证券代码：688331 证券简称：荣昌生物 公告编号：2026-006 港股代码：09995 港股简称：榮昌生物 （2）公司预计 2025 年度实现归属于母公司所有者的净利润约 71,600 万元， 与上年同期相比，实现扭亏为盈。 （3）公司预计 2025 年度归属于母公司所有者扣除非经常性损益后的净利润 约 7,850 万元，与上年同期相比，实现扭亏为盈。 （三）本期业绩预告相关的财务数据未经注册会计师预审计。 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 一、本期业绩预告情况 （一）业绩预告期间 2025 年 1 月 1 日至 2025 年 12 月 31 日。 （二）业绩预告情况 （1）经荣昌生物制药（烟台）股份有限公司（以下简称"公司"）财务部 门初步测算，预计 2025 年度营业收入约 325,000 万元，与上年同期相比，将增 加收入约 153,314 万元，同比增加约 89%。 荣昌生物制药（烟台）股份有限公司 2025 年年度业绩预告 二、上年同期业绩情况 2024 年度营业收入 171,686.17 万 ...

2025年,我国创新药BD出海授权交易总金额达 1356.55亿美元,交易总数量达157笔,均创历史新高。 安宝是金 2026年创新药BD延续火爆. 多个BD已落地. 荣昌生 物1月拿下最高56亿美元超级BD大单,创下开年BD 交易最高纪录。 又签大单! 的所容 BDH 3 5 把握落股道创新药布局窗口 热点机会 数据来源:国家药监局、上市公司公告等公开信息,截至2026年1月28日。 港股通创新药ETF 辑 520880 100%布局创新药研发类公司 AP S 品 反弹行情强进攻 港股通创新药ETF (520880) 标的指数高纯度、高弹 性、高锐度、在创新药反弹行情中展现超强进攻性。 520880标的指数2025年以来领跑同类 80% 77.60% 74.61% 72.06% 60% 42.97% 40% 31.57% 22.35% 20% 0% 恒生港股通 恒生港股通 恒生创新药 SHS创新药 创新药30 CS创新药 创新药 创新约精选 数据来源于Wind,统计区间:2025年1月1日-2026年1月27日。恒生港股通创新药精 选指数基日为2020年12月31日. 发布日期为2023年7月17日, 20 ...

Core Viewpoint - China Galaxy Securities is optimistic about the pharmaceutical industry's investment opportunities in 2026, focusing on hard technology in medicine, innovation, and overseas expansion, while seeking alpha in niche segments [1] Group 1: Investment Trends - In Q4 2025, public fund holdings in pharmaceuticals decreased, indicating an overall low allocation level [1] - The market value of pharmaceutical theme funds decreased by 9.73% to 205.9 billion yuan, which is 66.54% higher than the average since 2019 [1] - The market value of the pharmaceutical biotechnology sector fell by 18.81% to 312.5 billion yuan, with a holding ratio of 8.12%, below the historical average by 3.89 percentage points [1] Group 2: Stock Performance - The top five pharmaceutical stocks held by public funds in Q4 2025 saw significant reductions in both the number of funds and total market value, with notable declines in stocks like Heng Rui Medicine and WuXi AppTec [2] - The concentration of holdings has shifted from innovative drugs to medical devices and services, indicating a change in market investment focus [2] Group 3: Industry Data Overview - The pharmaceutical manufacturing industry's revenue has shown a slight decline, with a year-on-year decrease of 1.2% in Q4 2025 [3] - Medical service volumes remained stable, with a total of 1.86 billion outpatient visits in early 2025, reflecting a 0.1% year-on-year decrease [3] - The overall operation of the medical insurance fund has been stable, with total income of 2.632 trillion yuan and total expenditure of 2.110 trillion yuan from January to November 2025 [3] Group 4: Market Comparison - The pharmaceutical industry has underperformed compared to the CSI 300 index, with a rolling P/E ratio of 38.19 compared to 14.14 for the CSI 300, indicating a premium of 170.14% over the index [3] - The SW pharmaceutical biotechnology index increased by 1.44% from early 2024 to January 28, 2026, while the CSI 300 rose by 37.15%, showing a relative underperformance of 35.71% for the pharmaceutical sector [3]

Core Viewpoint - Pfizer has unveiled a significant R&D plan for 707/PF'4404 (PD-1/VEGF) in collaboration with 3SBio, with an accelerated pace and breadth beyond expectations, aiming to initiate four global Phase III clinical trials by 2026 across five major first-line indications [1][2] Group 1: Clinical Development - Pfizer plans to launch four Phase III clinical trials in 2026 targeting first-line squamous/non-squamous NSCLC, mCRC, endometrial cancer, and urothelial carcinoma [2] - The company has already completed the first patient enrollment for Phase III trials targeting first-line NSCLC and mCRC, as well as Phase II/III trials for first-line ES-SCLC [2] - Pfizer will also initiate Phase III clinical studies combining 707 with various ADCs, such as Padcev for first-line treatment of urothelial carcinoma [2] Group 2: Competitive Landscape - Four multinational corporations (MNCs) are competing in the PD-(L)1/VEGF space, including Pfizer, BMS, Merck, and AbbVie, with Pfizer expected to stand out due to its "speed, breadth, and depth" advantages [2] - BMS and BioNTech have announced extensive clinical plans, but their progress in core indications like first-line NSCLC and mCRC lags behind Pfizer [2] Group 3: Pipeline and Financials - 3SBio is increasing R&D investments with multiple pipelines expected to yield clinical data, including 705 (PD-1/HER2) and 706 (PD-1/PD-L1) in Phase II trials in China [3] - The core business fundamentals of 3SBio remain robust, with projected revenue of approximately 4.2 billion yuan in 2025, including 2.89 billion yuan from the upfront payment for 707 licensing [3] - Excluding the upfront payment, the internal business revenue of 3SBio is estimated to grow by about 9% year-on-year [3] Group 4: Investment Rating - The company maintains a "Buy" rating with a target price of 37.43 HKD, supported by an estimated net cash position of approximately 13 billion yuan [4] - Confidence in 707 becoming a global blockbuster is reaffirmed due to Pfizer's unexpected clinical advancement [4]

Group 1 - The biopharmaceutical sector experienced a decline of 1.98% on January 28, with Baipusais leading the drop [1] - The Shanghai Composite Index closed at 4151.24, up 0.27%, while the Shenzhen Component Index closed at 14342.9, up 0.09% [1] - Notable gainers in the biopharmaceutical sector included Kanghua Biological, which rose by 3.02% to a closing price of 74.70, and Liaoning Chengda, which increased by 2.55% to 12.86 [1] Group 2 - Baipusais saw a significant drop of 10.57%, closing at 58.18, with a trading volume of 57,400 shares and a transaction value of 342 million [2] - Other notable decliners included Kangla Weishi, down 6.16% to 10.97, and Jinchuan Protein, down 5.90% to 46.58 [2] - The biopharmaceutical sector experienced a net outflow of 1.252 billion in main funds, while retail investors saw a net inflow of 653 million [2] Group 3 - Rongchang Biological had a net inflow of 38 million from main funds, representing 6.49% of its total, while it faced a net outflow of 58.99 million from retail investors [3] - Liaoning Chengda also saw a net inflow of 14.86 million from main funds, but a net outflow of 15.01 million from retail investors [3] - The overall trend indicates a mixed sentiment in the biopharmaceutical sector, with main funds withdrawing while retail investors are actively buying [3]

Market Performance - The market showed mixed performance from January 19 to January 23, with the Shanghai Composite Index rising by 0.84% and the Shenzhen Component Index increasing by 1.11%[5] - The average daily trading volume was 2.80 trillion yuan, a decrease compared to the previous week[5] Healthcare Sector - At the JPM 2026 conference, over 20 Chinese innovative pharmaceutical companies showcased their products, with significant business development (BD) transactions announced[16] - In 2025, the value of China's innovative drug patent licensing transactions reached approximately $135.7 billion, a 143% increase year-on-year, with 157 total transactions[20] Consumer Sector - The Qianwen APP integrated with Alibaba's ecosystem, achieving over 100 million monthly active users within two months of launch, marking its entry into the "billion-level club"[25] - This integration allows for a seamless process from search to decision-making and payment, establishing a comprehensive AI application ecosystem[26] Hard Technology Sector - The supply of storage and logic chips remains tight, leading to widespread price increases across the industry[32] - The price of enterprise SSDs continues to rise, with a projected increase of 33-38% for NAND Flash products due to supply constraints[36] High-end Manufacturing - The State Grid announced a total fixed asset investment of 4 trillion yuan for the 14th Five-Year Plan period (2026-2030), a 40% increase from the previous period, averaging 800 billion yuan annually[42] - The goal is to achieve a 30% share of renewable energy in total power generation by 2030, indicating significant growth potential for the solar and wind energy sectors[46]

Market Performance - The market showed mixed performance from January 19 to January 23, with the Shanghai Composite Index rising by 0.84% and the Shenzhen Component Index increasing by 1.11%[5] - The average daily trading volume was 2.80 trillion yuan, a decrease compared to the previous week[5] Healthcare Sector - At the JPM 2026 conference, over 20 Chinese innovative pharmaceutical companies showcased their advancements, with significant business development (BD) transactions reported[16] - In 2025, the value of China's innovative drug patent licensing transactions reached approximately $135.7 billion, a 143% year-on-year increase, with 157 total transactions[20] Consumer Sector - The Qianwen APP integrated with Alibaba's ecosystem, achieving over 100 million monthly active users within two months of launch, marking its entry into the "billion-level club"[25] - This integration allows for a seamless process from search to decision-making and payment, establishing a comprehensive AI application ecosystem[26] Hard Technology Sector - The supply of storage and logic chips remains tight, leading to widespread price increases across the industry[32] - The price of enterprise SSDs continues to rise due to increased demand from AI servers, with NAND Flash supply expected to decrease by 41.7% in 2026[35] High-end Manufacturing - The State Grid announced a total fixed asset investment of 4 trillion yuan for the 14th Five-Year Plan period (2026-2030), a 40% increase from the previous period, averaging 800 billion yuan annually[42] - By 2030, renewable energy generation is expected to account for approximately 30% of total power generation, indicating significant growth potential in the solar and wind sectors[46]

Group 1 - The core focus of the 2026 JPM Conference is on the strategic importance of IO (Immuno-Oncology) and ADC (Antibody-Drug Conjugates) in the oncology sector, with a significant emphasis on combination therapies [1] - The conference, held from January 12 to 15, 2026, in San Francisco, is recognized as a key event for insights into new drug development trends, capital flows, and business development collaborations in the healthcare industry [1] - Major multinational corporations (MNCs) are prioritizing second-generation IO and ADC, with a notable contribution from domestic innovations, particularly the introduction of sac-TMT by Merck as a focal point in oncology development [2] Group 2 - The exploration of combination therapies involving IO and ADC is accelerating, with multiple clinical trials underway, including 16 Phase III trials for sac-TMT and 4 Phase III trials for PD-(L)1/VEGF dual antibodies by Pfizer [2] - The year 2026 is identified as a pivotal year for the combination of IO and ADC, with expectations for increased demand for ADCs as they gain a core position in current cancer treatments [3] - Key players in the ADC market include companies such as Kangfang Biopharma, Sanofi, Rongchang Biopharma, and others, indicating a competitive landscape for ADC development [3]

Investment Rating - The report maintains a "Positive" outlook for the pharmaceutical and biotechnology industry in China [6] Core Insights - The focus remains on the combination of IO (Immuno-Oncology) and ADC (Antibody-Drug Conjugates), with significant advancements expected in their joint application [10][11] - The year 2026 is identified as a critical year for the combination of IO and ADC, with expectations for increased demand for ADCs, particularly in the context of various cancer treatments [11][41] Summary by Sections Section 1: Focus on Second-Generation IO and ADC - Merck's sac-TMT is a strategic focus, with 16 ongoing Phase III clinical trials, particularly in gynecological cancers [14][15] - AstraZeneca has 8 ADCs in clinical stages, with significant data readouts expected in 2026 [19][20] - Pfizer is advancing 4 Phase III clinical trials for its PD-1/VEGF dual antibody SSGJ-707, highlighting its strategic importance in oncology [26][27] - Johnson & Johnson aims to become the leading oncology company by 2030, focusing on multiple myeloma and various cancers [30] - Bristol-Myers Squibb (BMS) is advancing its PD-L1/VEGF dual antibody and oral CELMoD therapies, with significant data catalysts expected in 2026 [32][33] - Roche is focusing on breast cancer, with its oral SERD Giredestrant expected to be approved soon [37][38] Section 2: The Year of IO+ADC Combination - The combination of IO and ADC is seen as a key development direction, with various clinical trials underway [41] - The first-generation IO+ADC combinations are competitive, with sac-TMT emerging as a significant player [42] - The second-generation IO combined with chemotherapy is led by AK112, with multiple milestones expected in the coming years [47] - The second-generation IO combined with ADC is still in early exploration, with AstraZeneca leading the way [49] Section 3: Investment Recommendations and Targets - The report identifies several investment targets, including Kangfang Biotech, 3SBio, and others, highlighting their potential in the oncology sector [11][56]

Investment Rating - The report maintains a "Positive" outlook for the pharmaceutical and biotechnology industry in China [6] Core Insights - The focus remains on the combination of IO (Immuno-Oncology) and ADC (Antibody-Drug Conjugates), with significant advancements expected in their joint applications [10][11] - The year 2026 is identified as a critical year for the confirmation of IO combined with ADC, with expectations for increased demand for ADCs, particularly in the context of various cancer treatments [11][41] Summary by Sections Section 1: Focus on Second-Generation IO and ADC - Merck's sac-TMT is a strategic focus, with 16 ongoing Phase III clinical trials, particularly in gynecological tumors [14][15] - AstraZeneca has 8 ADCs in clinical stages, with significant data readouts expected in 2026 [19][20] - Pfizer is advancing 4 Phase III trials for its PD-1/VEGF dual antibody SSGJ-707, highlighting its strategic importance in oncology [26][27] - Johnson & Johnson aims to become the leading oncology company by 2030, focusing on multiple myeloma and other cancers [30] - Bristol-Myers Squibb (BMS) is advancing its PD-L1/VEGF dual antibody with multiple ongoing trials [32] Section 2: Confirming the Year of "IO+ADC" Combination - The combination of IO and ADC is seen as a key development direction, with various clinical trials underway [41] - The first-generation IO combined with ADC is competitive, with sac-TMT emerging as a significant player [42] - The second-generation IO combined with chemotherapy is led by AK112, with multiple milestones expected in the coming years [47] - The second-generation IO combined with ADC is still in early exploration, with AstraZeneca leading the way [49] Section 3: Investment Recommendations and Targets - The report identifies several investment targets, including Kangfang Biotech, 3SBio, and others, emphasizing their potential in the oncology sector [11][56]