股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年12月31日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 無錫藥明康德新藥開發股份有限公司 呈交日期: 2026年1月6日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | H | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 02359 | 說明 | | | | | | | | | | 法定/註冊股份數目 | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 510,476,909 RMB | | | 1 RMB | | 510,476,909 | | 增加 / 減少 (-) | | | 0 | | | RMB | | 0 | | 本月底結存 | | | 510,476,909 RMB | | | 1 RMB | | 510,476,909 | 由於無錫藥明康德新藥開發股份有限公司(「本公司」)在中 ...

Core Viewpoint - The company, WuXi AppTec, is experiencing positive market performance, with a recent stock increase of 1.78% and a total market capitalization of 287.87 billion yuan, benefiting from its position as a leading Contract Research Organization (CRO) and the depreciation of the Chinese yuan [1][3]. Group 1: Company Overview - WuXi AppTec is an international leader in providing comprehensive and integrated new drug research and production services for the global biopharmaceutical industry [2]. - The company is a domestic leader in the pharmaceutical outsourcing industry, being one of the earliest to engage in CRO and CMO integrated services, with over 200 authorized and pending patent achievements [2]. - The main business involves the discovery, research, and production of small molecule chemical drugs, offering a full range of services to global pharmaceutical companies [2][7]. Group 2: Financial Performance - For the period ending September 30, 2025, WuXi AppTec achieved a revenue of 32.857 billion yuan, representing a year-on-year growth of 18.61%, and a net profit attributable to shareholders of 12.076 billion yuan, reflecting an 84.84% increase [7]. - The company’s revenue from overseas accounts for 78.67%, benefiting from the depreciation of the yuan [3]. - The revenue composition includes 78.37% from chemical business, 12.93% from testing services, 6.02% from biological services, and 1.90% from other supplementary services [7]. Group 3: Market Activity - The stock has seen a net inflow of 1.84 million yuan from major investors today, with a total net inflow of 2.38 million yuan over the last three days [4][5]. - The average trading cost of the stock is 95.67 yuan, with the current price approaching a resistance level of 96.50 yuan, indicating potential for upward movement if this level is surpassed [6].

转自：前瞻产业研究院 以下数据及分析来自于前瞻产业研究院医药研发外包(CRO)研究小组发布的《中国医药研发外包（CRO） 行业市场前瞻与投资战略规划分析报告》。 行业主要上市公司：目前国内CRO行业主要的上市公司有药明康德(603259.SH)、康龙化成(300759.SZ)、泰 格医药(300347.SZ)、凯莱英(002821.SZ)、昭衍新药(603127.SH)、九洲药业(603456.SH)、皓元医药 (688131.SH)、博腾股份(300363.SZ)、成都先导(688222.SH)、药石科技(300725.SZ)等。 本文核心数据：企业主营业务收入、企业经营毛利率 1、中国CRO产业链全景梳理 中国CRO产业链贯穿研发阶段、生产阶段和产品销售整个药品生命周期，分别对应药物研发服务(CRO)、 医药生产服务(CMO/CDMO)以及医药销售服务(CSO)。研发阶段覆盖临床前与临床两大核心环节，其中临 床前主要做有关药物发现、化合物合成、合成工艺研发及制剂研发等早期基础研发工作;临床阶段主要进行 临床试验、医学统计、数据整理与数据分析等流程。生产阶段，针对不同药物类型提供生产服务，化学原 料药包含了 ...

Group 1 - The medical ETF (512170) opened high on January 6, rising over 1% and reaching a 20-day high, with real-time transaction volume exceeding 350 million yuan. The ETF recorded a daily increase of over 5%, marking five consecutive days of gains [1][5] - Brain-computer interface stocks, including Sanbo Brain Science and Meihua Medical, both hit the 20% daily limit up, achieving two consecutive boards. Conversely, the CXO sector saw a pullback, with Tigermed falling over 1% [1][5] Group 2 - On January 5, 2026, Elon Musk announced that Neuralink plans to start large-scale production of brain-computer interface devices, advancing the commercialization of the technology. Concurrently, the National Medical Products Administration held a meeting to expedite the review and approval of related medical devices [3][6] - According to CITIC Securities, China's brain-computer interface technology is relatively advanced globally, with potential to cultivate leading companies in the sector. This could enhance the valuations of related listed companies in the secondary market and stimulate financing in the primary market, creating a synergy between capital and industry development [7] - Zhongtai Securities noted that the pharmaceutical sector is expected to rebound in 2025 after four consecutive years of decline, driven by the realization of innovative drug export logic and industry recovery post-policy reform. Certain areas of the medical device sector may also see a reversal of difficulties [7]

Summary of Key Points from the Conference Call Industry Overview - The pharmaceutical sector is currently in a left-side layout phase after adjustments in 2025, with both institutional holdings and valuations positioned for upward elasticity, particularly in innovative drugs and their supply chains for 2026, benefiting from China's strengthening innovation competitiveness [1][4] - The recovery of the innovative industry chain is expected to continue, with CDMO orders and performance starting to recover from 2024, further improving in 2025 and expected to sustain into 2026 [1][9] Core Insights and Arguments - The driving forces behind the enhancement of China's innovation competitiveness include the successful implementation of business development (BD), overseas clinical progress, and commercialization, along with breakthroughs in new technologies such as XDC, dual antibodies, and small nucleic acids [5] - Investment opportunities in 2026 are concentrated in globally competitive assets, including innovative drugs, high-end manufacturing, and domestic demand-related sectors, particularly those with recovery logic [2] - The domestic demand recovery trend is clear, strengthening quarter by quarter in 2025, driven by high domestic innovation BD, a warming primary and secondary market, and an increase in IPOs in both A-shares and Hong Kong stocks [20] Notable Companies and Technologies - Key companies to watch include Innovent Biologics, Botai Biological Products, and Engen Biologics, which are core recommended assets due to their potential for significant data readouts and BD catalysts [6][10] - In the CRO sector, companies like Tigermed and Zhaoyan New Drug are expected to see performance turning points in 2026, supported by a recovery in domestic demand [3][21] - The CDMO sector is projected to continue its growth trajectory, with leading companies such as WuXi AppTec and Kelun Biotech expected to perform well due to increasing orders from overseas [22][23] Emerging Technologies and Investment Opportunities - Emerging technologies such as brain-computer interfaces and AI in pharmaceuticals are anticipated to bring new investment opportunities, with potential IPOs in these areas [12][29] - The central OTC sector is expected to see marginal recovery in 2026, with key companies like China Resources and Dong'e Ejiao being highlighted for their potential growth [13][30] Upcoming Catalysts and Key Events - Important upcoming events include the JPMorgan conference, which may provide data updates and BD changes, and significant data readouts expected in Q1 and April from major conferences [8][10] - The performance of companies in the first quarter of 2026 is anticipated to show significant elasticity and fundamental support, particularly in the CRO and innovative drug sectors [11][20] Conclusion - The pharmaceutical industry is positioned for a recovery phase with significant investment opportunities in innovative drugs, CDMO, and CRO sectors, driven by domestic demand recovery and technological advancements. Key companies and upcoming events will play a crucial role in shaping the market dynamics in 2026 [1][2][4][20]

两融数据显示，该股最新融资余额为68.12亿元，近5日减少3.88亿元，降幅为5.38%。（数据宝） （原标题：药明康德现19笔大宗交易 合计成交1033.84万股） 药明康德1月5日大宗交易平台共发生19笔成交，合计成交量1033.84万股，成交金额9.29亿元。成交价格 均为89.84元，相对今日收盘价折价5.00%。从参与大宗交易营业部来看，机构专用席位共出现在4笔成 交的买方或卖方营业部中，合计成交金额为6.11亿元，净买入6.11亿元。 进一步统计，近3个月内该股累计发生62笔大宗交易，合计成交金额为26.27亿元。 证券时报•数据宝统计显示，药明康德今日收盘价为94.57元，上涨4.34%，日换手率为2.95%，成交额为 68.80亿元，全天主力资金净流入1.48亿元，近5日该股累计上涨2.86%，近5日资金合计净流出6.27亿 元。 注：本文系新闻报道，不构成投资建议，股市有风险，投资需谨慎。 1月5日药明康德大宗交易一览 | 成交量 | 成交金 | 成交价 | 相对当 日 | | | | --- | --- | --- | --- | --- | --- | | （万 | 额 | 格 | 收盘 ...

Group 1 - A total of 75 stocks in the A-share market experienced block trading today, with a total transaction value of 2.562 billion yuan [1] - The top three stocks by transaction value were WuXi AppTec at 929 million yuan, Changchuan Technology at 169 million yuan, and CIMC Vehicles at 152 million yuan [1] - Among the stocks, 9 were traded at par, 3 at a premium, and 63 at a discount; the highest premium rates were for Zhangqu Technology at 12.6%, Nanmo Biology at 8.17%, and Guolian Minsheng at 2.74% [1] Group 2 - The ranking of institutional buy amounts was led by WuXi AppTec at 611 million yuan, followed by Changchuan Technology at 142 million yuan and CIMC Vehicles at 112 million yuan [2] - Other notable institutional purchases included Salt Lake Co. at 76.725 million yuan and Perfect World at 75.15 million yuan [2] - The ranking of institutional sell amounts was topped by Zhongyou Technology at 37.584 million yuan, followed by Chuanheng Co. at 6.75 million yuan and Huadong Co. at 5.3075 million yuan [3]

Core Insights - The medical services sector experienced a significant increase of 4.77% on January 5, with Sanbo Brain Science leading the gains [1] - The Shanghai Composite Index closed at 4023.42, up 1.38%, while the Shenzhen Component Index closed at 13828.63, up 2.24% [1] Medical Services Sector Performance - Sanbo Brain Science (301293) closed at 70.78, with a rise of 20.01% and a trading volume of 106,700 shares, amounting to a transaction value of 755 million [1] - Likang Life (300143) saw a closing price of 11.38, increasing by 15.18% with a trading volume of 473,200 shares, totaling 518 million [1] - Chengdu Xian Dao (688222) closed at 26.14, up 11.47%, with a trading volume of 277,100 shares, resulting in a transaction value of 704 million [1] - Other notable performers include She Nei Medical (301060) at 10.20 (+10.27%), International Medical (000516) at 4.72 (+10.02%), and Zhaoyan New Drug (603127) at 38.51 (+10.00%) [1] Capital Flow Analysis - The medical services sector saw a net inflow of 1.028 billion from institutional investors, while retail investors contributed a net inflow of 174 million [2] - Notable net inflows from institutional investors include Zhaoyan New Drug (603127) with 235 million and Sanbo Brain Science (301293) with 214 million [3] - Conversely, retail investors showed significant outflows from several stocks, including Sanbo Brain Science (301293) with a net outflow of 136 million and Likang Life (300143) with 27.9 million [3]

Core Viewpoint - In 2025, the level of cash dividends from listed companies is expected to rise, transitioning capital returns from an "optional" to a "mandatory" aspect, influenced by strengthened regulatory constraints and a clearer preference for long-term capital [1][3] Group 1: Company Performance and Shareholder Returns - As of December 25, A-share listed companies have distributed over 2.61 trillion yuan in cash dividends this year, marking a historical high [1] - WuXi AppTec, as a leading CXO enterprise, has demonstrated a strong shareholder return strategy through a combination of cash dividends and share buybacks, signaling stable and clear returns to the market [1] - WuXi AppTec has announced a total cash dividend of 4.88 billion yuan for 2024 and 2025, along with two share buybacks totaling 2 billion yuan, enhancing shareholder value by reducing the number of shares outstanding [1][2] Group 2: Financial Stability and Cash Flow - WuXi AppTec's net cash flow from operating activities reached 10.87 billion yuan, reflecting a 35% year-on-year increase, which supports high levels of shareholder returns [2] - The company has maintained a stable cash dividend policy since its IPO in 2018, with a long-term payout ratio around 30%, further reinforcing its commitment to shareholder returns [2] Group 3: Market and Regulatory Context - Regulatory bodies have increasingly enforced cash dividend policies, shifting from "advisory arrangements" to "binding rules," which enhances the importance of capital return methods in valuation structures [3] - Sustainable and predictable dividend arrangements, along with share buyback strategies aligned with stock price cycles, are becoming key indicators of corporate governance quality and capital efficiency [3] - WuXi AppTec's approach to dividends and buybacks is viewed as a long-term commitment to providing tangible and sustainable capital returns, addressing market expectations for certainty and long-term value [3]

Investment Rating - The report maintains an "Outperform" rating for the following A-share targets: Jiangsu Heng Rui Medicine, Sichuan Kelun Pharmaceutical, Huadong Medicine, Jiangsu Nhwa Pharmaceutical, Xiamen Amoytop Biotech, Zhejiang Jingxin Pharmaceutical, Innovent Biologics, WuXi AppTec, Hangzhou Tigermed Consulting, Lepu Medical, MicroPort EP MedTech [5][36][8] - The report also maintains an "Outperform" rating for the following H-share targets: Hansoh Pharmaceutical Group, 3SBio, PATEO Biotech, Akeso, and related targets: Innovent Biologics, WuXi AppTec [8][36] Core Insights - The report continues to recommend the innovative drug and device industry and its supply chains, indicating a positive outlook for this sector [1][36] - In December 2025, the pharmaceutical sector underperformed the market, with the SW Pharmaceutical and Biological index falling by 4.1%, while the SHCOMP rose by 2.1%, ranking 26th among Shenwan primary industries [15][37] - The report highlights that the premium level of the pharmaceutical sector relative to all A-shares is currently at a normal level, with a relative premium rate of 63.2% as of the end of December 2025 [25][37] Summary by Sections A-Share Targets - The report includes a monthly portfolio of A-share targets that outperformed the pharmaceutical index, with a monthly average decline of 1.8% compared to the overall pharmaceutical index decline of 3.9% in December 2025 [11][36] - The top three stock gains in December 2025 were Luyan Pharma (+118.8%), CareRay Digital Medical Technology Co., Ltd. (+36.6%), and Hubei Hongyuan Pharmaceutical Technology Co., Ltd. (+34.0%) [24][37] H-Share Targets - The report notes that the Hong Kong stock pharmaceutical sector also underperformed the market, with the Hang Seng Healthcare index falling by 9.5% and the Hong Kong Biological Technology index falling by 10.6% in December 2025 [26][38] U.S. Market Performance - In December 2025, the U.S. pharmaceutical sector underperformed the market, with the S&P 500 Healthcare Select Sector declining by 1.5% while the S&P 500 fell by only 0.1% [26][39]