Group 1 - The innovative drug concept stocks are experiencing significant activity, with Jimin Health hitting the daily limit up [1] - JianKai Technology has seen an increase of over 10% [1] - Other companies such as YueKang Pharmaceutical, NuoSiGe, QianYan Bio, XinLiTai, and Chengdu XianDao are also following the upward trend [1]

创新药概念股盘初拉升，悦康药业涨超10%，前沿生物涨超9%，常山药业、博腾股份、福元医药涨幅 居前。 ...

Core Viewpoint - Yuyuan Pharmaceutical experienced a 5.16% increase in stock price, reaching 28.95 CNY per share, with a trading volume of 1.59 billion CNY and a market capitalization of 13.028 billion CNY [1] Company Overview - Yuyuan Pharmaceutical Group Co., Ltd. is located in Beijing Economic and Technological Development Zone and was established on August 14, 2001, with its listing date on December 24, 2020 [1] - The company focuses on the research and production of high-end chemical drugs, with major revenue contributions from cardiovascular drugs, digestive system drugs, diabetes medications, and anti-infection drugs [1] - Key products contributing significantly to revenue include Ginkgo biloba extract injection, Tianma injection, Lansoprazole injection, Omeprazole enteric-coated capsules, Metformin sustained-release tablets, Cefuroxime sodium injection, and Ceftriaxone sodium injection [1] - The revenue composition is as follows: cardiovascular drugs 55.67%, anti-infection 20.88%, raw materials 8.73%, digestive system 6.87%, diabetes 4.85%, others 2.62%, and technical services 0.02% [1] Shareholder Information - Southern Fund's Southern Medical Health Flexible Allocation Mixed A Fund (000452) is among the top ten circulating shareholders of Yuyuan Pharmaceutical, holding 7.2677 million shares, unchanged from the previous period, representing 1.62% of circulating shares [2] - The fund has achieved a year-to-date return of 51.91%, ranking 599 out of 8254 in its category, and a one-year return of 48.77%, ranking 2666 out of 8037 [2] Fund Management - The fund manager of Southern Medical Health Flexible Allocation Mixed A is Wang Zhengjiao, who has been in the position for 7 years and 39 days, managing a total fund size of 2.417 billion CNY [3] - During Wang's tenure, the best fund return was 70.35%, while the worst was -53.83% [3] Fund Holdings - Southern Medical Health Flexible Allocation Mixed A Fund holds 7.2677 million shares of Yuyuan Pharmaceutical, unchanged from the previous period, making it the third-largest holding in the fund, accounting for 5.72% of the fund's net value [4]

Investment Rating - The report provides a positive outlook on the MASH non-invasive diagnosis technology, suggesting it could accelerate new drug development in the pharmaceutical and biotechnology sector [2]. Core Insights - The pharmaceutical and biotechnology sector experienced a decline of 0.65% from August 25 to August 29, underperforming compared to the Wind All A index (1.9%) and the CSI 300 index (2.71%). Only the medical research outsourcing (4.9%) and other biological products (0.14%) sectors saw gains, while in vitro diagnostics (-4.12%), raw materials (-3.34%), and vaccines (-0.59%) faced significant declines [2][7]. - The FDA has accepted the proposal for using VCTE-LSM as a reasonable alternative endpoint for clinical trials in adults with MASH and moderate to advanced fibrosis. This non-invasive method is expected to enhance patient compliance and could lead to a surge in drug development in the MASH area within the next two to three years [2][13]. - The report emphasizes the potential for domestic companies in China to leverage their cost advantages and forward-looking strategies in the field of non-invasive companion diagnostics, particularly in the MASH drug development competition [2]. Market Weekly Review - The pharmaceutical and biotechnology sector's performance was notably weaker than the broader market indices, with specific sub-sectors like medical research outsourcing and other biological products showing resilience [7][8]. - Individual stocks such as Tianchen Medical (30.1%), Ailis (25.6%), and Maiwei Biotech-U (22.4%) performed well, while stocks like Lifang Pharmaceutical (-13.9%), Yuekang Pharmaceutical (-11.9%), and Kanghua Biotech (-11.1%) faced significant losses [10][12]. Industry News and Key Company Announcements - On August 28, Kangfang Biotech announced that its drug AK112 received approval for treating advanced non-squamous non-small cell lung cancer, with promising clinical trial results expected to be presented at an international conference [12]. - The report highlights various companies' financial performances, with notable revenue changes and profit margins, indicating a mixed outlook across the sector [16][17].

Group 1 - The second meeting of the Supervisory Board of Yuekang Pharmaceutical Group Co., Ltd. was held on August 28, 2025, with all three supervisors present, complying with relevant laws and the company's articles of association [1] - The Supervisory Board approved the proposal regarding the company's 2025 semi-annual report and its summary, confirming that the report was prepared and reviewed in accordance with legal regulations and accurately reflected the company's situation [1] - The Supervisory Board also approved the special report on the storage and use of raised funds for the first half of 2025, affirming compliance with relevant regulations and confirming no misuse of funds [2]

Core Insights - The company reported a revenue of 1.17 billion yuan for the first half of 2025, with R&D investment amounting to 209 million yuan, representing 17.91% of revenue, an increase of 7.54 percentage points year-on-year [1] - The company has established eleven core technology platforms focusing on various drug types, including nucleic acid drugs and high-end traditional Chinese medicine, and has a pipeline of over twenty key projects [1] - As of June 30, 2025, the company has 42 R&D projects, including 21 innovative drugs and 21 generic drugs, and has accumulated 349 patents, with 21 new applications and 32 new patents granted in the first half of 2025 [1] R&D Progress - The company made significant advancements in key innovative drugs, with several products in the NDA review stage, including traditional Chinese medicine injections and other innovative formulations [2] - The company has successfully launched its small nucleic acid drug and mRNA vaccine R&D and pilot production platforms, which are now operating efficiently [2] - The company aims to focus on three major therapeutic areas: cardiovascular diseases, tumors, and infectious diseases, while continuing to develop a diverse pipeline through various methods such as independent R&D and collaborations [2]

Core Insights - The company reported a significant decline in revenue for the first half of 2025, with total revenue reaching 1.167 billion, representing a year-on-year decrease of 40.14% [1] - The net profit attributable to the parent company was negative at 98.8291 million, compared to a profit of 119 million in the same period last year [1] - The non-recurring net profit attributable to the parent company also showed a decline, amounting to negative 108 million, down from 117 million in the previous year [1]

证券代码：688658 证券简称：悦康药业 公告编号：2025-036 悦康药业集团股份有限公司 第二届监事会第十八次会议决议公告 本公司监事会及全体监事保证本公告内容不存在任何虚假记载、误导性陈 述或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 一、监事会会议召开情况 二、监事会会议审议情况 （一）审议通过《关于公司<2025 年半年度报告及其摘要>的议案》 监事会认为：公司《2025 年半年度报告及其摘要》编制和审议程序符合法 律法规、《公司章程》和公司内部管理制度的各项规定；报告内容真实、准确、 完整，不存在任何虚假记载、误导性陈述或者重大遗漏，客观地反映了公司 2025 年半年度财务及经营状况。 表决结果：赞成票 3 票，反对票 0 票，弃权票 0 票。 具体内容详见公司于上海证券交易所网站（www.sse.com.cn）及指定媒体 披露的《悦康药业集团股份有限公司 2025 年半年度报告》及《悦康药业集团股 份有限公司 2025 年半年度报告摘要》。 （二）审议通过《关于<2025 年半年度募集资金存放与使用情况的专项报 告>的议案》 悦康药业集团股份有限公司（以下简称"公司"） ...

悦康药业集团股份有限公司2025 年半年度报告 公司代码：688658 公司简称：悦康药业 悦康药业集团股份有限公司 2025 年半年度报告 1 / 218 悦康药业集团股份有限公司2025 年半年度报告 重要提示 一、 本公司董事会、监事会及董事、监事、高级管理人员保证半年度报告内容的真实性、准确 性、完整性，不存在虚假记载、误导性陈述或重大遗漏，并承担个别和连带的法律责任。 二、 重大风险提示 公司已在本报告中详细阐述公司在经营过程中可能面临的各种风险及应对措施，敬请查阅本 报告"第三节 管理层讨论与分析"之"四、风险因素"。除此之外，公司无其他需要单独提示的 重大风险。 三、 公司全体董事出席董事会会议。 四、 本半年度报告未经审计。 五、 公司负责人于伟仕、主管会计工作负责人刘燕及会计机构负责人（会计主管人员）冯洁声 明：保证半年度报告中财务报告的真实、准确、完整。 六、 董事会决议通过的本报告期利润分配预案或公积金转增股本预案 无 七、 是否存在公司治理特殊安排等重要事项 □适用 √不适用 八、 前瞻性陈述的风险声明 √适用 □不适用 本报告所涉及的公司未来计划、发展战略等前瞻性陈述，不构成公司对投 ...

悦康药业集团股份有限公司 2025 年度"提质增效重回报"行动方案的 半年度评估报告 2025 年上半年，公司研发投入为 20,904.36 万元，占营业收入的比例达到 17.91%，较上年同期增加 7.54 个百分点。目前，公司已建成了以核酸药物、细 胞与基因治疗药物、多肽药物、高端中药、高端化药、全流程 AI 药物研发等为 核心的十一大技术平台，储备了二十几项重点管线，具备了技术积累与管线布 局双重优势。截至 2025 年 6 月 30 日，公司研发项目合计 42 项，其中在研创新 药 21 项，在研仿制药及一致性评价项目 21 项，公司累计获得专利 349 项， 2025 上半年公司新申请专利 21 项，新获得专利 32 项。 为积极贯彻落实关于开展沪市公司"提质增效重回报"专项行动的倡议， 践行"以投资者为本"的上市公司发展理念，维护公司全体股东利益，悦康药 业集团股份有限公司（以下简称"公司"或"悦康药业"）于 2025 年 3 月 15 日 发布了《2025 年度"提质增效重回报"行动方案》。2025 年上半年，公司根据 "提质增效重回报"行动方案内容积极开展和落实相关工作，在保障投资者权 益、树 ...