Core Viewpoint - The era of producing high-value products from CO₂ in the air has arrived, marking significant industrial advancements in the biomanufacturing conversion of carbon-rich gases [1][2]. Group 1: Industrial Challenges and Innovations - The Ministry of Agriculture and Rural Affairs of China has officially approved the use of Debaryomyces hansenii protein as a new feed raw material, representing the first product certificate with independent intellectual property rights derived from CO₂ as the main carbon source [2][4]. - This approval signifies a critical step in the industrial application of this technology, transitioning from laboratory research to practical use [2][4]. - The gas fermentation technology developed by GTLB utilizes inorganic carbon sources (CO₂, CO) to convert them into organic products, overcoming significant industrial challenges [4][6]. Group 2: Production Efficiency and Nutritional Value - The feed protein produced using this gas fermentation technology can achieve production efficiency thousands of times higher than traditional agricultural methods [7]. - A yeast protein factory occupying 150 acres can produce 100,000 tons of high-quality yeast protein annually, equivalent to the output of approximately 600,000 acres of soybean protein [8]. - Yeast protein is recognized for its high and evenly distributed essential amino acid content, rich in trace elements and polysaccharides, making it a safe and high-quality protein source [9]. Group 3: Addressing Resource Shortages - China faces a severe shortage of feed protein resources, with an estimated total consumption of 70 million tons in 2024 and an import dependency exceeding 80%, posing a significant threat to national food security [11]. - The innovative technology aligns with national strategies to develop synthetic biology technologies and explore "artificial protein" as a new food source, aiming to reduce reliance on traditional protein sources like soybean and fishmeal [12]. - The approval of Debaryomyces hansenii protein as a single feed raw material will help create a more sustainable and resource-efficient protein feed supply chain, significantly reducing dependence on land-intensive crops and marine resources [12].

Core Insights - The "14th Five-Year Plan" has concluded, and the "15th Five-Year Plan" is being formulated, highlighting a clear and distinct evolution in China's strategic layout in the field of biomanufacturing [1] Group 1: Development Goals - The "15th Five-Year Plan" is a critical period for the comprehensive rise of China's biomanufacturing industry, with a key goal of achieving an added value of over 4 trillion yuan in advanced biomanufacturing and related services, and a biomanufacturing penetration rate exceeding 8% [3] Group 2: Industry Structure - The plan aims to establish three major systems: innovation, industry, and management services, accelerating the development of a "7+1" biomanufacturing industry system, which includes biopharmaceuticals, bio-based chemicals and materials, bioenergy, fermentation, bioengineering food, animal feed, biotechnology equipment, and bio-services [4] Group 3: Future Opportunities - The upcoming SynBioCon 2025 conference will focus on the intersection of AI and biomanufacturing, exploring trends in green chemicals, new materials, future food, future agriculture, and beauty raw materials, while inviting international leading companies and experts to discuss innovative technologies and products that will sustain the vitality of the biomanufacturing industry [14]

Core Viewpoint - Zhejiang Province is accelerating the innovation and development of the synthetic biology industry, aiming for a total industry scale of 150 billion by 2027, with core enterprises achieving a production value of 20 billion [1][2]. Group 1: Industry Development Plan - The "Implementation Plan for Accelerating the Innovation and Development of the Synthetic Biology Industry in Zhejiang Province" outlines six major development directions, eleven regional industrial layouts, key tasks for nine universities and research institutes, and ten core technology breakthroughs [1][2]. - The plan aims to establish an internationally influential synthetic biology industry innovation development hub in Zhejiang [1]. Group 2: Alliance Formation - The Zhejiang Synthetic Biology Industry Technology Alliance, guided by the Zhejiang Provincial Department of Economy and Information Technology, is a non-profit organization initiated by Zhejiang University Hangzhou International Innovation Center, aiming to promote technological innovation and industry cultivation [2]. - The alliance will leverage the advantages of Zhejiang University in talent cultivation, technological innovation, and high-level platforms to support the synthetic biology industry [2]. Group 3: Research and Development Facilities - The Zhejiang University Hangzhou International Innovation Center has established the Bio and Molecular Manufacturing Research Institute and the iBioFoundry, the largest and most integrated automated high-throughput scientific device in the field globally [4]. - This facility enables full-process automation from sample intelligent access to product detection and is now open as a shared research platform for teams and enterprises [4]. Group 4: Upcoming Conference - The 2025 Fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on AI and biological manufacturing, as well as four application areas: green chemicals and new materials, future food, future agriculture, and beauty raw materials [6][8]. - The conference aims to explore the development trends of the bio-manufacturing industry and promote the transfer and transformation of scientific and technological achievements [6].

Core Viewpoint - The article emphasizes the importance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, including China, which is advancing its manufacturing capabilities through initiatives like green manufacturing and intelligent manufacturing [1]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing [1]. - The conference aims to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan and identify innovative technologies and products that will sustain the industry's vitality [1]. Group 2: Organizing Institutions - The conference is organized by Ningbo Detai Zhongyan Information Technology Co., Ltd. (DT New Materials) and co-organized by Ningbo Meisai Biological Engineering Co., Ltd. [2]. Group 3: Highlights of the Conference - The conference will feature forums and closed-door activities to gain insights into the development trends of biomanufacturing during the 14th Five-Year Plan, exploring new products, technologies, and collaborations [4]. - There will be over 100 financing project roadshows to discover new cooperation opportunities [4]. - Key industry leaders, top universities, and capital from industrial parks will gather to discuss advancements in the biomanufacturing sector [4]. Group 4: Agenda and Special Activities - The first day will include a closed-door seminar focusing on the development trends and growth points of biomanufacturing, inviting 30 industry leaders and experts for in-depth discussions [7]. - The second and third days will feature a macro forum on biomanufacturing, covering the development trends and progress of policies related to the industry [10]. Group 5: Specialized Forums - The conference will host specialized forums on various topics, including green chemicals and new materials, AI in biomanufacturing, future food and agriculture, and beauty raw materials [11]. - Each forum will address specific themes such as the development of bio-based chemicals, green manufacturing technologies, and the application of AI in biomanufacturing processes [11].

Core Viewpoint - O-acetyl-L-homoserine (OAH) is a significant platform compound for producing L-methionine and other valuable chemicals, with recent advancements in sustainable production methods using E. coli, achieving a record yield of 94.1 g/L through innovative metabolic engineering strategies [1][16]. Group 1: Research Content and Key Technical Breakthroughs - The team enhanced OAH production by integrating a dual-module approach with L-homoserine and MetX, increasing initial yield from 5.29 g/L to 8.30 g/L, a 56.9% improvement [3]. - A dynamic regulation strategy for acetyl-CoA was developed, leading to an OAH yield of 11.59 g/L by optimizing multiple pathways and reducing competition [4]. - The use of sRNA for identifying rate-limiting steps in OAH synthesis revealed four critical areas for optimization, including precursor carbon flux distribution and amino supply [7]. - A multi-node fine-tuning approach led to a series of yield improvements, with the final strain OAH33 achieving 19.40 g/L by addressing nutrient deficiencies and optimizing metabolic pathways [12]. Group 2: Production Optimization Techniques - The innovative two-stage pH control in a 5 L bioreactor allowed for the efficient synthesis of OAH, achieving a yield of 94.1 g/L within 68.7 hours, enhancing production by 15.5%-37.3% compared to single pH control [16]. - The research demonstrated that the combination of ATP turnover enhancement and metabolic pathway optimization significantly improved OAH production, with the final strain OAH37 achieving a yield of 20.08 g/L, a 137% increase from the initial strain [14]. Group 3: Future Research and Development - The findings from this research are set to be published in "Metabolic Engineering" in July 2025, indicating ongoing advancements in the field of synthetic biology and metabolic engineering [17].

Core Viewpoint - The article highlights the recent developments of Inner Mongolia Ruifen Biotechnology Co., Ltd., including the establishment of a new production base for functional sugar alcohols, which signifies a technological breakthrough in the field of functional sweeteners [1][2]. Company Overview - Ruifen Biotechnology, founded in 2007, is a national high-tech enterprise focused on the research and production of natural health food ingredients. The company aims to provide innovative and convenient solutions for the food, beverage, and nutritional supplement industries, emphasizing health, natural ingredients, and high technology [5]. Project Details - The new project involves an investment of 300 million yuan to build a production base with an annual capacity of 30,000 tons of functional sugar alcohols. The project includes the construction of various facilities such as a comprehensive building, R&D center, warehouses, workshops, and energy supply systems [2]. - A cooperation agreement was signed on April 26 between Hohhot Economic and Technological Development Zone and Ruifen Biotechnology for a project with a total investment of approximately 400 million yuan, which will be developed in two phases. The first phase will cover 120 acres and is scheduled to start construction in June 2023, with completion expected by November 2025 and production commencing in March 2026 [4]. Technological Advancements - Ruifen Biotechnology has become the third company in China to obtain approval for D-allohexose-3-epimerase, marking a significant technological advancement in the legal production of allohexose. The company has achieved self-controlled enzyme catalysis technology, which is a critical aspect of its production process [2].

Core Viewpoint - Shougang Longze Technology Co., Ltd. has delayed its global offering and listing plan, returning application funds, originally scheduled for July 9 on the Hong Kong Stock Exchange [1][2]. Company Overview - Shougang Longze focuses on the carbon capture, utilization, and storage (CCUS) industry, producing low-carbon products such as ethanol and microbial protein, and providing comprehensive low-carbon solutions [4]. - The company’s ethanol can be used as fuel and as a raw material for various products, while its microbial protein is the first novel feed protein raw material in China [4]. Financial Performance - In the previous year, Shougang Longze reported revenue of 560 million RMB, a year-on-year decline of 4.9%, with a net loss attributable to shareholders of 140 million RMB, an increase of 1.1 times [6]. - Financial projections indicate a revenue increase to 592.6 million RMB in 2023, followed by a slight decrease to 563.6 million RMB in 2024 [7]. Fund Utilization Plan - The company plans to allocate approximately 37.9% of the net proceeds for the construction and development of SAF production facilities in Baotou, Inner Mongolia, 21.2% for the second phase facility in Hebei, and 11.4% for research and development of strains, production equipment, and smart production management systems [8].

Core Viewpoint - The "15th Five-Year Plan" marks a critical period for the comprehensive rise of China's biomanufacturing industry, aiming for an added value of over 4 trillion yuan and a penetration rate exceeding 8% [3]. Group 1: Strategic Goals - The key objective during the "15th Five-Year Plan" is to achieve an added value of over 4 trillion yuan in advanced biomanufacturing and related services, with a target penetration rate of over 8% [3]. - The industry is expected to transition towards mid-to-high-end development [3]. Group 2: Development Framework - The plan emphasizes the establishment of three major systems: innovation, industry, and management services [4]. - A "7+1" biomanufacturing industry system will be accelerated, which includes biopharmaceuticals, bio-based chemicals and materials, bioenergy, fermentation, bioengineering food, animal feed, biotechnology equipment, and bio-services [4]. Group 3: Industry Events - The 2025 SynBioCon will be held in Ningbo, Zhejiang, focusing on the intersection of AI and biomanufacturing, along with four application areas: green chemicals and new materials, future food, future agriculture, and beauty raw materials [14]. - The conference aims to explore the development trends of the biomanufacturing industry during the "15th Five-Year Plan" and identify innovative technologies and products that will sustain the industry's vitality [14].

Core Viewpoint - The article emphasizes the importance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, including China, which is advancing its manufacturing capabilities through initiatives like green manufacturing and intelligent manufacturing [1]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing [1]. - The conference aims to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan and identify innovative technologies and products that will sustain the industry's vitality [1]. Group 2: Organizers and Highlights - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and co-organized by Ningbo Meisai Biological Engineering Co., Ltd. [2]. - Key highlights include forums on biomanufacturing trends, youth innovation sharing, project roadshows, and participation from leading enterprises, top universities, and investment institutions [4]. Group 3: Agenda and Special Activities - The first day features a closed-door high-level seminar focusing on the development trends and growth points of biomanufacturing, with 30 industry leaders and experts invited [7]. - The second and third days will include a macro forum on biomanufacturing, specialized sub-forums on green chemicals, AI in biomanufacturing, future food and agriculture, and beauty raw materials [11]. Group 4: Focus Areas in Sub-forums - Sub-forum topics include the development of bio-based chemicals, green manufacturing technologies for fine chemicals, and the use of non-food raw materials for high-value product development [11]. - AI applications in biomanufacturing will also be discussed, including enzyme discovery and industrial fermentation process control [11].

Core Viewpoint - The article discusses the advancements in green bio-manufacturing, particularly focusing on the synthesis of aliphatic short-chain diamines and diols from renewable resources, highlighting the importance of reducing reliance on fossil resources and addressing environmental concerns [3][4][5]. Group 1: Importance of Green Bio-Manufacturing - The chemical industry is a significant part of the national economy, with over 100,000 types of fine chemical products globally. Traditional production methods heavily rely on fossil resources, leading to resource depletion and CO2 emissions [4]. - Transitioning to renewable resources for bio-manufacturing is crucial for achieving a clean, low-carbon, and sustainable environment. China has set goals to replace traditional chemical raw materials with bio-based materials [4][5]. Group 2: Advances in Bio-Synthesis - Significant progress has been made in the bio-synthesis of 1,3-propanediamine, 1,4-butanediamine, and their corresponding diols, with commercial applications already realized by companies like DuPont and Genomatica, achieving cost reductions of 37% and energy savings of 30% compared to petrochemical processes [5][6]. - Companies such as Ningxia Yipin Biotechnology and Shanghai Kaisi Bio-Industry have successfully scaled up the production of 1,5-pentanediamine using whole-cell catalysis, claiming a 30% cost reduction compared to traditional methods [5][6]. Group 3: Challenges in Bio-Synthesis - Despite advancements, challenges remain in the bio-synthesis of most diamines and diols, including high production costs and the lack of natural biosynthetic pathways for certain compounds [6][7]. - Research is focused on developing bio-synthesis routes using non-food biomass and one-carbon feedstocks to reduce fossil resource dependence and CO2 emissions [6][7]. Group 4: Metabolic Pathways and Carbon Cycling - The article outlines the carbon cycling and metabolic pathways involved in utilizing renewable resources for bio-manufacturing, emphasizing the role of biomass derived from agriculture, forestry, and waste [8][9]. - Various metabolic pathways for sugars derived from lignocellulosic biomass have been identified, which can be utilized for synthesizing short-chain diamines and diols [11][13]. Group 5: Synthesis Routes for Specific Compounds - Detailed synthesis routes for 1,3-propanediamine and 1,3-propanediol are discussed, highlighting the use of key amino acid precursors and various microbial pathways [20][21]. - The synthesis of 1,4-butanediamine and 1,4-butanediol involves multiple pathways, including those utilizing ornithine and arginine, with significant advancements in microbial engineering to enhance yields [23][24]. - The article also covers the synthesis routes for 1,5-pentanediamine and 1,5-pentanediol, focusing on the use of lysine as a precursor and the challenges in achieving high yields [25][26].