今日焦点中国中车：近期签订合计547.4亿元重大合同 中国中车公告称，公司及下属企业于近期（主要为2024年12月至2025年5月）签订了若干项重大合同， 合计金额约547.4亿元人民币。主要合同包括城市轨道车辆、设备销售及维保合同，动车组销售合同， 动车组高级修合同，风电设备销售合同和储能设备销售合同，机车销售合同以及货车修理合同。上述合 同总金额约占公司中国会计准则下2024年营业收入的22.2%。 阳光诺和：拟购买朗研生命100%股权，股票明日复牌 南方财经5月12日电，阳光诺和(688621.SH)公告称，公司拟通过发行股份及可转换公司债券购买资产并 募集配套资金，购买利虔、朗颐投资等38名朗研生命股东持有的朗研生命100%股权。并向不超过35名 特定投资者发行股份募集配套资金。朗研生命专注于高端化学药及原料药的研发、生产和销售，并对外 提供药品生产服务，在高端化学药、原料药等领域深耕多年，已经形成了较为成熟的医药生产体系。公 司股票将于5月13日开市起复牌。 沃尔核材：筹划发行H股股票并申请在香港联交所主板上市 沃尔核材公告称，公司拟发行H股股票并申请在香港联交所主板挂牌上市，以推进国际化战略，提升 ...

Company Announcements - Zhaowei Electromechanical plans to reduce its shareholding by no more than 1.5%, equating to approximately 3.6 million shares [1] - China CNR Corporation has signed several major contracts totaling approximately 54.74 billion yuan, representing about 22.2% of its expected revenue for 2024 [2] - Yunnan Copper is planning to acquire a 40% stake in Liangshan Mining, leading to a temporary suspension of its stock [2] - Sunshine Nuohua intends to acquire 100% of Langyan Life, with its stock set to resume trading [3] - Wolong Materials is planning to issue H-shares and apply for a listing on the Hong Kong Stock Exchange [3] - Hanyu Pharmaceutical has signed a joint development agreement for a novel peptide drug targeting metabolic diseases [3] - Lijun Co. confirms that its operations are normal and there are no undisclosed significant matters [3] Investments & Acquisitions - China Medical plans to acquire 100% of Jinsui Technology for 302 million yuan [4] - Shuangyi Technology intends to acquire 100% of Marky Industries for 18 million AUD, along with specific assets [5] Strategic Partnerships - Sileck has signed a strategic cooperation agreement with Lihua Power for the development of large cylindrical batteries [6] - Hongchang Technology plans to invest 15 million yuan in a humanoid robot industry chain company [7] - Macroview Technology is establishing a wholly-owned subsidiary focused on artificial intelligence [8] - Yihua Jiaye has signed a strategic cooperation framework agreement with Hanyu Pharmaceutical and Hanyu Health to develop a sleep health ecosystem [9] - Wanda Film is investing in Lezi Tiancheng and will engage in strategic cooperation in IP toy product development [10] Shareholding Changes - Tiandi Online's controlling shareholder is transferring 6.97% of its shares to introduce a strategic investor [12] - Longjiang Transportation plans to reduce its shareholding by no more than 3% [13] - Boyun New Materials intends to reduce its shareholding by no more than 3% [14] - Tongrun Equipment's major shareholder plans to reduce its stake by no more than 2% [15] Financing & Capital Increase - Tangyuan Electric plans to raise no more than 864 million yuan through a private placement [16] - Shangsheng Electronics intends to issue convertible bonds to raise up to 330 million yuan [17] Other Developments - Xianju Pharmaceutical has obtained a domestic production registration certificate for Dydrogesterone tablets [18] - Rongchang Bio has received a clinical trial application acceptance notice for its antibody-drug conjugate RC278 [19] - Jiangsu Leili's subsidiary Dingzhi Technology is implementing a stock incentive plan [20]

Group 1 - Aikolan's controlling shareholder Liu Yi terminated the share transfer agreement for 4 million shares, which represents 5% of the company's total share capital, with no change in control [1] - Wancheng Group announced a cash dividend of 4.00 yuan per 10 shares, totaling 71.9959 million yuan, with the record date on May 19, 2025 [1] - Wanda Film plans to invest in Lezi Tiancheng and engage in strategic cooperation, acquiring a total of 7% equity in the company [2] Group 2 - China Resources Double Crane's subsidiaries received approval for two drugs, indicating progress in their product pipeline [3] - Fosun Pharma's subsidiary's drug was included in the breakthrough therapy program, highlighting its innovative potential [4] - Zhongheng Group's subsidiary received approval for naloxone injection, enhancing its product offerings [5] Group 3 - Shenzhen Airport reported a passenger throughput of 5.3202 million in April, a year-on-year increase of 23.50% [8] - Hangzhou Bank successfully issued 5 billion yuan in technology innovation bonds, aimed at supporting tech innovation [10] - Jiuzhou Pharmaceutical received approval for a raw material drug used in treating severe depression, expanding its product range [12] Group 4 - Aihua Group reported a 25.38% decline in revenue for the first four months of the year, indicating potential challenges [27] - Changhua Group received a project designation notice from a well-known new energy vehicle company, with an expected total sales amount of approximately 108 million yuan [28] - Nanchao Food reported a slight revenue decrease of 0.98% in April, reflecting market conditions [30]

一、 基本情况介绍 | | | 荣昌生物制药（烟台）股份有限公司 自愿披露关于维迪西妥单抗一线治疗 HER2 表达的尿路上 皮癌Ⅲ期临床研究达到主要研究终点的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者重 大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 荣昌生物制药（烟台）有限公司（以下简称"公司"或"荣昌生物"）自主研发的 抗体偶联药物（ADC）维迪西妥单抗（代号：RC48，商品名：爱地希®）联合特瑞普利单 抗对比化疗治疗 HER2 表达的一线局部晚期或转移性尿路上皮癌的Ⅲ期临床研究 （RC48-C016）达到无进展生存期（PFS）和总生存期（OS）两项主要研究终点。现将情 况公告如下： RC48-C016 研究是一项随机对照、多中心Ⅲ期临床研究，于 2022 年 6 月启动，全 国 74 家临床研究中心参与，共入组 484 例受试者，在既往未接受过系统治疗且存在 HER2 表达（HER2 IHC 1+、2+或 3+）的局部晚期或转移性尿路上皮癌患者中，对比维迪西妥 单抗联合特瑞普利单抗和吉西他滨联合顺铂/卡铂的疗效和安全性。 二、 临床进展情况 维迪西妥单抗联合特 ...

| 证券代码：688331 | 证券简称：荣昌生物 | 公告编号：2025-021 | | --- | --- | --- | | 港股代码：09995 | 港股简称：榮昌生物 | | 荣昌生物制药（烟台）股份有限公司 自愿披露关于抗体偶联药物 RC278 获得药物临床试验申请 受理通知书的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者重 大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 一、 药品基本情况 由于医药产品具有高科技、高风险、高附加值的特点，药品的前期研发以及产品从 研制、临床试验报批到投产的周期长、环节多，容易受到一些不确定性因素的影响。敬 请广大投资者谨慎决策，注意防范投资风险。 审批结论：根据《中华人民共和国行政许可法》第三十二条的规定，经审查，决定 予以受理。 二、 药品的其他相关情况 RC278 是由荣昌生物自主研发的一款具有 First-in-Class/Best-in-Class 潜质的 ADC 分子，该分子能特异识别一个新型肿瘤靶点，并具有创新的连接子—毒素系统，在 临床前研究中展现出广谱抗肿瘤活性、良好的安全性和药代动力学特征，将为晚期实体 ...

Summary of the Conference Call Industry Focus - The report focuses on the pharmaceutical industry, specifically highlighting innovative drugs and contract research organizations (CXO) Core Insights and Arguments - Continuous recommendation of innovative drugs with positive growth outlook, including: - 恒瑞医药 (Hengrui Medicine) - 华东医药 (East China Pharmaceutical) - 翰森制药 (Hansoh Pharmaceutical) - 贝达药业 (Betta Pharmaceuticals) - 信立泰 (Sinopharm) - 科伦药业 (Kelun Pharmaceutical) - 百利天恒 (Baili Tianheng) - 荣昌生物 (Rongchang Biopharmaceutical) - 科伦博泰生物 (Kelun Biotech) - 石药集团 (Shijiazhuang Pharmaceutical Group) [1][1][1] - Recommendation of CXOs showing signs of profit growth turning points, including: - 药明生物 (WuXi Biologics) - 药明康德 (WuXi AppTec) [1][1] - Positive outlook on domestic replacement of innovative medical devices, specifically: - 惠泰医疗 (Huitai Medical) [1] - Anticipation of recovery in consumer healthcare, particularly: - 爱尔眼科 (Aier Eye Hospital) [1] Other Important Points - The report emphasizes the ongoing trend of recommending companies that are positioned well within the pharmaceutical sector, particularly those that are expected to benefit from market dynamics and growth opportunities - The focus on innovative drugs and CXOs indicates a strategic approach to capitalize on emerging trends in the healthcare market - The mention of domestic replacements in medical devices suggests a shift towards local production and innovation, which could impact market competition and supply chains - The recovery in consumer healthcare points to potential growth areas as the market stabilizes post-pandemic

Investment Rating - The report maintains a rating of "Buy" for the pharmaceutical and biotechnology industry [1]. Core Insights - GLP-1 drugs have emerged as leading products, with recommendations to focus on companies such as BoRui Pharmaceutical, Innovent Biologics, and Federated Pharmaceutical [1][15]. - The global GIP-1 market shows significant potential, with Q1 2025 sales surpassing PD-1 antibodies. The WHO is developing guidelines for the use of GLP-1 in adult obesity, expected to be released in August-September 2025 [1][15]. - The report highlights a shift in R&D trends from single-target to multi-target drugs, with a focus on oral formulations and both peptide and small molecule drugs [1][16]. Summary by Sections Industry Performance - The A-share pharmaceutical index has increased by 1.0% this week and 1.2% year-to-date, underperforming the CSI 300 by 1.0% and outperforming by 3.4% respectively [9]. - The H-share biotechnology index has decreased by 4% this week but increased by 27% year-to-date, outperforming the Hang Seng Technology Index by 19% and 29% respectively [9]. GLP-1 Drug Market - Sales of semaglutide reached 78.64 billion USD in Q1 2025, surpassing Keytruda's 72.05 billion USD [15]. - The WHO is expected to finalize guidelines for GLP-1 RA use in obesity treatment by late 2025, which could significantly boost sales [15]. R&D Trends - The report notes a transition from single-target to multi-target drug development, with multi-target drugs showing superior clinical efficacy [16][17]. - Clinical data indicates that semaglutide and dual-target drugs like tirzepatide are leading in weight loss efficacy, with ongoing trials for multi-target drugs showing promising results [17]. Investment Recommendations - The report ranks preferred sub-sectors as follows: innovative drugs > CXO > traditional Chinese medicine > medical devices > pharmacies > pharmaceutical commerce [10]. - Specific stock recommendations include BoRui Pharmaceutical, Innovent Biologics, Federated Pharmaceutical, and others based on growth potential and valuation metrics [10].

1 關於維迪西妥單抗（RC48，商品名：愛地希®） 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不就因本公告全部或任何部分內容而產生或因倚 賴該等內容而引致的任何損失承擔任何責任。 RemeGenCo. , Ltd.* 榮 昌 生 物 製 藥（ 煙 台 ）股 份 有 限 公 司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：9995） 自願公告 國家藥品監督管理局批准注射用維迪西妥單抗 （商品名：愛地希®）用於治療HER2陽性且存在肝轉移的 晚期乳腺癌在中國上市 本公告由榮昌生物製藥（煙台）股份有限公司（「本公司」）自願作出。 本公司董事會（「董事會」）欣然宣佈，注射用維迪西妥單抗（商品名：愛地希®）正 式獲得中國國家藥品監督管理局（「NMPA」）在中國上市的批准，用於治療HER2 陽性且存在肝轉移的晚期乳腺癌的患者。 本適應症獲得批准是基於RC48-C006 III期臨床研究，詳細數據在2024年12月的 聖安東尼奧乳腺癌研討會(SABCS)公布，結果顯示：相比拉帕替尼聯合卡培他濱 組，維迪西妥單抗組顯著延長了無進展生 ...

Group 1 - The Hong Kong stock market opened lower on May 8, with the Hang Seng Index down 0.45% and the Hang Seng Tech Index down 0.28%, while the Hong Kong Innovation Drug Index rose by 0.18% [1] - The Hong Kong Innovation Drug ETF (159567) opened higher and increased by 1.16%, with notable gains in component stocks such as Ascentage Pharma-B up over 3% and Lepu Biopharma-B up over 2% [1] - The Hong Kong Innovation Drug ETF closely tracks the Hong Kong Innovation Drug Index, which reflects the performance characteristics of biotechnology companies listed under the Hong Kong Stock Connect [1] Group 2 - According to Everbright Securities, the commercialization of domestic weight-loss drugs is imminent, and sales capabilities will be a significant factor in assessing future competitive advantages for companies [2] - China Galaxy Securities noted that the pharmaceutical sector has experienced a prolonged adjustment, with overall valuations at low levels and public fund holdings underweight, suggesting a potential recovery in the pharmaceutical market in 2025 [2] - Cinda Securities anticipates that the second quarter of 2025 may see catalysts for innovative drugs, including expected negotiations for medical insurance and the implementation of the Class B medical insurance directory [2]

Investment Rating - The report rates the pharmaceutical industry as "Outperform" [1] - Sub-industry ratings include "Add" for pharmaceutical manufacturing and pharmaceutical services [1] Core Insights - The report is optimistic about innovative drugs, CXO, and strong consumer performance in Q1 2025 [5][27] - In April 2025, the pharmaceutical sector performed similarly to the market, with the SHCOMP index down 1.7% and SW Pharma Bio down 2.1%, ranking 11th among Shenwan primary industries [9][28] - The premium of the pharmaceutical sector over all A-Shares is currently at a normal level of 81.01% [18][28] Summary by Sections 1. Focus on Innovative Drugs and CXO - Key A-share stocks recommended include Jiangsu Heng Rui Medicine, Betta Pharmaceuticals, Shenzhen Salubris Pharmaceuticals, Sichuan Kelun Pharmaceutical, Remegen, Huadong Medicine, WuXi AppTec, APT Medical, and AIER EYE HOSPITAL GROUP [5][27] - H-share top picks include Wuxi Biologics Cayman, PATEO, Innovent Biologics, and Zai Lab, with beneficiaries being CSPC Pharmaceutical Group, Gushengtang, and Angelalign [27] 2. April 2025 Pharmaceutical Sector Performance - The pharmaceutical sector's performance was on par with the market, with notable sub-sectors being chemical preparations (+2.8%), pharmaceutical commerce (+1.5%), and chemical raw materials (+0.7%) [12][28] - Top gainers included Apichope Pharmaceutical (+56.2%), Qianjiang Yongan Pharmaceutical (+55.9%), and Kexing Biopharm Co., Ltd. (+55.2%), while top losers were Hainan Poly Pharm (-71.9%), Landfar Bio-Medicine Co., Ltd (-40.0%), and Jiangsu Wuzhong Industrial (-39.5%) [17][28] 3. Performance Disparities in 2024 and Q1 2025 - In 2024, the pharmaceutical sector's overall revenue fell by 1.5% YoY, and net profit decreased by 12.5% YoY, with medical consumables, chemical preparations, and blood products showing positive growth [22][28] - In Q1 2025, the sector's revenue fell by 6.1% YoY, and net profit fell by 9.7% YoY, with medical R&D outsourcing, consumables, and hospitals performing well [22][28] 4. Profitability Metrics - The gross profit margin (GPM) for the pharmaceutical sector fell by 0.5pp YoY in 2024, while the net profit margin (NPM) fell by 0.8pp YoY [24][28] - In Q1 2025, GPM decreased by 1.6pp YoY, and NPM decreased by 0.4pp YoY, with medical R&D outsourcing showing improvements in both GPM and NPM [24][28]