花旗发表研报指，将药明生物列为委托开发制造商(CDMO)领域首选标的之一，考虑收入增长加快及盈 利能力改善，目标价由35港元上调至40港元，予"买入"评级。另外，该行将2025至27年各年收入预测分 别上调2%、2%及1%，净利润预测分别上调15%、10%及11%。 ...

Core Viewpoint - CICC maintains its earnings forecast for Kingser Bio-Tech (01548) for 2025 and 2026, reiterating an outperform rating while raising the target price by 22.2% to HKD 21.50, indicating a potential upside of 21.3% from the current stock price [1] Group 1: Financial Performance - For 1H25, the company reported revenue of USD 519 million, a year-on-year increase of 81.9%, with adjusted net profit of USD 178 million, corresponding to a net profit margin of 34.3% [2] - The gross profit was USD 321 million, resulting in a gross margin of 61.8%, reflecting improved profitability driven by capacity utilization and product mix upgrades [2] - The net loss attributable to shareholders was USD 25 million, significantly narrowed from the previous year, primarily due to a loss of USD 194 million from the associate Legend Biotech [2] Group 2: Business Segments - The Life Sciences segment achieved revenue of USD 250 million in 1H25, up 11.3% year-on-year, driven by protein business growth of 52% and demand for gene editing and AI-related R&D [3] - The CDMO segment saw revenue of USD 250 million, a remarkable increase of 511.1%, with significant contributions from a one-time payment of USD 214 million related to the licensing of Lixin [4] - The Industrial Synthetic Biology segment reported revenue of USD 39 million, an 8.4% increase, although it faced an adjusted operating loss of USD 58,000 due to increased R&D investments [5] Group 3: Strategic Initiatives - The company is focusing on enhancing its global presence and market position through continuous investment in R&D and sales efforts, which has slightly impacted short-term profitability [3][5] - The CDMO segment is expected to achieve key milestones, including potential licensing transactions by the end of 2025 to early 2026 [4] - The Industrial Synthetic Biology segment's innovative product, sweet protein, has received FDA GRAS recognition, with commercial production facilities expected to be operational by mid-2026 [5]

Group 1 - CRO concept stocks have shown significant gains, with notable increases in share prices for companies such as Viatris (up 12.83% to HKD 2.11), Zhaoyan New Drug (up 9.23% to HKD 24.62), and others [1] - WuXi AppTec has raised its full-year sales forecast after reporting a 141.6% year-on-year increase in TIDES business revenue, reaching RMB 5.03 billion in the first half of the year, driven by high demand in the GLP-1 sector [1] - CICC believes that the valuation center for innovative drug sectors has been adjusted upwards, which will enhance domestic new drug R&D demand and increase financing activity for primary innovative drug projects [1] Group 2 - The U.S. Bureau of Labor Statistics reported stable inflation in July, reducing barriers for potential interest rate cuts by the Federal Reserve in September, indicating a recovery trend in overall investment and financing [2] - The domestic market for preclinical CRO, clinical CRO, and CDMO services has stabilized in pricing, with a steady recovery in new orders expected to lead to an industry turnaround [2] - Internationally, the CDMO pricing system remains reasonable, and the impact of high pandemic baselines has been absorbed, suggesting a positive trend for overseas orders [2]

Core Viewpoint - The financial performance of the company shows mixed results, with revenue growth but a significant decline in net profit, indicating potential challenges in cost management and operational efficiency [1][3]. Financial Performance Summary - Total revenue for the first half of 2025 reached 920 million yuan, a year-on-year increase of 23.48% compared to 745 million yuan in 2024 [1]. - Net profit attributable to shareholders was 72.5 million yuan, down 26.54% from 98.7 million yuan in the previous year [1]. - Gross margin decreased to 31.05%, down 24.05% year-on-year, while net margin fell to 7.88%, a decline of 40.51% [1]. - The company reported a significant increase in operating cash flow per share, which rose by 240.51% to 2.34 yuan [1]. Accounts Receivable and Cash Management - Accounts receivable amounted to 299 million yuan, representing a decrease of 25.27% from 400 million yuan in the previous year, but still high at 136.06% of net profit [1][5]. - The company improved cash management, leading to a 14.51% increase in cash and cash equivalents [3]. Cost Structure and Expenses - Total sales, management, and financial expenses were 136 million yuan, accounting for 14.77% of revenue, a decrease of 18.81% year-on-year [1]. - Operating costs increased by 44.0%, attributed to revenue growth and changes in business structure [3]. Production Capacity and Orders - The company maintains a production capacity utilization rate of 60-70%, which is considered reasonable for the industry [7]. - New orders have been increasing, with overseas orders accounting for 60-70% and domestic orders for 30-40% [7][8]. Investment and Future Outlook - The company has over 70 clinical phase III and commercialization projects, with a growing proportion of strategic clients contributing to future revenue [8]. - Analysts expect the company's performance in 2025 to reach 217 million yuan, with an average earnings per share of 1.09 yuan [5].

Group 1 - The core viewpoint of the report is a recommendation for Jiuzhou Pharmaceutical (603456.SH) with a latest price of 18.46 yuan, highlighting its growth potential in the CDMO business and emerging technologies [2] - The revenue structure shows steady growth in the CDMO business, while the specialty API segment has experienced a year-on-year decline [2] - The project funnel for CDMO continues to expand, with a steady increase in the number of commercialized projects [2] - The establishment of new technology platforms has shown significant results, with rapid growth in overseas orders for TIDES business [2]

Summary of Jiuzhou Pharmaceutical Conference Call Company Overview - **Company**: Jiuzhou Pharmaceutical - **Industry**: Pharmaceutical Contract Development and Manufacturing Organization (CDMO) Key Points CDMO Business Growth - Jiuzhou Pharmaceutical's CDMO business is experiencing steady growth with a rich project pipeline, including 38 projects that have been launched and 90 in Phase III clinical trials, along with over 1,000 projects in Phase I and II [2][4][5] - The company serves over 80 global clients, covering more than 100 active projects, including innovative drugs, generics, and high-barrier formulations [2][4] Emerging Business Segments - Rapid growth in emerging businesses such as peptides and pentavalent vaccines, with over 20 new clients acquired, and orders nearing $10 million [2][6] - Successful delivery of over ten projects in these segments, indicating significant future growth potential [2][6] Generic Drug Business - Steady progress in the generic drug sector, with two specialty raw materials and two generic formulations approved in the first half of the year [2][7] - A total of 22 projects in the generic pipeline, with 8 approved and 9 under review [2][7] Financial Performance - For the first half of 2025, Jiuzhou Pharmaceutical reported revenue of 2.87 billion yuan, a year-on-year increase of 3.86%, and a net profit of 526 million yuan, up 10.7% [3] - The company has strengthened relationships with major clients, particularly in the Japanese and Korean markets, leading to significant project growth [3] Capacity Utilization and Profit Margins - CDMO capacity utilization is steadily increasing, with optimistic gross margin expectations for the next two to three years due to process optimization and a higher proportion of high-value products [2][10] - The gross margin for the first half of 2025 was approximately 41%, with expectations for stability throughout the year [12] New Factory Developments - The new factory in Taizhou has completed validation for five CDM raw material projects and is attracting numerous follow-up projects due to high management standards and successful FDA inspections [2][13] - The factory's capacity utilization is expected to continue increasing in the coming years [13] Market Trends and Client Structure - The client structure remains predominantly large pharmaceutical companies, accounting for 70-75% of business, with significant growth in the U.S. market [14][15] - The company anticipates an increase in collaboration with large pharmaceutical firms, driven by successful partnerships and potential acquisitions of biotech clients [15] Future Plans and Capital Expenditure - Jiuzhou Pharmaceutical plans to enhance global R&D capabilities and expand advanced production capacity, with a multi-functional GMP production line expected to be operational by late 2025 [9][21] - The company has approximately 3 billion yuan in cash reserves for strategic investments and acquisitions [21] International Expansion - The company has made significant inroads into the Japanese market, becoming a supplier for over half of the top ten pharmaceutical companies in Japan, with a growth rate of 30-40% annually [22] - Plans for further expansion into Europe and the U.S. are underway, focusing on small molecule production lines [17] New Product Development - Jiuzhou Pharmaceutical is focusing on new business areas such as small nucleic acids and ADCs, with expectations for significant contributions in the next two to three years [23][24][26] - The company is also expanding its peptide production capacity to meet growing demand, with a new facility set to produce 800 kg annually [25] Overall Confidence - The company expresses strong confidence in continued growth across all business segments, particularly in overseas client expansion and recovery in industry cycles [31]

Investment Rating - The investment rating for the company is maintained as "Buy" with a target price of RMB 29.12 [1][7]. Core Views - The company has shown a positive growth trajectory in its revenue and profit, with a notable increase in the contribution from high-margin CDMO business [2][3]. - The company’s CDMO business achieved revenue of RMB 22.91 billion in the first half of 2025, reflecting a year-on-year growth of 16% [3]. - The company is expanding its new business capabilities, with significant progress in peptide and conjugated drug production, as well as small nucleic acid projects [4]. Summary by Sections Financial Performance - In the first half of 2025, the company reported revenue of RMB 28.71 billion, a year-on-year increase of 4%, and a net profit attributable to the parent company of RMB 5.26 billion, up 11% year-on-year [1]. - The second quarter of 2025 saw revenue of RMB 13.81 billion, with net profit increasing by 16% year-on-year [1]. CDMO Business - The CDMO business is a key growth driver, with a revenue contribution increasing from 71% in 2024 to 80% in the first half of 2025, leading to an improvement in gross margin from 35% to 37% [2]. - The company has a robust project pipeline, with 1,086 projects in clinical phases and 38 in commercialization as of the first half of 2025 [3]. New Business Development - The company has made strides in building capabilities for new business areas, including the expansion of facilities for peptide and conjugated drugs, and has onboarded over 20 new clients in the first half of 2025 [4]. Profit Forecast and Valuation - The forecast for net profit attributable to the parent company for 2025-2027 is RMB 9.14 billion, RMB 9.52 billion, and RMB 9.74 billion respectively, with corresponding EPS of RMB 1.03, RMB 1.07, and RMB 1.09 [5][10]. - The company is valued at RMB 259 billion using the SOTP method, with a target price of RMB 29.12 based on a total share count of 889 million [5][12].

Core Viewpoint - The company reported strong performance in 1H25, with revenue and net profit exceeding expectations due to recovery in core CDMO demand and stabilization of raw material prices [1][4]. Financial Performance - In 1H25, the company achieved revenue of 2.871 billion yuan, a year-on-year increase of 3.9%, and a net profit attributable to shareholders of 526 million yuan, up 10.7% year-on-year [1]. - For Q2 alone, revenue was 1.381 billion yuan, reflecting a year-on-year increase of 7.2% but a quarter-on-quarter decrease of 7.4; net profit for the quarter was 276 million yuan, up 15.7% year-on-year and 10.2% quarter-on-quarter [1]. Business Segments - The core CDMO business showed robust growth, generating revenue of 2.29 billion yuan in 1H25, a year-on-year increase of 16.3%, with a gross margin of 41.0% [2]. - The company has a healthy project pipeline, with 38 projects already on the market and 1,086 projects in various clinical phases [2]. - The raw material business generated revenue of 523 million yuan in 1H25, a year-on-year decline of 28.48%, but with a gross margin of 23.26%, which is an increase of 2.07 percentage points [3]. Strategic Developments - The company is actively building capabilities in peptide, conjugate, and small nucleic acid drug technologies, having onboarded over 20 new clients and completed more than 10 projects in 1H25 [2]. - The integration strategy of "raw materials + formulations" is ongoing, with 22 formulation projects, 8 of which have been approved and 9 submitted for approval as of 1H25 [3]. Profit Forecast and Valuation - Due to the recovery in CDMO demand and stabilization of raw material prices, the company has raised its net profit forecasts for 2025 and 2026 by 14.5% and 8.7% to 950 million yuan and 1.084 billion yuan, respectively [4]. - The target price has been increased by 43.6% to 22.40 yuan, corresponding to 21.0 times the 2025 P/E ratio and 18.4 times the 2026 P/E ratio, indicating a potential upside of 20.0% from the current stock price [4].

（企业公告） 公告介绍，公司CDMO项目管线日益丰富，已经形成了可持续的临床前/临床Ⅰ、II、III期的漏斗型项目 结构。截止报告期末，公司已承接的项目中，已上市项目38个，III期临床项目90个，Ⅰ期和II 期临床试 验的有1086个，项目涵盖抗肿瘤、抗心衰、抗病毒、中枢神经和心脑血管等治疗领域。已递交NDA的 新药项目数快速增加，将持续助推公司业务稳健增长。 在多肽和偶联业务方面，报告期内，引入新客户20多家，在手订单的项目主要涵盖降糖、癌症类治疗领 域，其中海外订单增速较快。公司已完成十多个项目的交付工作，获得客户的高度评价。随着多肽及偶 联药物全球市场的快速发展，未来项目承接数量将持续增加。 近日，九洲药业发布2025年半年报。披露上半年营收增长3.86%至28.71亿元，归属净利提高10.70%至 5.26亿元。 ...

Group 1: Small Molecule CDMO Business - The company focuses on technological innovation to build a leading global CDMO platform for innovative drugs, serving major pharmaceutical companies like Novartis [1] - The sales of the company's Noxintin project raw materials have significantly increased, with sales growing from $507 million in 2017 to $7.822 billion in 2024, reflecting a CAGR of 47.83% [1] - In the first half of 2025, sales reached $4.618 billion, representing a year-on-year growth of 22.27% [1] Group 2: Peptide Conjugate CDMO Services - The company has established a TIDES division to expand peptide conjugate drug and small nucleic acid technology platforms, providing comprehensive CDMO services from preclinical research to commercial production [2] - The company is actively expanding its peptide production capacity, with the second phase of peptide capacity construction initiated by the end of 2024, including the expansion of OEB5 level high-activity workshops [2] Group 3: API Business - The company is strategically positioning itself in the market by focusing on specialty APIs in areas such as anti-infectives, central nervous system drugs, non-steroidal anti-inflammatory drugs, and hypoglycemic agents [3] - Sales of anti-infective APIs increased from 292.46 tons in 2021 to 325.32 tons in 2024, with a CAGR of approximately 3.61% [3] - Sales of central nervous system APIs grew from 863.34 tons in 2021 to 1003.08 tons in 2024, with a CAGR of approximately 5.13% [3] - Sales of non-steroidal APIs rose from 298.93 tons in 2021 to 368.45 tons in 2024, with a CAGR of approximately 7.22% [3] - Sales of hypoglycemic APIs increased from 328.26 tons in 2021 to 362.66 tons in 2024, with a CAGR of approximately 3.38% [3] Group 4: Investment Recommendations - The company is projected to achieve net profits attributable to shareholders of 921 million yuan, 1.052 billion yuan, and 1.158 billion yuan from 2025 to 2027, representing year-on-year growth of 52.0%, 14.2%, and 10.0% respectively [4] - Based on the average valuation of comparable A-share listed companies, a PE ratio of 23 times is assigned for 2025, with an expected EPS of 1.04 yuan per share, leading to a target price of 23.92 yuan per share in six months [4]