Core Viewpoint - The prevalence of Parkinson's disease is increasing, closely linked to population aging and the rise of neurodegenerative diseases like Alzheimer's and Parkinson's [1][3]. Group 1: Understanding Parkinson's Disease - The understanding of Parkinson's disease has evolved significantly over the past 31 years, particularly with the introduction of PET imaging agents that allow for the visualization of dopamine transporters in the brain [3][4]. - The core issue in Parkinson's disease is the loss of dopamine neurons, which leads to symptoms such as tremors, slowness, and stiffness [3][15]. - Tremors are commonly associated with Parkinson's disease, but not all patients exhibit this symptom; slowness is considered the most critical feature for diagnosis [6][8]. Group 2: Diagnosis and Symptoms - Objective tests, particularly PET imaging, are emphasized for accurate diagnosis, as Parkinson's disease symptoms can be subtle and difficult to assess [4][5]. - Key symptoms include slowness, stiffness, and tremors, with slowness being a necessary condition for diagnosis [7][8]. - Distinguishing between age-related slowness and slowness due to Parkinson's is crucial, as they present differently [10][13]. Group 3: Treatment Options - Standard treatment primarily involves medication, particularly dopamine precursors like levodopa, which can improve symptoms significantly [18][19]. - Long-term use of medication may lead to diminished effectiveness, but it is essential for maintaining quality of life [20][22]. - Surgical options, such as Deep Brain Stimulation (DBS), are available for patients who do not respond adequately to medication [23][24]. Group 4: Research and Future Directions - Research is ongoing into the role of alpha-synuclein protein aggregation in Parkinson's disease, with new imaging agents being developed to monitor this process [15][17]. - There is potential for stem cell therapy, but it remains in the clinical trial phase and requires careful evaluation [27][28]. - Preventive measures include lifestyle changes such as exercise and dietary adjustments, which may help reduce the risk of developing Parkinson's disease [32].

他是马斯克和乔布斯共同的导师，他读了三所大学没有拿到过一张文凭，但是最后却成为一个年入18亿 美金的CEO，他会不惜一切代价来获胜，无论任何事情他不会愿意屈居第二。除了事业成功之外，他还 有全球最快的车、2亿美元的豪宅、全球最快的帆船，他就是拉里·埃里森——甲骨文公司的创始人。 ...

Core Insights - The article emphasizes the importance of avoiding certain behaviors and mindsets that lead to financial and personal dissatisfaction, rather than providing direct advice on how to achieve happiness or financial success. Group 1: Financial Missteps - Focusing on a higher socioeconomic group as a source of happiness can lead to dissatisfaction, as the current group was once the target of aspirations [2] - Sacrificing independence for status can result in a lack of personal freedom, which is essential for true happiness [3] - Making money and spending money the core of one's identity detracts from building a fulfilling life [4] - Relying heavily on others for financial stability can lead to vulnerability and dissatisfaction [5] - Believing that more money will solve all problems can create unrealistic expectations and lead to disappointment [5] - Viewing money solely as a source of greed and evil ignores its potential as a tool for independence and comfort [6] - Extreme saving without enjoying life can turn financial management into a hobby rather than a means to improve life [7] Group 2: Psychological Traps - Attributing all personal success to effort while blaming failures on bad luck creates a distorted self-perception [8] - Comparing oneself to others can lead to envy and dissatisfaction, as external appearances do not reflect true happiness [9] - Ignoring the social and emotional costs of spending can lead to poor financial decisions [10] - Being unaware of regret tendencies can result in a life filled with missed opportunities [11] - Equating net worth with self-worth can lead to a misguided understanding of success [12] - Treating financial decisions as purely mathematical ignores emotional and experiential needs [13] - Following the lifestyle expectations of the most successful people can create a perpetual sense of inadequacy [14] - Overly optimistic expectations can lead to dissatisfaction when reality does not meet those expectations [15] - Risking essential needs for unnecessary wants can lead to significant personal loss [16] Group 3: Strategies for Improvement - Experimenting with various spending methods within budget can help identify what truly adds value [11] - Being influenced by advertising can lead to dissatisfaction with one's life [12] - Learning to quickly reject unsuitable options is more important than knowing what to buy [13] - Acknowledging what does not work for oneself is a sign of making progress in financial decisions [14] - Long-term wealth accumulation is more about small, consistent decisions rather than major ones [15]

Core Points - The Chinese Ministry of Commerce announced countermeasures against five U.S. subsidiaries of Hanwha Ocean Co., Ltd. due to their involvement in supporting U.S. government investigations, which allegedly threaten China's sovereignty and security [1][3]. Group 1: Market Reaction - Following the announcement, Hanwha's stock price fell sharply, with a maximum decline of 9% before closing down 5.8%. The South Korean benchmark index also dropped by 0.6% during the same trading session [2]. Group 2: Company Background - Hanwha Group, originally founded as Korea Explosives Co. in 1952, has evolved into a major conglomerate, with significant expansions through acquisitions and diversification into various sectors, including defense and aerospace [4][10][12]. - Hanwha Ocean, the second-largest shipbuilding company globally, was formed from the acquisition of Daewoo Shipbuilding & Marine Engineering, which faced financial difficulties before restructuring [13][12]. Group 3: Strategic Developments - Hanwha Ocean has established a global production network across Eastern Europe, the Middle East, East Asia, and the Americas, and is involved in the construction of advanced naval vessels, including LNG carriers and submarines [23][14]. - The company has recently made significant investments in the U.S., including the acquisition of the Philadelphia Shipyard, which is part of a broader strategy to integrate into the U.S. military-industrial complex [28][43]. Group 4: Implications of Sanctions - The sanctions specifically target Hanwha's U.S. operations, which are relatively new or inactive, suggesting that the immediate business impact may be limited. However, the sanctions serve broader strategic purposes, including reinforcing U.S. supply chains and limiting Hanwha's integration into Chinese markets [34][37]. - The sanctions may also create competitive advantages for other South Korean conglomerates, such as HD Hyundai, which are vying for U.S. defense contracts [39][41]. Group 5: Future Outlook - Hanwha Ocean's ongoing projects, including a $5 billion investment to enhance shipbuilding capacity at the Philadelphia Shipyard, indicate a commitment to expanding its role in U.S. defense logistics and ship maintenance [43][42]. - The geopolitical landscape suggests that South Korean companies may face increasing pressure to choose between U.S. and Chinese markets, impacting their strategic decisions moving forward [45][46].

首富换人可不单单是排名的变化，还是一个时代的信号。 ...

Core Insights - Chinese capital once surged into Bordeaux, making wine estates a symbol of wealth and taste, but the reality has turned grim over the years [1][3][14] Group 1: Investment Trends - Since 2008, Chinese investors have purchased approximately 150 Bordeaux estates, which represent a minuscule portion of the Bordeaux region, yet their symbolic significance exceeds economic value [2][16] - The initial enthusiasm for investing in Bordeaux wine estates has diminished, with reports of low-priced sales, asset seizures, and debt issues among Chinese owners [3][17] Group 2: Case Studies - The Latour Laguens estate, owned by Chinese investor Cheng Haiyan, is listed for sale at a starting price of €150,000 (approximately 1.25 million RMB), highlighting the decline in value of such investments [4] - Cheng Haiyan's attempts to transform the estate into a resort with wine tasting rooms and accommodations involved over 10 million RMB in investments, but ultimately failed due to poor business performance [6][7] Group 3: Cultural and Operational Challenges - Many Chinese investors have struggled with the traditional operational models of French wine estates, often underestimating the costs and time required for profitability [26] - Cultural clashes have also been evident, as seen in the controversial renaming of estates by Chinese investors, which sparked protests and backlash from local officials and cultural commentators [11][12] Group 4: Market Dynamics - The demand for Bordeaux wine in China has halved since 2017, with exports dropping to about 40 million bottles annually, down from a peak of 80 million [17][18] - The overall Chinese wine market is experiencing a cooling period, with significant declines in wine imports and a shift in consumer preferences towards other alcoholic beverages [18][21] Group 5: Future Outlook - Despite the exit of some investors, a new wave of younger, internationally experienced Chinese buyers is beginning to enter the Bordeaux market, aiming to integrate wine estates with tourism and outdoor activities [27]

本文来自微信公众号：毛豆吃不腻，作者：毛豆吃不腻，题图来自：AI生成 不瞒大家说，我可能是出来工作久了，在家呆的时间太少了。 我总自以为见过更多光鲜亮丽的生活，也在有些规模的公司里谋生，不知不觉我的眼光高了，也有点不自量力了。 我不知天高地厚地认为，我们小镇上做生意的小老板们，都是斤斤计较，鼠目寸光的。 我小时候，总是看到一些老板们为了一点点蝇头小利，和别人争得面红耳赤，没有一点长远发展的眼光。 可这次国庆回家，我妈带我去榨花生油，我有了很大的改观。 作者供图 一 我们老家很喜欢吃榨的花生油。 先不说卫生和有无害的问题吧，反正我们那里的都会去榨点来吃。 我们镇上有好几家榨油的作坊，生意都挺不错。 那天，我妈带着我绕了好几家都人满为患，最后找了家店面较大，老板也年轻热情的作坊榨油。 在等待榨油的过程中，我百般无聊地玩玩手机，又到处观察这个店。 这家店面积挺大的，堆满了一袋一袋的花生，在店的一个小角落里，又堆了很多快递盒，老板娘正在埋头打包。 100斤的花生米，能榨出46斤左右的花生油来，不过实际有多少，我也没称。 花生榨油时，会产生花生渣，俗称花生粕，我们的家乡话好像叫麸。 作者供图 这个又可能拿来卖，别人收了 ...

Core Points - The rise of AI-generated digital hosts in the fashion live-streaming industry has led to concerns about authenticity and consumer trust [4][21][32] - Consumers are increasingly frustrated with the disconnect between live-streamed presentations and the actual products received, exacerbated by the use of virtual hosts [5][36][56] Group 1: AI Hosts in Fashion Live-Streaming - AI-generated digital hosts have infiltrated fashion live-streaming, raising questions about the authenticity of the shopping experience [4][21] - Many well-known fashion brands have adopted virtual hosts, often without consumers noticing the subtle indications of AI involvement [22][24] - The ability of AI hosts to operate continuously without breaks makes them appealing to brands seeking to maximize live-streaming hours [26][27] Group 2: Consumer Experience and Expectations - Consumers expect a realistic shopping experience akin to physical stores, where live hosts provide detailed product insights and personal interactions [38][52] - The lack of genuine interaction and emotional connection from AI hosts leads to dissatisfaction among consumers who value the human touch in shopping [57] - Many consumers feel that the introduction of AI hosts has diminished the quality of product representation, making it harder to find satisfactory clothing [36][56] Group 3: Economic Implications for Brands - The cost-effectiveness of AI hosts is significant, with reports indicating that AI-generated content can reduce visual content production costs by over 90% [48] - AI hosts can generate substantial sales, achieving up to 70% of the sales volume of human hosts while costing less than 10% of their expenses [28][30] - The shift towards AI in live-streaming reflects a broader trend in the fashion industry towards efficiency and cost reduction, often at the expense of consumer experience [55]

张雪峰老师可能真的走到头了，9月底张雪峰全平台总共超过6000万粉丝的主号，一夜之间被禁止关注 了，基本上就等于"赛博入狱"了。很多人问张雪峰到底犯了什么忌讳，他一个为民请命，帮助千万学子 改变命运的正能量导师人设怎么就被点名了呢？ ...

这个神话的第一个桥段，叫做"最初的匮乏"。全世界的历史教科书里面都有一个"原始人"的形象：以采 摘和狩猎为生的旧石器时代的人类，因为技术低下，不会生产，而不得不为了填饱肚子终日觅食，即使 如此，也有上顿没下顿，更不要说有什么储备或者富余了。这种原始经济被冠以"维生经 济"（subsistence economy）的称呼。 而当代的"去增长"呼声之所以会越来越大，是因为有一些继承了卢梭一身反骨的进步怀疑论者，提出了 一个更激进的问题：我们认为可以为之牺牲很多东西的那个"增长"是真正意义上的增长吗？我们以为财 富在增长的时候，它真的在增长吗？ ta们提出了一个惊世骇俗的观点：我们之所以能算出不断增长的财富，是因为我们没有减去这件事情需 要付出的代价。而这并不是出于疏忽或者认知上面的不足，这是进步观得以建立的一个先决条件——我 们选择不做减法，才可以保证财富增长。 这样的情况下，财富的增长是一个伪装成事实的神话。 01. 原始人比现代人更"匮乏"吗？ 大家有没有想过一个问题：经济发展一定是一件好事吗？ 很多人都听说过"负增长"的说法，那么"去增长"呢？对于今天世界上大多数人来说，负增长（negative growt ...