Core Insights - The Waigaoqiao Group has launched the "Brain-Computer Interface Innovation Development Partnership Program" to enhance its position in the brain-computer interface (BCI) sector, aiming to become a preferred "landing point" and "accelerator" for BCI innovations [1] Group 1: Partnership Program Details - The partnership program aims to unite enterprises, hospitals, and government departments to collaboratively build an innovative ecosystem that addresses bottlenecks in clinical transformation, cross-border data, and market access for BCI technology [1] - Participating companies will receive the "Waigaoqiao Brain-Computer Interface Product Service Package," which includes comprehensive support from cross-border R&D pilot projects to clinical approval acceleration and market expansion [1] - Initial participants will also benefit from preferential support in terms of space and guidance on relevant industrial policies provided by the Waigaoqiao Group [2] Group 2: Industry Context and Developments - The BCI sector is on the verge of transitioning from laboratory research to clinical application, with companies aiming to establish a full-service capability from R&D to market entry to capture future industry opportunities [2] - Recently, Ladder Medical's "Implantable Wireless Brain-Computer Interface System" has entered the special review process by the National Medical Products Administration, marking a significant milestone for invasive BCI products in China [2] - Ladder Medical has developed the world's smallest brain-controlled implant and is progressing towards full domestic production, collaborating with Fudan University Huashan Hospital for prospective clinical trials [2] Group 3: Strategic Advantages - The development of BCI technology relies heavily on interdisciplinary collaboration, cross-border R&D, and international cooperation, which aligns with Waigaoqiao's strategic advantages [3] - Waigaoqiao offers "bonded R&D" policy functions and serves as a hub connecting domestic and international markets, facilitating data cross-border and personnel movement [3] - The company provides comprehensive policy adaptation services for BCI enterprises, covering the entire process from clinical trials to overseas registration [4]

Core Insights - The article discusses the successful implantation of a brain-computer interface (BCI) in a spinal cord injury patient in China, marking a significant advancement in the clinical application of BCI technology [3][4] - This procedure is the first in China to be executed under a government-approved medical service pricing system, indicating a shift from research to standardized medical practice for BCI [3][4] Group 1: Clinical Application of BCI - The first invasive BCI surgery in China was performed on a 31-year-old patient, who suffered from high-level paraplegia due to an accident, using a device with 64-channel flexible electrodes to monitor brain signals [3] - The surgery was conducted at Huazhong University of Science and Technology's Tongji Hospital, with the procedure costing 6,552 yuan per instance, excluding the cost of the BCI device [3][4] Group 2: Policy and Regulatory Framework - In March 2023, the Hubei Provincial Medical Insurance Bureau established the first national pricing for BCI medical services, setting the invasive BCI implantation fee at 6,552 yuan per instance [4] - The implementation of this pricing policy is seen as a crucial step in integrating BCI technology into the standardized medical treatment system, paving the way for broader clinical applications in the future [4]

Core Insights - The first clinical implantation of a brain-computer interface (BCI) in China was successfully completed at Huazhong University of Science and Technology Tongji Hospital, marking a significant step in the commercialization and accessibility of BCI technology [1][2] - The procedure is the first to be executed under a government-approved medical service pricing project, indicating a shift from research to clinical application [2][3] Group 1: Clinical Implementation - The surgery was performed on a 31-year-old patient with spinal cord injury, utilizing a BCI device with 64-channel flexible electrodes to monitor brain signals related to hand movement and sensation [1][2] - The operation was funded by research grants, as BCI technology is still in the clinical trial phase and has not yet entered market application [2] Group 2: Policy and Pricing - In March 2025, Hubei Province will implement the first national pricing project for BCI medical services, establishing fees for invasive and non-invasive procedures [2] - The invasive BCI implantation fee is set at 6,552 yuan per procedure, with additional fees for extraction and non-invasive adaptation, providing a regulatory framework for clinical application [2] Group 3: Future Implications - The successful execution of this surgery is seen as a foundational step for future large-scale clinical applications of BCI technology, establishing a critical institutional basis for subsequent healthcare reimbursements [3]

Event Overview - The Fifth Brain Science Frontier and Industry Conference will be held in Shenzhen from December 28 to 29, 2025, focusing on brain science, technology, health, intelligence, diseases, and rehabilitation [1] Industry and Policy Trends - The brain-machine interface industry is entering a phase of resonance between industry and policy, with significant government support [3] - In July, a joint opinion was released by seven departments, including the Ministry of Industry and Information Technology, to promote innovation in the brain-machine interface industry [3] - The brain-machine interface has been included as one of the six major directions in the national strategic plan for future industries [3] - In June, China became the second country globally to enter the clinical trial phase for invasive brain-machine interface technology [3] - The "North Brain No. 1" GCP multi-center clinical trial was launched in October, marking a significant advancement in semi-invasive brain-machine systems [3] Market Potential - According to McKinsey, the global market for brain-machine interfaces in the medical application sector is expected to reach $40 billion by 2030 and exceed $145 billion by 2040 [5] - By 2027, breakthroughs in key technologies for brain-machine interfaces are anticipated, establishing advanced technical, industrial, and standard systems [5] Investment Landscape - Current investment events in China's brain-machine interface industry are primarily concentrated in the A round and earlier, with the highest number of angel round investments [3] - Over half of the funding is directed towards invasive overall solutions, followed by brain-like chips and non-invasive brain-machine interface solutions [3] Stock Performance - The stock of leading innovative medical companies has seen a rise of over 65% in the eight trading days following the release of the government opinion [5] Related Stocks - A list of relevant stocks in the industry has been compiled by Zhongyou Securities [7]

Core Viewpoint - The article discusses how technology is transforming the support for disabled individuals from a model based on humanitarian aid to one that systematically addresses their core challenges through advanced technology, particularly focusing on brain-computer interface (BCI) and smart prosthetics [2][6]. Group 1: Technological Innovations - Strong Brain Technology is a leading company in non-invasive brain-computer interface technology, which helps individuals with autism communicate with the outside world and assists physically disabled individuals through smart prosthetics [2][6]. - The smart prosthetics developed by Strong Brain Technology, such as the bionic hand and the lightweight M3 bionic leg, utilize AI algorithms to interpret muscle and nerve signals, enabling users to perform various tasks with precision and ease [4][5]. - The bionic hand can perform complex movements, including playing the piano and climbing, while the M3 bionic leg adapts in real-time to the user's movements, providing a natural walking experience [4][5]. Group 2: Social Impact and Accessibility - Strong Brain Technology aims to expand its impact from individual improvements to societal norms through ongoing public welfare collaborations and product innovations [2][8]. - The company has partnered with various organizations to provide free or low-cost smart prosthetics to disabled individuals, enhancing their quality of life and enabling them to participate actively in society [7][8]. - A recent initiative in Zhejiang Province, supported by local organizations, has successfully provided smart prosthetics to 400 individuals, demonstrating the positive social response to such technology-driven projects [8]. Group 3: Future Directions - Strong Brain Technology plans to continue upgrading its smart prosthetics in terms of functionality, comfort, and cost-effectiveness, aiming to make them more accessible to a broader range of users [8]. - The company is also focusing on expanding its offerings in brain disease rehabilitation, particularly for autism and cognitive recovery in older adults, to cover the entire lifecycle of care from rehabilitation to prevention [8].

Core Insights - The first clinical application of invasive brain-computer interface (BCI) in China has been successfully performed, marking a new phase in the country's BCI development [1] - The procedure was conducted at Huazhong University of Science and Technology's Tongji Hospital, with a government-approved service price of 6552 yuan per procedure, excluding the cost of the BCI device [1][5] - This development signifies the transition of BCI technology from research to a standardized medical service, paving the way for broader accessibility and industrialization [1][5] Summary by Sections - **Clinical Application**: The first invasive BCI surgery was performed on a 31-year-old patient with spinal cord injury, demonstrating the potential of BCI technology in clinical settings [1] - **Cost Structure**: The established cost for the invasive BCI procedure is 6552 yuan per session, which is a significant step towards integrating BCI into the healthcare payment system [5] - **Regulatory Framework**: The implementation of a standardized pricing model for BCI procedures by the Hubei Provincial Medical Insurance Bureau is a pioneering move that facilitates the inclusion of BCI in regular medical services [5] - **Future Implications**: The successful surgery and its regulatory backing are expected to lay a crucial foundation for the large-scale clinical application of BCI technology in the future [5]

Industry Overview - The year 2025 is regarded as the "year of brain-computer interfaces" in China, with significant policy support and investment activity in the sector [1][2] - The "14th Five-Year Plan" has identified brain-computer interfaces as one of the six key future industries for strategic development [4] Policy Support - In July, multiple government departments released implementation opinions to promote innovation and development in the brain-computer interface industry, setting clear development timelines [3] - By 2027, breakthroughs in key technologies are expected, with the establishment of advanced technical, industrial, and standard systems [3] - By 2030, the industry aims to enhance innovation capabilities and cultivate globally influential leading enterprises [3] Investment Landscape - As of November, the brain-computer interface sector in China has completed 28 financing rounds, totaling over 5 billion yuan [1] - The brain-computer interface concept index (8841700.WI) has seen a 50.74% increase over the past year, outperforming the Shanghai and Shenzhen 300 index, which rose by 17.64% [1] Company Developments - A total of 24 companies in the A-share market are involved in the brain-computer interface sector, with average revenues of 3.428 billion yuan and average net profits of 431 million yuan in the first three quarters [8] - However, there is significant variance in performance, with 8 companies reporting losses and 11 companies with net profits below 100 million yuan [10] - Companies like Mindray Medical and 37 Interactive Entertainment reported net profits exceeding 1 billion yuan [10] Clinical Advancements - In June, China became the second country globally to conduct invasive clinical trials for brain-computer interfaces, marking a significant milestone in the field [6] - The "North Brain No. 1" GCP multi-center clinical trial was launched in October, representing the first high-throughput, wireless, fully implanted semi-invasive brain-computer system [7] Market Potential - The brain-computer interface industry is expected to grow rapidly, with companies like Lepu Medical and Meihua Medical actively pursuing commercialization of their products [10][11] - Lepu Medical is working on deep brain stimulation devices, while Meihua Medical collaborates with global cochlear implant leaders to develop invasive brain-computer interface products [10][11] - Aipeng Medical has received approval for its EEG collection products and is focusing on ADHD treatment solutions, with new pricing policies being introduced for brain-computer interface services [11]

Group 1 - The 10th insurance private equity fund, Yangguang and Yuan private securities investment fund, has begun operations after being registered with the China Fund Industry Association, marking a significant step in the long-term investment trial for insurance funds with an approved scale of 20 billion yuan [1] - The Ministry of Industry and Information Technology and five other departments have issued a plan to promote the orderly development of platform consumption and new business formats such as live e-commerce, encouraging the use of AI and other technologies to enhance consumer experiences [2] - The same departments have also outlined plans to expand low-altitude tourism and aviation sports, promoting diverse interest consumption products while ensuring safety [3] Group 2 - Morgan Stanley's chief equity strategist for China expressed confidence in the continued inflow of funds into the Chinese market, suggesting that significant fiscal policy adjustments could lead to a more positive outlook [4] - Paradromics, a US brain-computer interface company, has received FDA approval for its first long-term clinical trial, which aims to explore the ability to detect neural activity related to imagined hand movements [5] - Novo Nordisk announced that the European Commission has approved its Kyinsu product, the world's first weekly insulin and GLP-1 receptor agonist combination for adults with type 2 diabetes [6] Group 3 - The Chinese Center for Disease Control reported that the country has entered a rapid rise phase of influenza, with the highest proportion of flu-like cases in four years, particularly noting a higher incidence in northern provinces [7] - OpenAI projects that the number of paid subscribers for ChatGPT will exceed 220 million within five years, potentially generating nearly 200 billion dollars in annual revenue [8] - A former member of Tesla's Optimus team has joined Xiaomi's robotics team to accelerate the development of dexterous hand technology [9] - Dongfeng has delivered its first Mach Power 2.0T engine designed for low-altitude flight scenarios, which is based on a vehicle engine and has a power-to-weight ratio of 1.87 kW/kg, aimed at large drones and logistics aircraft [10]

编辑丨王多鱼 排版丨水成文 慢性脑生理信号监测器件有助于及时诊断和治疗发作性或复发性神经系统疾病。与传统无源金属电极相比，有源薄膜晶体管可提供微弱脑电信号的提取放大降噪 优势、提高采集信噪比。单晶硅纳米薄膜是一种超薄二维材料，由于其具备完美晶格对称性与高电子迁移率 （ 10 cm /V·s） ，具有广泛应用前景。基于 硅基- 碳基界面 的高密度集成晶体管阵列有望带来新一轮变革性突破，可实现高密度、高保真度、高信噪比的脑信号长效记录。 尽管有源器件在脑电监测方面取得了重大进展，诊断/治疗神经系统疾病通常需要多模态参数的综合监测，特别是像癫痫、肿瘤这些慢性神经疾病经常涉及脑皮层 温度异常等现象，甚至需要光遗传学等手段进行干预。然而，目前对植入式神经电、热和光模态的综合监测仍然较少报道，大多局限于单模态的脑信号传感，无 法满足当前神经动力学研究日益增长的需求。 近日，复旦大学 宋恩名 、 张荣君 课题组联合 提出了一种 硅基 -碳基组织界面 的 多模态脑机 接口系统 ，该系统支持 实时连续监测 脑 电、热和光动力信号 。 系统的 材料和结构设计基于 单晶硅 有源器 件 和用于 微弱脑信号的 电容耦合机制 （信噪比 ...

Core Insights - Brain-computer interface (BCI) technology is advancing, enabling applications from medical rehabilitation to consumer products, unlocking the potential of the brain [1] - Researchers have developed brain-like tissues that can process simple problems and communicate intentions through BCIs, indicating significant advancements in mixed intelligence and brain-like intelligence [1] - The Chinese government is actively promoting the BCI industry, with a projected market size exceeding 3.8 billion yuan by 2025, supported by policies from various departments and local governments [1] Industry Development - The Ministry of Industry and Information Technology and six other departments have issued implementation opinions to drive innovation in the BCI industry [1] - Major cities like Beijing and Shanghai have launched specific action plans to support the development of the BCI sector [1] - A preliminary industrial chain has been established in China, covering upstream components like electrodes and chips, midstream algorithms and software, and downstream applications in healthcare, wellness, and entertainment [1]