Market Sector - The Sci-Tech Innovation Board (STAR Market) index increased by 51.20% in the first three quarters of 2025, ranking second among various sector indices, outperforming the North Exchange 50, Shenzhen 50, and Shanghai 50 indices [2] - As of the end of Q3 2025, the total market capitalization of the STAR Market reached 10.95 trillion yuan, an increase of 3.33 trillion yuan from 7.62 trillion yuan at the end of Q2 2025, representing a growth rate of 43.66%, which is higher than other sectors [4] - The total trading volume of the STAR Market reached 25.93 trillion yuan in the first three quarters of 2025, with an average trading volume of 440.32 billion yuan per stock, which is lower than the average trading volumes of stocks in the Shanghai and Shenzhen main boards and the ChiNext [6] - The average daily turnover rate of the STAR Market was 2.99% in the first three quarters of 2025, higher than that of the Shanghai main board but lower than that of the Shenzhen main board, ChiNext, and North Exchange [8] - The price-to-book ratio of the STAR Market was 5.78 times at the end of Q3 2025, higher than that of the ChiNext and Shanghai and Shenzhen main boards [11] - The financing balance of the STAR Market reached 244.335 billion yuan at the end of Q3 2025, an increase of 99.034 billion yuan from 145.301 billion yuan at the beginning of the year [13] - The margin trading balance of the STAR Market was 0.829 billion yuan at the end of Q3 2025, an increase of 0.037 billion yuan from 0.459 billion yuan at the beginning of the year [15] Individual Stocks - As of the end of Q3 2025, SMIC led with a market capitalization exceeding 700 billion yuan, followed by Haiguang Information, Cambricon Technologies, and BeiGene, with 11 companies having market capitalizations exceeding 100 billion yuan [18] Industry Themes - In the first three quarters of 2025, companies listed on the STAR Market were primarily distributed across three Wind Sci-Tech theme industries, with the new generation information technology industry leading with four companies, followed by high-end equipment manufacturing and biotechnology industries, each with one company [29] - Among the seven companies issued on the STAR Market in the first three quarters of 2025, six were listed under Standard One, which requires positive net profits for the last two years and a cumulative net profit of no less than 50 million yuan, or a positive net profit for the last year with operating income of no less than 100 million yuan, and an expected market capitalization of no less than 1 billion yuan [31] - The companies issued on the STAR Market in the first three quarters of 2025 came from Beijing and Jiangsu (two each), and Hubei, Zhejiang, and Guangdong (one each) [34] - The total IPO financing on the STAR Market in the first three quarters of 2025 was 7.901 billion yuan, a year-on-year decrease of 9.99%, with three companies raising over 1 billion yuan, three raising between 500 million to 1 billion yuan, and one raising less than 500 million yuan [36] - Yitang Co., Ltd. led the IPO financing in the first three quarters of 2025 with 2.497 billion yuan, while Yingshi Innovation and Xingfu Electronics each raised over 1 billion yuan [40]

Core Insights - The report from Zhongyou Securities highlights that BeiGene achieved a net profit attributable to shareholders of 450 million yuan in the first half of the year, a significant improvement from a net loss of 2.88 billion yuan in the same period last year [1] - In Q2 2025, the company reported a net profit of 540 million yuan, compared to a net loss of 970 million yuan in the same quarter of the previous year [1] - BeiGene has raised its full-year revenue guidance from the previous range of 4.9-5.3 billion USD to a new range of 5.0-5.3 billion USD, while maintaining its guidance for positive GAAP operating profit for the year [1] Financial Performance - The company reported a substantial turnaround in net profit, moving from a loss of 2.88 billion yuan to a profit of 450 million yuan year-on-year [1] - The Q2 2025 results show a net profit of 540 million yuan, indicating a strong recovery compared to the previous year's loss of 970 million yuan [1] Product Performance - The sales of the drug Zebrutinib showed stable growth quarter-on-quarter, while the drug Dazalutamide experienced rapid market expansion [1] - BeiGene is positioned as a leading company in the innovative drug export sector, showcasing strong global commercialization capabilities [1] Future Outlook - The company is approaching a harvest period for its research pipeline, indicating potential for future growth and profitability [1] - The initial coverage of the company has been rated as "Buy," reflecting positive sentiment towards its future performance [1]

Investment Rating - The report assigns a "Buy" rating for the company, marking its first coverage [2][9]. Core Insights - The company reported a significant increase in revenue and net profit for the first half of 2025, with total revenue reaching 17.52 billion yuan, a 46% increase year-on-year, and a net profit of 450 million yuan compared to a loss of 2.88 billion yuan in the same period last year [5][6]. - The company has raised its full-year revenue guidance from 4.9-5.3 billion USD to 5-5.3 billion USD, while maintaining its guidance for positive GAAP operating profit for the year [5][6]. Financial Performance - In Q2 2025, the company achieved a revenue of 9.47 billion yuan, a 42.7% increase year-on-year, and a net profit of 540 million yuan, compared to a loss of 970 million yuan in the same quarter last year [5][6]. - The global revenue for the drug Zebutinib reached 1.74 billion USD in the first half of 2025, with a year-on-year growth of 54.7%, driven by strong performance in the US and Europe [6][7]. Product Development - The company is advancing its product pipeline, with several key trials underway, including a Phase III trial for a combination therapy involving Zebutinib [7][8]. - The company anticipates significant data releases in the second half of 2025 for various products, including a KRAS inhibitor and ADCs [8]. Earnings Forecast - The company is projected to achieve revenues of 37.1 billion yuan, 47.15 billion yuan, and 58.18 billion yuan for the years 2025, 2026, and 2027, respectively, with corresponding net profits of 820 million yuan, 4.07 billion yuan, and 8.07 billion yuan [9][11].

Core Viewpoint - BeiGene's stock price has shown significant volatility and growth in 2023, with a notable increase in revenue and net profit for the first half of the year [2][3]. Stock Performance - As of September 30, BeiGene's stock rose by 2.02% to 307.09 CNY per share, with a trading volume of 5.59 billion CNY and a market capitalization of 473.13 billion CNY [1]. - Year-to-date, BeiGene's stock price has increased by 90.72%, with a 1.17% rise in the last five trading days, a 5.47% decline over the past 20 days, and a 37.62% increase over the last 60 days [2]. Financial Performance - For the period from January to June 2025, BeiGene reported a revenue of 17.518 billion CNY, representing a year-on-year growth of 46.03%, and a net profit attributable to shareholders of 450 million CNY, up 115.63% year-on-year [2]. Shareholder Information - As of June 30, 2025, the number of shareholders for BeiGene was 23,300, a decrease of 3.90% from the previous period, with an average of 4,976 circulating shares per shareholder, an increase of 4.11% [2]. - Among the top ten circulating shareholders, notable changes include an increase in holdings by China Europe Medical Health Mixed A and a decrease in holdings by Wan Jia You Xuan [3].

Core Conclusion - The investment logic for innovative drugs indicates that 2025 will mark a new recovery starting point for China's innovative drug industry after a deep adjustment, driven by a "triple resonance" of policy, industry, and capital [3][5][7]. Policy Insights - The Chinese government has explicitly supported innovative drugs in the 2025 Government Work Report, with subsequent policies aimed at high-quality development and commercial insurance for innovative drugs, clearing development obstacles across the entire chain [3][5]. Industry Dynamics - The internationalization process is accelerating, with the License-out model becoming a key path for value realization. In the first three quarters of 2025, upfront payments for licensing transactions reached $5.7 billion, surpassing the total for 2024 and accounting for 23.4% of the global total, indicating a significant enhancement in the global value chain position of Chinese innovative drug assets [5][7]. Capital Market Trends - After a deep adjustment from 2022 to 2024, industry valuations are returning to rational levels, with continuous improvement in the fundamentals of companies. In the first half of 2025, sales revenue from 17 commercialized innovative drug companies grew by 30% year-on-year, with leading companies like Innovent Biologics achieving profitability, marking a phase of value reassessment in the industry [7]. Market Size and Growth - The global innovative drug market is expected to reach $782.6 billion in 2024, accounting for 51.3% of the global pharmaceutical market, and is projected to grow to $1,119 billion by 2029, with a compound annual growth rate (CAGR) of 7.4%, outpacing the overall pharmaceutical market growth of 6.4% [14]. Industry Structure - The innovative drug industry chain is divided into three main segments: upstream (raw materials and support), midstream (R&D and production), and downstream (distribution and payment), forming a complete value chain from scientific discovery to market application [19][21][24]. Business Model Transformation - Chinese innovative drug companies are transitioning from a single reliance on domestic market sales to a dual-driven international strategy of "domestic sales + License-out," marking a new phase where product strength and business model innovation are equally emphasized [28][29]. Revenue Sources - The revenue sources for innovative drug companies are diversifying, including domestic insurance sales, License-out income, and overseas market sales. In 2023, insurance spending on innovative drugs reached 90 billion yuan, maintaining rapid growth since 2019 [28][29][34]. BD Model Growth - The BD (Business Development) model has become a core engine for commercialization, with the total amount of BD transactions involving Chinese innovative drug companies skyrocketing from $5.06 billion in 2020 to $41.76 billion by August 2025, indicating a fundamental shift in the industry's business model [37][38]. Key Segments to Watch - The innovative drug industry includes six key segments: small molecule drugs, large molecule drugs, cell therapy, gene therapy, mRNA vaccines, and precision medicine, each deserving in-depth research [43].

Core Insights - The report by Zhongyou Securities focuses on the development of drugs in the autoimmune (self-immune) field, analyzing market demand, dual-antibody research priorities, and related investment targets [1][3]. Market Demand - The autoimmune field has a large patient base and long medication cycles, leading to the potential for blockbuster drugs, such as Dupilumab (Dupi), which has annual sales exceeding $10 billion. Key indications like atopic dermatitis (AD), asthma, and chronic obstructive pulmonary disease (COPD) have millions of affected patients, with nearly 9 million patients accessible to biological agents [1][2]. - Existing therapies still have unmet needs, including the need for long-acting formulations to reduce dosing frequency and improve efficacy, as well as expanding the patient population currently limited by screening criteria [1][2]. Dual-Antibody Research Focus - From the perspective of type 2 inflammation mechanisms, targets can be categorized into upstream (e.g., TSLP, IL-33) and downstream (e.g., IL-4, IL-13). Single-target monoclonal antibodies have limited efficacy, making dual antibodies an important direction due to their synergistic effects. In respiratory diseases, the TSLP×IL-13 (or IL-4R) dual antibody shows significant advantages, with clinical data indicating better reductions in FeNO and eosinophils compared to single-target drugs [2][3]. - The report emphasizes the potential of TSLP dual antibodies, highlighting leading global progress from companies like Sanofi (Lunsekimig) and Pfizer (triple antibodies), as well as domestic advancements from companies like Kangnuo (CM512) and Innovent (IBI3002) [2][3]. Investment Targets - Key investment targets include Kangnuo (CM512), which is leading in domestic progress, Innovent (IBI3002), and Qianxin Biotechnology (QX030N), with a focus on dual-antibody development [3]. Conclusion - Overall, TSLP dual antibodies in the autoimmune field show significant potential and may become the next generation of blockbuster drugs, driven by high patient numbers and unmet medical needs [1][3].

Core Viewpoint - The potential imposition of a 100% tariff on imported brand and patented drugs by the Trump administration starting October 1, 2025, has raised concerns among pharmaceutical companies, particularly those in China, leading to a decline in their stock prices [2][3]. Group 1: Impact on Pharmaceutical Companies - The announcement of the tariff has caused significant declines in the stock prices of Chinese pharmaceutical companies, with Heng Rui Pharmaceutical dropping 3.03% in A-shares and 2.23% in Hong Kong shares, and BeiGene falling 4.38% in A-shares and 1.55% in Hong Kong shares [2]. - The Hang Seng Innovative Drug Index (HSIDI) fell by 2.37%, with notable declines in stocks such as Fosun Pharma, which dropped 5.82%, and 3SBio, which fell by 5.34% [3]. - Industry experts suggest that the impact of the tariff on Chinese pharmaceutical companies may be limited, as many are focused on generic drugs and active pharmaceutical ingredients (APIs) [4]. Group 2: Industry Perspectives - Some industry leaders believe that the tariff policy may not be implemented as proposed, citing the high cost of drugs in the U.S. and the potential for political changes in future administrations [4][5]. - Companies like Heng Rui Pharmaceutical indicated that their current exports primarily consist of generics and APIs, suggesting minimal impact from the proposed tariffs [4]. - Other companies, such as Lepu Biopharma, noted that their licensing partnerships would shield them from significant effects [5]. Group 3: U.S. Policy Context - The Trump administration has previously threatened to impose tariffs on imported drugs, with discussions around a 200% tariff and subsequent smaller tariffs leading to a potential increase over time [6][7]. - Major multinational pharmaceutical companies have responded to the tariff threats by committing to significant investments in U.S. manufacturing, with companies like Novartis and Roche pledging $23 billion and $50 billion respectively over the next five years [8].

Core Viewpoint - The potential implementation of a 100% tariff on all brand-name and patented drugs by the U.S. government starting October 1, 2025, unless companies are building drug manufacturing plants in the U.S. [2] Group 1: Market Reaction - Pharmaceutical stocks in multiple markets, including China, Japan, and South Korea, experienced a collective decline following the announcement [3] - Specific declines included a 3.03% drop in Hengrui Medicine (600276.SH/01276.HK) A-shares and a 2.23% drop in Hong Kong shares, while BeiGene (ONC.NASDAQ/06160.HK/688235.SH) saw a 4.38% drop in A-shares and a 1.55% drop in Hong Kong shares [3] - The Hang Seng Innovative Drug Index (HSIDI) fell by 2.37%, with notable declines in stocks such as Fosun Pharma (600196.SH/02196.HK) down 5.82% and 3SBio (01530.HK) down 5.34% [4] Group 2: Industry Perspectives - Industry experts suggest that Chinese pharmaceutical companies aiming to expand internationally need to consider the potential implementation of this policy and explore possible solutions [5] - Some executives believe that the high cost of drugs in the U.S. may hinder the realization of this policy [5] - Hengrui Medicine's executive noted that the impact of the potential policy would be limited as their exports mainly consist of generic drugs and APIs [5] - Other companies, such as Lepu Biopharma, indicated that their licensing partnerships would not be significantly affected [5] - Investors pointed out that this is a political issue that could change with future administrations, suggesting that while there may be short-term negative impacts, the long-term effects may not be significant [5] Group 3: Historical Context - Historically, pharmaceuticals have been excluded from tariff lists, but President Trump has repeatedly threatened to impose tariffs on imported drugs this year [5] - The Trump administration initiated a "232 investigation" under the Trade Expansion Act of 1962, which allows for tariffs if imports threaten national security [6] - Previous statements from Trump indicated plans for escalating tariffs on imported drugs, with initial small tariffs leading to potential increases up to 250% [7] Group 4: Investment Commitments - In response to the tariff threats, several multinational pharmaceutical companies have committed to investing in U.S. manufacturing facilities, with significant investments announced by companies like Novartis, Roche, Sanofi, and AstraZeneca [8] - Notably, Novartis and Roche pledged $23 billion and $50 billion respectively over five years, while AstraZeneca committed to a $50 billion investment by 2030 [8]

2025 中期報告 BeOne Medicines Ltd. （根據瑞士法律註冊成立的公司） Cancer has no borders. Neither do we. 目錄 | 公司資料 | 2 | | --- | --- | | 前瞻性陳述 | 4 | | 管理層討論及分析 | 7 | | 其他資料 | 28 | | 未經審核中期簡明綜合經營表 | 82 | | 未經審核中期簡明綜合全面虧損表 | 83 | | 未經審核中期簡明綜合資產負債表 | 84 | | 未經審核中期簡明綜合股東權益報表 | 86 | | 未經審核中期簡明綜合現金流量表 | 87 | | 未經審核中期簡明綜合財務報表附註 | 89 | | 釋義 | 124 | | 技術詞彙 | 128 | 1 百濟神州有限公司 • 2025 中期報告 公司資料 董事會 執行董事 歐雷強先生 （主席兼首席執行官） 非執行董事 王曉東博士 獨立非執行董事 Olivier Brandicourt博士 Margaret Han Dugan博士 Michael Goller先生 Anthony C. Hooper先生 Ranjeev Krishana先生 A ...

BeOne Medicines Ltd. 百濟神州有限公司 (a corporation incorporated under the laws of Switzerland) （根據瑞士法律註冊成立的公司） (Stock Code 股份代號: 06160) Dear non-registered shareholder(s), September 26, 2025 Reminder Letter regarding the Arrangement of Electronic Dissemination of Corporate Communications With reference to the notification letter dated February 28, 2024 titled "Arrangement of Electronic Dissemination of Corporate Communications", BeOne Medicines Ltd. (the "Company") is writing to remind you that the Company has ad ...