今年的9月29日是第26个世界心脏日。当前，我国心血管疾病患病人数约3.3亿，且发病率随年龄增长持 续攀升。其中，心脏瓣膜疾病已成为继冠心病、高血压之后的第三大心血管疾病，是影响国民健康的重 要公共卫生问题。 数据显示，我国约有2500万人受到瓣膜病影响，平均每10位65岁以上老人中，大约就有1位存在心脏瓣 膜问题，是老年人心力衰竭和猝死的重要原因之一。 如何治疗 多位临床专家向21世纪经济报道记者表示，瓣膜病在老年人群中高发，其症状隐匿且不典型、常与多种 慢性病共存，这为早期识别和规范诊疗带来特殊挑战，严重影响老年人的生活质量。未来，随着人口老 龄化进程不断加快，包括主动脉瓣狭窄在内的心脏瓣膜疾病负担将会进一步加重，成为我国突出的健康 挑战。 近年来，随着医学的高速发展和对疾病发病机制认识的不断深入，针对瓣膜疾病的创新治疗方案不断涌 现，人工瓣膜材料也在不断迭代更新，治疗方式日趋微创化和个体化，显著改善了患者的临床预后。随 着人均寿命的延长和对生活质量要求的提高，全程化、系统化的全生命周期管理理念的临床应用也越来 越重要。 尽早干预 中国老年人口数量多，人口老龄化速度快，面临着非常严峻的瓣膜健康挑战。 中国 ...

政策层面，八部门明确"以标准升级引领产品质量提升"，加快新能源汽车、动力电池、自动驾驶等重点领域标准研制，同时加强生产一 致性监管，推动企业提升产品安全、节能、低温适应等核心性能。这一要求直指产业转型痛点——电动化、智能化转型中技术与质量的 平衡，体现出从标准制定到落地执行的全链条管控思路。 行业共识进一步细化实践路径，泰达汽车论坛明确了汽车企业需"建立全生命周期的产品安全保障能力"，在技术创新中恪守安全底线。 中国质量大会提出"质量赋能新质生产力"理念，从更高维度为产业定调，将质量提升与产业升级、创新发展深度绑定。三者相互呼应， 形成"标准引领、安全为基、全周期管控"的产业质量发展框架，使"质量"从产品属性升级为产业可持续发展的核心动力。 "多维标准+高效研发" 金秋9月，2025年全国"质量月"以"加强全面质量管理 促进质量强国建设"为主题，为各行各业高质量发展注入新动能。在汽车产业加速 转型的关键期，"推进高质量发展、实现量质齐升"已成为行业共识。作为行业领军企业，上汽大众以德系基因传承为底色，以全生命周 期质量管理为抓手，用实际行动诠释大厂担当，为汽车产业高质量发展提供了可借鉴的实践样本。 产业升级进 ...

整理 | GLP1减重宝典内容团队 为规范和指导重组胰高血糖素样肽-1受体激动剂的药学研究，在国家药品监督管理局的部署下，我中心组织制定了《重组胰高血糖素样肽-1受 体激动剂药学研究与评价技术指导原则（试行）》（见附件）。根据《国家药监局综合司关于印发药品技术指导原则发布程序的通知》（药监 综药管〔2020〕9号）要求，经国家药品监督管理局审查同意，现予发布，自发布之日起施行。 特此通告。 附件：重组胰高血糖素样肽-1受体激动剂药学研究与评价技术指导原则（试行） 国家药监局药审中心 2025年9月3日 重组胰高血糖素样肽–1 受体激动剂 药学研究与评价技术指导原则(试行) 国家药品监督管理局药品审评中心 2025 年 9 月 | 一、前言 . | | --- | | 二、适用范围 . | | 三、一般原则 . | | (一)研发策略 | | (二)全生命周期管理 . | | (三)杂质研究 | | 四、原液生产工艺 . | | (一)生产用原材料 3 | | (二)化学分子修饰剂 . | | (三)重组 GLP-1 短肽的表达和修饰 6 | | (四)与其他蛋白融合的 GLP-1 受体激动剂 8 | | 五、 ...

肺癌和乳腺癌等恶性肿瘤正成为国民健康的重大威胁，疾病诊疗和管理面临多重挑战。在近日举办的第 28届中国临床肿瘤学会(CSCO)学术年会期间，安徽省肿瘤医院副院长、CSCO乳腺癌、转化医学、心脏 安全专委会副主任委员潘跃银教授，苏州大学附属第一医院陶敏教授等多位临床和行业的专家与代表， 就如何突破恶性肿瘤诊疗瓶颈、回应患者真实需求、构建更完善的疾病诊疗体系，分享深刻洞察。 建立规范诊疗体系，让精准诊疗触达基层 超越"治疗"，倾听患者声音 现阶段，包括肺癌、乳腺癌在内的部分亚型已经逐渐向慢病化转变，从单纯"治疗疾病"走向"全生命周 期管理"。当更多患者能够实现长生存之后，也催生了对肿瘤治疗的新需求。填补这些需求缺口，仅靠 单一主体难以实现。正如潘跃银教授所言，医疗机构、医药企业、患者组织各司其职、紧密联动，才能 构建以患者为核心的高效诊疗生态，真正实现从"治疗到愈人"。 尽管肿瘤诊疗已迈入精准医疗时代，但临床实践中仍面临诸多待解难题。在肺癌诊疗领域，主要面临三 大"壁垒"。陶敏教授指出，不同地区、不同级别医院的肺癌诊疗，在规范与技术能力上存在显著差异， 导致患者生存预后不均；而基因检测普及率、标准化不足使精准治疗 ...

Group 1 - The core viewpoint emphasizes the importance of accelerating project construction to support economic recovery and achieve annual development goals, with over 300 billion yuan allocated for the third batch of "two heavy" construction projects by the National Development and Reform Commission [1] - Project construction serves as both a "stabilizer" for economic growth and a "booster" for structural transformation, necessitating a focus on high-end, intelligent, and green transitions in industry [1] - There is a call to avoid redundant low-level construction and instead focus on resource endowments and actual needs to strengthen key areas and improve livelihoods [1] Group 2 - The initiative aims to enhance private enterprise participation in project construction by creating a transparent investment project list and providing essential information to encourage private capital investment [2] - Continuous efforts are needed to streamline channels for private capital, with detailed financing support and property protection policies to facilitate quick investment [2] - Emphasis is placed on comprehensive lifecycle management of projects, ensuring effective planning and management to transition projects from concept to reality, while addressing key indicators and potential issues [2]

Group 1 - The Panama-flagged cargo ship "Bo Run Jiu Zhou" set sail from Qinzhou Port carrying 229 pieces of intelligent wind turbine blades, marking the first entry of "Qinzhou-made" wind turbine blades into the global market [1][3] - The intelligent wind turbine blades, measuring 89.6 meters in length, were developed by Envision Energy at its Qinzhou Smart Energy Industrial Base, utilizing artificial intelligence for customized research and development [3][5] - Envision Energy is a leading company in China's renewable energy sector, with a cumulative installed capacity of over 80 GW globally by the end of 2024, contributing to a reduction of approximately 2.35 billion tons of carbon emissions [5] Group 2 - The Qinzhou Smart Energy Industrial Base includes manufacturing of intelligent wind turbine systems, blades, and a global offshore blade testing center, representing Guangxi's first offshore wind power equipment manufacturing industrial cluster [5] - Wind power is emerging as a strong growth driver for China's exports, alongside other key products, with the Qinzhou Customs committed to enhancing services to support the global presence of "Chinese intelligent manufacturing" [5]

Core Viewpoint - The land supply plan of Qingyang for 2025 signals a strong commitment to high-quality development, focusing on industrial land to drive economic growth through a dual approach of "industry + cultural tourism" [1][15]. Group 1: Land Supply Plan - Qingyang's 2025 land supply plan features a high proportion of industrial land, accounting for 72.5% (151.82 hectares), indicating a strong determination to become a "manufacturing strong county" [2]. - The eight land parcels available for sale are all classified as secondary industrial land, with a floor area ratio controlled between 1.0-1.4 and a building density of 40%, emphasizing the pursuit of intensive land use [2][6]. - All land parcels require a contract to be signed with local towns within seven days post-transaction, ensuring that land development is closely tied to tax revenue and employment benefits [6]. Group 2: Industrial Development - The Baomei light alloy project is set to launch its first 100,000-ton production line in 2025, which is expected to boost the magnesium-aluminum industry chain's output value to over 1 billion yuan, attracting upstream and downstream enterprises [7]. - The expansion of the Shian Park is accelerating, targeting high-end manufacturing sectors such as prefabricated buildings and new energy vehicle components, resonating with the "Qingyang Intelligent Manufacturing" corridor [7]. Group 3: Population and Infrastructure - The opening of the Chi-Huang High-speed Railway has led to an average daily passenger flow of over 4,000 at Jiuhua Mountain Station, significantly boosting the local hospitality economy [10]. - Qingyang has introduced a "Youth Party Member Return Entrepreneurship Plan," offering land incentives and tax reductions to attract young entrepreneurs, fostering a positive cycle between cultural tourism and agriculture [10]. - Infrastructure improvements, including the completion of major highways and the addition of 600 parking spaces, are enhancing the livability and connectivity of Qingyang, creating a "15-minute living circle" [13]. Group 4: Strategic Logic Behind Land Supply - Qingyang's land supply strategy integrates land use planning, industrial policy, and public needs, emphasizing both bottom-line thinking and flexible development [14]. - The strategy aims to maintain a balance between agricultural land protection and industrial land efficiency, ensuring sustainable growth [14]. - The development model promotes a gradient development pattern, leveraging the tourism resources of Jiuhua Mountain while avoiding homogeneous competition among towns [14].

Core Insights - The forklift industry in China is experiencing a significant shift towards electric forklifts, with sales expected to exceed 739,334 units in the first half of 2025, of which electric forklifts account for over 74% [2][10][11] - The demand for electric forklifts is driven by lower costs and increased efficiency, leading to a rapid rise in orders and production capacity [7][8][19] - The integration of AI technology is transforming the industry, with electric unmanned forklifts becoming a new growth engine [11][19] Sales and Market Trends - In the first half of 2025, electric forklift sales reached 550,000 units, representing over 70% of total forklift sales [2] - A specific forklift company in Hangzhou reported record shipping volumes in June, with daily shipments reaching over 100 containers [3] - Large forklifts over 10 tons have seen a notable increase, with orders for port machinery growing by 315% and shipping volumes increasing by 460% [5] Cost and Production Dynamics - The cost of electric forklifts has decreased, leading to a price parity with internal combustion forklifts, while their operational costs remain lower [7] - A forklift company in Anji has shifted all production capacity to electric forklifts due to rapid demand from downstream companies transitioning from oil to electric [8] Technological Advancements - The use of AI and digital twin technology is enhancing the capabilities of electric unmanned forklifts, allowing for improved efficiency and cost reductions of over 30% in logistics and warehousing [17][19] - The DAS system implemented in smart factories enables faster material retrieval, reducing the time from half a day to 10-15 minutes [15] Future Outlook - The electric forklift market is projected to grow by over 15% year-on-year, with the penetration rate expected to rise from under 20% a decade ago to over 73% by 2024 [10][11] - Domestic unmanned forklifts are anticipated to evolve from product-level exports to system-level solutions, enhancing competitiveness in the global market [20]

Core Insights - The conference on Digital Product Passport (DPP) V1.0 aimed to establish an international cooperation framework for product lifecycle management, focusing on green and sustainable supply chain practices [1][2] - The MA-DPP Universal Framework V1.0 was launched as the world's first DPP framework, designed to support a collaborative and trustworthy data infrastructure for global supply chains [3] Group 1: Digital Product Passport Development - The DPP serves as a digital carrier throughout the product lifecycle, emphasizing its growing importance in international cooperation for global development [2] - The steel industry is among the first sectors in the EU to implement the DPP, with a public service platform launched to support green initiatives for Chinese steel enterprises [3] Group 2: International Collaboration and Standards - Experts from various international organizations discussed the progress of the EU's DPP system and its role in lifecycle management standards, providing a global perspective on DPP standardization [4] - Strategic partnerships were formed between organizations like Zhongguancun Institute and Siemens (China) to develop ecological solutions for battery passports and carbon footprints [5]

Company Insights - CIFI Construction Management has established a presence in over 80 cities [1] - Greentown Management expanded its new entrusted construction projects with a management fee of 5 billion RMB in the first half of the year [1] - Ningxia Zhongfang Construction Management has entered Xining for the first time, signing a high-end residential project on Hailake Road [1] Project Highlights - Happiness Anji has delivered the Shenyang Sujiatun relief project with a total area of 720,000 square meters, where state-owned/government projects account for 51% and re-entrusted projects account for 25% [1] - The company reported a nearly 60% increase in cash collection, a 160% surge in sales, and a simultaneous improvement in profit margins [1] - A project in Suzhou's Wuzhong District aims to transform an old commercial building into a low-density mountain residence, covering an area of approximately 54,000 square meters [2] - A project in Dalian's Jinpu New District will develop high-quality residential products in a prime location, with a total construction area of about 85,000 square meters [2] Financial Performance - Greentown Management's newly expanded entrusted construction projects have a total contracted building area of 19.89 million square meters, representing a year-on-year growth of approximately 13.9% [3] - The estimated management fee for these new projects is 5 billion RMB [3] - The total contracted sales area for the non-self-invested properties managed under the "He Sheng" brand is approximately 41,231 square meters, with a contracted sales amount of about 3.736 billion RMB [3] Typical Projects - A project in Taizhou's Luqiao District has a total volume of 184,195 cubic meters, with a winning bid amount of 806 million RMB [6] - A housing project in Qingtian County has a total volume of 295,126 cubic meters, with a winning bid amount of 984 million RMB [6]