuous increase in the proportion of Chinese innovative drug license-outs [2] Group 2: CXO and Life Sciences - The CXO market is witnessing improved supply-demand dynamics, with CDMO companies entering a high prosperity cycle due to strong demand for new molecules like ADCs and peptides [2] - The life sciences upstream sector is experiencing a comprehensive recovery in downstream demand, with listed companies actively pursuing mergers and acquisitions to expand [3] Group 3: AI in Healthcare - The "Artificial Intelligence+" policy is leading to widespread applications of AI in healthcare, with significant developments driven by companies like Deepseek [3] Group 4: High-end Medical Equipment - The high-end medical equipment sector is poised for growth due to domestic procurement recovery, import substitution, and accelerated international expansion [3] Group 5: Orthopedic Joint Consumables - The negative impact of centralized procurement is clearing, and the aging population is driving market expansion, with potential growth in surgical robotics [3] Group 6: Traditional Chinese Medicine - There are signs of operational improvement in traditional Chinese medicine, with factors like flu season and basic drug catalog adjustments potentially catalyzing a new market cycle [4]

Investment Rating - The investment rating for the pharmaceutical and biotechnology industry is "Positive" [2]. Core Viewpoints - The recent performance of the pharmaceutical sector has been sluggish, with the innovative drug sector experiencing a significant rise in expectations earlier this year, now undergoing a correction. However, innovative medical devices are expected to benefit from ongoing government support for medical equipment upgrades and accelerated domestic replacement of high-end medical devices, alongside continuous expansion into overseas markets. A recovery is anticipated starting in Q3 2025, with performance gradually improving in 2026 [3][9]. - The high-end medical device sector is driven by the recovery of in-hospital procurement, suggesting a focus on companies such as United Imaging, Shandong Weigao, and Mindray Medical. The demand for consumer medical devices is gradually recovering, with a shift in market share from imported brands, indicating potential in companies like Kefu Medical and Yuyue Medical. The orthopedic consumables market has reached a price floor, with opportunities for market share growth in orthopedic robotics and overseas expansion, highlighting companies like Aikang Medical and Chuangli Medical [3][9]. - The pharmaceutical equipment sector is undergoing a cyclical recovery, with rapid overseas growth opening new avenues for growth. Domestic margins are expected to stabilize and profitability to improve, with a return to rational competition anticipated from late 2024. The recovery in innovative drug financing and frequent business development transactions are expected to drive a revival in contract manufacturing organizations (CMOs), positively impacting the pharmaceutical equipment industry. Additionally, global strategic safety backups and commitments from multinational pharmaceutical companies to invest in the U.S. market are projected to accelerate fixed asset expenditures in the pharmaceutical sector over the next three years, with a focus on companies like Senson International and Dongfulong [3][9]. - In the CXO and upstream life sciences supply chain, leading global CXO companies such as WuXi AppTec and Kanglong Huacheng are highlighted. Domestic clinical CRO leaders like Tigermed and Pruce are also recommended, along with resource-based CXOs such as Zhaoyan New Drug and Mediso. The upstream life sciences supply chain includes companies like Baipusais and Haier Biomedical [3][9]. Summary by Sections Market Performance - The pharmaceutical and biotechnology sector's return was -1.04% last week, ranking 17th among 31 sub-industry indices. The medical services sub-sector had the highest weekly return at 1.67%, while the pharmaceutical commercial sub-sector had a return of -4.26% [3][9]. Industry Trends - The report emphasizes the ongoing low performance of the pharmaceutical sector, particularly in innovative drugs, while highlighting the potential recovery in innovative medical devices and the pharmaceutical equipment sector [3][9]. Recommendations - Specific companies to watch include United Imaging, Mindray Medical, Kefu Medical, and Aikang Medical in the high-end medical device sector, as well as Senson International and WuXi AppTec in the pharmaceutical equipment and CXO sectors [3][9].

12月14日晚间，维亚生物(01873)发布一则公告，宣布全球生物制药公司Swedish Orphan Biovitrum AB(简称"Sobi")已与维亚生物参与投资孵化的Arthrosi达成 收购协议。根据协议条款，本次收购Sobi将支付高达15亿美元的交易总对价，包括9.5亿美元的预付款(需进行惯常调整)以及高达5.5亿美元的监管和商业里程 碑付款。该交易预计于2026年上半年完成。 在该公告中，维亚生物提到，根据本次交易，其预计将获得最高约4000万美元的投资回报，具体金额将取决于后续监管审批及商业化进展等里程碑的达成情 况。而这也为维亚生物股价带来了一次"冲高"的机会。 智通财经APP观察到，12月15日，维亚生物早盘高开，开盘5分钟内公司股价冲到最高2.21港元，涨幅达到13.92%。只是如此高涨的市场情绪仅维持了约10 分钟，随后维亚生物股价涨幅一路收窄，早盘收盘前，公司股价甚至一度跌至"水下"，早盘股价振幅达到14.95%。 连跌2个月，市场更倾向"落袋为安"? 从筹码分布图来看，在股价持续下跌2个月后，维亚生物的筹码获利比例已从10月8日的100%跌至12月12日的24.69%，但筹码平均成 ...

Summary of the Conference Call on the Pharmaceutical Industry Industry Overview - **Industry**: Pharmaceutical Industry - **Rating**: Leading - **2026 Outlook**: Value recovery, upward trend continues, selective layout amidst differentiation [1] Core Insights and Arguments - **Industry Trends**: - The industry is expected to maintain a relatively fast growth rate despite tightening drug regulations and increasing challenges in new drug development in the U.S. [2] - The integration trend within the industry is just beginning, with leading players in high-growth segments showing strong long-term certainty [2] - **Private Hospitals**: - High-quality private hospital targets are recommended as cost control pressures ease and outdated capacities are eliminated, allowing for a return to faster growth [3] - Recommended stocks include Gushengtang and Haijia Medical, which are expected to rebound in the short term and have clear long-term expansion paths [3] - **Valuation Summary**: - A detailed table of various pharmaceutical companies with their stock codes, ratings, target prices, closing prices, earnings per share (EPS), price-to-earnings ratios (P/E), and other financial metrics is provided [4] Important but Overlooked Content - **Market Performance**: - The MSCI China Pharmaceutical Index increased by 62.0% year-to-date, outperforming the MSCI China Index by 31.8 percentage points [10] - The pharmaceutical sector has officially entered a rebound phase, with significant performance differentiation among sub-sectors [10] - **Policy Environment**: - The policy environment is improving, with the government supporting innovative drug development and introducing commercial insurance funds to supplement the medical insurance directory [11] - The latest round of medical insurance negotiations has successfully included 127 drugs outside the directory, indicating a shift towards a more balanced pricing strategy [11] - **Innovation and R&D**: - The industry is witnessing a positive cycle of R&D breakthroughs and global licensing, with many companies entering a "R&D investment - clinical breakthrough - global licensing" cycle [11] - As of September 2025, Chinese pharmaceutical companies have completed 103 overseas transactions, exceeding 77% of the total transaction amount for 2024 [11] - **Financial Performance**: - The overall revenue of the A-share pharmaceutical sector showed a marginal recovery in Q3 2025, with a 0.7% year-on-year increase, indicating strong operational resilience [17] - The sector's earnings growth expectations are improving, with leading companies showing rapid recovery in performance [11][20] - **Investment Opportunities**: - The report emphasizes two main investment lines: focusing on innovative companies with strong differentiation and product export potential, and capitalizing on the recovery of valuation multiples and earnings growth [32][34] - Specific recommendations include companies like Sanofi Pharmaceutical, Deqi Pharmaceutical, and Baiji Shenzhou, which have rich catalysts and are still undervalued [35] - **AI in Healthcare**: - The application of AI in healthcare is highlighted as a new theme for industry innovation, with significant market expansion potential [33] - **Future Outlook**: - The pharmaceutical industry is expected to maintain a stable upward trend in 2026, with a focus on fundamental performance and valuation [30] - The introduction of the commercial insurance innovative drug directory and ongoing policy reforms are anticipated to further enhance market sentiment and fundamental expectations [37]

Investment Rating - The industry rating is "Outperform the Market" [7][76] Core Insights - The report emphasizes the importance of external demand-driven CXO investment opportunities due to the recent interest rate cuts by the Federal Reserve and the elimination of policy uncertainties related to the new Biosecurity Act [4][29] - The report highlights a mixed performance in the pharmaceutical sector, with a notable focus on innovative drugs and medical devices as key investment areas for the upcoming year [5][34] Summary by Sections Market Review - The CITIC Pharmaceutical Index fell by 1.1% during the week of December 8-12, 2025, underperforming the CSI 300 Index by 1.0 percentage points, ranking 15th among CITIC's primary industry classifications [3][34] - Year-to-date, the CITIC Pharmaceutical Biotech Index has risen by 15.6%, still underperforming the CSI 300 Index by 0.8 percentage points, ranking 16th [3][34] - Top-performing stocks for the week included Zhaoyan New Drug (+23.4%), Hotgen Biotech (+16.8%), and Haichuang Pharmaceutical (+13.9%) [3][53] Investment Opportunities - The Federal Reserve's recent interest rate cut is expected to improve overseas biotech investment and financing conditions, which will benefit CDMO (Contract Development and Manufacturing Organization) orders [4][21] - The new Biosecurity Act, which has passed the House and is awaiting Senate approval, is expected to have a limited impact on external demand for CXO companies, alleviating valuation pressures in the sector [4][28] Sector Performance - The pharmaceutical sector's overall valuation as of December 12, 2025, is 28.79, reflecting a slight decrease of 0.17, with a relative valuation premium of 12.02% compared to the broader market [44] - The total trading volume for the pharmaceutical sector during the week was 423.43 billion, accounting for 4.3% of the total A-share trading volume, with a 3.9% increase from the previous week [50][53]

行 业 研 究 医药生物 2025 年 12 月 14 日 生物安全法案出现积极变化，重视 CXO 机会！ 投资要点： 行 业 定 期 报 告 行情回顾：本周（2025 年 12 月 8 日- 2025 年 12 月 12 日）中信医药指 数下跌 1.1%，跑输沪深 300 指数 1.0 pct，在中信一级行业分类中排名第 15 位；2025 年初至今中信医药生物板块指数上涨 15.6%，跑输沪深 300 指数 0.8 pct，在中信行业分类中排名第 16 位。本周涨幅前五的个股为：昭衍新 药（+23.4%）、热景生物（+16.8%）、海创药业（+13.9%）、万泽股份（+13.4%）、 重药控股（+13%）。 降息落地及政策不确定性消除，重视外需型 CXO 投资机会：（1）美联 储 12 月降息如期落地，26 年预期再降 25 个基点。从海外生物科技一级市 场（PE/VC）投融资情况来看，25Q2-Q3 环比 25Q1 有所波动，我们认为主 要系美联储降息预期有所延后所致。随着美联储降息继续落地，海外生物 科技的一级市场投融资金额有望持续改善，带动 CDMO 的海外订单需求持 续回暖。（2）新版《生物安全法 ...