Core Viewpoint - The Chinese innovative drug industry is gradually catching up with Europe and the United States in terms of technology, with some targets and technical pathways already leading globally. The number and value of new drugs authorized for overseas markets continue to increase, leading to world-class pricing and non-linear investment elasticity. The domestic market is experiencing strong growth in demand, with domestic new drug sales continuing to rise, and several innovative pharmaceutical companies have turned losses into profits, entering a stable growth phase [2]. Group 1: Innovative Drugs - The innovative drug sector is witnessing a significant increase in sales driven by strong domestic demand, with a number of innovative companies achieving profitability [2]. - The trend of domestic innovative drugs going overseas is accelerating, with increasing numbers and values of new drug authorizations [2]. - The pricing power of innovative drugs is improving, reflecting the global competitiveness of Chinese pharmaceutical companies [2]. Group 2: High-Value Medical Consumables - The orthopedic sector is expected to see mild price reductions due to continued domestic substitution and accelerated overseas business progress [2]. - The neurosurgery and neurointervention fields are experiencing stable growth post-collection, with new products being launched [2]. - The high-value consumables market is expected to benefit from ongoing domestic replacement and the introduction of new products [2]. Group 3: Medical Devices - The medical device sector is seeing a recovery in bidding prices, with ongoing high-speed growth in bidding data this year [2]. - Companies are entering a phase of inventory reduction, with performance expected to improve in the second half of the year [2]. - The low-value consumables sector is experiencing product upgrades and accelerated expansion into overseas markets [2]. Group 4: Blood Products - The supply side of the blood products industry is concentrating on central state-owned enterprises, gradually clearing the competitive landscape [2]. - The demand side is expected to see continuous upgrades to new products, with industry sentiment gradually improving [2]. Group 5: API (Active Pharmaceutical Ingredients) - The API sector is benefiting from the end of a capital expenditure peak, with three growth logic points driving upward trends: new high-end market products, integrated consolidation and overseas expansion, and cost-leading CDMO [2]. - Leading companies in the API sector are expected to see explosive growth in revenue and profits [2]. Group 6: CXO (Contract Research Organization) - The CXO sector is witnessing a recovery in A+H financing activity, with multiple significant business developments enhancing market confidence [2]. - The focus is on optimizing the supply-side landscape and increasing market share for leading CRO companies [2]. Group 7: Traditional Chinese Medicine and Retail Pharmacy - The traditional Chinese medicine sector is showing signs of recovery, with friendly pricing for new drugs and ongoing observation of collection progress [2]. - The retail pharmacy sector is influenced by the pace of supply-side clearing and business model upgrades, with expectations of increased store closures in the second half of 2025 [2]. Group 8: Research and Development Services - The domestic innovative drug business development is heating up, likely driving downstream demand recovery [2]. - The overseas market presents significant growth opportunities for domestic companies, leveraging cost-effectiveness and service differentiation [2].

www.asymchem.com 目錄 | 公司資料 | 2 | | --- | --- | | 財務摘要 | 4 | | 管理層討論與分析 | 5 | | 企業管治及其他資料 | 28 | | 獨立審閱報告 | 62 | | 中期簡明綜合損益表 | 63 | | 中期簡明綜合全面收益表 | 64 | | 中期簡明綜合財務狀況表 | 65 | | 中期簡明綜合權益變動表 | 67 | | 中期簡明綜合現金流量表 | 68 | | 中期簡明綜合財務資料附註 | 70 | | 釋義及詞彙 | 86 | 公司資料 Asymchem Laboratories (Tianjin) Co., Ltd. 凱 萊 英 醫 藥 集 團（ 天 津 ）股 份 有 限 公 司 ( 於中華人民共和國註冊成立的股份有限公司 ) www.asymchem.com 股份代號 : 6821 中期報告 2025 一、董事會 1. 執行董事 Hao Hong博士 楊蕊女士 張達先生 洪亮先生 2. 非執行董事 Ye Song博士 張婷女士 3. 獨立非執行董事 孫雪嬌博士 侯欣一博士 謝維愷先生 （於2025年8月6日獲委任） 李家聰先生 （於2 ...

凯莱英(6821.HK)盘中一度跌4.75%报97.35港元，市值351.4亿港元。联交所最新权益披露资料显示，凯莱英于9月16日遭Norges Bank在场内以每股均价 104.5283港元减持26.28万股，涉资约2747万港元。减持后，其持股比例由14.51%下降至13.56%。(格隆汇) | 表格序號 | 大股東/董事/最高行政人員名 | 作出披露的 買入 / 費出或涉及的 | | 每股的平均價 | 持有權益的股份數目 | | 佔已發行的 有關事件的日期 | | --- | --- | --- | --- | --- | --- | --- | --- | | | | 股份數目 原因 | | | (請參閱上述*註 | | 有投票權股 (日 / 月 / 年) | | | | | | | 1 | | 份百分比 1 % ) | | CS20250917E00436 | Norges Bank | 1201(L) | 262,800(L) | HKD 104.5283 | | 3,735,400(L) | 13.56(L)16/09/2025 | | | | ■ 肌菜英 分时 多日 日K 周K 月K 季K 年 ...

Group 1 - The Hong Kong innovative drug sector experienced a decline in the afternoon session on September 13, with notable drops in stock prices [1] - Innovent Biologics saw a decrease of over 7%, while Rongchang Biopharmaceutical and Green Leaf Pharmaceutical fell by more than 4% [1] - Other companies such as WuXi Biologics, Junshi Biosciences, and Kelun Pharmaceutical also experienced declines [1]

格隆汇9月19日丨根据联交所最新权益披露资料显示，2025年9月16日，凯莱英(06821.HK)遭Norges Bank在场内以每股均价104.5283港元减持26.28万股，涉 资约2747万港元。 减持后，Norges Bank最新持股数目为373.54万股，持股比例由14.51%下降至13.56%。 | 表格序號 | 大股東/董事/最高行政人員名 作出披露的 買入 / 賣出或涉及的 每股的平均價 | | | | | 持有權益的股份數目 佔已發行的 有關事件的日期 相 | | | --- | --- | --- | --- | --- | --- | --- | --- | | | | 原因 | 股份數目 | | | (請參閱上述*註 | 有投票權股 (日 / 月 / 年) 材 | | | | | | | 解) | | 份百分比 | | Company of Canadian Carder Station Company of Children | | | | | and and other for a local of can and research and any and the commens ...

香港联交所最新数据显示，9月16日，Norges Bank减持凯莱英（002821）(06821)26.28万股，每股作价 104.5283港元，总金额约为2747万港元。减持后最新持股数目为373.54万股，最新持股比例为13.56%。 ...

智通财经APP获悉，香港联交所最新数据显示，9月16日，Norges Bank减持凯莱英(06821)26.28万股，每 股作价104.5283港元，总金额约为2747万港元。减持后最新持股数目为373.54万股，最新持股比例为 13.56%。 ...

Core Viewpoint - The Chinese innovative drug industry is gradually catching up with Europe and the United States in terms of technology, with some targets and technical pathways already leading globally. The number and value of new drugs authorized for overseas markets continue to increase, leading to world-class pricing and non-linear investment elasticity. The domestic market is experiencing strong growth in demand, with domestic new drug sales continuing to rise, and several innovative pharmaceutical companies have turned losses into profits, entering a stable growth phase [2]. Group 1: Innovative Drugs - The innovative drug sector is witnessing a significant increase in sales driven by strong domestic demand, with a number of innovative companies achieving profitability [2]. - The trend of domestic innovative drugs going overseas is accelerating, with increasing numbers and values of new drug authorizations [2]. - The industry is positioned for a "Davis double" effect, where both performance and valuation are expected to improve [2]. Group 2: High-Value Medical Consumables - The orthopedic sector is expected to see mild price reductions, while domestic replacements continue to grow, and overseas business progresses rapidly [2]. - The neurosurgery and neurointervention fields are stabilizing after centralized procurement, with new products expected to contribute to growth [2]. Group 3: Medical Devices - The medical device sector is experiencing a high-speed growth in bidding data, with companies entering a destocking phase, which is expected to improve performance in the second half of the year [2]. - The low-value consumables sector is seeing continuous product upgrades and accelerated expansion into overseas markets [2]. Group 4: Blood Products - The supply side of the blood products industry is increasingly concentrated among state-owned enterprises, leading to a clearer competitive landscape [2]. - The demand side is expected to upgrade towards new products, gradually improving the industry's overall health [2]. Group 5: API (Active Pharmaceutical Ingredients) - The industry is at an upward turning point due to the end of a capital expenditure peak, combined with three growth drivers: new high-end market products, integrated consolidation and overseas expansion, and cost-leading CDMO [2]. - Leading companies are expected to see explosive growth in revenue and profits in the medium term [2]. Group 6: CXO (Contract Research Organization) - The CXO sector is seeing a revival in A+H financing activity, with multiple significant business developments enhancing market confidence [2]. - The focus is on optimizing the supply-side landscape and increasing market share for leading CRO companies [2]. Group 7: Traditional Chinese Medicine and Retail Pharmacy - The traditional Chinese medicine sector is showing signs of recovery, with friendly pricing for new drugs, while the retail pharmacy sector is influenced by supply-side adjustments and business model upgrades [2]. - The performance of offline pharmacies is expected to improve in the second half of 2025, with leading chains like YaoXingTang making progress in store upgrades [2]. Group 8: Research Reports - A series of in-depth research reports on various companies and sectors within the pharmaceutical and medical device industries have been published, highlighting their growth potential and market positioning [3][4].

Core Points - The Medical Health R Index (480016) closed at 8278.77 points, down 0.33%, with a trading volume of 31.765 billion yuan and a turnover rate of 1.08% [1] - Among the index constituents, 18 stocks rose while 31 fell, with Yirui Technology leading the gainers at a 4.4% increase and Zexin Pharmaceutical leading the decliners at a 5.37% decrease [1] Index Constituents Summary - The top ten constituents of the Medical Health R Index include: - WuXi AppTec (sh603259) with a weight of 13.58% and a market cap of 315.96 billion yuan [1] - Hengrui Medicine (sh600276) with a weight of 10.87% and a market cap of 458.96 billion yuan [1] - Mindray Medical (sz300760) with a weight of 8.17% and a market cap of 290.50 billion yuan [1] - United Imaging Healthcare (sh688271) with a weight of 4.14% and a market cap of 126.08 billion yuan [1] - Other notable constituents include Pianzai Shou (sh600436), Yierfu Technology (sz300015), Kelun Pharmaceutical (sz002422), New Hope Liuhe (sz002001), Fosun Pharma (sh600196), and East China Pharmaceutical (sz000963) [1] Capital Flow Analysis - The net outflow of main funds from the index constituents totaled 1.638 billion yuan, while retail investors saw a net inflow of 1.098 billion yuan [1] - Notable capital flows include: - Kailai Ying (002821) with a main fund net inflow of 101 million yuan [2] - Mindray Medical (300760) with a main fund net inflow of approximately 90.77 million yuan [2] - Yuyue Medical (002223) with a main fund net inflow of 24.60 million yuan [2]

Investment Rating - The report gives a "Buy" rating for the company, with a target price of 136.15 CNY based on a valuation of 35 times the expected earnings per share in 2026 [3][10]. Core Views - The company has established a strong foundation in small molecule CDMO (Contract Development and Manufacturing Organization) services and is gradually entering a harvest phase with its emerging businesses. The dual growth drivers are expected to position the company as a leading technology-driven one-stop CDMO service provider [2][8]. Summary by Sections Small Molecule CDMO - The small molecule CDMO business is the cornerstone of the company's operations, leveraging advanced technologies such as continuous reaction and biocatalysis to create competitive advantages in cost and efficiency. The company is expected to maintain steady growth in this segment due to increasing demand for high-value orders and expansion into international markets [9][26]. - In 2024, the small molecule business is projected to generate revenue of 45.71 billion CNY, with a gross margin of 47.95%. The company anticipates 12 projects in the validation phase for 2025, ensuring a robust order backlog for sustained growth [26][49]. Emerging Businesses - The company has diversified into several emerging business segments, including chemical macromolecule CDMO, clinical CRO (Contract Research Organization), and biopharmaceutical services. These segments are expected to contribute significantly to revenue growth, with the emerging business generating 12.26 billion CNY in 2024, reflecting a year-on-year growth of 2.25% [57][60]. - The chemical macromolecule CDMO segment, which includes peptides and oligonucleotides, is experiencing rapid commercialization, with a revenue increase of 13.3% in 2024 [59]. Financial Projections - The company is projected to achieve net profits of 11.70 billion CNY, 14.04 billion CNY, and 17.00 billion CNY for the years 2025, 2026, and 2027, respectively, with corresponding growth rates of 23.3%, 20.0%, and 21.1% [10][16]. - Earnings per share (EPS) are expected to rise from 3.24 CNY in 2025 to 4.71 CNY by 2027, indicating a strong upward trajectory in profitability [10][16]. Market Position and Strategy - The company aims to enhance its global footprint by expanding its production capabilities in Europe and Japan, particularly through the acquisition of the Sandwich Site in the UK, which is expected to bolster its service offerings and client penetration in these regions [54][56]. - The report highlights the company's commitment to maintaining a high level of research and development investment, which is crucial for sustaining its competitive edge in the rapidly evolving pharmaceutical landscape [21][22].