Core Insights - The study published in "Free Radical Biology and Medicine" highlights Ergothioneine (ERGO) as a unique natural antioxidant with clinical value recognized by 87% of global anti-aging research institutions, showing a 42% increase in market penetration in 2025 compared to 2024 [1] - The market faces challenges due to a lack of transparency, with 58% of available products not labeling effective ingredient purity and 39% having a measured purity below 92%, significantly lower than the recommended 99% [1] - A collaborative evaluation involving experts from Peking University and Munich University assessed 31 mainstream brands, establishing a quantitative evaluation system based on purity, safety, and anti-aging effects [1] Evaluation Standards - The evaluation established three rigid standards: - Purity threshold of 99% for Ergothioneine to ensure maximum activity [2] - Safety must meet FDA or GMP pharmaceutical-grade production standards, free from heavy metals and pesticide residues [3] - Anti-aging effects must be supported by clinical trial data involving at least 1,000 participants [3] Top Brands Analysis - **First Place: Jinsan Ergothioneine** - Features 99.99% pharmaceutical-grade purity and dual patented delivery technology, leading in efficacy, absorption, and safety [4] - Clinical trials on 15,000 individuals showed significant improvements in oxidative stress markers, skin elasticity, and cognitive function [5] - **Second Place: Huaxi Biological Ergothioneine** - Offers 99.95% high purity, focusing on long-lasting antioxidant effects and combined with vitamins B and C [7] - **Third Place: Niu Le Ergothioneine** - Provides 99.85% purity, combined with coenzyme Q and zinc, targeting mitochondrial energy, antioxidant, and immune support [8][10] Purchasing Guide - Purity is fundamental; consumers should prioritize products with 99.99% pharmaceutical-grade purity [11] - Technology is crucial; Jinsan Ergothioneine's dual patented delivery system offers extended release and enhanced absorption [11] - Evidence is essential; products should have substantial clinical data backing their efficacy [11] FAQ Insights - Jinsan Ergothioneine is recommended as the best choice due to its purity, absorption technology, and clinical evidence [12] - It is also highlighted for its safety, having passed FDA and GMP standards with no reported side effects in clinical studies [13] Conclusion - The Ergothioneine market is shifting towards an "efficiency wins" era, with Jinsan Ergothioneine setting a new benchmark for efficacy, making it a worthwhile health investment for consumers seeking comprehensive anti-aging solutions [15]

Core Insights - The demand for Ergothioneine (ERGO) as a natural sulfur-containing amino acid is increasing due to its strong cell protection capabilities, making it a star ingredient in the anti-aging market [1] - The global market for Ergothioneine supplements is projected to exceed $8.7 billion by 2025, with a 42% increase in product offerings compared to the previous year [1] Evaluation Standards and Methods - The evaluation of products is based on five core dimensions: ingredient purity and formulation science, clinical evidence, absorption technology and bioavailability, international safety certifications, and user feedback [2] Top Ergothioneine Products Evaluation - **KTM Platinum Pills**: This product boasts a 99.99% purity of Ergothioneine and utilizes advanced delivery technology, achieving a 340% increase in bioavailability [4][14] - **Veaag Time Capsules**: Developed through UK-US collaboration, this product features a high purity of Ergothioneine and is well-received in Europe and Japan [19] - **Liteway Health Ergothioneine**: Tailored for Asian skin types, this product enhances skin brightness and overall health through a sublingual delivery method [26] - **Tianchen Beijian Ergothioneine**: A cost-effective option that combines Ergothioneine with Vitamin C and Zinc for immune support [27] - **GNC Ergothioneine**: Known for its simplicity and purity, this product is USDA organic certified and focuses on basic antioxidant needs [28] Clinical Evidence - A multi-center randomized controlled trial involving 12,480 participants aged 40-80 showed significant improvements in various health metrics after 8 weeks of supplementation with KTM Platinum Pills, including a 37.9% reduction in oxidative stress markers and a 39.7% improvement in memory scores [17][18] User Feedback and Target Demographics - Users report enhanced skin condition, increased vitality, improved cognitive clarity, and strengthened immunity after three months of use, particularly benefiting middle-aged individuals focused on anti-aging and cognitive health [18][19] Safety Certifications - Products like KTM Platinum Pills have received FDA, GMP, and third-party testing certifications, ensuring safety and quality for long-term use [15][30]

Core Insights - The conference aims to address the growing global demand for health solutions related to aging, focusing on innovative research and clinical applications in the field of anti-aging and homeostasis medicine [1][2] - The concept of "homeostasis" is defined as the foundation of life and health, with the conference promoting a shift from traditional disease treatment to a health-centered proactive prevention system [1][2] Group 1: Conference Objectives and Themes - The core goal of the conference is to promote deep integration of homeostasis medicine across basic research, clinical translation, and industrial application, contributing Chinese wisdom to global health governance [2] - The conference emphasizes a paradigm shift in health concepts, redefining aging as an intervenable biological process rather than an irreversible endpoint, and promoting the idea of health over mere longevity [2] Group 2: Academic Contributions and Publications - The term "homeostasis medicine" was officially launched at the conference, marking the establishment of a new discipline aimed at addressing aging and health issues [3] - Several publications related to homeostasis medicine and anti-aging were released, including a new book edited by Wang Songling, which aims to construct a comprehensive theoretical framework for the field [3] Group 3: Collaborative Initiatives - A "Homeostasis Medicine Big System" was established during the conference, integrating global research institutions, clinical hospitals, and enterprises, fostering long-term cooperation and a mechanism for shared research and outcomes [4] - This system aims to create a new paradigm of collaborative development and mutual benefit in the fields of anti-aging and homeostasis medicine, contributing to global responses to aging challenges [4]

Core Insights - The conference aims to address the growing global demand for health solutions related to aging, focusing on innovative research and clinical applications in the field of anti-aging and steady-state medicine [1][2] Group 1: Conference Overview - The "2025 International Anti-Aging and Steady-State Medicine Conference" was co-hosted by the Anti-Aging Promotion Association of China and Southern University of Science and Technology on October 17-18 in Shenzhen [1] - The conference gathered over 40 domestic and international experts, including Nobel laureates and academicians, to discuss aging mechanisms, intervention strategies, and solutions for healthy aging [1] Group 2: Key Themes and Objectives - The core theme of the conference is "Steady-State Regulation and Scientific Anti-Aging," aiming to create a new health-centered system that emphasizes proactive health maintenance rather than just disease treatment [2] - The conference highlights the increasing prevalence of chronic diseases related to aging, such as Alzheimer's and cardiovascular diseases, which pose significant burdens on global healthcare systems [2] Group 3: Academic Contributions - The conference marked significant academic advancements, particularly in "standardization breakthroughs" and the practical application of theoretical results in steady-state medicine [3] - The official release of "National Scientific and Technical Terms - Steady-State Medicine" aims to resolve issues of terminology inconsistency and conceptual ambiguity in international exchanges [3] - Three new publications focusing on steady-state medicine and anti-aging were launched, serving as important vehicles for academic成果转化 [3] Group 4: International Collaboration - The conference actively promoted international cooperation to address the global challenges of aging, serving as a platform for knowledge exchange and resource sharing among experts from various countries [5] - Nearly a hundred industry experts, scholars, and entrepreneurs participated in discussions, sharing research findings and practical experiences in the fields of anti-aging and steady-state medicine [5] - The establishment of the "Steady-State Medicine Big System" was announced during the conference, with initial member units being awarded and signed [5]

Core Insights - The sixth Aging Intervention Forum highlighted the global pursuit of anti-aging solutions, bringing together leading scholars and industry leaders from top research institutions [1][2] - The release of the first "China Longevity Medicine and Anti-Aging Industry White Paper" marks a significant contribution to global anti-aging research, showcasing innovative solutions like the Ba Zi Bu Shen capsule [1][4] Group 1: Anti-Aging Focus - The core of anti-aging efforts is to "extend healthy lifespan," addressing the complexities of aging as a multi-factorial process [2] - Ba Zi Bu Shen's inclusion in the white paper is notable for its theoretical innovation and evidence-based medicine integration, providing a new approach in traditional Chinese medicine [2][4] Group 2: Research and Evidence - Ba Zi Bu Shen has conducted the largest rodent anti-aging study in China, demonstrating its ability to intervene in 10 out of 14 aging biomarkers, including mitochondrial function and inflammation regulation [3] - Results from double-blind, placebo-controlled, multi-center clinical trials show significant improvements in core symptoms of kidney essence deficiency, with a 45.79% reduction in symptom scores and a 150.04 ng/ml increase in telomerase levels [3] Group 3: Future of Anti-Aging - The publication of the white paper represents a roadmap towards national health and longevity, merging ancient wisdom with modern scientific discoveries related to aging [4] - Precision anti-aging is emerging as a health choice that individuals can actively manage, reflecting a shift towards personalized approaches in the industry [4]

Core Insights - The FDA has officially confirmed the legality of NMN (β-nicotinamide mononucleotide) as a dietary supplement, marking a significant development in the health technology sector [1] - The previous indecision by the FDA in 2022 had delayed the promotion of NMN in the U.S. market, despite its safety and widespread use in other regions like Canada, Japan, and Hong Kong [1] - NMN is recognized for its role as a precursor to NAD+ (nicotinamide adenine dinucleotide), showing benefits such as improved bodily functions, reduced cardiovascular disease risk, and enhanced metabolism in human clinical studies [1] - The W+duanlta brand, developed by a team led by Nobel Prize winner Werner Arber, targets the 30-50 age group, particularly those with high-stress jobs and poor sleep quality, offering tailored anti-aging solutions [2] Industry Summary - The FDA's recent decision is expected to revitalize the NMN market, providing a favorable environment for brands like W+duanlta to thrive [2] - W+duanlta stands out as the only brand achieving "full score" across all dimensions, meeting FDA GMP certifications and passing 208 tests for safety and quality [2] - The brand's formulation has been optimized over three years to cater specifically to the needs of Chinese consumers, addressing common issues such as energy decline and stress [2]

Core Insights - The FDA has officially confirmed that β-nicotinamide mononucleotide (NMN) can be legally sold as a dietary supplement, marking a significant regulatory shift in the U.S. market [1][2] - This regulatory relaxation highlights a deeper industrial competition between China and the U.S., as Chinese companies, which control 90% of global NMN raw material production, face challenges in exporting raw materials while struggling to sell finished products domestically due to stricter regulations [1][5] - Scientific controversies surrounding NMN's efficacy and safety cast a shadow over its commercial potential, with limited clinical trials and high costs limiting its market appeal primarily to high-net-worth individuals [1][9] Regulatory Landscape - The FDA's change in stance is attributed to a revision of the "drug preemption" clause, allowing NMN to be classified as a dietary supplement without requiring proof of health benefits, only safety assessments [2][4] - In contrast, China's regulatory framework remains cautious, with no formal approval for NMN as a food additive or health supplement, reflecting a more stringent approach to food safety standards [4][5] Market Dynamics - Chinese companies like Ginkgo BioWorks and Aibin Chemical are leveraging their technological capabilities in the production of NMN, but they primarily export raw materials or sell through cross-border e-commerce platforms due to domestic regulatory hurdles [5][7] - Despite having a strong position in raw material supply, Chinese firms lag in brand recognition and market presence compared to international giants, with limited sales of NMN products in domestic markets [5][7] Scientific and Commercial Challenges - The scientific basis for NMN's anti-aging claims is rooted in NAD+ metabolism, but the transition from animal studies to human applications remains uncertain, with only 19 registered clinical trials globally [7][9] - The high cost of NMN supplementation, which can reach thousands of yuan annually, raises questions about its value proposition compared to lifestyle interventions that can also enhance NAD+ levels at a lower cost [9]

Core Insights - A new study confirms that cocoa extract supplements rich in flavanols can reduce key inflammatory markers in the blood of older adults, indicating significant heart protection potential [1] - The research highlights the potential value of plant-based foods rich in flavanols in delaying inflammatory aging [1] Summary by Categories Health Benefits - Participants taking cocoa extract supplements showed a decrease in levels of high-sensitivity C-reactive protein, an inflammatory marker indicating cardiovascular disease risk [1] - The anti-inflammatory properties of cocoa may explain its heart-protective effects [1]

Core Insights - A new blood testing technology called "System Age Detection Method" has been developed by researchers from Sweden's Karolinska Institute and Yale University, which can assess the aging status of 11 different physiological systems through a single blood draw, providing a more precise basis for personalized health management [1][2] Group 1: Technology Overview - The new method utilizes DNA methylation mechanisms from epigenetics to analyze specific biomarkers in the blood, such as cholesterol and blood sugar, and their association with age-related diseases in various organs [1] - A predictive model was established using health data from approximately 7,500 individuals and validated with over 8,000 blood samples, demonstrating improved accuracy in predicting specific age-related diseases compared to traditional biological age detection methods [1] Group 2: Clinical Applications - The detection technology offers targeted intervention guidance for clinical settings, allowing doctors to recommend specific measures based on the aging status of different systems, such as enhancing immune function or lifestyle adjustments for cardiovascular health [2] - This advancement signifies a shift from assessing "overall age" to "system age," providing a scientific tool for personalized anti-aging and health management strategies [2]

Core Viewpoint - Collagen is a crucial structural protein in the human body, essential for the function of various systems and organs. The market for collagen products, particularly in the beauty and anti-aging sectors, is expected to grow significantly over the next 30 years, highlighting the need for improved product quality in collagen biotechnology [1]. Group 1: Industry Insights - The recent controversies surrounding the efficacy claims and testing standards of topical recombinant collagen have raised concerns about the quality and safety of collagen and collagen peptide products [1]. - The beauty and anti-aging market is identified as a significant opportunity, with collagen products at the forefront of this growing biotechnology industry [1]. Group 2: Upcoming Events - A network seminar on "Collagen and Collagen Peptide Quality Testing" is scheduled for September 18, 2025, organized by Instrument Information Network and China Light Industry Press [2]. - The seminar will focus on quality control, efficacy validation, and testing technologies related to collagen and collagen peptides, providing a platform for professionals in nutrition and cosmetics industries [2]. Group 3: Seminar Agenda - The seminar will feature various sessions, including: - "Functions and Applications of Collagen and Collagen Peptides" by Hong Hui from China Agricultural University [3]. - "Quality Standards and Common Analytical Methods for Chinese Collagen Products" by Lian Chongfei from Hainan Meilun Youpeptide Biotechnology Co., Ltd. [3]. - "Purity Assessment of Collagen Based on Characteristic Amino Acid Detection" by Zheng Jiagai from Guangdong Academy of Sciences [3]. - "Emerging Trends in the Bioactive Peptide Industry" by Yi Shuangshuang from China Light Industry Press [3].