Core Viewpoint - The A-share and H-share innovative drug/biotechnology sectors continue to rise, driven by significant licensing agreements and strong clinical results from domestic companies [1][3]. Group 1: Market Performance - The Hang Seng Biotechnology ETF (513280) rose over 2%, while the Biopharmaceutical ETF (159839) increased by more than 1% [1]. - The Hang Seng Biotechnology ETF is noted for its low management fee of 0.15%, making it a unique option in the market [1][7]. - The year-to-date performance of the Hang Seng Biotechnology ETF has exceeded 37%, outperforming the Hang Seng Tech Index by over 17 percentage points [7]. Group 2: Licensing Agreement - A significant licensing agreement was established between 3SBio and Pfizer for the PD-1/VEGF bispecific antibody SSGJ-707, with an upfront payment of $1.25 billion and potential milestone payments of up to $4.8 billion [1][3]. - This transaction marks the highest licensing amount recorded for a domestic pharmaceutical company [1]. - The agreement is expected to enhance 3SBio's financial returns and support its research and development capabilities [3][4]. Group 3: Clinical Development - SSGJ-707 has shown promising clinical results, with excellent overall response rates (ORR) and disease control rates (DCR) in non-small cell lung cancer (NSCLC) patients [3][4]. - The drug has received breakthrough therapy designation from the CDE and has FDA IND approval, indicating its potential for first-line treatment in specific cancer types [3][4]. - Ongoing clinical studies are also being conducted for SSGJ-707 in colorectal cancer and gynecological tumors [3]. Group 4: Industry Outlook - The pharmaceutical industry is expected to benefit from policies encouraging innovation, with a focus on globally competitive innovative drug companies [5][6]. - The CXO sector is anticipated to recover in 2025, with a return to positive growth following previous adjustments [6]. - The raw material drug sector is gradually returning to normal supply-demand dynamics, contributing to performance improvements [6].

Investment Rating - The investment rating for the company is "Outperform the Market" (maintained) [2][4]. Core Viewpoints - The company has signed a significant licensing agreement with Pfizer for its drug 707, granting Pfizer global rights (excluding China) for research, production, and commercialization. The upfront payment is $1.25 billion, with potential total payments up to $4.8 billion, including milestone payments and a double-digit percentage of sales [3][4]. - Drug 707 is a PD-1xVEGF dual antibody that has shown promising early clinical data and is currently in advanced clinical trials for various cancers, including non-small cell lung cancer (NSCLC) and colorectal cancer [4][5]. - The company is expected to maintain steady growth, with projected net profits of 2.39 billion, 2.71 billion, and 3.07 billion yuan for 2025-2027, reflecting year-on-year growth rates of 14.1%, 13.7%, and 13.1% respectively [4][9]. Summary by Sections Licensing Agreement - The licensing agreement with Pfizer for drug 707 includes an upfront payment of $1.25 billion and potential milestone payments totaling $4.8 billion, along with a double-digit percentage of sales [3][4]. Clinical Development - Drug 707 is currently in clinical trials for first-line PD-L1 positive NSCLC and other solid tumors, with over 300 patients enrolled in various studies [5][6]. - The drug has received breakthrough therapy designation from the CDE for its first-line PD-L1 positive NSCLC indication, accelerating its development and commercialization [4][9]. Financial Projections - The company forecasts net profits of 2.39 billion, 2.71 billion, and 3.07 billion yuan for 2025-2027, with growth rates of 14.1%, 13.7%, and 13.1% respectively [4][9]. - The company is expected to maintain a robust growth trajectory, supported by its innovative drug pipeline and successful licensing agreements [4][9].

Group 1 - The pharmaceutical sector in Hong Kong is experiencing a strong rally, with notable gains in stocks such as Kailaiying, which rose over 14%, and Sangfor Pharmaceuticals, which increased by 7.6% [1][2] - Sangfor Pharmaceuticals announced a licensing agreement with Pfizer, receiving an upfront payment of $1.25 billion, which significantly boosted investor confidence [1] - The China National Medical Products Administration has accepted a new drug application for cyclosporine eye gel from Zhaoke Ophthalmology, indicating positive regulatory developments in the industry [1] Group 2 - Longcheng Securities expressed optimism about the pharmaceutical sector, citing frequent favorable policies that are expected to lead to a steady recovery in industry sentiment [1] - Morgan Stanley's research report maintains a positive outlook on the Chinese pharmaceutical industry, highlighting supportive policies for innovation and low dependency on U.S. exports, which mitigates risks from geopolitical tensions and uncertainties in U.S. drug pricing [1]

Group 1: Market Performance - The Hong Kong pharmaceutical and biotechnology sector has shown strong performance, with the Hang Seng Healthcare Index ETF (159557) rising 1.9% as of May 21, aiming for a fourth consecutive increase, with a premium rate of 0.23% [1] - Over the three trading days from May 16 to May 20, the Hang Seng Healthcare Index ETF (159557) accumulated a total increase of approximately 6.4% [1] - Notable individual stock performances include Ascentage Pharma-B rising over 10%, and other companies like CanSino Biologics, Innovent Biologics, and 3SBio increasing by over 6% [1] Group 2: Company Developments - 3SBio announced a significant agreement with Pfizer on May 20, granting exclusive rights for the global development, production, and commercialization of its PD-1/VEGF bispecific antibody SSGJ-707, excluding mainland China [2] - The agreement includes an upfront payment of $1.25 billion and potential milestone payments totaling up to $4.8 billion, leading to a total potential transaction value of $6.05 billion, which exceeds 43 billion RMB at current exchange rates [2] - This transaction sets a new record for the highest upfront payment for a domestic innovative drug license-out deal [2] Group 3: Industry Outlook - The innovative drug sector is expected to maintain its growth trajectory, driven by "innovation + internationalization," supported by policy backing and enhanced global competitiveness [3] - There is an anticipated recovery in demand for domestic healthcare services by 2025, with potential improvements in the medical device sector as well [3] - AI in healthcare is highlighted as a significant technological trend that could bring new changes to the pharmaceutical industry [3] - Long-term prospects suggest that companies with strong innovation capabilities and rich product pipelines will benefit from ongoing procurement initiatives in pharmaceuticals and consumables [3]

Investment Rating - The report maintains a "Buy" rating for the company [5] Core Viewpoints - The company has entered into a licensing agreement with Pfizer for its innovative PD-1/VEGF bispecific antibody SSGJ-707, which is expected to enhance its global presence and financial returns [1][2] - SSGJ-707 has shown promising clinical results, achieving excellent overall response rates (ORR) and disease control rates (DCR) in non-small cell lung cancer (NSCLC) patients, indicating its potential as a best-in-class treatment [2] - The company is expected to see significant revenue growth, with projected revenues of 10.23 billion RMB in 2025, reflecting a year-on-year growth rate of 12.3% [4] Financial Projections - The company’s net profit is projected to reach 2.36 billion RMB in 2025, with a growth rate of 13.0% [4] - The earnings per share (EPS) is expected to increase from 0.65 RMB in 2023 to 0.98 RMB in 2025 [4] - The company’s revenue is forecasted to grow from 7.82 billion RMB in 2023 to 12.65 billion RMB by 2027, with a compound annual growth rate (CAGR) of approximately 10.6% [4] Product Pipeline and Market Strategy - The company is focusing on expanding its product pipeline, with SSGJ-707 being a key driver for growth, alongside other mature products that are expected to continue generating revenue [3] - The company has established a global strategy, with products being sold in 16 countries and ongoing collaborations to expand its PD-1 pipeline [3]

Core Viewpoint - The Hang Seng Healthcare Index (HSHCI) has shown strong performance, with significant increases in constituent stocks, indicating a positive trend in the healthcare sector [3][4]. Group 1: Market Performance - As of May 21, 2025, the HSHCI rose by 3.00%, with notable gains from stocks such as Ascentage Pharma-B (up 10.17%) and 3SBio (up 7.92%) [3]. - The Hang Seng Healthcare ETF (513060) increased by 1.60%, marking its fourth consecutive rise, with a latest price of 0.51 yuan [3]. - The ETF's trading volume reached 5.98 billion yuan, with a turnover rate of 5.97% [3]. Group 2: Company Developments - 3SBio announced a partnership with Pfizer, granting exclusive rights for the global development and commercialization of the PD-1/VEGF bispecific antibody SSGJ-707, excluding mainland China [3]. - 3SBio retains rights for SSGJ-707 in mainland China and will grant Pfizer an option for commercialization in that region based on agreed financial terms [3]. Group 3: Industry Trends - The Chinese innovative drug market is projected to grow from $132.5 billion in 2019 to $159.2 billion by 2024, maintaining a global market share of around 15% [4]. - In 2024, China completed 94 license-out transactions for innovative drugs, totaling $51.9 billion, a 26% increase year-on-year [4]. - The focus on platform technologies such as ADCs, bispecific antibodies, and gene editing is increasing among multinational corporations (MNCs), highlighting the growing recognition of Chinese innovative drugs [4]. Group 4: ETF Performance Metrics - The latest size of the Hang Seng Healthcare ETF is 9.859 billion yuan, ranking it in the top third among comparable funds [5]. - The ETF has achieved a 26.90% net value increase over the past year, with a maximum monthly return of 28.34% since inception [5]. - The ETF's Sharpe ratio stands at 1.12, ranking it in the top half among comparable funds, indicating high returns relative to risk [5]. Group 5: Valuation Insights - The HSHCI's current price-to-earnings ratio (PE-TTM) is 24.38, indicating it is at a historical low, below 90.91% of the time over the past year [6]. - The top ten weighted stocks in the HSHCI account for 57.2% of the index, with companies like WuXi Biologics and Innovent Biologics among the leaders [6].

生物医药ETF（159859）紧密跟踪国证生物医药指数（399441.SZ）。该指数以沪深北交易所属于生物 医药产业相关上市公司为样本空间，根据市值规模和流动性的综合排名，选出前30只证券作为指数样本 股，反映了生物医药行业的整体运行情况，向市场提供了细分行业的指数化投资标的。该ETF还配备了 联接基金（A：011040，C：011041）。 创新药沪港深ETF（517380）紧密跟踪恒生沪深港创新药50指数（HSSSHID.HI），该指数为唯一横跨 三地的创新药指数，精选50只优质创新药龙头。截至5月20日，该指数近5年市销率分位数32.18%。 创新药沪港深ETF 100%布局创新药产业链，前十大权重合计占比超50%，涵盖恒瑞医药、百济神州、 信达生物等热门标的。 招银国际认为，受益于创新药出海交易、国内集采政策优化、创新药丙类医保目录落地、医疗设备招标 复苏、内需复苏等积极因素推动，医药行业有望在2025年继续迎来估值修复。 5月21日，A股三大指数集体上涨，创新药概念延续强势。 相关ETF方面，生物医药ETF（159859）截至发稿涨0.85%，成交额超2876万元，换手率0.83%，盘中 交投活跃。 ...

根据公告，公司将PD-1/VEGF双抗在中国内地之外全球权益授权给辉瑞，公司将保留在中国内地的开 发、制造、商业化及其他开发权，辉瑞拥有在中国商业化该许可产品的选择权，辉瑞负责许可地区未来 所有开发及监管费用。辉瑞将支付12.50亿美元首付款，最高为48.00亿美元里程碑付款以及许可地区产 品净销售额双位数百分比的梯度销售分成。同时，辉瑞也将在协议生效后按照30日成交量加权平均价认 购公司1亿美元普通股。 中金发布研报称，维持三生制药(01530)2025/2026年经调整净利润24.07亿元/26.02亿元不变(暂不涵盖BD 首付款收入)，当前股价对应2025/2026年17.3/16.0倍经调整市盈率。维持跑赢行业评级，考虑板块估值 中枢提升，该行上调目标价56.3%至21.10港元，对应2025/2026年19.0/17.6倍经调整市盈率，隐含10%上 行空间。 中金主要观点如下： 公司近况 5月20日公司公告，将PD-1/VEGF双抗(SSGJ-707)的中国内地之外全球权益授权给辉瑞，辉瑞还将获得 中国市场商业化的选择权，三生国健亦将透过该协议作为签署方加入。 本次海外BD将为公司业绩带来较大弹性 ...

智通财经5月21日电，舒泰神20CM涨停，此前三生国健3连板，赛升药业、海创药业、海辰药业、诺思 格、君实生物等跟涨。消息面上，港股创新药企三生制药公告称，其与辉瑞公司就前者自主研发的PD- 1/VEGF双特异性抗体SSGJ-707签订了独家许可协议。本次协议中12.5亿美元的首付款再次刷新了国产 创新药出海首付款金额纪录。 创新药概念延续强势 舒泰神20CM涨停 ...

Investment Rating - The report maintains a "Buy" rating for the company [5] Core Viewpoints - The company has entered into a licensing agreement with Pfizer for its innovative PD-1/VEGF bispecific antibody SSGJ-707, which is expected to enhance its global presence and financial returns [1][2] - SSGJ-707 has shown promising clinical results, achieving excellent overall response rates (ORR) and disease control rates (DCR) in non-small cell lung cancer (NSCLC) patients, indicating its potential as a best-in-class treatment [2] - The company is expected to see significant revenue growth driven by its core products and innovative pipeline, with projected net profits increasing from 2.36 billion RMB in 2025 to 2.98 billion RMB in 2027 [3][4] Financial Projections - The company’s revenue is projected to grow from 7.82 billion RMB in 2023 to 12.65 billion RMB in 2027, with year-over-year growth rates of 13.9% in 2023 and declining to 10.6% by 2027 [4] - The net profit is expected to increase from 1.55 billion RMB in 2023 to 2.98 billion RMB in 2027, with a notable recovery in 2024 at a growth rate of 34.9% [4] - The earnings per share (EPS) is projected to rise from 0.65 RMB in 2023 to 1.24 RMB in 2027 [4] Product and Market Strategy - The company is focusing on expanding its product offerings and market reach, with SSGJ-707 being a key component of its strategy to enhance its competitive position in the oncology market [2][3] - The company has established a global strategy, with products being sold in 16 countries and collaborations with international partners to expand its pipeline [3]