Core Viewpoint - The commemoration of Qian Xuesen's return to China highlights the importance of inheriting the spirit of older generations of scientists, emphasizing dedication and focus in addressing key technological challenges [1][2]. Group 1: Commemoration Activities - The Chinese Academy of Sciences' Institute of Mechanics held a commemorative event for the 70th anniversary of Qian Xuesen's return, featuring a special exhibition titled "For the Country's Sword: Qian Xuesen and China's Aerospace Industry" [1]. - Liu Guiju, the Party Secretary of the Institute of Mechanics, reflected on Qian Xuesen's contributions and the institute's achievements over the past 70 years in scientific research and talent cultivation [1]. Group 2: Youth Team's Responsibilities - Zhang Chen'an, a representative of the Qian Xuesen Technology Assault Youth Commando Team, expressed the transformation of the team's identity and the responsibility that comes with it, emphasizing the need to honor the legacy of Qian Xuesen [2]. - The team is committed to producing innovative results that live up to the expectations associated with Qian Xuesen's name, focusing on the importance of integrity and respect in their research [2]. Group 3: Technological Advancements - Zhang Chen, an engineer at the Institute of Mechanics and a member of the youth team, shared the team's efforts in advancing hypersonic technology under Qian Xuesen's "engineering science" philosophy [3]. - The team has made significant strides in addressing national demands for high-speed, low-cost, and practical flight technologies, achieving multiple domestic firsts through innovative design and rapid iteration processes [3].

Core Insights - The news highlights the significant advancements in digital transformation within the manufacturing sector in Zhaoqing High-tech Zone, Guangdong, particularly in the electric vehicle and precision manufacturing industries. Group 1: Digital Transformation in Manufacturing - The Zhaoqing High-tech Zone has implemented a "government-led, platform-enabled, leading enterprises, and diversified services" mechanism to promote digital transformation in manufacturing, resulting in a production value of 25.033 billion yuan in the new energy vehicle sector from January to July this year [1] - Kubo Precision Technology Co., Ltd. has achieved an automation level of 80% in its production processes, aiming for over 85%, enhancing product quality and competitiveness [2] - The Zhaoqing High-tech Zone has successfully created a "smart energy + intelligent connected new energy vehicle" industrial internet integration application innovation park, recognized as a model for digital transformation in Guangdong Province [3] Group 2: Innovations and Efficiency Improvements - Maxil Electric Technology Co., Ltd. has introduced a modular production line and AI dynamic scheduling system, leading to a 12.9% reduction in energy consumption per unit of output and a 9.58% increase in inventory turnover rate [4] - The Zhaoqing High-tech Zone has facilitated digital transformation for 240 enterprises, resulting in an average efficiency improvement of over 15% and a reduction in labor costs by over 30% [5]

Core Insights - The Chinese biopharmaceutical industry has achieved significant international recognition and growth, transitioning from a follower to a key contributor in the global market during the "14th Five-Year Plan" period [1][5]. Group 1: International Collaborations and Financial Milestones - In just two days, Chinese innovative drugs secured five major international deals, with several transactions exceeding $1 billion, including a $16.4 billion collaboration between Shenzhen Pruijun Biopharmaceutical Co., Ltd. and Gilead Sciences' Kite Pharma [1]. - The total value of China's innovative drug licensing agreements reached nearly $66 billion in the first half of 2025, surpassing the entire 2024 total of $51.9 billion [5]. Group 2: Technological Advancements in Drug Development - The integration of artificial intelligence and other cutting-edge technologies has transformed drug development in China, allowing for a more precise and efficient approach [2][3]. - China's share of new drug research and development has exceeded 20% globally, positioning the country as the second-largest in new drug development [2]. Group 3: Clinical Trials and International Recognition - Chinese innovative drugs are increasingly being presented at international academic conferences, demonstrating their clinical trial results that directly compete with global leading drugs [4]. - The development of new drugs such as the CDK2/4/6 inhibitor by Zhengda Tianqing Pharmaceutical Group has showcased China's capability to produce competitive therapies on the international stage [4]. Group 4: Investment in Research and Development - Chinese biopharmaceutical companies are significantly increasing their R&D investments, with some companies reporting annual R&D expenditures exceeding 4 billion yuan [4]. - The focus on original innovation and translational medicine is driving the industry towards achieving globally competitive products [5].

Core Insights - By 2025, AI will be fully integrated into daily life, impacting work, entertainment, education, and research, with its influence becoming increasingly tangible in physical environments [1] - The emergence of AI agents is expected to revolutionize workflows by 2026, enabling them to autonomously manage complex tasks and interact with various systems [2] - The rise of AI and automation will lead to the creation of new job roles while traditional positions may decline, necessitating adaptation and transformation in the workforce [3] - AI is progressively being embedded into routine medical processes, enhancing diagnostic capabilities and patient monitoring, with expectations for broader clinical applications by 2026 [4] - A significant portion of online content is predicted to be AI-generated by 2026, raising concerns about the proliferation of misinformation and the challenge of maintaining valuable human insights [5][6] Group 1 - AI will become a physical presence in homes, factories, and workplaces, redefining human-technology interactions [1] - AI agents will evolve from simple tools to proactive systems capable of managing daily tasks and complex projects [2] - New job roles such as prompt engineers and AI integration specialists will emerge, while some traditional jobs may disappear [3] Group 2 - AI's integration into healthcare will enhance diagnostic accuracy and patient care, marking a shift from experimental to routine clinical use [4] - The potential for AI-generated content to dominate the internet raises concerns about the quality and authenticity of information [5] - The challenge for individuals will be to ensure their unique insights are not overshadowed by the overwhelming volume of AI-generated content [6]

Core Viewpoint - The establishment of a coal-based solid waste resource utilization production line in Shenmu City, Shaanxi Province, marks a significant step towards the industrialization of coal-based solid waste recycling in China, utilizing waste materials such as fly ash and coal gangue to produce low-carbon building materials [1][2]. Group 1: Production and Technology - The production line has an annual capacity of 600,000 cubic meters of cloud concrete stone, effectively transforming solid waste into high-value building materials [1][2]. - The research team has developed a comprehensive process package for recycling coal-based solid waste into microcrystalline glass, cloud concrete stone, and expanded clay, creating a pathway from "black waste" to "green building materials" [2][3]. - The Shenmu production line is described as a "solid waste digestive system," capable of processing 600,000 tons of solid waste annually [2]. Group 2: Economic and Environmental Impact - The Shenmu cloud concrete stone production line generates an average annual profit exceeding 20 million yuan, demonstrating the economic viability of solid waste resource utilization [3]. - The projects not only showcase the potential for environmental protection and economic benefits to coexist but also highlight the vast market for solid waste resource utilization [3]. - The initiative aligns with China's dual carbon goals, emphasizing the importance of solid waste recycling in environmental governance, energy security, industrial upgrading, and a low-carbon future [3].

Core Viewpoint - The successful operation of the 500 kV Tieling Substation project marks a significant advancement in China's energy infrastructure, showcasing the full domestic control and innovation in the power sector [1] Group 1: Project Overview - The Tieling Substation project is China's first fully domestically controlled 500 kV substation, achieving complete localization of core materials, key chips, operating systems, databases, and technical standards [1] - The project consists of the 500 kV Tieling-Shiling line and the 500 kV Xiquan Substation, which demonstrates new operational characteristics of the power system [1] Group 2: Technological Innovation - The Xiquan Substation incorporates 16 types of original technological achievements across five areas, recognized as a national demonstration project for original technology by the State Grid Corporation [1] Group 3: Environmental Impact - The Tieling Substation project can accommodate over 2 million kW of wind and solar power, contributing to an annual increase of over 3 billion kWh in clean energy consumption, equivalent to a reduction of 900,000 tons of standard coal [1] - The project supports the development of renewable energy in northern Liaoning, aiding in the construction of a clean energy province and accelerating the establishment of a new power system in Liaoning, contributing to the "dual carbon" goals [1]

与此同时，何亚琼坦言，行业还存在一些有待解决的问题，如算法模型质量有待提升，中试服务平台体 系建设相对滞后，创新产品的市场化宣传不足等。 谈及未来生物制造的方向时，谭天伟表示，需要着力提高自主创新能力，包括研发一些新的软件和设计 工具、高通量的筛选和反应器等。 近期，工业和信息化部遴选发布了16项人工智能在生物制造领域应用典型案例，组织开展了生物制造标 志性产品、生物制造中试平台遴选发布，以及生物反应器"揭榜挂帅"等工作。何亚琼表示，接下来工业 和信息化部将加快新成果在应用场景方面的先行先试和成果转化，加大力量推动生物制造产业创新发 展。 （文章来源：科技日报） 记者日前从在湖南省常德市举行的以"生机无限制引未来"为主题的生物制造科技创新论坛上获悉，我国 生物制造产业总规模已近万亿元，发酵产能占全球70%以上。工业和信息化部消费品工业司司长何亚琼 在论坛上表示，一批有竞争力的生物制造产业集聚区逐步成长壮大。 中国工程院院士、北京化工大学校长谭天伟介绍，生物制造就是以工业生物技术为核心，利用生物体， 结合工程学原理进行产品的规模化生产。与传统制造业相比，生物制造具有高效性、更好的安全环保 性。 "生物制造凭借其 ...

Core Insights - A drug named "Suxamethonium," a carbonic anhydrase inhibitor, significantly reduces apnea episodes in patients with obstructive sleep apnea, improving sleep quality [1] - The clinical study involved 298 moderate to severe obstructive sleep apnea patients across four European countries, with a double-blind design [1][2] - High-dose Suxamethonium reduced apnea events by up to 47% compared to placebo, with notable improvements in blood oxygen levels [1] Group 1 - Obstructive sleep apnea is a common sleep disorder that can lead to serious health risks if untreated, including hypertension, cardiovascular diseases, stroke, and type 2 diabetes [1] - Continuous positive airway pressure (CPAP) is the primary treatment, but many patients struggle to adhere to it, with up to 50% abandoning treatment within a year due to discomfort [2] - Suxamethonium is already approved for treating pediatric epilepsy, and researchers have explored its potential for treating sleep apnea [2]

然而，这些癌症干细胞仿佛无法忍受失去的"癌症身份"，没有停留在恢复正常细胞状态上，而是选择了 自我毁灭。 为了验证这一方法的临床潜力，团队将药物测试推广到患者来源的类器官模型中。他们还开发了一种基 因签名，即一种可通过基因激活模式预测患者对这种治疗反应的方法。通过对2100多名患者的模拟分析 发现，CDX2基因功能恢复后，结肠癌患者的复发和死亡风险可降低50%。 （文章来源：科技日报） 为了应对这些顽固的癌细胞，研究团队创造了一个名为癌症相关节点分化靶向（CANDiT）的机器学习 工具。该工具能够根据特定肿瘤的独特基因组，识别新的治疗靶点。CANDiT的工作原理是从一个关键 基因入手，这个基因对健康细胞的正常生长至关重要，但在侵袭性癌症细胞中通常缺失。接着， CANDiT会深入分析与该基因相关的基因网络，并提出可通过调控这些网络恢复细胞健康的潜在治疗靶 点。 团队选择结肠癌中的关键基因CDX2作为研究起点。利用CANDiT工具，他们对4600多种不同的肿瘤样 本进行了基因组扫描。通过分析，团队意外地发现了一个新的治疗靶点——PRKAB1蛋白质，它的作用 是促进细胞在应激状态下的生存。随后他们利用现有药物激活P ...

与以往需要外部电源和连接电缆的眼部假体不同，PRIMA芯片依靠光伏效应，仅需光即可产生电流， 因此可完全无线运行并植入视网膜下。患者开始佩戴设备后，所有人的视觉功能均在数月训练后显著提 升。在完成一年试验的32名患者中，27人恢复了阅读能力，26人的视力实现了临床意义上的改善（即在 标准视力表上至少多读两行）。平均而言，患者的视力提高了五整行，其中一人甚至提高了12行。 目前，PRIMA仅提供黑白视觉，无中间灰度。团队在开发新软件，以实现全范围灰度成像，这对于人 脸识别等高级视觉任务至关重要。 （文章来源：科技日报） 该设备名为PRIMA，是首个为无法治愈的视力丧失患者恢复功能性"形式视觉"的眼部假体。"形式视 觉"指能够感知形状和图案的能力，而不仅仅是感知光线。此前，所有尝试通过假体装置恢复视觉的努 力大多仅能实现对光的感知。 PRIMA设备由安装在一副眼镜上的微型摄像头负责捕捉外部图像，并通过红外光将图像实时投射到植 入眼底的无线芯片上。芯片接收到红外信号后，将其转换为电刺激，从而替代因疾病而丧失功能的天然 感光细胞，将视觉信息传递至视网膜中仍完好的神经元。这一装置是数十年研究、原型开发、动物实验 以及早 ...