Summary of WuXi AppTec Co Ltd Investor Day Company Overview - **Company**: WuXi AppTec Co Ltd - **Industry**: Contract Development and Manufacturing Organizations (CDMOs) - **Date of Investor Day**: September 29, 2025 - **Location**: Changzhou, Jiangsu province, China Key Points Industry Insights 1. **R&D Pipeline Contribution**: Small molecules and synthetic new modalities are the mainstay of global R&D, contributing 54% of pipeline candidates in 2024 [2] 2. **Innovation from Small Biopharma**: The share of global R&D spending by small biopharma companies increased from 17% in 2015 to 20% in 2024, projected to reach 26% by 2030 [2] 3. **Venture Capital Funding**: Small molecules received 37% of venture capital funding from 2022 to mid-2025, followed by biologics at 26% and cell/gene therapies at 17% [3] 4. **China's Biopharma Ecosystem**: China's early-stage biopharma companies are approximately half of those in the US, indicating a growing innovation ecosystem [4] 5. **Outsourcing Trends**: The global outsourcing rate to Contract Research Organizations (CROs) rose from 35% in 2015 to 52% in 2024, projected to reach 62% by 2030 [4] Company Performance 6. **Molecular Complexity**: WuXi AppTec's contracts showed increased molecular complexity from 2021 to 2025, with a 22% rise in synthetic steps for long-route molecules and a 63% increase in the proportion of molecules weighing over 600 Daltons [4] 7. **Customer Utilization**: Approximately one-third of active customers in oncology, infectious disease, immunology, metabolic disease, and neuroscience utilize WuXi's discovery services [4] 8. **FDA Approvals**: WuXi produced 20% of novel small molecule drugs approved by the US FDA from 2024 to mid-2025, totaling 8 out of 40 approved drugs [4] Market Position 9. **GLP-1 Contracts**: WuXi currently holds 23 GLP-1 contracts, translating to a 24% market share of pipeline drugs by number [5] 10. **Licensing and M&A Activity**: Of 213 licensing and M&A deals for synthetic drugs globally from 2024 to mid-2025, 62 (or 29%) involved WuXi's customers [5] Financial Metrics 11. **Stock Rating**: The stock is rated as Overweight with a price target of HK$106.00, showing a slight downside from the current price of HK$107.60 [7] 12. **Market Capitalization**: The current market cap is approximately RMB 296.437 billion [7] 13. **Revenue Growth**: Projected revenue growth from RMB 39.241 billion in 2024 to RMB 58.491 billion by 2027 [7] 14. **Earnings Per Share (EPS)**: Expected EPS growth from RMB 3.23 in 2024 to RMB 5.87 in 2027 [7] Risks and Opportunities 15. **Upside Risks**: Potential inflection of Fed rates could lead to increased biotech funding, along with favorable government policies and margin expansion [41] 16. **Downside Risks**: Risks include talent turnover, margin pressure from US business, global competition, and geopolitical risks [41] Conclusion WuXi AppTec is positioned strongly within the CDMO sector, with significant contributions to the global R&D landscape and a robust pipeline of contracts. The company is navigating a competitive environment while capitalizing on growth opportunities in the biopharma space.

Core Viewpoint - WuXi AppTec's stock price has shown significant growth this year, with a year-to-date increase of 101.41%, indicating strong market performance and investor interest [1][2]. Financial Performance - For the first half of 2025, WuXi AppTec reported revenue of 20.799 billion yuan, a year-on-year increase of 20.64%, and a net profit attributable to shareholders of 8.561 billion yuan, which represents a remarkable growth of 101.92% [2]. - The company has distributed a total of 14.06 billion yuan in dividends since its A-share listing, with 10.406 billion yuan distributed over the past three years [3]. Stock Market Activity - As of September 30, WuXi AppTec's stock price was 107.47 yuan per share, with a market capitalization of 317.198 billion yuan. The stock experienced a net inflow of 12.9546 million yuan from major funds [1]. - The trading volume on September 30 was 544 million yuan, with a turnover rate of 0.21% [1]. Shareholder Information - As of June 30, 2025, WuXi AppTec had 235,500 shareholders, with the average circulating shares per person remaining at zero [2]. - The second-largest circulating shareholder is Hong Kong Central Clearing Limited, holding 302 million shares, an increase of 56.0239 million shares from the previous period [3].

25只个股今日获机构买入型评级，7股机构首次关注。 证券时报·数据宝统计显示，今日机构研报共发布26条买入型评级记录，共涉及25只个股。药明康德关 注度最高，共获2次机构买入型评级记录。 从机构评级变动看，今日机构买入型评级记录中，有7条评级记录为机构首次关注，涉及安孚科技、沪 电股份等7只个股。 市场表现方面，机构买入型评级个股今日平均上涨2.19%，表现强于沪指。股价上涨的有23只，涨停的 有领益智造、新澳股份等。涨幅居前的有菲利华、泸州老窖、金博股份等，今日涨幅分别为5.24%、 4.30%、3.91%。跌幅较大的个股有珀莱雅、海泰新光等，跌幅分别为0.63%、0.56%。 行业来看，医药生物行业最受青睐，药明康德、美好医疗等5只个股上榜机构买入评级榜。电子、通信 等行业也较受机构关注，分别有4只、3只个股上榜。（数据宝） 机构今日买入型评级记录 | 代码 | 简称 | 机构名称 | 最新评级 | 上次评级 | 预测目标价（元） | 最新收盘价（元） | | --- | --- | --- | --- | --- | --- | --- | | 603259 | 药明康德 | 招银国际 | 买入 | 买 ...

| 代码 | 名称 | 收盘价 | 涨跌幅 | 成交量(手) | 成交额(元) | | --- | --- | --- | --- | --- | --- | | 002622 | 皓宸医疗 | 3.21 | -6.96% | 91.76万 | 2.95 Z | | 603127 | 昭衍新药 | 35.31 | -4.39% | 32.87万 | 11.51亿 | | 688046 | 药康生物 | 17.66 | -4.13% | 3.39万 | 6034.58万 | | 688131 | 皓元医药 | 77.66 | -1.97% | 4.39万 | 3.40亿 | | 000504 | *ST生物 | 9.16 | -1.72% | 2.36万 | 2169.47万 | | 835670 | 数字人 | 15.37 | -1.54% | 2.52万 | 3907.47万 | | 688073 | 毕得医药 | 75.92 | -1.27% | 8913.84 | 6690.90万 | | 688710 | 益诺恩 | 46.80 | -1.24% | 9044.18 | 4239.32万 | | 60 ...

Core Viewpoint - Bank of America Securities has raised its revenue forecasts for WuXi AppTec (02359) for 2026 and 2027 by 0.2% and 0.3% respectively, citing better-than-expected prospects in its biological and chemical businesses [1] Group 1: Financial Projections - The earnings per share forecast has been increased by 0.4% and 0.8% due to enhanced project values and improved production efficiency [1] - The target price for WuXi AppTec has been raised from HKD 123 to HKD 130.7, maintaining a "Buy" rating [1] Group 2: Market Position and Performance - Since 2021, WuXi AppTec has maintained a 33% market share in the oncology drug development sector among active clients, which includes drug discovery and preclinical stage clients [1] - Revenue from non-oncology in vivo pharmacology business has grown by 42% in the first half of this year [1] - Despite intensified price competition in the industry, the value of new preclinical orders has increased by 14.5% year-on-year [1] - WuXi's chemical business has served approximately 2,550 clients as of the first half of the year, with management expecting revenue growth to exceed 20% for the year [1]

Core Viewpoint - Bank of America Securities has raised its revenue forecasts for WuXi AppTec (02359) for 2026 and 2027 by 0.2% and 0.3% respectively, citing better-than-expected prospects in its biological and chemical businesses [1] Group 1: Financial Projections - The gross margin forecast has been increased due to enhanced project values and improved production efficiency, leading to an upward revision of earnings per share by 0.4% and 0.8% [1] - The target price for WuXi AppTec has been raised from HKD 123 to HKD 130.7, with a reiterated "Buy" rating [1] Group 2: Market Position and Performance - Since 2021, WuXi AppTec has maintained a 33% market share in the oncology drug development sector among active clients, which includes drug discovery and preclinical stage clients [1] - Revenue from non-oncology in vivo pharmacology business grew by 42% in the first half of this year [1] - Despite intensified price competition in the industry, the value of new preclinical orders still increased by 14.5% year-on-year [1] - As of the first half of the year, WuXi AppTec's chemical business served approximately 2,550 clients, with management expecting revenue growth to exceed 20% for the year [1]

Investment Rating - The report maintains an "Overweight" rating for the pharmaceutical and biotechnology sector [5]. Core Viewpoints - The acquisition of Metsera by Pfizer, valued at approximately $4.9 billion, underscores the significant potential and long-term growth prospects of the weight loss drug market, particularly in the GLP-1 segment [2][24]. - The report emphasizes the urgent demand for next-generation therapies, such as oral formulations and multi-target drugs, indicating a competitive landscape in the global GLP-1 research race [2][24]. - The Chinese weight loss drug industry is poised for growth, with a focus on companies that demonstrate strong sales execution and advanced research capabilities [3][24]. Summary by Sections Market Review - The pharmaceutical and biotechnology index fell by 2.20%, underperforming the CSI 300 index by 3.27 percentage points, ranking 24th among 31 sub-industries [1][16]. Key Company Insights - Companies to watch include Innovent Biologics (H), Heng Rui Medicine, Borui Medicine, Zhongsheng Pharmaceutical, Nawei Technology, WuXi AppTec (A+H), and Kelaiying (A+H) as they are expected to benefit from the expanding GLP-1 industry chain [3][24]. Annual Investment Strategy - The report suggests a structural selection of investment opportunities based on payment willingness and ability, focusing on three payment channels: hospital payments, out-of-pocket payments, and overseas payments [25]. - Key areas of interest include hospital policy support for innovative drugs and devices, expanding public demand for blood products, home medical devices, and the weight loss drug industry chain [25]. Company Earnings Forecast and Valuation - The report provides earnings per share (EPS) and price-to-earnings (PE) ratios for key companies, indicating a "Buy" rating for WuXi AppTec and Innovent Biologics, and an "Overweight" rating for Heng Rui Medicine [4]. Market Trends - The global weight loss drug market is experiencing rapid growth, with Pfizer's acquisition of Metsera highlighting the increasing market space associated with obesity-related health issues [28]. - The report notes that the commercialization of domestic weight loss drugs will hinge on sales capabilities and research advancements [3][24]. Important Company Announcements - Recent announcements include clinical trial updates and new drug applications from various companies, indicating ongoing innovation and development within the sector [27]. Financial Data - The basic medical insurance income for the first seven months of 2025 reached 1,684.7 billion yuan, with expenditures amounting to 1,369.7 billion yuan, reflecting the financial landscape impacting the pharmaceutical industry [30]. Price Trends - The report notes a decline in antibiotic prices and stability in cardiovascular raw material drug prices, which may influence the cost structure for pharmaceutical companies [36][43]. Conclusion - The report presents a positive outlook for the pharmaceutical and biotechnology sector, particularly in the weight loss drug market, driven by significant acquisitions and a growing demand for innovative therapies [2][24].

Core Insights - WuXi AppTec held an investor day event, highlighting the strong momentum in its TIDES business, rapid capacity expansion, and a rich pipeline [1] - Early-stage research shows signs of further recovery, which is expected to drive growth in early-stage business revenue, accounting for approximately one-third of total company revenue [1] - Enhanced operational efficiency supports the company's resilient profitability amid macro uncertainties and global capacity expansion, with adjusted gross margin and net profit margin reaching historical highs of 44.5% and 30.4% respectively in 1H25 [1] - Management expresses confidence in maintaining resilient profitability, leading to a slight upward adjustment of the target price to RMB 118.79 to reflect positive signals from global early-stage research demand [1] - The rating remains "Buy" [1]

格隆汇9月29日｜招银国际研报指出，药明康德举办了投资者日活动，该行认为此次会议的要点如下： 1）TIDES 业务发展势头不变，产能扩张迅速、管线储备丰富；2）早期研发显现进一步复苏的信号， 将拉动占公司总收入约1/3 的早期业务收入的增长；3）精细化运营助力公司在面对宏观不确定性以及 进行全球产能扩张的同时保持有韧性的盈利能力。1H25 公司的经调整毛利率和净利润率达到44.5%和 30.4%，均为公司历史最高。管理层有信心保持有韧性的盈利能力。该行小幅上调药明康德目标价至 118.79元人民币，以反映全球早期研发需求改善的积极信号。维持"买入"评级。 ...

Core Viewpoint - Morgan Stanley expects that the new drug tariff policy will not have a direct impact on Chinese CDMO companies like WuXi AppTec, as clients typically bear the tariff costs, and WuXi AppTec is expanding its production capacity in the U.S. to meet local production demands [1] Group 1: Company Analysis - WuXi AppTec is identified as the largest contract research and manufacturing organization in China, with strong business fundamentals [1] - The competition in the small molecule CRDMO sector is considered relatively mild, which bodes well for WuXi AppTec's market position [1] - The growth momentum of WuXi AppTec's TIDES business remains robust, indicating a positive outlook for the company's future performance [1] Group 2: Market Outlook - Morgan Stanley maintains an "Overweight" rating on WuXi AppTec, with a target price set at HKD 138 [1] - The report follows the announcement by former President Trump regarding a 100% tariff on imported brand-name and patented drugs starting October 1, unless related manufacturers have begun construction of production facilities in the U.S. [1]