Core Viewpoint - Modern fermentation technology is revolutionizing various industries, including agriculture, medicine, energy, and materials, by integrating natural wisdom with technological advancements, leading to a new era of precision health science [1][3][9] Traditional Fermentation Technology - Traditional fermentation is a treasure of human wisdom, producing unique foods that reflect regional culture and history, such as Korean kimchi and Chinese soy sauce [3] - The essence of traditional fermentation lies in its naturalness and cultural heritage, but its artisanal production model struggles to meet modern demands for scalability and standardization [3][4] Modern Fermentation Technology - Modern fermentation technology emphasizes scientific and innovative approaches, utilizing synthetic biology and metabolic engineering to optimize microbial metabolic pathways, significantly enhancing production efficiency [4][6] - Techniques such as CRISPR and metabolic pathway design enable the creation of microbial cell factories that can produce high-value compounds like human milk oligosaccharides and heme for plant-based meat [5][6] Economic Impact and Sustainability - Modern fermentation technology is driving industries towards a "biomanufacturing closed loop," converting agricultural waste into energy and purifying industrial wastewater, thus forming a zero-carbon chain [6][7] - It is projected that by the end of the 21st century, biomanufacturing will account for one-third of global chemical production, potentially generating $30 trillion in economic value [7] Applications in Traditional Medicine - Modern fermentation technology offers new opportunities for the modernization of traditional Chinese medicine, such as significantly increasing the yield of artemisinin from 0.1% to 25 g/L through engineered yeast [7][8] - Fermentation can enhance the efficacy of traditional herbal medicines by converting inactive components into active ones and improving bioavailability, as seen with ginsenoside Rh2 [8] Future Prospects - The integration of artificial intelligence and big data into fermentation research is expected to accelerate development cycles and enhance production processes [5][9] - As modern fermentation technology continues to evolve, it is anticipated to transform the health industry, making concepts like "precision nutrition" and "sustainable health" a reality in daily life [9]

Core Viewpoint - The establishment of the American Bio-Manufacturing Alliance (AAB) aims to enhance the U.S. bio-manufacturing capabilities, promote domestic innovation, and increase the country's influence in the rapidly growing global bio-economy [1][2] Group 1: Alliance Formation - The AAB was formed on May 21, 2023, and includes stakeholders from the bio-manufacturing sector, such as CEOs from Manus, Pivot Bio, Novonesis North America, Kula Bio, and LanzaTech Global [1] - The formation of the alliance follows a call from the emerging biotechnology national security council (NSCEB) for a coordinated national strategy to strengthen U.S. leadership in the field [1] Group 2: Objectives of AAB - AAB has two main objectives: to increase demand for bio-based products and technologies in the U.S. and to ensure a comprehensive market for existing and emerging bio-products [2] - Founding members highlighted the economic and environmental potential of bio-manufacturing, emphasizing the development of low-cost, high-performance agricultural inputs to reduce reliance on global supply chains [2] Group 3: Industry Impact - Bio-manufacturing is applicable across various sectors, including agriculture, energy, chemicals, materials, nutrition, and pharmaceuticals, utilizing biological materials to produce sustainable products [1] - The global bio-manufacturing market is currently valued at $20 billion and is expected to experience significant growth over the next decade [1]

Core Viewpoint - The article highlights the advancements in plant-based indigo dye technology by Hehua Zhizhi Biotechnology Co., showcasing their 40% purity plant indigo product at the Bio-based 2025 conference in Shanghai [1][4]. Company Overview - Hehua Zhizhi Biotechnology Co., established in 2022 in Fenggang County, Zunyi City, Guizhou Province, has an investment of 20 million RMB and operates a 5,000-acre plantation with an annual production capacity of 80 tons and sales revenue of 48 million RMB, creating jobs for 30 local residents [4]. - The company has achieved significant milestones, including obtaining environmental assessment approvals, securing four patent technologies, and demonstrating a plant indigo purity of 40%-50% through large-scale pilot production [4]. Product Highlights - The showcased plant indigo dye has a purity of 40%, achieved through innovative patented extraction technology, which enhances dyeing processes, improves color fastness, and optimizes color performance [4][5]. - The natural plant indigo dye meets green, eco-friendly, and health standards, and aims to compete with synthetic dyes in the market due to its cost-effective and intelligent production methods [4][5]. Market Context - There is a notable increase in domestic demand for eco-friendly textile dyeing materials driven by global environmental needs, alongside a continuous growth in the international market for such products [5]. Industry Engagement - Hehua Zhizhi has joined the "bio-based link" global bio-based and bio-manufacturing industry service platform, enhancing its visibility and industry connections [7].

建设内容：在本公司"微元合成绿色生物制造二期项目"车间内，建设"微元合成绿色生物制造二期健 康糖项目"，利用现有发酵、公用工程和检验等设备，新增膜分离、离交、浓缩、结晶、分离干燥等 设备， 项目建成后， 柔性生产阿洛酮糖和甘露糖醇（食品级）， 年产量共计2000吨 。 阿洛酮糖 作为一种新型低倍甜味剂，具备多种生理功效，如抑制人体对糖类的吸收、降血糖、抗氧 化等，是蔗糖的理想替代品。 甘露糖醇 则广泛应用于医药、食品、化工等领域，作为甜味剂、保湿 剂、赋形剂等。 2、在建项目 "微元合成绿色生物制造二期项目"，项目运用生物提取技术，以一水合葡萄糖、柠檬酸、磷酸二氢 钾、硫酸钾等组分组成的培养液为基本原料，利用菌体进行发酵得到产物胆红素后进行纯化提取，从 而制出胆红素产品。目前项目正在建设过程中，建成后年生产胆红素5吨。 3、微元合成 【SynBioCon】 获悉，近日，关于 微元合成生物技术（秦皇岛）有限公司 微元合成绿色生物制造 二期健康糖项目在相关网站批复前公示。 1、项目基本情况 项目名称：微元合成绿色生物制造二期健康糖项目 建设单位：微元合成生物技术（秦皇岛）有限公司 项目投资：4000万元 微元合成 ...

Core Insights - The 10th Bio-based Conference and Exhibition was held in Shanghai from May 26-27, 2025, focusing on AI-enabled innovation in new materials and applications in bio-based materials [1][3][19] - The conference featured discussions on the development trends of the bio-manufacturing industry in China, highlighting its potential as a global bio-manufacturing center [3] - Various experts presented on the integration of AI in chemical new materials research and production, emphasizing the challenges and opportunities in this field [7][16] Group 1: Industry Trends and Insights - YiKai Capital's partner shared insights on the definition and market size of the global and Chinese bio-manufacturing industry, along with development trends and capital market reviews for 2024 and 2025 [3] - The Shanghai Academy of Science's researcher discussed a dual-driven molecular pre-training model that significantly improved reaction selectivity by five times and designed new biodegradable polymer materials [5] - The roundtable discussions included perspectives from investment institutions and scientific experts on how AI can enhance the efficiency of bio-based material research and development [9][15] Group 2: AI Applications in Material Science - The market director of Magnesium Technology presented on the application of AI in the research and production of chemical new materials, addressing the challenges faced in implementing these technologies [7] - A report on high-resolution atomic imaging analysis using deep learning highlighted the limitations of traditional models and introduced a new framework for analyzing structural diversity [11] - The application of AI in polymer material design was discussed, showcasing recent advancements and case studies in composite materials and organic photovoltaic materials [13]

Core Viewpoint - The article emphasizes the importance of C1 biomanufacturing as a sustainable alternative to traditional chemical production, highlighting its potential to address global challenges related to resource depletion and carbon emissions [1][12]. Group 1: C1 Biomanufacturing Overview - C1 biomanufacturing utilizes one-carbon compounds such as CO₂, CO, CH₄, and CH₃OH as raw materials, converting them into high-value chemicals and fuels through microbial processes [3][5]. - The technology integrates metabolic engineering, synthetic biology, and fermentation techniques, aiming to transition from laboratory to industrial scale while ensuring economic viability and environmental sustainability [3][5]. Group 2: Economic and Technical Challenges - Current carbon conversion efficiencies in C1 biomanufacturing are below 10%, leading to increased capital and operational costs, with fermentation equipment costs exceeding 92% in some cases [7][9]. - The article identifies two sustainable pathways for improving production: a dual-stage bioconversion system using steel mill flue gas and a hybrid process coupling CO₂ electrochemical reduction to methanol with microbial conversion [5][9]. Group 3: Raw Material Supply Issues - C1 biomanufacturing faces challenges related to the supply of raw materials, which are geographically dispersed and subject to significant cost fluctuations, with raw material costs accounting for over 57% of operational expenses [9][10]. - Developing technologies that utilize waste materials as raw inputs is crucial for enhancing economic viability and ensuring stable supply chains [9][10]. Group 4: Policy and Collaborative Efforts - Establishing a collaborative mechanism among industry, academia, and research institutions is essential for securing raw material supply, enhancing conversion efficiency, and creating a transparent profit-sharing model [10][12]. - Successful examples include partnerships like Lanzatech's collaboration with Shougang Group for ethanol production from steel mill emissions, demonstrating the importance of upstream and downstream cooperation [10]. Group 5: Environmental Benefits and Future Directions - C1 biomanufacturing shows significant carbon reduction potential, with the ability to achieve net reductions of 17.20 to 1219.03 tons of CO₂ equivalent per ton of chemical produced [11]. - The article suggests that advancements in technology and ongoing cost optimization will pave the way for the commercialization of C1 biomanufacturing in the near future [8][11].

Core Insights - The 10th Bio-based Conference and Exhibition successfully concluded in Shanghai, featuring over 100 speakers and 60 participating companies, attracting more than 1000 attendees [1][4][5] Group 1: Conference Overview - The conference focused on international trends, opportunities in the bio-based industry, technology and industrialization, downstream applications, and innovation [1] - Key activities included three major awards, over 20 specialized sessions, and more than 10 core topic discussions, receiving high praise from the industry [1] Group 2: Key Presentations - Notable speakers included academicians and industry leaders discussing topics such as the development trends of the petrochemical industry during the 14th Five-Year Plan, advancements in bio-based polymers, and the industrialization of biodegradable rubber [1][4] - Presentations covered a wide range of subjects including nanocellulose, bio-based olefins, and sustainable thermosetting resins [4][5] Group 3: Sustainable Applications - The conference featured specialized forums on sustainable applications in automotive and packaging, discussing the green transition trends in the automotive industry and sustainable packaging developments [7][9] - Key discussions included the challenges and opportunities in sustainable packaging applications and the use of bio-based materials in automotive applications [9][7] Group 4: International Cooperation - The International Cooperation Forum highlighted Finland's leadership in sustainable development, challenges and opportunities in the European bio-based industry, and investment opportunities in the bio-plastics sector [13] - Discussions also included synthetic biological protein fibers and China's innovation cooperation practices [13] Group 5: Future Materials and AI - The AI Empowered Future Materials Innovation Development Forum addressed China's emergence as a global bio-manufacturing center and the role of AI in chemical new materials research and production [18][19] - Key themes included the challenges of bio-manufacturing and the opportunities presented by the AI era [18] Group 6: Industry-Specific Forums - The HMF-FDCA-PEF Industry Forum focused on the industrialization of non-grain glucose dicarboxylic acid and the sustainable material applications in cosmetic packaging [21] - Discussions also included the development trends of bio-based PEF materials and the engineering challenges in FDCA mass production [21] Group 7: Bio-based Leather - The Sustainable Applications Forum on Bio-based Leather featured discussions on mycelium leather materials and low-carbon circular production [26] - The forum also explored the core value and commercialization of the bio-based leather industry [26]

Core Viewpoint - The article highlights the advancements and innovations of Suzhou Juwei Yuanchuang Biotechnology Co., Ltd. in the field of bio-manufacturing, particularly focusing on the use of straw as a raw material for producing high-quality glucose and other bio-based products, aligning with sustainability goals and carbon reduction strategies [1][6][11]. Group 1: Company Overview - Suzhou Juwei Yuanchuang Biotechnology Co., Ltd. specializes in bio-manufacturing using straw as a raw material, developing a full chain of self-research and production capabilities [11]. - The company has established a straw saccharification and bio-manufacturing capacity of 100,000 tons per year [6][11]. - The core management team comprises experts from prestigious institutions such as Tsinghua University and MIT, with extensive research achievements in various fields [11]. Group 2: Product Offerings - The company showcased a series of products at the 10th Bio-based Conference, including straw-derived glucose, lignin, oligosaccharides, and non-food-based succinic acid [1][6]. - The straw sugar source can be widely used in the production of bio-based materials, animal nutrition products, and industrial enzymes [9][11]. Group 3: Industry Impact - Bio-manufacturing is positioned as a crucial driver for creating greener and more sustainable production models, with straw sugar as a key component for cost reduction and efficiency improvement [6]. - The company's innovations are expected to significantly reduce carbon emissions, aligning with the "dual carbon" strategic goals [6]. Group 4: Sample Distribution Initiative - The company is offering 1,000 free samples of its products, inviting various units to apply for trial use [5][9]. - The application process involves verifying information and tracking project progress through various communication methods [8][10].

Core Viewpoint - Bota Bio and Proya have entered a strategic partnership to integrate synthetic biology, artificial intelligence, and biomanufacturing for innovation in cosmetic ingredients and sustainable practices [1][3][4]. Group 1: Technological Innovation - The collaboration aims to reshape the paradigm of cosmetic ingredient development through an intelligent development system that combines high-throughput screening and machine learning, with a goal to create an innovative matrix of over 50 bioactive ingredients within three years [3]. - Three patented ingredients targeting sensitive skin repair and photo-aging protection are already in the pilot testing phase [3]. - Proya's Chief R&D Officer, Dr. Sun Peiwen, stated that they are establishing the industry's first AI model for evaluating the efficacy of bioactive ingredients, which is expected to enhance R&D efficiency by 300% [3]. Group 2: Market Transformation - The partnership will pioneer a new segment in "precision biological skincare," utilizing Bota Bio's modular biosynthesis technology to develop intelligent skincare products that adapt dynamically to different skin types and environmental conditions [3]. - The first product featuring "environment-responsive active ingredients" is anticipated to launch in 2025, with technology that allows ingredient activity to adjust automatically based on UV intensity [3]. Group 3: Sustainable Development - The collaboration aims to establish the beauty industry's first "negative carbon raw material" development standard, replacing traditional chemical extraction with biomanufacturing, which is projected to reduce the carbon footprint of raw material production by 65% [4]. - Progress has been made in developing biodegradable packaging materials [4]. - Bota Bio's CEO, Dr. Cui Hao, emphasized the need to redefine the beauty industry boundaries, asserting that beauty should not come at the expense of the environment [4].

Group 1 - The 10th Bio-based Conference and Exhibition has over 1200 registrations, highlighting industry growth and support [1] - The theme "Bio-based 2025" focuses on "Going Green and Seeking Quality" with a global perspective [1] - The event includes 1 award, 6 major forums, and 17 specialized sessions covering various topics such as macro forums, key materials, international cooperation, and AI in new materials [1] Group 2 - Over 100 academicians and industry leaders will share insights during the conference [1] - Special matchmaking events are organized to promote technology, funding, and international collaboration [1] - The exhibition features 54 exhibitors showcasing new products and technologies, with over 100 end-user brands participating for face-to-face procurement and collaboration [1]