Core Viewpoint - The innovative drug sector in A-shares has experienced significant value reassessment in 2023, with the innovative drug index rising over 70% year-to-date, driven by favorable policies and major transactions in the industry [3][4]. Group 1: Market Performance - On July 28, 2023, Heng Rui Medicine announced a potential deal worth $12 billion (approximately 86 billion RMB) with GlaxoSmithKline, leading to a surge in its stock price, which hit a four-year high with a market cap of 411.8 billion RMB [3]. - The innovative drug sector saw a collective increase of over 3% on the same day, reflecting strong investor sentiment [3]. Group 2: Policy Support - The National Healthcare Security Administration and the National Health Commission released measures on July 1, 2023, to support the high-quality development of innovative drugs, including the establishment of a diversified payment system and improving accessibility [3]. - A press conference on July 24, 2023, indicated a shift in drug procurement policies, moving away from a simple lowest price reference to promote healthier industry development [3]. Group 3: Fund Performance - All 265 innovative drug-themed funds reported positive returns in 2023, with 152 funds achieving returns over 30%, and the highest return exceeding 80% [4]. - The top-performing fund in the 1 million to 10 million RMB category is the Hua Bao Health Mixed A fund, with a return of 82.55% year-to-date [5][6]. - In the 1 billion to 5 billion RMB category, the Chang Cheng Health Mixed A fund led with a return of 74.64% [7]. - The Peng Hua Medical Technology Stock A fund topped the 5 billion to 20 billion RMB category with a return of 81.85% [8][9]. - The top fund in the 20 billion RMB and above category is the Zhong Ou Medical Innovation Stock A fund, achieving a return of 58.65% [10][11].

Group 1 - The core viewpoint is that the large patient base for COPD and the limitations of traditional treatment options create a significant opportunity for innovative therapies, which are expected to reshape the treatment landscape and generate substantial market growth [1][2]. - COPD is a prevalent chronic disease in China, affecting approximately 100 million people, and is the third leading cause of death in 2021, highlighting the urgent need for better treatment options [1]. - The current awareness and standardized treatment rates for COPD in China are low, with only 0.9% awareness and 4.5% lung function testing rates, indicating a significant opportunity for improvement in diagnosis and treatment [1]. Group 2 - Recent approvals of innovative therapies, such as ensifentrine and dupilumab, have broken the long-standing absence of new mechanism drugs in the COPD field, leading to an accelerated iteration of treatment options [2]. - The FDA approved ensifentrine in June 2024 as the first new mechanism inhalation product for COPD maintenance treatment in over 20 years, representing a significant advancement in therapy [2]. - Merck's acquisition of Verona for approximately $10 billion underscores the value of innovative COPD treatments and the potential for further market expansion [2]. Group 3 - Chinese innovative pharmaceutical companies are actively developing key targets for COPD treatment, with notable progress in the PDE3/4 inhibitor space, exemplified by companies like Hengrui Medicine and China Biologic Products [3]. - Hengrui Medicine's innovative drug HRS-9821 has entered a collaboration agreement with GSK, which includes a $500 million upfront payment and a potential total deal value of around $12 billion, highlighting the global recognition of Chinese innovation [3]. - The ongoing development of various innovative pipelines in the COPD sector indicates a promising future for Chinese companies in securing external licensing opportunities [3].

医疗板块器械、CXO齐发力，迈瑞医疗大涨超4%，药明康德续涨逾2%。A股最大医疗ETF（512170） 盘中涨逾1%，价格创2024年11月13日以来新高，实时成交超5亿元。今日有望实现日线11连阳，续创上 市6年来最长连阳纪录！ 近期制药、医疗板块利好频发，催化密集。 药明康德交出"史上最强"半年报。上半年营业收入、净利润、在手订单均创下历史新高，第二季度单季 营收首次站上百亿元台阶。公司启动首次中期分红10亿元，并上调全年收入增速预期至13%-17%。 A股"吃药"行情继续！7月30日早盘，创新药、中药联袂拉涨，全市场首只也是目前唯一跟踪制药指数 的药ETF（562050）盘中摸高1.37%，成份股华润双鹤一度涨停，科伦药业、达仁堂涨超5%居前。 把握中国龙头药企价值重估机遇，配置工具关注国内首只药ETF（562050）。聚焦A股50大龙头药企， 重仓创新药，兼顾高壁垒仿制药及中药，且完全不含医疗和CXO。 把握CXO、医疗器械拐点向上机遇，可以关注A股最大医疗ETF（512170）。聚焦"医疗器械+医疗服 务"，与AI医疗高相关，覆盖6只CXO龙头股。场外联接基金（A类 162412 / C类 0123 ...

Summary of the Conference Call for 恒瑞医药 Company Overview - **Company**: 恒瑞医药 (Hengrui Medicine) - **Industry**: Pharmaceutical Key Points and Arguments Financial Projections - 恒瑞医药 expects revenue for 2025, 2026, and 2027 to be 35.77 billion, 42.4 billion, and 50.8 billion RMB respectively, with net profit attributable to shareholders projected at 9.3 billion, 11.5 billion, and 13.7 billion RMB respectively, indicating strong growth potential [2][4][23] Strategic Partnerships - A significant collaboration with GSK was established, involving a $500 million upfront payment and $12 billion in milestone payments, covering PDE3/4 inhibitors and 11 preclinical projects in oncology, respiratory, and autoimmune inflammation, which will significantly enhance revenue in 2025 [2][4][7][23] Pipeline Development - 恒瑞医药 has over 30 pipelines with potential for external licensing, covering respiratory, oncology, and autoimmune fields, despite not leading in the PD-1 VGF and ADC sectors [2][3][8][22] Respiratory Sector Performance - The company has shown strong performance in the respiratory sector, with its PDE3/4 inhibitors being among the first to enter clinical trials in China, and the development of DPI formulations enhancing medication convenience [9][10][11] Competitive Landscape - The acquisition of the Firozane asset by Merck for $10 billion has extended the life of the COPD sector, benefiting Chinese companies and potentially prompting AstraZeneca to strengthen its presence in this area [12][18][19] Globalization Strategy - 恒瑞医药 is implementing a "less but better" strategy, focusing on high-quality innovative drugs for overseas development and has engaged in significant partnerships with multinational pharmaceutical companies [17][21] Future Development Potential - The company is expected to continue expanding its innovative pipeline, with 133 projects in development, including emerging technologies like AR Protec, CGT drugs, and mRNA cancer vaccines, which are anticipated to enter clinical stages in the coming years [17][21][22] BD (Business Development) Potential - 恒瑞医药's strong clinical data disclosure enhances its BD potential, with a mix of assets ready for licensing and those with internal data that may not yet be publicly disclosed, indicating a robust pipeline for future collaborations [21][22] Recent Developments - The recent partnership with GSK has validated 恒瑞医药's strong willingness for external licensing and strategic transformation, leading to an upward revision of the company's profit forecast for 2025 [23] Additional Important Insights - The company is actively participating in international conferences to showcase clinical data and promote business development collaborations, enhancing its global competitiveness [17][21] - The competitive landscape in the respiratory sector is evolving, with GSK being a leading player, and other companies like Roche and Sanofi also making significant moves [14][19]

Summary of Key Points from the Conference Call Industry Overview - The Chinese innovative pharmaceutical industry is experiencing a significant enhancement in strength, with its share of global first-in-class drugs increasing to 19% [7] - Multinational corporations (MNCs) are facing a severe patent cliff, with major companies like Merck, AbbVie, and BMS having over 60%, 58%, and 69% of their 2024 revenues coming from drugs facing patent expiration within the next five years [8][9] - MNCs are actively seeking business development (BD) transactions to address these challenges, with strong cash reserves available for such activities [10] Business Development Trends - The trend of Chinese innovative drugs going global is robust, driven by the strengthening capabilities of Chinese companies and the impending patent cliffs faced by MNCs [2] - MNCs are expected to engage in more BD transactions, particularly in the second half of 2025 and into 2026, as they seek to replenish their pipelines [2] Oncology Sector Insights - The oncology field is shifting from PD-1 combined with chemotherapy to next-generation immuno-oncology (IO) and antibody-drug conjugates (ADC) [3] - Potential MNC buyers in this space include AstraZeneca, Pfizer, and Merck, all of which are looking to enhance their portfolios with next-generation IO and ADC assets [3] Metabolic Disease Developments - The metabolic field is evolving from merely focusing on weight loss to comprehensive metabolic management, including fat reduction and muscle preservation [4][5] - Companies like Novo Nordisk and AstraZeneca are exploring oral medications and multi-target approaches in this area [4] Immune and Inflammatory Disease Innovations - New directions in the immune and inflammation sector include novel targets and engineering innovations, with significant investments from companies like AbbVie and Sanofi [6] - Emerging targets such as TL1a are attracting substantial investments, indicating a strong interest in this area [20] Market Position of Chinese Innovative Drugs - Chinese innovative drug companies have made significant strides in global markets, with improved clinical data quality and increased academic recognition [7] - The presence of Chinese companies in the oncology sector is growing, with several projects in advanced stages of development [14] MNC Strategies for BD Transactions - MNCs are focusing on four main strategies for BD transactions: consolidating core areas, entering new fields, exploring opportunities, and investigating new technologies [11] - The willingness of MNCs to invest in promising assets at the preclinical stage is evident, particularly in high-potential areas like TL1a [20] ADC and TCE Technology Developments - The ADC field is characterized by a tiered approach, with MNCs diversifying their portfolios across various targets [15] - T-cell engagers (TCE) are being developed for blood cancers and autoimmune diseases, with ongoing clinical trials showing promising results [16] Conclusion - The ongoing trends in the Chinese pharmaceutical industry, coupled with the challenges faced by MNCs, are creating a fertile ground for increased collaboration and investment opportunities in the global market [29]

Group 1 - The Hong Kong Innovative Drug ETF (513120) reached a record size of 16.12 billion yuan as of July 29, 2025, with a year-to-date growth of 111.29%, making it the top-performing pharmaceutical ETF in Hong Kong [1] - The CSI Hong Kong Innovative Drug Index (931787) surged by 3.85% on July 29, 2025, with notable increases in constituent stocks such as WuXi AppTec (02359) up 10.76% and Innovent Biologics (01801) up 8.77% [1] - The ETF's liquidity was strong, with a turnover rate of 74.62% and a total trading volume of 11.64 billion yuan on July 29, 2025, leading the market in pharmaceutical ETFs [1] Group 2 - The CSI Hong Kong Innovative Drug Index tracks up to 50 listed companies involved in innovative drug research and development, with a significant focus on biopharmaceuticals and chemical pharmaceuticals, which together account for 92.5% of the index [2] - As of June 30, 2025, the top ten weighted stocks in the index accounted for 67.94%, including companies like Innovent Biologics (01801) and WuXi Biologics (02269) [2] Group 3 - In the first half of 2025, global pharmaceutical transactions reached 456, a 32% year-on-year increase, with total upfront payments soaring by 136% to 11.8 billion USD [3] - Chinese companies contributed nearly 50% of the total transaction value and over 30% of the transaction volume in the global innovative drug market [3] - On July 28, 2025, Heng Rui Medicine announced a deal with GSK for the global exclusive rights to the HRS-9821 project, with an upfront payment of 500 million USD and potential milestone payments totaling around 12 billion USD [3] Group 4 - On July 25, 2025, the National Healthcare Security Administration held a meeting to discuss new policies supporting innovative drugs and medical devices, aiming to accelerate the clinical application of high-level technological innovations [4] - China’s innovative drug assets are gaining global recognition, with increasing business development (BD) licensing amounts and numbers, indicating a growing global influence [4] - The Hong Kong Innovative Drug ETF (513120) supports T+0 trading, allowing investors to trade multiple times within a trading day, enhancing liquidity and capital efficiency [4]

Group 1 - The pharmaceutical sector is experiencing a positive trend, with the innovative drug ETF (517110) rising by 4.26% and the biopharmaceutical ETF (512290) increasing by 2.72% [1] - Heng Rui Medicine has reached a license-out cooperation agreement with GSK worth over $10 billion, which includes an upfront payment of $500 million and potential milestone payments totaling approximately $12 billion [1] - The strong performance of CXO leader WuXi AppTec, which revised its 2025 half-year performance guidance upwards, reflects the resilience of the innovative drug industry and boosts market confidence in the sector [1] Group 2 - The government has introduced multiple policies to optimize drug procurement and support innovative drugs, indicating a favorable policy environment for the pharmaceutical industry [2] - The newly issued Sci-Tech Innovation Drug ETF (589723) aims to track the Shanghai Stock Exchange Sci-Tech Innovation Board Innovative Drug Index, which has shown stronger rebound potential compared to the broader market [2]

Group 1 - The pharmaceutical sector is experiencing a positive trend, with the innovative drug ETF (517110) rising by 4.26% and the biopharmaceutical ETF (512290) increasing by 2.72% [1] - Heng Rui Medicine has reached a license-out cooperation with GSK worth over $10 billion, with an initial payment of $500 million and potential milestone payments totaling approximately $12 billion [1] - The strong performance of CXO leader WuXi AppTec, which revised its 2025 half-year performance guidance upwards, reflects the resilience of the innovative drug industry and boosts market confidence in the sector [1] Group 2 - The government has introduced multiple policies to optimize drug procurement and support innovative drugs, indicating a favorable policy environment for the pharmaceutical industry [2] - The newly issued Sci-Tech Innovation Drug ETF (589723) aims to track the Shanghai Stock Exchange Sci-Tech Innovation Board Innovative Drug Index, which has shown stronger rebound potential compared to the broader market [2]

Market Overview - The A-share market experienced a divergence with the Shanghai Composite Index stabilizing above 3600 points, but individual stocks showed weakness, indicating underlying complexities in market dynamics [1] - The upcoming Federal Reserve meeting is anticipated to have significant implications for global capital markets, with a high probability of maintaining interest rates unchanged [3] Federal Reserve Insights - The Federal Reserve's meeting is expected to reveal potential dissenting votes advocating for a 25 basis point rate cut, which would be a rare occurrence since 1993 [3] - Market participants are closely monitoring Chairman Powell's statements for any dovish signals regarding a potential rate cut in September, particularly concerning economic risks and inflation [3] External Market Influences - U.S. stock indices experienced a pullback, with the Dow Jones down 0.46%, while European markets, particularly the German DAX, rose by 1.03% due to easing trade tensions [3] - The extension of a 24% reciprocal tariff suspension between China and the U.S. and the easing of high-end chip export restrictions are seen as positive developments for the semiconductor and AI sectors [3] A-share Market Dynamics - Northbound capital saw a net inflow of 1.82 billion yuan, reversing six consecutive days of net selling, with significant investments in the semiconductor and pharmaceutical sectors, particularly in innovative drug companies [4] - There is a noticeable divergence in main capital flows, with some sectors like real estate and biopharmaceuticals seeing increased investment, while automotive and machinery sectors faced sell-offs due to disappointing consumer recovery [4] Technical Analysis - The Shanghai Composite Index's stability above 3600 points is accompanied by a lack of strong buying momentum, as indicated by a low trading volume of 73.5 billion yuan in the first half hour [4] - The ChiNext Index showed a strong performance, breaking through 2400 points, driven by gains in the pharmaceutical and technology sectors [4] Policy Developments - A significant press conference is scheduled to announce new childcare subsidies and fertility support measures, which could provide a short-term boost to the maternal and educational consumption sectors [4] - Long-term investors are encouraged to focus on sectors with sustained policy benefits, such as innovative drugs and domestic AI computing capabilities [4] Investment Strategies - Short-term market fluctuations are expected to continue around the 3600-point mark, with three key areas of focus: semiconductor components, innovative drugs, and military industry due to rising expectations from the upcoming Zhuhai Airshow [5] - Long-term investors are advised to remain focused on the overarching themes of trade easing and corporate profit growth, regardless of short-term market volatility [5]

Core Viewpoint - The collaboration between Heng Rui Pharmaceutical and GlaxoSmithKline (GSK) marks a significant step in expanding Heng Rui's global market presence, with substantial financial implications and validation of its innovative research capabilities [3][4]. Group 1: Partnership Details - On July 28, 2025, Heng Rui Pharmaceutical announced a major collaboration with GSK, granting GSK exclusive global rights to HRS-9821 and up to 11 additional projects, excluding certain regions [3]. - GSK will pay Heng Rui an upfront fee of $500 million, with potential milestone payments totaling approximately $12 billion if all projects are successfully developed and commercialized [4]. Group 2: Market Expansion - The agreement allows GSK to leverage its international sales capabilities to help Heng Rui's products enter global markets, enhancing Heng Rui's position as a leading innovative pharmaceutical company in China [5]. - By potentially adding about 10% to its innovative drug pipeline through this collaboration, Heng Rui is expected to significantly boost its sales expectations and market valuation [5].