0:00 10月9日，药明康德公告， 公司10月8日通过大宗交易继续出售所持有的药明合联3030万股股票，约占 药明合联当前总股本的2.47%，成交金额约23.46亿港元（不包含手续费等交易费用），占公司最近一期 （2024年度）经审计归属母公司股东净资产的3.67%。 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確 性或完整性亦不發表任何聲明，並表明概不就因本公告全部或任何部份內容而產生或因倚賴 該等內容而引致的任何損失承擔任何責任。 （於中華人民共和國註冊成立的股份有限公司） WUXI APPTEC CO., LTD. * 無錫藥明康德新藥開發股份有限公司 （股份代號：2359） 海外監管公告 出售部分股票資產 茲提述無錫藥明康德新藥開發股份有限公司（「本公司」）日期為2025年4月2日的 海外監管公告（「該公告」），內容有關出售部分股票資產。本公告乃由本公司根 據香港聯合交易所有限公司證券上市規則（「《香港上市規則》」）第13.10B條作出。 本次出售情況 本公司通過間接控股子公司持有藥明合聯生物技術有限公司（「藥明合聯」）的 若干股票，藥明合聯的股份於香港聯合交易所有限公司主板上市（股份代號： 2268）。 誠如該公告以及其所載的詳情所披露，本公司出售藥明合聯部分股票。 2025年10月8日，本公司通過大宗交易繼續出售所持有的藥明合聯30,300,000股 股票（「本次出售」），約佔截止本公告日期藥明合聯總股本的2.47%，成交金額 ...

此外，药明康德表示，本次出售的股票资产在公司财务报表中列示为"长期股权投资"。经公司财务部门 按中国企业会计准则初步核算，本次出售药明合联股票的投资净收益对公司2025年度税后净利润的影响 约为16.79亿元，占公司最近一期经审计归属净利润的比例超过10%。 药明康德表示，公司通过出售上述股票资产所获得的现金收益，将用于加速推进全球产能及能力建设， 吸引并保留优秀人才，持续强化公司独特的一体化CRDMO业务模式，从而高效满足全球客户和患者日 益增长且不断变化的需求。 北京商报讯（记者 丁宁）10月9日晚间，药明康德（603259）发布公告称，10月8日，公司通过大宗交 易继续出售所持有的药明合联3030万股股票，约占药明合联当前总股本的2.47%，成交金额约23.46亿港 元（不包含手续费等交易费用），占公司最近一期经审计归属母公司股东净资产的3.67%。 ...

证券代码：603259 证券简称：药明康德 公告编号：临 2025-066 无锡药明康德新药开发股份有限公司 关于出售部分股票资产的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 一、交易情况 2025 年 9 月 23 日，无锡药明康德新药开发股份有限公司（以下简称"公司"） 2025 年第二次临时股东大会审议通过《关于授权公司投资部处置所持已上市流 通股份的议案》，同意授权董事会，并同意董事会进一步授权公司投资部在处置 股份授权额度内确定具体处置方案（包括但不限于确定处置标的、出售价格、数 量及方式等），前述授权的有效期为股东大会审议通过本议案之日起至处置股份 授权届满之日止。具体内容请见公司于 2025 年 9 月 3 日及 9 月 24 日披露的相关 公告。 2025 年 10 月 8 日，公司通过大宗交易继续出售所持有的药明合联 30,300,000 股股票，约占药明合联当前总股本的 2.47%，成交金额约 23.46 亿港元（不包含 手续费等交易费用），占公司最近一期（2024 年度）经审计归属母公司股东净资 ...

Core Viewpoint - WuXi AppTec (603259) announced on October 9 that it will continue to sell 30.3 million shares of WuXi AppTec Co., representing approximately 2.47% of the current total share capital, through block trading on October 8, 2025, with a transaction value of about HKD 2.346 billion, which accounts for 3.67% of the company's latest audited net assets attributable to shareholders for the fiscal year 2024 [1] Summary by Categories - **Company Actions** - WuXi AppTec plans to sell 30.3 million shares of WuXi AppTec Co. through block trading [1] - The sale is scheduled for October 8, 2025 [1] - **Financial Impact** - The transaction value is approximately HKD 2.346 billion [1] - This amount represents about 3.67% of the company's latest audited net assets attributable to shareholders for the fiscal year 2024 [1] - **Shareholding Details** - The shares being sold account for approximately 2.47% of the current total share capital of WuXi AppTec Co. [1]

格隆汇10月9日｜药明康德(603259.SH)公告称，公司于2025年10月8日通过大宗交易出售所持有的药明 合联3030万股股票，约占其当前总股本的2.47%，成交金额约23.46亿港元。本次出售药明合联股票的投 资净收益对公司2025年度税后净利润的影响约为人民币16.79亿元，占公司最近一期(2024年度)经审计归 属母公司股东净利润的比例超过10%。2025年度累计出售药明合联股票的投资净收益对公司2025年度税 后净利润的影响约为人民币43.51亿元。 ...

Core Viewpoint - The domestic innovative drug industry is transitioning from a follower to FIC/BIC innovation, supported by engineer dividends, abundant clinical resources, and favorable policies, indicating a qualitative improvement as it enters the 2.0 era [1][2] Group 1: Industry Development - The innovative drug sector is expected to benefit from policy reforms in payment systems, enhancing the profitability of innovative drug companies as they commercialize domestic products [2] - The upcoming ESMO conference in mid-October is anticipated to provide new investment opportunities through the release of relevant clinical data and business development (BD) activities [2] Group 2: Investment Climate - The investment landscape has improved since early this year, with a notable reversal in the financing trend for the innovative drug industry, particularly in the A/H market [3] - The recovery of IPO projects and financing activities in the secondary market is expected to positively impact investment data in Q3, benefiting domestic CROs and upstream research sectors [3] Group 3: Policy Support - Continuous advancement of commercial medical insurance policies since 2025 is likely to accelerate payment system reforms, easing supply-demand conflicts and supporting domestic innovation [4] - Fiscal policy enhancements are expected to increase market interest in domestic medical equipment stocks [4] Group 4: Target Companies - A-share targets include: BeiGene (688235.SH), Hengrui Medicine (600276.SH), Kelun Pharmaceutical (002422.SZ), WuXi AppTec (603259.SH), Tigermed (300347.SZ), New Industry (300832.SZ), BGI Genomics (688114.SH), Huatai Medical (688617.SH), and Dian Diagnostics (300244.SZ) [5] - H-share targets include: Kelun Biotech (06990), CSPC Pharmaceutical (01093), China Biologic Products (01177), CanSino Biologics (09926), WuXi Biologics (02269), Junshi Biosciences (01877), and Zai Lab (09688) [5]

Investment Rating - The report maintains an "Overweight" rating for the industry [3] Core Viewpoints - The report continues to recommend innovative pharmaceuticals and medical devices along the industry chain [2][7] - The performance of the pharmaceutical sector in September 2025 was weaker than the broader market, with the SW Pharmaceutical Biotech index declining by 1.7% compared to a 0.6% increase in the Shanghai Composite Index [16][22] - The report highlights that the medical service sub-sector performed relatively well, increasing by 1.8%, while medical devices and chemical preparations saw slight declines [22] Summary by Sections - **Investment Recommendations**: The report includes a list of A-share stocks with an "Overweight" rating, including Heng Rui Pharmaceutical, Kelun Pharmaceutical, East China Pharmaceutical, Changchun High-tech, Enhua Pharmaceutical, WuXi AppTec, Tigermed, Lepu Medical, United Imaging Healthcare, and Huatai Medical [7][9] - **Performance Analysis**: The report notes that the monthly portfolio of Guotai Junan Pharmaceuticals outperformed the pharmaceutical index in September 2025, with an average increase of 1.1% compared to a 0.7% increase in the overall pharmaceutical index [12][13] - **Market Comparison**: The report indicates that the pharmaceutical sector's premium level relative to all A-shares is currently at a normal level, with a relative premium rate of 77.5% as of the end of September 2025 [26][28]

Investment Rating - The report indicates a positive outlook for the CDMO industry, with expectations for improved order flow, revenue growth, and profit margins by 2026, particularly benefiting from the recovery of Chinese funding and increased demand for early projects [1][4]. Core Insights - The CDMO industry maintains a high overall profit margin, driven by the growing demand for emerging therapies and higher quality requirements from clients [2][4]. - Chinese CDMO companies are more aggressive in capacity expansion and new model investments, with capital expenditures accounting for approximately 22% of sales, while Indian companies adopt a more cautious approach [1][5]. - New trends in the CDMO industry include overseas expansion, automation, digital investments, and the development of peptide drugs and antibody-drug conjugates (ADCs) [1][6]. Summary by Sections Current Demand Situation - The global CDMO industry demand remains stable, supported by CMO projects and emerging therapies, with a notable focus on GLP-1, peptide capacity, and ADCs [2]. - Despite some pressures, overall profit margins are high due to increased demand for emerging therapies and quality assurance [2]. Investment Strategies - Chinese CDMO companies are proactive in expanding capacity and investing in new models, while Indian companies are more conservative, linking investments to visible market demand [5][12]. - Indian CDMO companies focus on geopolitical diversification and maintaining a good RFP/RFQ momentum, although the conversion of orders to actual financial results is slower than expected [8][11]. Future Market Outlook - R&D investments are expected to fluctuate in 2025, but most companies anticipate improvements in order flow, revenue growth, and profit margins by 2026, particularly due to the recovery of Chinese funding [4][15]. - The performance of Chinese companies is currently superior to that of Indian companies, with Indian firms expected to see financial results materialize by the 2026 fiscal year [11]. New Trends in the Industry - Key trends include overseas expansion, automation, digital investments, and advancements in peptide drugs and ADCs, with Chinese companies accelerating facility construction in response to geopolitical uncertainties [6][10]. - Companies like Samsung Biologics have begun operating their ADC capacity and have received significant orders from major global clients [6][10]. Geopolitical Factors - The impact of geopolitical factors on the CDMO industry has diminished, with normal business operations continuing without major disruptions [7][14]. - Some clients still consider potential disruptions from political factors, but technical strength and execution capabilities remain paramount [7]. Performance Comparison - In the peptide formulation sector, Chinese companies significantly outpace Indian firms in capacity, while Indian companies express optimism in the ADC field [10][11]. - The financial commercialization results for Indian companies are expected to lag behind those of Chinese companies, with growth rates projected to be in the mid-single digits for 2026 [11].

Core Insights - Targeted protein degradation technology has seen significant development in China, providing new strategies for treating diseases such as cancer, neurodegenerative diseases, and autoimmune diseases [1][8] - The market size for targeted protein degradation in China is projected to reach approximately 102 million yuan in 2024, reflecting a year-on-year growth of 112.50% [1][8] - The increasing demand for novel drugs is driven by an aging population and the rise of chronic diseases, highlighting the technology's potential to meet unmet clinical needs [1][8] Industry Overview - Targeted protein degradation involves hijacking cellular degradation mechanisms to specifically degrade target proteins, addressing diseases caused by protein accumulation or dysfunction [2][4] - The technology overcomes limitations of traditional small molecule inhibitors, enabling the targeting of "undruggable" proteins [2][4] Industry Development History - The industry has evolved over two decades, starting from basic research to global competition, with significant milestones including the introduction of PROTAC concepts and the establishment of early technology platforms [4][5] - Recent years have seen a surge in clinical trials and the establishment of a robust pipeline, with 35 clinical programs reported as of 2024 [4][5] Industry Value Chain - The upstream of the industry includes raw materials such as E3 ubiquitin ligase ligands and various production equipment [5][6] - The midstream focuses on research and development, while the downstream applications target oncology and neurodegenerative diseases [5][6] Key Companies and Performance - Leading companies in the PROTAC space include HaiChuang Pharmaceutical and KaiTou Pharmaceutical, with significant clinical advancements in prostate and breast cancer treatments [8][10] - Jiangsu Hengrui Medicine has adopted a "fast-follow + innovation" strategy, achieving a 22.63% increase in revenue in 2024 [10][11] Industry Trends - Continuous technological innovation is expected to break through core technical bottlenecks in PROTAC, molecular glue, and LYTAC/AUTAC technologies [12][13] - The market is expanding into rare disease applications, with targeted protein degradation strategies being developed for conditions like Alzheimer's disease [13] - The industry ecosystem is being restructured with deepening international collaborations, positioning China as a key player in global biopharmaceutical innovation [14]