Core Viewpoint - Zhuohe Pharmaceutical Group Co., Ltd. is a comprehensive enterprise focusing on drug research and development, sales, and marketing authorization holder (MAH), with a strategy that combines raw materials and formulations, innovative drugs, and specialty generics, aiming for both domestic and global markets [1] Group 1: Talent and Innovation - Talent is a strong driving force for innovation in the biopharmaceutical sector, and the company has implemented a comprehensive employee quality improvement system, including business training and skill competitions [2] - The company has established a "1+1" mentor training model to cultivate young talents and has recognized several individuals as high-level innovative talents at various governmental levels [2] - The head of the R&D analysis department has led the team to overcome challenges in multiple new drug projects and has been recognized for her contributions, including a national invention patent [2] Group 2: Innovation System - The company emphasizes that R&D innovation is the source of its development and has established several provincial-level research centers and specialized R&D platforms [3] - Currently, the company has over 70 ongoing research projects in various disease areas and has received 22 domestic and international invention patents, with over 100 patent applications filed [3] - Notable achievements include the approval of a traditional Chinese medicine innovative drug and the advancement of a new generation JAK1 selective inhibitor into phase III clinical trials [3] Group 3: Global Market Expansion - Zhuohe Pharmaceutical is actively expanding its international business, with 13 raw material products certified in major markets, including the U.S., EU, and Japan [4] - The company has achieved significant market presence, with its raw material product, Neomycin sulfate, holding over 50% of the global high-end market [4] - Recent milestones include FDA registration for its oral formulation workshop and the approval of a new drug application for a specific capsule, marking entry into mainstream international markets [4]

Core Insights - Roche plans to invest $50 billion in the U.S. market over the next five years, following Novartis's $23 billion investment, as part of a response to the "America First" tariff policy [1] - This investment is expected to create over 12,000 direct jobs, including 6,500 in infrastructure and 1,000 from new factory construction and existing capacity expansion [1] - Roche aims to transition its U.S. subsidiary from a net importer to a net exporter of pharmaceuticals, enhancing the competitiveness of the domestic pharmaceutical industry [2] Investment Details - The investment will focus on building research and production facilities in Indiana, Pennsylvania, Massachusetts, and California, covering cutting-edge fields such as biopharmaceuticals and gene therapy [1] - The CEO of Roche emphasized that this investment is a commitment to the U.S. market and aims to ensure that the U.S. remains a leader in global biopharmaceutical innovation [1] Strategic Implications - The concentrated investment by multinational pharmaceutical companies indicates the ongoing strategic value of the U.S. market in the global biopharmaceutical landscape [2] - By establishing new R&D bases and smart factories, Roche aims to mitigate the cost impacts of tariff policies on its supply chain [2]

股票简称：智翔金泰 股票代码：688443 重庆智翔金泰生物制药股份有限公司 Chongqing Genrix Biopharmaceutical Co., Ltd. （重庆市巴南区麻柳大道 699 号 2 号楼 A 区） 首次公开发行股票 科创板上市公告书 保荐人（主承销商） 上海市广东路 689 号 二〇二三年六月十九日 特别提示 重庆智翔金泰生物制药股份有限公司（以下简称"智翔金泰"、"发行人"、 "公司"、"本公司"）股票将于 2023 年 6 月 20 日在上海证券交易所科创板上市。 本公司提醒投资者应充分了解股票市场风险及本公司披露的风险因素，在新 股上市初期切忌盲目跟风"炒新"，应当审慎决策、理性投资。 1 第一节 重要声明与提示 一、重要声明 本公司及全体董事、监事、高级管理人员保证上市公告书所披露信息的真实、 准确、完整，承诺上市公告书不存在虚假记载、误导性陈述或重大遗漏，并依法 承担法律责任。 上海证券交易所、有关政府机关对本公司股票上市及有关事项的意见，均不 表明对本公司的任何保证。 本 公 司 提 醒 广 大 投 资 者 认 真 阅 读 刊 载 于 上 海 证 券 交 易 所 网 站 ...