报告导读： Moderna 个体化 mRNA 癌症疫苗 V940 在高危黑色素瘤中的 5 年随访结果 支持疫苗机制能提供持久免疫应答，为后续 III 期与注册推进提供了更充分的临床依据。 事件。 2026 年 1 月 21 日， Moderna 与默沙东联合披露个体化 mRNA 癌症疫苗 V940 （ mRNA-4157 ）联合 Keytruda 用于高危黑色素瘤辅助治疗的 IIb 期 5 年随访结果。该联合治疗方案在较长时间内维持了既往观察到的疗效水平，支持其能够诱导并维持相对持久的免疫应答。 核心读出数据支持疫苗机制能提供持久免疫应答。 KEYNOTE-942 研究结果显示 V940 联合 Keytruda 降低 49% 高危黑色素瘤患者复发或死亡风险，疗效 从 2 年随访时的 44% 提升至 3 年的 49% 并在 5 年随访时仍维持在 49% 。同时未发现新的安全性信号。 V940 的整体推进节奏在同类项目中较为靠前。 mRNA-4157 目前已开展 8 项 II/III 期临床研究，适应症覆盖黑色素瘤、非小细胞肺癌、膀胱癌及肾细胞癌 等多种实体瘤。其中黑色素瘤 III 期临床试验已完成入组，预计将于 ...

Core Viewpoint - The market may present certain structural opportunities in the upcoming week, despite a generally pessimistic market sentiment indicated by technical models [1][2]. Market Overview - Last week (January 26-30, 2026), the Shanghai Composite Index rose by 1.13%, while the CSI 300 Index increased by 0.08%. Conversely, the CSI 500 Index fell by 2.56%, and the ChiNext Index decreased by 0.09% [3]. - The current overall market PE (TTM) stands at 23.3 times, which is at the 82.0% percentile since 2005 [3]. Quantitative Indicators - The liquidity shock indicator for the CSI 300 Index was 5.07 on Friday, slightly lower than the previous week (5.09), indicating current market liquidity is 5.07 times the average level over the past year [2]. - The PUT-CALL ratio for the SSE 50 ETF decreased to 0.89 from 0.98, suggesting a decline in investor caution regarding the short-term performance of the SSE 50 ETF [2]. - The five-day average turnover rates for the Shanghai Composite Index and Wind All A were 1.75% and 2.49%, respectively, indicating increased trading activity [2]. Macro Factors - The RMB exchange rate fluctuated last week, with onshore and offshore rates increasing by 0.07% and 0.27%, respectively [2]. - The official manufacturing PMI for China in January was reported at 49.3, lower than the previous value (50.1) and below the consensus expectation (50.18) [2]. Seasonal Trends - Historical data since 2005 shows that major indices have a high probability of rising in the first half of February, with average gains of 2.85% for the Shanghai Composite, 3.61% for the CSI 300, 5.34% for the CSI 500, and 4.65% for the ChiNext [2]. Technical Analysis - The SAR indicator for the Wind All A Index broke downwards on January 20 but rebounded upwards on January 23 [2]. - The market score based on moving average strength is currently at 172, placing it at the 59.50% percentile for 2023 [2]. - The sentiment model score is at 0 (out of 5), indicating a negative trend signal [2]. Industry Crowding - The industry crowding levels are relatively high in telecommunications, non-ferrous metals, comprehensive sectors, electronics, and basic chemicals, with notable increases in electronics and defense industries [4].

Core Insights - The report indicates an increase in trading activity, with the Shanghai Composite Index leading the gains, particularly the Shanghai 50 index, which saw a rise in valuation [1][4] - Valuation changes are mixed across broad indices, with the Shanghai 50 index leading with a PE-TTM increase of 3.7 percentage points and a PB-LF increase of 6.4 percentage points [4][5] - The report highlights that the food and beverage sector leads in PE valuation, while the oil and petrochemical sector leads in PB valuation [4][5] Index Valuation - The report notes that the Shanghai 50 index has a PE-TTM historical percentile of 80.1, with a 3.7 percentage point increase, and a PB-LF historical percentile of 54.1, with a 6.4 percentage point increase [5] - The overall valuation for the broad indices shows mixed results, with the Shanghai 50 index leading the gains [4][5] Sector Valuation - The food and beverage sector shows a PE increase of 2.4 percentage points, leading among industries, while the oil and petrochemical sector shows a PB increase of 6.4 percentage points [4][5] - The report identifies that the power equipment and new energy sectors offer good value in terms of PE-G comparison [4][5] Market Sentiment - Trading activity has increased, with turnover rates rising across indices, particularly the Shanghai 50 index, which saw a 3.7% increase in turnover rate [4][5] - The total trading volume across indices has risen, with the Shanghai 50 index leading with a 29.6% increase in trading volume [4][5] - The margin trading balance as of January 29, 2026, is reported at 2.70 trillion, reflecting a 0.58% increase compared to January 23, 2026 [4][5] Risk Premium - The report notes a slight increase in the equity risk premium (ERP), which stands at 3.98%, up by 0.06 percentage points from January 23, 2026 [4][5]

低频选股因子周报（2026.01.23-2026.01.30） [Table_Authors] 郑雅斌(分析师) 风险提示：市场环境变动风险，有效因子变动风险。 | | 021-23219395 | | --- | --- | | | zhengyabin@gtht.com | | 登记编号 | S0880525040105 | | | 罗蕾(分析师) | | | 021-23185653 | | | luolei@gtht.com | | 登记编号 | S0880525040014 | [Table_Report] 相关报告 绝对收益产品及策略周报（260119-260123） 2026.01.29 大额买入与资金流向跟踪（20260119-20260123） 2026.01.27 风格 Smart beta 组合跟踪周报（2026.01.19- 2026.01.23） 2026.01.26 红利风格择时周报（0119-0123） 2026.01.26 高频选股因子周报（20260119-20260123） 2026.01.25 证 券 研 究 报 告 请务必阅读正文之后的免责条款部分 1 月份沪深 300 ...

本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者重大遗漏，并对其内容 的真实性、准确性和完整性依法承担法律责任。 2026年1月31日 附：保荐代表人陈时彦先生简历 陈时彦先生，国泰海通投资银行部先进制造行业一部助理董事，保荐代表人，金融学硕士。曾主持或参 与的项目有：上海洗霸IPO、国科军工IPO、锦江股份非公开发行、悦心健康非公开发行、未名医药公 司债、光明食品公司债等项目。陈时彦先生具有丰富的投资银行业务经验，在保荐业务执业过程中严格 遵守《证券发行上市保荐业务管理办法》等相关规定，执业记录良好。 特此公告。 附：陈时彦先生简历 江西国科军工集团股份有限公司 董事会 江西国科军工集团股份有限公司（以下简称"公司"）于近日收到国泰海通证券股份有限公司（以下简 称"国泰海通"）出具的《关于更换江西国科军工集团股份有限公司持续督导保荐代表人的函》。国泰海 通为公司首次公开发行股票并上市项目的保荐机构及主承销商，保荐代表人为贾世超先生和陈轶劭先 生，持续督导期间为2023年6月21日至2026年12月31日。因工作内容变动，贾世超先生无法继续履行公 司持续督导工作职责，为保证持续督导工作有 ...

2 离任高级管理人员的相关信息 1 公告基本信息 ■ 送出日期：2026年1月30日 ■ 3 其他需要说明的事项 2026年1月30日 上述变更事项经上海海通证券资产管理有限公司董事会审议通过，并将按相关法律法规的规定进行备 案。 上海海通证券资产管理有限公司 ...

Core Insights - The evaluation results for the 2025 annual performance quality of securities companies were released by the Beijing Stock Exchange and the National Equities Exchange and Quotations, assessing 115 firms on their professional capabilities, compliance levels, and business operations [1] Group 1: Overall Industry Performance - The majority of securities companies scored above the baseline score of 100, indicating a positive accumulation in industry performance quality [1] - Guotai Junan ranked first with a total score of 145.04, followed by Huatai Securities (143.41), China Merchants Securities (140.49), Shenwan Hongyuan Securities (136.43), and CITIC Securities (135.49), showcasing strong performance in professional quality [1] Group 2: Distribution of Scores - The score distribution shows a "large middle, small ends" pattern, with a few top-tier firms leading the industry while the majority fall into the second and third tiers, indicating overall compliance and notable business highlights [1] - Some firms scored in the fourth tier due to low professional scores or high compliance deductions, suggesting a need for improvement in specific business areas or risk management capabilities [1] Group 3: Business Structure and Specialization - The evaluation system detailed scores for various sub-items within the Beijing Stock Exchange and National Equities Exchange, revealing differences in business structures among firms [2] - Certain firms, like Huatai Securities and Dongfang Securities, achieved high scores through deep engagement in Beijing Stock Exchange business, particularly in sponsorship and mergers and acquisitions [2] - Other firms, such as Kaiyuan Securities and Shenwan Hongyuan, excelled in the National Equities Exchange business, especially in recommending listings and ongoing supervision, demonstrating their service capabilities for new three-board enterprises [2] Group 4: Contribution of Brokerage and Research - Brokerage and research services, which connect investors with the market, contributed significantly to the professional quality scores of firms like Galaxy Securities and Guotai Junan [2]

母 1 / 7 / 7 / 7 / 7 / 7 / 7 / 7 / 7 / 7 / 7 / 7 / 7 / 7 / 7 / 7 / 7 / 7 / 7 / 7 / 7 / 7 / 7 / TONG SECURITIES KE 国泰海通证券2026春季策略会 3月24-26日 · 深圳 重要提醒 本订阅号所载内容仅面向国泰海通证券研究服务签约客户。因本资料暂时无法设置访问限制，根据《证 券期货投资者适当性管理办法》的要求，若您并非国泰海通证券研究服务签约客户，为保证服务质量、 控制投资风险，还请取消关注，请勿订阅、接收或使用本订阅号中的任何信息。我们对由此给您造成的 不便表示诚挚歉意，非常感谢您的理解与配合！如有任何疑问，敬请按照文末联系方式与我们联系。 法律声明 本公众订阅号(微信号 GTHT RESEARCH )为国泰海通证券股份有限公司(以下简称"国泰海通证券") 研 更多国泰海通研究和服务 亦可联系对口销售获取 ...

人形机器人产业正以惊人的速度崛起，成为全球投资者关注的焦点。这不仅是一场技术革命，更是对未来生产与 生活方式的深刻重塑。 国泰海通证券机械行业首席分析师肖群稀在新书《硅基觉醒》中，深入剖析人形机器人产业的发展历程，指出具 身智能技术正逼近技术奇点，并全方位展现该产业的图景。同时，本书试图回答以下问题： ● 技术迷雾： 具身智能、驱控方案、感知技术、新材料，它们的商业化瓶颈与成熟度拐点在哪里? ● 穿越场景迷宫： 从替代危险、繁重的人工操作，到走进家庭提供深度服务，哪些细分应用场景将率先实现?其 规模经济性和落地可行性如何? ● 估值困惑： 在技术快速迭代、商业模式尚在探索的机器人产业中，如何建立合适的产业价值评估体系? · 专家推荐语 · 肖群稀著，机械工业出版社，2026年1月出版。 从精密减速器到 Al 大模型,从工业场景到家庭客厅,一本书拆解人形机器人全栈价值链。技术、商业、 政策三线并进,为投资者与创业者绘制穿越周期的产业蓝图,把握硅基觉醒的时代红利。 一石照耀 北京工业大学教授,教育部长江学者特聘教授,国家产业基础专家委员会委员 国际标准化组织齿轮标准委员会 (ISO/TC60) 委员,全国减速机标 ...

Core Viewpoint - The article discusses the potential introduction of new monetary policy tools in China, particularly focusing on the establishment of ONRRP-like tools and two-way overnight repos to manage liquidity and interest rate fluctuations in the financial market [1][2]. Group 1: New Monetary Policy Tools - The possibility of creating tools aimed at non-bank institutions, similar to the Federal Reserve's ONRRP, is highlighted. These tools would primarily serve to prevent excessively low funding rates [1]. - The central bank has indicated a shift towards providing liquidity to non-bank institutions under specific scenarios, moving from "exploring" to "establishing" such mechanisms [2]. - The new mechanism is expected to be non-regular and specifically target non-bank entities, aiming to reduce funding stratification and volatility [2]. Group 2: Two-Way Overnight Repos - The introduction of two-way overnight repos for commercial banks is seen as a natural extension of DR001 becoming the benchmark interest rate. This would align the new repo with the existing policy rate [3]. - The current weighted average of DR001 has returned to 1.36%, supporting the view that the new repo could replace the 7-day OMO as the primary policy rate [3]. Group 3: Necessity of Short-Term Innovations - The necessity for short-term innovations in monetary policy tools is considered relatively limited, as the 7-day OMO rate is expected to be confirmed as the sole policy rate by mid-2024 [4]. - The overlapping functions of the proposed two-way repos and existing tools suggest that immediate changes to the toolset may not be essential [4]. - The current operational framework, which includes high-frequency OMO and low-frequency reserve requirement ratio adjustments, is deemed effective, indicating that there may not be a pressing need for a complete overhaul of the toolset [4].