Summary of Key Points Core Viewpoint - On July 25, 2025, a total of 8 stocks in the A-share market will face the lifting of restrictions on share sales, with a total of 1.872 billion shares being unlocked, amounting to a market value of 50.111 billion yuan based on the previous trading day's closing price [1]. Group 1: Stock Unlocking Details - The top three stocks by the number of shares unlocked are: - Daqian Energy (688303) with 1.593 billion shares [1][2] - Jintuo Co., Ltd. (603211) with 204 million shares [1][2] - Wanlang Magnetic Plastic (603150) with 31.966 million shares [1][2] Group 2: Market Value of Unlocked Shares - The top three stocks by market value of unlocked shares are: - Daqian Energy (688303) with a market value of 43.921 billion yuan [1][2] - Jintuo Co., Ltd. (603211) with a market value of 3.692 billion yuan [1][2] - Wanlang Magnetic Plastic (603150) with a market value of 1.066 billion yuan [1][2]

Core Viewpoint - The innovative drug sector is expected to thrive in 2025, with significant capital inflow and a focus on products with overseas potential, leading to substantial stock price increases in this segment [1][3]. Group 1: Market Performance - From early 2025 to date, the innovative drug sector has seen an average increase of over 50%, with nearly 50 stocks rising more than 30% [1]. - The Hongtu Innovation Healthcare Fund has achieved a cumulative increase of nearly 64% since early 2025, outperforming the industry [1][5]. - Historical performance of the Hongtu Innovation Healthcare Fund shows a year-to-date return of 63.66%, ranking 92 out of 594 funds [2]. Group 2: Industry Trends - The long-term development trend of China's innovative drug sector remains strong, supported by national strategies and favorable capital market policies [3]. - The market for innovative drugs in China is projected to exceed 250 billion RMB in 2024, with expectations to grow to approximately 450 billion RMB by 2030 [3]. - The overall market size, including all aspects of the drug development chain, is expected to approach 5.5 trillion RMB by 2024 and surpass 20 trillion RMB by 2030 [3]. Group 3: Investment Strategy - The investment strategy of the Hongtu Innovation Healthcare Fund focuses on high-elasticity innovative drug companies, particularly those with significant clinical breakthroughs and potential for international market entry [7][11]. - Key investment targets include companies with promising clinical data and those that are expected to achieve commercial success through domestic market integration and overseas licensing [7][10]. - The fund manager has successfully captured structural opportunities in the pharmaceutical sector, leading to superior long-term performance compared to peers [12]. Group 4: Notable Stocks - Major holdings in the Hongtu Innovation Healthcare Fund include companies like Xinlitai, Shutaishen, and Yifang Biotechnology, which have shown significant price increases and promising clinical data [8][9]. - The fund emphasizes investments in companies with first-in-class (FIC) and best-in-class (BIC) potential, focusing on those that can disrupt current clinical supply [11][12]. Group 5: Future Outlook - The innovative drug sector is expected to continue its upward trajectory, driven by overseas licensing opportunities and supportive domestic policies [12]. - The ongoing global business development (BD) transactions and key clinical data releases are anticipated to catalyze further growth in high-value innovative drug companies [12].

Core Viewpoint - The equity change involves the expiration of the concerted action agreement among the controlling shareholders and actual controllers of Yifang Biotechnology (Shanghai) Co., Ltd., leading to a passive dilution of their shareholding due to stock incentive vesting. This change will not affect the company's controlling shareholders or actual controllers, nor its governance structure and ongoing operations [1][8]. Summary by Sections 1. Background of the Concerted Action Agreement - In October 2020, a concerted action agreement was signed by key stakeholders, confirming the actual controllers of the company and establishing that certain parties would act in concert with them on major operational decisions [2]. - A supplementary agreement was signed in June 2021, allowing YAOLIN WANG LLC to join the original agreement without altering the rights and obligations of the other parties [3]. 2. Details of the Termination of Concerted Action - LING ZHANG LLC and LING ZHANG intend to terminate their concerted action relationship due to personal reasons, with LING ZHANG LLC holding 0.54% of the company's shares as of the announcement date [4]. - YAOLIN WANG LLC is changing its manager and will also terminate its concerted action relationship. The new manager, HONG MEI, will not affect the shareholding of YAOLIN WANG LLC, which holds 0.61% of the shares [6][7]. 3. Impact of the Equity Change - Before the equity change, the controlling shareholders and their concerted action parties held a total of 164,263,228 shares, representing 28.58% of the company. Following the vesting of stock incentives, their shareholding was diluted to 28.40%, resulting in a new total of 157,605,902 shares, or 27.26% [9][10]. - The termination of the concerted action relationship will not lead to a change in the controlling shareholders or actual controllers, as the combined shareholding of LING ZHANG LLC and YAOLIN WANG LLC is only 1.15%, which is relatively low and will not significantly impact control [11][12]. 4. Compliance and Future Commitments - The parties involved in the termination of the concerted action relationship will continue to comply with relevant regulations regarding share reduction and commitments made during the initial public offering [13].

Group 1 - Morgan Stanley's fund manager Wang Dapeng expresses optimism about the pharmaceutical industry, highlighting its potential for innovation, manufacturing, and consumption upgrades [1][3] - The second quarter report shows a strong performance in the equity market, with a focus on A-share and Hong Kong stock innovative drugs, benefiting from better-than-expected business development in representative innovative drug companies [2][3] - The top ten holdings of the fund as of June 30, 2025, include companies like Innovent Biologics and BeiGene, accounting for 79.90% of the fund's net asset value, an increase of over 11 percentage points from the previous quarter [2] Group 2 - The pharmaceutical sector is expected to benefit from a stable growth trend in medical insurance and supportive policies for innovative drug payments, leading to a return to endogenous growth [3] - Policy support includes increased pensions and healthcare subsidies, as well as ongoing normalization of centralized procurement and industry restructuring, which are expected to favor the development of innovative drugs [3] - Long-term growth in the pharmaceutical industry is anticipated due to factors such as an aging population, rising income levels, and increased health awareness, with expected growth rates surpassing GDP growth [3]

证券代码：688382 证券简称：益方生物 公告编号：2025-027 一、原《一致行动协议》及其补充协议签署情况 本次权益变动系益方生物科技（上海）股份有限公司（以下简称"公 司""益方生物"）控股股东、实际控制人的一致行动人到期解除与控 股股东、实际控制人的一致行动关系，以及股权激励归属导致控股股 东、实际控制人的持股比例被动稀释； 本次权益变动不会导致公司控股股东、实际控制人发生变化；不会影 响公司的治理结构和持续经营。公司控股股东仍为 InventisBio Hong Kong Limited（以下简称"香港益方"）、YUEHENG JIANG LLC 及 XING DAI LLC ， 实 际 控 制 人 仍 为 YAOLIN WANG （ 王 耀 林 ）、 YUEHENG JIANG（江岳恒）以及 XING DAI（代星）。 2020 年 10 月 ， YAOLIN WANG （ 王 耀 林 ）、 XING DAI （ 代 星 ）、 YUEHENG JIANG（江岳恒）、LING ZHANG（张灵）、香港益方、XING DAI LLC、YUEHENG JIANG LLC、LING ZHANG LLC ...

Group 1: ETF Performance - The liquidity of the Kexin Pharmaceutical ETF managed by Jiashi showed a turnover rate of 16.97% with a transaction volume of 33.88 million yuan, indicating active market trading [2] - Over the past year, the Kexin Pharmaceutical ETF has seen a significant growth in scale, increasing by 119 million yuan, ranking first among comparable funds [2] - The net asset value of the Kexin Pharmaceutical ETF has risen by 48.37% over the past year, placing it in the top 15.05% among index equity funds [2] Group 2: Stock Performance - The top ten weighted stocks in the Shanghai Stock Exchange Science and Technology Innovation Board Biopharmaceutical Index account for 50.3% of the index, with leading stocks including United Imaging Healthcare and BeiGene [2] - Recent stock performance includes United Imaging Healthcare with a rise of 2.04% and BeiGene with a slight increase of 0.21%, while Huatai Medical saw a decline of 2.71% [4] Group 3: Industry Trends - The biopharmaceutical industry is entering a dual-driven phase of policy and technology, with innovation drug support policies advancing to phase 2.0 [5] - The medical device sector is experiencing a core trend of replacement and technology export, with regulatory upgrades promoting innovation and industry breakthroughs [5] - State-owned capital entering the biopharmaceutical sector is injecting financial vitality, accelerating R&D investment and industry chain integration [5] Group 4: Licensing Agreements - Chinese innovative pharmaceutical companies are reporting significant "Licence Out" transactions, with Kexin Pharmaceuticals announcing a deal with ERIGEN for an exclusive overseas licensing agreement worth up to 1.32 billion USD [4]

Core Insights - Foreign public funds have shown strong performance in Q2, with a focus on structural opportunities in the Chinese market, particularly in artificial intelligence, innovative pharmaceuticals, and high-dividend assets [1][2][3] Group 1: Fund Performance - Several foreign public equity products achieved notable returns in Q2, with the Robeco China Healthcare Equity Fund leading at a 28.51% increase in net value [1] - BlackRock's Advanced Manufacturing Fund and Fidelity's Dividend Growth Fund reported net value increases of 21.83% and 13.64%, respectively [1] Group 2: Investment Strategies - Robeco emphasized a multi-dimensional evaluation of companies in the innovative sector, focusing on quality, talent, R&D investment, and clinical data to select high-potential firms [1] - BlackRock's fund manager highlighted a strategic focus on artificial intelligence and technology sectors, achieving significant excess returns [2] - Fidelity's managers noted strong performance in traditional dividend sectors, attracting risk-averse capital due to low valuations and high dividend certainty [2] Group 3: Future Outlook - Fund managers expressed optimism about the attractiveness of A-share valuations, supported by policy backing and positive industry trends, indicating ongoing structural opportunities [2] - Future investment will continue to prioritize high-quality technology assets and sectors with concentrated distribution, such as TMT, machinery, pharmaceuticals, and chemicals [3] - The Chinese pharmaceutical industry is expected to enhance its global competitiveness, with a clear trend towards international expansion in innovative drugs and medical devices [3]

Group 1: ETF Performance - The liquidity of the Kexin Pharmaceutical ETF (嘉实) showed an intraday turnover of 18.19%, with a transaction volume of 40.9491 million yuan, indicating active market trading [3] - Over the past week, the Kexin Pharmaceutical ETF (嘉实) experienced a scale increase of 16.9597 million yuan, ranking first among comparable funds [3] - The Kexin Pharmaceutical ETF (嘉实) saw a share increase of 7.5 million shares over the past week, also ranking first among comparable funds [3] - As of July 21, the Kexin Pharmaceutical ETF (嘉实) has achieved a net value increase of 43.45% over the past year, placing it in the top 16.56% among 2,929 index equity funds [3] Group 2: Stock Performance - The top ten weighted stocks in the Shanghai Stock Exchange Science and Technology Innovation Board Biopharmaceutical Index account for 50.3% of the index, with leading stocks including 联影医疗 (9.73%), 百济神州 (6.04%), and 惠泰医疗 (5.69%) [5][3] - The highest monthly return since inception for the Kexin Pharmaceutical ETF (嘉实) was 23.29%, with the longest consecutive monthly increase being 5 months and an average monthly return of 7.43% [3] Group 3: Market Trends - Huazhong Securities maintains a bottom-up view of the pharmaceutical sector, emphasizing the importance of hard technology innovations, particularly in innovative drugs and devices, which are becoming market hotspots [6] - The recent announcement from the Shanghai Sunshine Pharmaceutical Procurement Network regarding the 11th batch of national centralized procurement includes 55 drug varieties, with key principles focusing on stability, quality assurance, and anti-competitive practices [5]

Market Performance - A-shares steadily advanced this week, with the ChiNext Index reaching a new high for the year and the Shenzhen Component Index hitting a four-month high, approaching its highest point of the year [1] - Weekly trading volume increased to 7.73 trillion yuan, marking the largest weekly trading volume in three months [1] Fund Inflows - Leverage funds actively entered the market, with most industries under the Shenwan first-level industry classification seeing net buying, particularly the computer industry with over 4.4 billion yuan and the electronics industry with over 3 billion yuan [2] - The electronic, biopharmaceutical, and automotive sectors each received over 20 billion yuan in net inflows, while the non-bank financial sector saw a net outflow of over 8.3 billion yuan [2] Rare Earth Demand - The rare earth sector performed strongly, with the rare earth permanent magnet index reaching a three-and-a-half-year high [3] - Demand for rare earths is expected to grow rapidly due to advancements in humanoid robots and electric vehicles, with estimates suggesting a demand of at least 70,000 tons of neodymium-iron-boron by 2025 [3] Energy Metals - The energy metals sector, including lithium and cobalt, reached a two-year high, with lithium carbonate futures breaking 70,000 yuan/ton, marking a 20% increase from recent lows [4] - Short-term lithium salt supply may decline due to reduced exports from Chile and domestic production halts, leading to a potential price stabilization [4] Biopharmaceutical Sector - The biopharmaceutical sector saw significant gains, with the innovative drug index hitting record highs multiple times this week [6] - Notable stocks in the sector, such as Lianhuan Pharmaceutical and Aosaikang, experienced consecutive trading halts, with some stocks showing year-to-date gains exceeding 200% [6][7] Earnings Forecasts - Several pharmaceutical companies have recently forecasted substantial profit increases for the first half of 2025, with estimates suggesting net profit growth exceeding 19 times for some firms [7]

Core Viewpoint - The article highlights a significant surge in the innovative drug sector, driven by new policies from the National Healthcare Security Administration aimed at supporting the development of innovative drugs and optimizing procurement processes [1][2]. Summary by Sections Innovative Drug Market Surge - On July 17, there was a notable increase in the stock prices of innovative drug companies, with companies like ShenZhou Cell rising over 15% and KangnuoYa increasing over 14% [1]. - The article mentions that the 11th batch of national drug centralized procurement has been initiated, emphasizing that new drugs will not be included in centralized procurement to protect industry innovation [1]. Policy Support for Innovative Drugs - The "Measures" issued on June 30 by the National Healthcare Security Administration and the National Health Commission aim to support the entire chain of innovative drug development from laboratory to bedside [1]. - The measures include dynamic adjustments to the medical insurance catalog, allowing eligible innovative drugs to be included, and establishing more scientifically reasonable payment standards [1]. Establishment of Commercial Health Insurance Directory - A groundbreaking proposal to establish a "Commercial Health Insurance Innovative Drug Directory" is introduced, which will include innovative drugs with significant clinical value that exceed basic medical insurance coverage [2]. - Drugs in this directory will enjoy special treatment, such as confidential price negotiations and exemption from centralized procurement monitoring, creating new payment channels for high-priced breakthrough therapies [2]. Investment Opportunities - Analysts from Bohai Securities suggest that the introduction of innovative drug policies and the potential establishment of the commercial health insurance directory present investment opportunities in related innovative drug companies and their supply chains [2]. - Xiangcai Securities predicts that by 2025, the domestic innovative drug industry may experience a turning point, shifting from capital-driven to profit-driven trends, leading to dual recovery in performance and valuation [2].