Group 1 - Key Point 1: As of March 28, 2025, a total of 109 institutional investors disclosed holdings in Kailaiying (002821.SZ), with a total shareholding of 193 million shares, accounting for 52.39% of the total share capital [1] - Key Point 2: The top ten institutional investors hold a combined shareholding ratio of 49.02%, with a slight decrease of 0.39 percentage points compared to the previous quarter [1] Group 2 - Key Point 1: In the public fund sector, six funds increased their holdings, including China Europe Medical Health Mixed A and China Europe Medical Innovation Stock A, with an increase ratio of 0.40% [2] - Key Point 2: Three public funds reduced their holdings, with a slight decrease in the holding ratio [2] - Key Point 3: A total of 79 new public funds were disclosed this period, including Innovative Medicine and Jiahua Medical Care Stock [2] - Key Point 4: One foreign fund, Hong Kong Central Clearing Limited, increased its holdings by 0.82% [2]

Financial Performance - The company's revenue for the year ended December 31, 2024, was approximately RMB 5,804.66 million, a decrease of 25.40% compared to RMB 7,781.44 million for the year ended December 31, 2023[5]. - Net profit attributable to shareholders of the parent company was approximately RMB 948.95 million, a decline of 58.17% from RMB 2,268.81 million in the previous year[6]. - The company achieved a net profit of RMB 238.62 million in the fourth quarter, a quarter-on-quarter increase of 12.99%[10]. - Adjusted net profit attributable to shareholders was RMB 803.07 million, a decrease of 65.12% compared to 2023[49]. - The proposed dividend for 2024 is RMB 11.00 per 10 shares, down from RMB 18.00 per 10 shares in 2023, indicating a reduction of 38.9%[148]. - The total proposed final dividend amount for 2024 is approximately RMB 390,367,340, a decrease of 39.2% from RMB 641,939,094 in 2023[148]. - Basic and diluted earnings per share for the year were RMB 2.69, compared to RMB 6.26 in 2023, reflecting a decline of 57.0%[152]. Revenue Breakdown - Revenue from small molecule CDMO services was RMB 4,570.73 million, with a year-on-year growth of 9.23% after excluding large orders[10]. - The company's overseas business revenue for the reporting period was RMB 4,284.75 million, a decrease of 32.46% year-on-year, primarily due to the conclusion of large orders[13]. - Revenue from U.S. clients amounted to RMB 3,370.91 million, with an 18.41% year-on-year increase when excluding large orders. The European market saw a significant revenue increase of 101.33% year-on-year[13]. - Emerging business revenue was RMB 1,226.37 million, reflecting a year-on-year increase of 4.80%, with a gross margin of 21.18% for the year[21]. - Domestic revenue reached RMB 1,519.91 million, an increase of 5.75% compared to 2023[49]. - Revenue from clinical stage projects was RMB 1,766.78 million, reflecting a year-on-year increase of 17.97%[51]. Cost and Profitability - The gross profit margin for the reporting period was approximately 41.03%, down 9.86 percentage points from 50.89% in the same period last year[6]. - The gross margin for domestic operations in China was 19.90%, down 2.60 percentage points, while the gross margin for overseas operations was 48.52%, down 8.81 percentage points[61]. - The company's total gross margin for 2024 is 41.06%, a decrease of 9.86 percentage points compared to 2023, primarily due to the conclusion of large orders[55]. - Revenue from the main business decreased by 25.44% in 2024, while the cost of main business decreased by 10.46%[55]. Research and Development - R&D expenditure for the year ending December 31, 2024, was RMB 614.49 million, accounting for 10.59% of total revenue, with plans for continued proportional investment in R&D[32]. - Research and development expenses for 2024 were RMB 614,490,000, a decrease of 13.2% from RMB 707,863,000 in 2023[152]. - The company has published 47 research papers in leading international journals, with 14 papers having an impact factor exceeding 10, showcasing its commitment to technological innovation[31]. - The company is committed to increasing R&D investment to establish a robust R&D platform that promotes cross-departmental collaboration in process, engineering, and equipment[101]. Operational Developments - The company expanded its customer base by adding over 200 new CDMO business clients in 2024[12]. - The company completed nearly 200 projects in the formulation CDMO business, with a year-on-year increase of approximately 30% in backlog orders[23]. - The company has established multiple R&D centers and production facilities in China, the USA, and the UK, with the addition of its first European production and R&D base by December 31, 2024[33]. - The company has successfully developed several internationally recognized patented technologies, which have been applied in commercial manufacturing[91]. Corporate Governance - The roles of Chairman and CEO are held by the same individual, Dr. Hao Hong, which the board believes does not compromise the balance of power and authority within the company[106]. - The board will continue to review the effectiveness of the corporate governance structure to assess the necessity of separating the roles of Chairman and CEO[107]. - The company is committed to maintaining high standards of corporate governance to protect shareholder interests and enhance corporate value[104]. Share Repurchase and Capital Management - The company has successfully repurchased a total of 12,300,701 A-shares, accounting for 3.6161% of the total A-share capital, with a total payment of RMB 999,644,601.56[111]. - The company is conducting a share repurchase plan approved by shareholders on February 29, 2024, using its own funds for employee stock ownership and capital reduction[110]. - The company completed the cancellation of 7,122,703 shares, representing 1.94% of the total share capital[150]. Future Outlook and Strategy - The company plans to continue investing in new technology development and business cultivation despite the challenges faced in the emerging business sector[11]. - The company aims to deepen relationships with major clients and diversify its customer base across various regional markets, focusing on both existing and new clients[20]. - The company is actively seeking investments to enrich its service offerings and expand its overseas presence, focusing on commercial production of APIs for multinational companies[95]. - The company aims to enhance its market leadership in the small molecule CDMO sector by leveraging its strong reputation, advanced R&D platforms, and high-quality customer service[88].

本公司及全体董事会成员保证公告内容真实、准确和完整，不存 在虚假记载、误导性陈述或重大遗漏。 凯莱英医药集团（天津）股份有限公司（以下简称"公司"）2025 年 3 月 28 日召开第四届董事会第六十一次会议和第四届监事会第四十八次会议，审议通过 了《关于使用闲置自有资金购买理财产品的议案》，同意公司及合并报表范围内 子公司使用额度不超过 500,000 万元人民币（或等额外币，含本数）的自有资金 购买短期金融机构理财产品，使用期限自本次董事会审议通过之日起 12 个月内， 在上述额度和期限内，资金可循环使用。 根据《公司法》《深圳证券交易所股票上市规则》《深圳证券交易所上市公 司自律监管指引第 1 号—主板上市公司规范运作》和《公司章程》等有关规定， 上述额度在公司董事会审批权限范围内，无需提交公司股东大会审议。现将相关 事宜公告如下： 一、使用闲置自有资金购买理财产品的基本情况 1、投资目的 2、额度及期限 证券代码：002821 证券简称：凯莱英 公告编号：2025-023 为提高资金的使用效率，为公司及股东获取更多的回报，在不影响公司正常 经营的情况下，公司及合并报表范围内子公司使用部分暂时闲置自有资 ...

凯莱英医药集团（天津）股份有限公司 2024年度内部控制评价报告 凯莱英医药集团（天津）股份有限公司全体股东： 根据《企业内部控制基本规范》及其配套指引的规定和其他内部控制监管 要求（以下简称企业内部控制规范体系），结合凯莱英医药集团（天津）股份有 限公司（以下简称公司或本公司）内部控制制度和评价办法，在内部控制日常监 督和专项监督的基础上，我们对公司截至 2024 年 12 月 31 日的内部控制有效性 进行了评价。 一、 重要声明 按照企业内部控制规范体系的规定，建立健全和有效实施内部控制，评价其 有效性，并如实披露内部控制评价报告是公司董事会的责任。监事会对董事会建 立和实施内部控制进行监督。管理层负责组织、领导企业内部控制的日常运行。 公司董事会、监事会及董事、监事、高级管理人员保证本报告内容不存在任何虚 假记载、误导性陈述或重大遗漏，并对其内容的真实性、准确性和完整性承担法 律责任。 本公司内部控制的目标是：合理保证企业经营管理的合法合规、资产安全、 财务报告及相关信息真实完整，提高经营效率和效果，促进企业实现发展战略。 由于内部控制存在固有局限性，故仅能对实现上述目标提供合理保证。此外，由 于情况 ...

凯莱英医药集团（天津）股份有限公司 关于开展外汇衍生品交易的可行性分析报告 一、开展外汇衍生品交易的背景 随着凯莱英医药集团（天津）股份有限公司（以下简称"公司"）业务拓 展迅速增长，为有效规避外汇市场风险，防范汇率大幅波动对公司造成不利影 响，合理降低财务费用，适度开展以保值为目的的外汇衍生品交易业务，有利 于加强公司的外汇风险管控能力。公司及合并报表范围内的子公司拟于2025年 度适度开展外汇衍生品交易业务。 二、公司开展外汇衍生品交易的基本情况 1、投资必要性 为有效规避外汇市场风险，防范汇率大幅波动对公司造成不利影响，合理 降低财务费用，适度开展以保值为目的的外汇衍生品交易业务，有利于加强公 司的外汇风险管控能力。 2、交易额度及授权有效期 公司及合并报表范围内的子公司拟开展不超过15亿美元（或等值人民币） 的外汇衍生品业务，自股东大会审议批准之日起12个月内有效。上述额度在审 批期限内可循环使用。有效期内公司及合并报表范围内的子公司开展外汇衍生 品交易业务，任意时点余额不超过15亿美元（或等值人民币）。 3、资金来源 公司拟开展的外汇衍生品交易资金来源于公司自有资金，不存在直接或间 接使用募集资金从 ...

证券代码：002821 证券简称：凯莱英 公告编号：2025-020 凯莱英医药集团（天津）股份有限公司 一、拟续聘会计师事务所的基本信息 （一）机构信息 （1）安永华明 1、基本信息 安永华明于 1992 年 9 月成立，2012 年 8 月完成本土化转制，从一家中外合 作的有限责任制事务所转制为特殊普通合伙制事务所。安永华明总部设在北京， 注册地址为北京市东城区东长安街 1 号东方广场安永大楼 17 层 01-12 室。截至 2024 年末拥有合伙人 251 人，首席合伙人为毛鞍宁先生。安永华明一直以来注 重人才培养，截至 2024 年末拥有执业注册会计师逾 1700 人，其中拥有证券相关 业务服务经验的执业注册会计师超过 1500 人, 注册会计师中签署过证券服务业 务审计报告的注册会计师逾 500 人。安永华明 2023 年度经审计的业务总收入人 民币 59.55 亿元，其中，审计业务收入人民币 55.85 亿元，证券业务收入人民币 24.38 亿元。2023 年度 A 股上市公司年报审计客户共计 137 家，收费总额人民币 9.05 亿元。这些上市公司主要行业涉及制造业、金融业、批发和零售业、采矿 ...

根据《上市公司监管指引第2号——上市公司募集资金管理和使用的监管要求》及 《深圳证券交易所上市公司自律监管指引第1号——主板上市公司规范运作》和《深圳 证券交易所上市公司自律监管指南第2号——公告格式》等有关规定，凯莱英医药集团 （天津）股份有限公司（以下简称"公司"或"本公司"）董事会编制《关于2024年 度募集资金存放及使用情况的专项报告》，详细情况如下： 一、资金募集基本情况 （一）实际募集资金金额、资金到位时间 经中国证券监督管理委员会证监许可[2020]1912号文《关于核准凯莱英医药集团 （天津）股份有限公司非公开发行股票的批复》核准，公司于2020年9月向特定投资者 发行人民币普通股（A股）股票10,178,731.00股，每股发行价为227.00元/股，募集资 金总额为人民币2,310,571,937.00元，扣除券商承销费用（不含税）32,696,772.70 元，公司实际收到募集资金人民币2,277,875,164.30元，扣除其他发行费用人民币 2,914,508.24元，实际募集资金净额人民币2,274,960,656.06元。上述资金到账情况 业经容诚会计师事务所（特殊普通合伙）出具 ...