Core Viewpoint - The Chinese innovative pharmaceutical sector is gaining international recognition, highlighted by significant deals and promising clinical data, leading to increased interest in related ETFs [1][3][4]. Group 1: Market Performance - The innovative drug ETF (517110) has rebounded nearly 15% since early April, reflecting strong performance in the pharmaceutical sector [1]. - The biopharmaceutical ETF and vaccine ETF also showed positive movements, with respective increases of 1.17% and 0.89% [2]. Group 2: ASCO Conference Insights - At the 2025 ASCO conference, over 70 research outcomes from Chinese pharmaceutical companies were presented, showcasing advancements in ADC and bispecific antibody technologies [3]. - Notable performances include Zai Lab's ZG005 and Huahai Pharmaceutical's HB0025, which exceeded expectations in early clinical trials for cervical and endometrial cancers, respectively [3]. Group 3: Business Development Trends - Recent business development (BD) activities in the innovative drug sector have seen record-breaking upfront payments, such as the $12.5 billion upfront payment from Pfizer for a PD-1/VEGF bispecific antibody from 3SBio [4][7]. - The increase in upfront payments and total deal values indicates growing international recognition of Chinese innovative drugs [7]. Group 4: Future Outlook - The innovative drug sector is expected to benefit from ongoing BD transactions, advancements in artificial intelligence across the pharmaceutical value chain, and the implementation of new healthcare policies [7]. - The overall sentiment and valuation in the pharmaceutical sector may improve due to domestic policy optimizations and a recovery in medical equipment procurement [7].

成交活跃股方面，沪市港股通前十大成交活跃股中，小米集团-W成交额为33.14亿港元，成交金额居 首；其次是美团-W、阿里巴巴-W，成交金额分别为31.69亿港元、27.24亿港元。以净买卖金额统计， 美团-W净买入额为17.80亿港元，净买入金额居首，该股收盘股价下跌5.48%。净卖出金额最多的是盈 富基金，净卖出14.66亿港元，收盘股价下跌1.26%。 深市港股通前十大成交活跃股中，成交额居首的是小米集团-W，成交金额23.12亿港元；其次是美团- W、腾讯控股，成交金额分别为22.17亿港元、17.29亿港元。以净买卖金额统计，有2只股为净买入，净 买入金额最多的是地平线机器人-W，净买入7.30亿港元，该股收盘下跌6.45%。净卖出金额最多的是腾 讯控股，净卖出11.46亿港元，收盘股价下跌1.54%。（数据宝） 5月26日恒生指数下跌1.35%，报收23282.33点，全天南向资金通过港股通渠道合计净卖出15.07亿港 元。 证券时报·数据宝统计，5月26日港股通全天合计成交金额为996.72亿港元，成交净卖出15.07亿港元。 具 体来看，沪市港股通成交金额639.69亿港元，成交净买入18.56 ...

Investment Rating - The report rates the industry as "Overweight" indicating that the industry index is expected to outperform the CSI 300 index by 10% or more over the next six months [39]. Core Insights - The pharmaceutical and biotechnology sector has shown strong performance, with a 1.78% increase in the last week, outperforming the CSI 300 index by 1.96 percentage points. Year-to-date, the sector has risen by 4.30%, ranking 6th among 31 industries [11][12]. - The sector's current PE valuation stands at 27.51 times, which is at a historically low level, with a 132% premium over the CSI 300 index [19]. - Notable individual stock performances include Sangfor Technologies, which surged by 99.96%, and Haicheng Pharmaceutical, which increased by 51.55% [26]. Market Performance - The pharmaceutical and biotechnology sector ranked first among 31 industries with a weekly increase of 1.78% [11]. - Year-to-date, the sector has increased by 4.30%, outperforming the CSI 300 index by 5.64 percentage points [12]. - The top three sub-sectors in terms of weekly growth were chemical pharmaceuticals (3.58%), biological products (1.74%), and medical services (1.42%) [11]. Industry News - On May 20, 2025, Sangfor Pharmaceuticals announced a deal with Pfizer, granting exclusive rights for the global development and commercialization of SSGJ-707, with an upfront payment of $1.25 billion and potential milestone payments of up to $4.8 billion [28]. - The 2025 ASCO annual meeting highlighted the strong performance of Chinese pharmaceutical companies, with over 70 research outcomes presented, marking a 33% increase from the previous year [29][30]. Investment Recommendations - The report suggests focusing on innovative drugs as the core investment theme, highlighting the significant competitive advantages and market potential of domestic innovative drugs [37]. - Recommended stocks include Betta Pharmaceuticals, Teva Biopharmaceuticals, Lingrui Pharmaceutical, Lao Baixing, and Baipusais [37]. - Additional stocks to watch include Kelun Pharmaceutical, Lijun Group, Kaili Medical, Huaxia Eye Hospital, and Qianhong Pharmaceutical [37].

智通财经APP获悉，5月26日港股市场，北水成交净卖出15.07亿港元，其中港股通(沪)成交净买入18.56 亿港元，港股通(深)成交净卖出33.63亿港元。 北水净买入最多的个股是美团-W(03690)、中国移动(00941)、地平线机器人-W(09660)。北水净卖出最 多的个股是腾讯(00700)、阿里巴巴-W(09988)、盈富基金(02800)。 | 股票名称 | 买入额 | 卖出额 | 买卖总额 | | --- | --- | --- | --- | | | | | 净流入 | | 小米集团-W | 16.57 乙 | 16.57 亿 | 33.14 乙 | | HK 01810 | | | -13.02万 | | 美团-W | 24.74 Z | 6.95亿 | 31.69 亿 | | HK 03890 | | | +17.80 乙 | | 阿里巴巴-W | 8.39亿 | 18.85 乙 | 27.24亿 | | HK 09988 | | | -10.46 Z | | 腾讯控股 | 7.79亿 | 17.25亿 | 25.04亿 | | HK 00700 | | | -9.45 Z | | 比 ...

香 港 交 易 及 結 算 所 有 限 公 司 及 香 港 聯 合 交 易 所 有 限 公 司 對 本 公 告 的 內 容 概 不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 就 因 本 公 告 的 全 部 或 任 何 部 份 內 容 所 產 生 或 因 依 賴 該 等 內 容 而 引 致 的 任 何 損 失 承 擔 任 何 責 任。 （於 開 曼 群 島 註 冊 成 立 的 有 限 公 司） （股 份 代 號：1530） 1 1. 省覽並採納本公司截至二零二四年十二月三十一日止年度之經審核綜合 財 務 報 表 及 董 事 報 告 與 核 數 師 報 告。 2. (A) 重選蘇冬梅女士為本公司執行董事（「董 事」）； (B) 重 選 張 皎 娥 女 士 為 非 執 行 董 事； (C) 重 選 楊 凱 蒂 女 士 為 獨 立 非 執 行 董 事； (D) 授權董事會（「董事會」）釐 定 董 事 之 薪 酬。 3. 從本公司的股份溢價賬中向於二零二四年七月二十五日（星 期 五）營業時間結 束時名列本公司股東名冊的股東宣派及派付截至二零二四年十二月三十一 ...

閣下如 對本通函或應採取之行動 有任何疑問，應諮詢 閣下之股票經紀、銀行經理、 律師、專業會計師或其他專業顧問。 閣下如已出售或轉讓 名下所有的 三生製藥 股份， 閣下應立即將本通函送交買主或承 讓人，或送交經手買賣之銀行、股票經紀或其他代理商，以便轉交買主或承讓人。 香港交易及結算所有限公司及香港聯合交易所有限公司對本通函之內容概不負責， 對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示 概 不 會 就 因 本 通 函 全 部 或 任 何 部分內容而產生或因倚賴該等內容而引致之任何損失承擔任何責任。 （於開曼群島註冊成立的有限公司） （股份代號：1530） 發行及購回股份之一般授權、 重選董事、 從本公司的股份溢價賬中宣派及派付末期股息、 此乃要件 請即處理 採納二零二五年購股權計劃、 採納二零二五年股份獎勵計劃 及 股東週年大會通告 三生製藥 謹訂於二零二五年六月二十五日上午十時正假座中華人民共和國瀋陽市瀋 陽經濟技術開發區十號路1甲3號 舉 行 股 東 週 年 大 會，召 開 大 會 的 通 告 載 於 本 通 函 第 61至70頁。隨 函 亦 附 奉 股 東 週 ...

Industry Investment Rating - The industry investment rating is "Outperform" [2] Core Viewpoints - The report highlights that the recent licensing deal between 3SBio and Pfizer for the PD-1/VEGF bispecific antibody SSGJ-707 marks a record in overseas transactions for Chinese innovative pharmaceutical companies, indicating a potential surge in licensing out activities [5][13] - The global market for bispecific antibodies is projected to exceed $80 billion by 2030, with PD-1/VEGF bispecifics being a focal point for multinational pharmaceutical companies [20] - In 2024, the total licensing out amount for Chinese innovative drugs surpassed $51.9 billion, a year-on-year increase of 27.4%, accounting for 30% of the global total [23] Summary by Sections Weekly Insights - 3SBio's licensing agreement with Pfizer involves an upfront payment of $1.25 billion and potential milestone payments up to $4.8 billion, along with a tiered sales revenue share [13][14] - The report notes that the biopharmaceutical sector has seen a weekly increase of 1.78%, outperforming the CSI 300 index by 1.96 percentage points [24][29] Subsector Performance - The report details that the biopharmaceutical sector's performance is diverse, with the other bioproducts sector showing the highest increase of 4.09%, while the hospital sector experienced the largest decline of 1.07% [6][28] Recommended and Benefiting Stocks - Recommended stocks include Weikang Medical, Maipu Medical, and Yifeng Pharmacy, among others [7][40] - Benefiting stocks from the recent trends include Hualan Biological Engineering, BGI Genomics, and Mindray Medical [7][45] Market Trends - The report emphasizes the acceleration of licensing out activities for Chinese pharmaceutical companies, with a notable increase in both the number and value of transactions in recent years [23][25] - The report suggests that the medical device sector is expected to see significant growth due to policy changes and increased procurement activities [31]

Investment Rating - The industry investment rating is "Outperform" [2] Core Insights - The report highlights that the recent licensing deal between 3SBio and Pfizer for the PD-1/VEGF bispecific antibody SSGJ-707 marks a record in overseas transactions for Chinese innovative pharmaceutical companies, indicating a potential surge in licensing out activities [5][13] - The global market for bispecific antibodies is projected to exceed $80 billion by 2030, with PD-1/VEGF bispecifics being a focal point for multinational pharmaceutical companies [5][20] - In 2024, the total amount of licensing out agreements for Chinese innovative drugs surpassed $51.9 billion, a year-on-year increase of 27.4%, accounting for 30% of the global total [5][23] Industry Performance - The pharmaceutical sector saw an increase of 1.78% this week, outperforming the CSI 300 index by 1.96 percentage points, ranking first among 31 sub-industries [24][29] - The biopharmaceutical sector experienced the highest growth this week, with a rise of 4.09% [6][28] Subsector Highlights - The report identifies several subsectors with notable performance: - Other biopharmaceuticals increased by 4.09% - Raw materials and medical research outsourcing sectors also saw increases of 4.03% and 3.6% respectively [6][28] - The report recommends several stocks, including Weikang Medical, Maipu Medical, and Yifeng Pharmacy, as potential beneficiaries of the current market dynamics [7][40] Clinical Development - SSGJ-707 has shown promising clinical data, with an overall response rate (ORR) of 70.8% in PD-1 positive NSCLC patients and a disease control rate (DCR) of 100% [17][20] - The drug is currently in Phase III clinical trials and has received breakthrough therapy designation in China [16][20] Market Trends - The report notes a significant trend towards the licensing out of innovative drugs from China, with the number of transactions increasing from 3% in 2019 to 13% in 2024 [23] - The report emphasizes the importance of AI and other technological advancements in driving growth within the medical device and pharmaceutical sectors [30][36]

Core Viewpoint - The recent developments in the innovative drug sector, particularly the record-breaking licensing deal and the upcoming ASCO conference, highlight the growing competitiveness and potential of Chinese pharmaceutical companies in the global market [4][5]. Group 1: Market Performance - The Hong Kong Innovative Drug ETF (159570) opened high but closed lower, experiencing a 1% pullback after four days of gains last week, with trading volume reaching 300 million, indicating strong liquidity [1]. - Major component stocks of the ETF mostly declined, with notable drops including a more than 4% decrease for 3SBio and over 3% for both WuXi AppTec and Rongchang Biopharmaceutical [2]. Group 2: Licensing Deal - A historic licensing agreement was reached where Pfizer will pay a $1.25 billion upfront fee to Chinese companies for the PD-1/VEGF dual antibody SSGJ-707, with potential total payments reaching $4.8 billion [4]. - This deal sets a new record for Chinese innovative drugs entering the international market and is expected to enhance market valuation expectations for the innovative drug sector [4]. Group 3: ASCO Conference Insights - The upcoming ASCO conference is anticipated to showcase the global competitiveness of Chinese pharmaceutical companies, with numerous clinical studies being presented [5]. - Key highlights include the performance of domestic drugs that have shown potential to outperform established treatments, such as the combination of Bemarituzumab and Anlotinib against Keytruda in NSCLC [5]. - CAR-T therapies are also making significant strides, with Kintor Pharmaceuticals presenting promising data for their CLDN18.2 CAR-T therapy [5]. Group 4: Innovative Drug ETF Characteristics - The Hong Kong Innovative Drug ETF (159570) has a high concentration in innovative drugs, with over 85% of its weight in this category, making it the highest among all pharmaceutical indices [6]. - The ETF features a low valuation, with a five-year price-to-sales ratio at the 48.5th percentile, indicating potential undervaluation in the innovative drug sector [6].

Group 1: Smart Manufacturing - The State Council has approved the "Green and Low-Carbon Development Action Plan for Manufacturing Industry (2025-2027)", emphasizing the need for green technology innovation and the promotion of advanced green technologies [1] - The plan aims to accelerate the deep green transformation of traditional industries, with a target of reaching 6,430 national-level green factories by 2024, contributing approximately 20% to the total manufacturing output value [1] - By 2030, the output value of green factories is expected to exceed 40% of the total manufacturing output value, indicating a significant shift towards sustainable practices in the manufacturing sector [1] Group 2: Economic Development Zones - The Ministry of Commerce has issued a plan to deepen the reform and innovation of national-level economic and technological development zones, supporting major industrial technology innovation platforms and digital transformation initiatives [2][3] - The plan aims to transform these zones from traditional manufacturing bases to open, innovative, and green economic hubs, with an expected total output value of 15 trillion yuan by 2025, accounting for 20% of the national GDP [3] Group 3: Digital Identity - The Ministry of Public Security and other departments have released the "National Network Identity Authentication Public Service Management Measures," which will take effect on July 15, 2025, aimed at protecting personal information while verifying user identities online [4] Group 4: Robotics - Shenzhen Kaihong Digital Industry Development Co., Ltd. has launched the first open-source HarmonyOS-based robot operating system, M-RobotsOS, which will support various types of intelligent robots [5] - The demand for operating systems in the robotics industry is expected to grow significantly, with an estimated market demand of over 21 billion yuan driven by the deployment of one million robots [5] Group 5: Low Earth Orbit Satellites - China's low Earth orbit satellite communication system has entered the public testing phase, with plans to provide network connectivity in areas lacking coverage by the second half of the year [6] - By April 2025, China Telecom, in collaboration with major smartphone brands, plans to launch 30 models of devices that support direct satellite connectivity, marking a shift from specialized to consumer markets [6] Group 6: Energy Storage - The first large-scale lithium-sodium hybrid energy storage station in China has been put into operation, integrating the advantages of lithium and sodium batteries to enhance the energy storage industry [7] - The energy storage sector is expected to see a rebound in profitability and growth opportunities, driven by new technologies and increasing demand for energy transition solutions [7]