Core Insights - The pharmaceutical industry is experiencing a surge in innovative products, with clear domestic demand and significant potential for international expansion [4][14][25] - Investment opportunities are concentrated in innovative drugs and their supply chains, with a notable performance from CRO/CMO and chemical pharmaceuticals [9][15][17] - The report emphasizes the importance of innovation as the primary solution to industry challenges, driven by stable demand and supportive policies [26][32][41] Industry Overview - The pharmaceutical sector has faced revenue declines, with a 0.9% year-on-year decrease in revenue for the first three quarters of 2025, and net profit down by 2.2% [15][16] - The innovative drug sector has outperformed, with CRO/CMO and chemical pharmaceuticals showing net profit growth of 31.0% and 16.6% respectively [17][18] - The overall market is characterized by low fund holdings and historical valuation bottoms, indicating high investment value [20][25] Demand and Payment Dynamics - The demand for healthcare services is steadily increasing, with a projected 5% growth in total medical visits and hospital admissions in 2024 [26][28] - The aging population is expected to drive long-term demand, with 220 million people aged 65 and above by 2050 [28][30] - The medical insurance fund's income growth has outpaced expenditure growth, leading to a significant increase in fund reserves [32][36] Financing and Market Trends - The IPO market for healthcare has rebounded, with 28 IPOs in the first three quarters of 2025, a 100% increase from the previous year [42][43] - License-out transactions have surged, with transaction numbers increasing by 41% and total amounts reaching $92 billion, indicating a robust market for innovative drug licensing [48][50] - The number of IND applications and new clinical trials for innovative drugs has been steadily increasing, with a notable rise in NDA approvals [53][57] Technological Advancements - The report highlights the emergence of new technologies such as ADC and small nucleic acids, with domestic companies leading in these areas [60] - The focus on dual antibodies and GLP-1 drugs is expected to drive significant growth, with multiple development directions emerging [9][60] - The report notes that domestic companies are increasingly recognized for their innovative capabilities, particularly in the ADC space [60]

Core Viewpoint - The current market is transitioning from high growth to moderate growth, with a trend of convergence between technology and value sectors in the new cycle [1] Group 1: Market Cycle Analysis - Understanding cyclical changes is essential for future market judgments, with significant shifts observed over the past two decades [2] - The first phase (2000-2010) was dominated by cyclical growth, benefiting heavy industries, resource sectors, and low-end manufacturing [3] - The second phase (2010-2021) saw a shift towards growth, driven by urbanization and the rise of consumer demand and emerging services, with the ChiNext index experiencing rapid growth [3] - Since 2021, the market has gradually shifted back to moderate growth, with value styles regaining dominance, as evidenced by the performance of the STAR Market index compared to the CSI Dividend Index [3] - Long-term migration of industry weights indicates structural upgrades, with technology, consumer healthcare, and cyclical finance gaining share in the CSI 300 over the past 16 years [3] Group 2: Future Outlook for 2026 - The outlook for 2026 is summarized by three keywords: technology leading, value following, and returning to leaders, based on long-term industry structural evolution [4] - The current AI narrative, represented by the STAR Market, mirrors the technology cycle from 2011 to 2015, but with different supporting backgrounds such as demographic changes and geopolitical factors [4] - Key signals for market improvement include PPI and inventory conditions, with expectations for corporate performance to improve in mid-2024 following a low PPI point [4][5] Group 3: Investment Directions - The market is witnessing a recovery in value sectors, which may present structural opportunities in 2026, especially after a year of significant underperformance compared to growth sectors [6] - Investment focus will include cyclical industries (oil, coal, basic metals), non-banking sectors (insurance, brokerage), high ROE industries (internet, traditional consumption), and new cycle industries (new energy, power equipment) [6] - Continuous themes may emerge in CXO, innovative pharmaceuticals, AI applications, and humanoid robotics, although market volatility is expected to increase [6] Group 4: Research and Investment Strategy - The exponential growth of fund numbers, asset management scale, and listed companies has increased information density, posing challenges for research and investment [7] - The company is developing a systematic investment approach through professional division of labor and industrialized production lines to meet client needs [7] - AI is anticipated to become a core capability in active management, fundamentally reshaping the research and investment chain over the next three years [7]

➢ 每日大市点评 12 月 9 日，投资者观望本周美联储议息结果，港股升势乏力。恒生指数高开后一路下跌，收盘下跌 331 点（1.3%），收 报 25,434 点；恒生科技指数下跌 107 点（1.9%），收盘报 5,554 点；全天大市成交额微增至 2,102 亿元。港股通净流入 减少至 5.3 亿元。盘面上，美国国会料通过法案，限制中资生物科技公司获得华府资助合约，生物科技医药股逆市造好， 药明生物（2269 HK）升 1.9%；药明康德（2359 HK）升 1.1%。特朗普允许英伟达向中国出售 H200 芯片，港股芯片板块 下跌，中芯国际（981 HK）和华虹半导体（1347 HK）下跌 4%-5%。内房股方面，雅居乐（3383 HK）被提出清盘呈请， 周二跌 18.4%，其他内房股受到拖累，龙湖（960 HK）跌 6%；华润置地（1109 HK）跌 3.7%；中海外（688 HK）跌 3.1%。 港股短期将维持震荡格局。 2025 年 12 月 10 日 星期三 国家统计局将于 12 月 10 日公布 11 月物价数据。市场预期，11 月食品价格上行将推动当月全国居民消费价格（CPI）同 比增速回升； ...

进入12月，药明康德迎来了成立的第25个年头。四分之一世纪的时光，这家CXO企业从上海一间650平 方米的实验室，成长为在亚洲、欧洲、北美拥有超过20个研发生产基地、服务全球数千家客户的一体化 CRDMO赋能平台。在这段发展历程中，药明康德用实践诠释了何谓穿越周期的"长期主义"。 一体化CRDMO模式打通增长通路 药明康德得以在多个经济与行业周期中持续增长，核心驱动力正是其长期坚持的"一体化，端到 端"CRDMO业务模式。这一模式实现了药物发现与研究(R)、工艺开发(D)和商业化生产(M)的无缝贯 通，通过内部高效协同形成增长飞轮。 例如，药明康德在靶向蛋白降解(TPD)领域的发展，正是其CRDMO模式优势的重要体现。早在科学转 化的初期，药明康德就从R端捕捉到创新趋势，于近10年前开始布局相关能力和技术，并跟随前沿科学 陆续构建了涵盖多种分子类型的技术平台。另一方面，R端对下游D&M端业务起到引流作用。如今， 已有超过18.8万种复杂的TPD化合物从药明康德的赋能平台走出，其中70多种已进入临床前候选药物阶 段，10多种已进入后期开发阶段。 在下游，D&M端的规模化、一体化能力，实现技术的快速放大与高效产出 ...

Group 1 - The MSCI China Healthcare Index has increased by 62.8% from the beginning of 2025 to November 21, outperforming the MSCI China Index by 32.2% [1] - The recent pullback in the pharmaceutical sector, with the MSCI China Healthcare Index declining by 8% from early October to November 21, is attributed to profit-taking by investors and high valuations of some innovative drug companies [1] - Despite the significant recovery in industry valuations, the pharmaceutical sector is expected to face challenges in achieving widespread growth in 2026, although there are opportunities for valuation and performance recovery in specific stocks such as medical services, pharmaceuticals, and CXO companies [1] Group 2 - As of October 2025, the upfront payments for Chinese innovative drug license-out transactions have reached $6.3 billion, a 53% year-over-year increase, surpassing the total for 2024 [2] - The interest from multinational corporations (MNCs) in Chinese innovative pipelines has increased, with 20% of the number and 39% of the value of top MNC's transactions in China occurring in the first nine months of 2025 [2] - The trend of Chinese innovative drugs going abroad is expected to continue into 2026, with a focus on the overseas clinical advancement of authorized pipelines due to higher certainty and potential for stock price catalysts [2] Group 3 - The demand for pharmaceutical research and development has begun to recover in 2025, with a 444% year-over-year increase in financing for Chinese innovative drugs in Q3 2025 [3] - Global innovative drug financing also showed positive growth in Q3 2025, increasing by 8.6% [3] - Chinese CXO companies, deeply involved in the global pharmaceutical R&D supply chain, are experiencing growth in global demand, as evidenced by WuXi AppTec's orders increasing by 41.2% year-over-year as of September 30 [3] Group 4 - The acceleration of centralized procurement for medical devices has continued in 2023, leading to significant performance differentiation across various segments [4] - In high-value consumables, the impact of centralized procurement is diminishing, with orthopedics entering a "post-procurement" recovery phase [4] - The medical device sector is experiencing a temporary high demand driven by equipment updates, with a 30% year-over-year increase in the bidding market for Q3 2025 [4] - The in vitro diagnostics (IVD) market is facing challenges due to centralized procurement and cost control measures, resulting in a year-over-year decline of 5% in the domestic IVD market in the first half of 2025 [4]

Core Viewpoint - The release of the 2025 version of the basic medical insurance directory and the first commercial insurance directory is expected to support innovation in the CXO industry, leading to a potential performance recovery in the second half of the year [1] Summary by Categories Industry Outlook - The report indicates that several companies' core innovative products have been included in the medical insurance directory [1] - Despite ongoing pressures on medical insurance revenue due to macroeconomic conditions and aging populations, attention is drawn to the renewal of national centralized procurement [1] Commercial Insurance - The initial commercial insurance directory is expected to have limited short-term impact on product sales due to the small scale of commercial insurance [1] - However, the significance of the commercial insurance directory is highlighted as it may pave the way for the expansion of commercial medical insurance in China, marking the beginning of a diversified payment system development [1] Company Recommendations - The report recommends buying shares in the following companies: - Sanofi (01530) - Genscript Biotech (02273) - WuXi AppTec (02268) - Genor Biopharma (02367) - Innovent Biologics (01801) - China Biologic Products (01177) [1]

Core Viewpoint - The pharmaceutical and biotechnology sector has demonstrated resilience and growth potential in 2023, driven by policy support and industry transformation, leading to a high-quality development phase characterized by innovation and cost control [1][4]. Industry Performance - As of December 8, 2023, the pharmaceutical and biotechnology sector has shown a weighted average increase of 30.64% in market capitalization, ranking 14th among 31 primary industries, but underperforming the CSI 300 index by 3.82 percentage points [2]. - The sector has exhibited significant internal differentiation, with innovation-driven segments outperforming others; for instance, other biological products, chemical preparations, and medical R&D outsourcing saw increases of 57.07%, 54.68%, and 51.87% respectively, while traditional Chinese medicine, vaccines, and blood products lagged behind with increases of only 3.89%, -0.73%, and -10.85% [2]. Market Dynamics - The strong performance of the innovative drug industry chain is attributed to four key factors: exceeding expectations in earnings from leading companies like BeiGene and WuXi AppTec, ongoing supportive policies for innovative drugs and devices, increased activity in domestic innovative drug business development (BD) transactions, and substantial clinical data disclosures at major global conferences [2][4]. Recent Adjustments - Since September 2023, the sector has experienced a temporary pullback, with a maximum drawdown of 12.72% from September 1 to November 21, primarily due to prior gains, unmet expectations in BD transactions, and geopolitical disturbances [3]. Valuation Insights - As of December 8, 2023, the sector's price-to-earnings (P/E) ratio stands at 51.75, with a premium of 267.54% over the CSI 300 index and 63.87% over all A-shares (excluding banks), indicating a relatively high valuation compared to historical levels [3]. Policy Support - The "14th Five-Year Plan" emphasizes support for innovative drugs and medical devices, transitioning from process optimization to comprehensive empowerment across the industry chain, with a focus on key technological breakthroughs in areas like dual antibodies, ADCs, and mRNA [6]. Investment Opportunities - Three main investment themes are highlighted: 1. The innovative drug sector, which is expected to thrive due to policy support and market expansion [7]. 2. The CXO sector, benefiting from increased demand for innovative drug development [7]. 3. Consumer healthcare, which is anticipated to recover as consumption policies promote growth [7]. Technological Integration - The integration of AI technologies into the biopharmaceutical industry is expected to enhance research efficiency and product development, with significant growth potential in AI-driven medical diagnostics and treatment processes [8].

Core Viewpoint - The pharmaceutical and biotechnology sector has shown resilience and growth potential in 2023, driven by policy support and industry transformation, with a clear focus on innovation and cost control shaping the industry landscape [1][5]. Industry Performance - The pharmaceutical and biotechnology sector has achieved a weighted average increase of 30.64% in market capitalization as of December 8, 2023, ranking 14th among 31 primary industries, but underperforming the CSI 300 index by 3.82 percentage points [1]. - The sector has exhibited significant internal differentiation, with innovation-driven segments outperforming others, such as biopharmaceuticals and medical R&D outsourcing, which saw increases of 57.07%, 54.68%, and 51.87% respectively, while traditional segments like traditional Chinese medicine and vaccines lagged behind [2]. Key Factors for Growth - The strong performance of the innovative drug industry chain is attributed to four core factors: exceeding expectations in earnings from leading companies like BeiGene and WuXi AppTec, continuous implementation of supportive policies, increased activity in domestic innovative drug business development (BD) transactions, and substantial clinical data disclosures at global academic conferences [2][3]. Financial Metrics - For the first three quarters of 2023, the pharmaceutical and biotechnology sector reported total revenue of 18,461.96 billion yuan, a year-on-year decrease of 1.27%, while net profit attributable to shareholders was 1,410.97 billion yuan, down 1.63%. However, the third quarter showed signs of recovery with a revenue increase of 1.21% and a net profit increase of 3.79% [4]. Policy Support - The "14th Five-Year Plan" emphasizes support for innovative drugs and medical devices, transitioning from process optimization to comprehensive empowerment across the industry chain, with a focus on key technological breakthroughs in areas such as dual antibodies, ADCs, and digital medicine [5]. Investment Opportunities - Three main investment themes are highlighted: 1. The innovative drug sector, which is expected to be the strongest investment theme due to policy support and market expansion [6]. 2. The CXO sector, benefiting from improved demand for innovative drug development and showing significant performance improvements [6]. 3. Consumer healthcare companies, which are anticipated to see a recovery in demand and performance due to supportive policies [6]. Technological Integration - The integration of AI technology into the biopharmaceutical industry is expected to enhance research efficiency and product development, with AI applications improving diagnostic processes and overall healthcare delivery [7].

Investment Rating - The report maintains a "Recommended" investment rating for the pharmaceutical industry [1] Core Insights - The 2025 National Medical Insurance and Commercial Health Insurance Innovation Drug Catalogs were released, adding 114 new drugs to the national insurance list, with a success rate of 88%, significantly higher than the previous year's 76% [2] - The first three quarters of 2025 saw a notable recovery in domestic innovative drug financing, with 324 financing events totaling $5.51 billion, a 67.6% increase year-on-year [3] - The flu positivity rate has not peaked yet, with a significant increase in flu cases, indicating a growing market for flu medications [4] - The report highlights breakthroughs in dual-target and new-target opportunities in the autoimmune field, with several companies making significant advancements [5] - There is a focus on inhalation formulations in respiratory diseases, with new drugs showing promising results [6] - Progress in liver-targeted small nucleic acids is noted, with companies like Arrowhead Pharmaceuticals making strides in this area [7] Summary by Sections 1. National Medical Insurance and Commercial Insurance Innovation Drug Catalogs - The 2025 catalog added 114 new drugs, including 50 innovative drugs, with a success rate of 88% [2] 2. Financing Trends and CXO Order Changes - Innovative drug financing events increased by 5.2% year-on-year, with total financing amounting to $5.51 billion [3] 3. Flu Positivity Rates - The flu positivity rate reached 51.1%, indicating a rising demand for flu medications [4] 4. Autoimmune Field Developments - Significant partnerships and advancements in dual-target drugs for autoimmune diseases were reported [5] 5. Inhalation Formulations in Respiratory Diseases - New inhalation drugs are showing positive clinical results, indicating a shift in treatment approaches [6] 6. Progress in Liver-Targeted Small Nucleic Acids - Arrowhead Pharmaceuticals achieved a milestone payment for its innovative RNA therapy, expanding its research pipeline [7] 7. Stock Recommendations - The report recommends stocks in various sectors, including inhalation formulations, small nucleic acids, and innovative drugs, highlighting specific companies for investment [8]

Core Viewpoint - The pharmaceutical and biotechnology market currently lacks a clear main theme, but the release of the first "Medical Insurance + Commercial Insurance Dual Directory" by the National Healthcare Security Administration on December 7 may boost investment enthusiasm for innovative drugs [1] Market Performance - Last week, the pharmaceutical and biotechnology sector had a return of -0.74%, underperforming the CSI 300 by 2.02%, ranking 21st among 31 primary sub-industry indices [2] - The pharmaceutical commercial sub-sector had the highest weekly return at 5.19%, outperforming the CSI 300 by 3.91%, while the medical services sub-sector ranked sixth with a return of -1.37%, underperforming the CSI 300 by 2.65% [2] Innovative Drugs - Companies recommended for investment in innovative drugs include: - Innovent Biologics - 3SBio - Hengrui Medicine - Kelun-Biotech - Baillie Gifford - Rongchang Biologics - Yimeng Biologics - Huyou Pharmaceutical - King’s Ray Biotech - Valiant Biotech - Lee's Pharmaceutical [2] CXO and Life Sciences Upstream Industry Chain - Recommended global CXO leaders include: - WuXi AppTec - WuXi Biologics - WuXi AppTec's subsidiary - Kanglong Chemical - Kailai Ying [3] - Recommended domestic clinical CRO leaders include: - Tigermed - Proprius - Nossg - Sunshine Nuohe [3] - Recommended resource-type CXOs include: - Zhaoyan New Drug - Yinos - Medicy - Baiaosaitu - Yaokang Biotech [3] - Recommended companies in the life sciences upstream industry chain include: - Baipusais - Haoyuan Pharmaceutical - Bid Pharmaceutical - Nami Technology - Aopumai - Haier Biomedical - Aladdin - Titan Technology [3] Companies with Improved Operations and High Dividends - Companies recommended for attention include: - Baiyunshan - Sinopharm [4] High-end Medical Equipment - Recommended companies benefiting from overseas pharmaceutical investments include: - Sensong International - Dongfulong - Chutian Technology [4] - Companies expected to see business growth from hospital procurement recovery include: - United Imaging - Kaili Medical - Xinhua Medical - Mindray Medical - Aohua Endoscopy - Mountain Outside Mountain [4] - Companies with domestic demand-driven medical device recovery include: - Yiyue Medical - Kefu Medical - Sanofi Biotech [4] - Companies with restored overseas orders include: - Meihua Medical - Haitai New Light - Ruimaite [4] - Companies with increasing market penetration in high-end medical consumables include: - Xinmai Medical - Micron Medical - Weigao - Micron Brain Science - Aikang Medical - Chunli Medical [4]