Core Viewpoint - The company reported 1H25 results that met expectations, with revenue of 1.412 billion yuan, a year-on-year increase of 37.75%, and a net loss attributable to shareholders of 588 million yuan [1] Group 1: Financial Performance - The company's core product revenue was in line with expectations, with product sales reaching 1.402 billion yuan, a year-on-year increase of 49.2% [1] - The gross margin for products was 79.25%, while the sales and marketing expense ratio decreased by 7.1 percentage points year-on-year to 47.80% [1] Group 2: Product Development and Clinical Trials - The company has established a commercialization team of over 1,000 sales personnel to maximize the domestic commercialization potential of its two core products, AK104 and AK112, which have been included in the national medical insurance directory [1] - The final analysis of the HARMONi-A trial showed statistically significant overall survival (OS) benefits for AK112 in treating 2L EGFRm NSCLC, with an OS hazard ratio of 0.80 [2] - AK112 has 13 ongoing registration/Phase III clinical trials globally, covering indications beyond lung cancer, with 8 trials specifically in the lung cancer field [2] Group 3: Profit Forecast and Valuation - The company maintains its profit forecasts for 2025 and 2026, with an upgraded target price of 225.00 HKD, reflecting an 87.5% increase and a 33.1% upside potential [3]

Core Viewpoint - CICC maintains the profit forecast for Kangfang Biopharma (09926) for 2025 and 2026, reiterating an outperform rating and raising the target price by 87.5% to HKD 225.00, indicating a 33.1% upside potential [1] Group 1: Financial Performance - The company's 1H25 revenue reached CNY 1.412 billion, representing a year-on-year growth of 37.75%, aligning with CICC's expectations [1] - The sales revenue of core products in 1H25 was CNY 1.402 billion, with a year-on-year increase of 49.2%, and a gross margin of 79.25%. The sales and marketing expense ratio decreased by 7.1 percentage points year-on-year to 47.80% [2] Group 2: Product Development and Clinical Trials - The final analysis of the HARMONi-A trial demonstrated statistically significant overall survival (OS) benefits for AK112 in treating 2L EGFRm NSCLC, with an OS hazard ratio of 0.80 and a maturity of 52%. This result highlights AK112's potential to significantly improve patient survival in a market with unmet clinical needs [3] - AK112 has 13 ongoing registration/Phase III clinical trials globally, covering indications beyond lung cancer. In the lung cancer domain, it has 8 registration/Phase III studies, with 4 achieving clinical endpoints. Additional trials are underway for various cancers, including biliary cancer and triple-negative breast cancer [4]

Group 1 - The core viewpoint of the report is that the target price for Kangfang Biotech (09926) has been raised by 21.7%, from HKD 115 to HKD 140, while maintaining a "Buy" rating [1] - Key short-term catalysts include: 1) Overseas application and complete data publication of the HARMONi study; 2) Publication of the AK112-306 study at ESMO 2025; 3) Results of multiple product/indication health insurance negotiations in Q4 2025; 4) Progress of more early-stage projects like ADC [1] - The company is optimistic about the overseas approval prospects of Ivosidenib, with a clearer path for it to become a new generation I/O cornerstone drug, replacing PD-(L)1 single-target therapies [1] Group 2 - Cardunili's overseas development has initiated liver cancer research, with the recent approval of its third indication for first-line cervical cancer in the general population, and potential participation in health insurance negotiations later this year [2] - The company is starting a Phase II study of Cardunili in combination with Lenvatinib overseas, with expectations of seeing more assets registered and listed in the next 2-3 years [2] - The differentiated ADC development strategy is progressing well, with the first ADC (HER3) entering clinical trials and the first bispecific ADC AK146D1 completing its first patient enrollment [2]

Group 1 - The National Healthcare Security Administration and the National Health Commission released measures to support the high-quality development of innovative drugs, including 16 policies to enhance the R&D environment and promote innovative drugs into insurance directories [1] - Domestic pharmaceutical companies have made breakthroughs in internationalization, with Dize Pharmaceutical's Shuwotini receiving FDA approval, marking it as the first domestic innovative drug approved for treating EGFR exon 20 insertion NSCLC in the U.S. [1] - The biopharmaceutical industry outperformed the pharmaceutical index and the broader market, with some companies benefiting from the recovery of the upstream pharmaceutical supply chain, indicating a trend of valuation recovery [1] Group 2 - The vaccine industry is facing performance pressure, but improvements in channel inventory may lead to a recovery or continued growth in sales for key vaccine products such as PCV13, diploid rabies vaccine, and MCV4 [1] - Blood product companies are experiencing price pressure post-collection for albumin and some blood products, but the industry is expected to see steady growth in plasma collection volume in 2024, supporting future growth [1] - The expansion of plasma stations and trends in mergers and acquisitions are areas of interest for future developments in the blood products sector [1]

Group 1 - The core viewpoint of the news is that the innovative drug sector in the Hong Kong stock market is experiencing a significant surge, with several companies seeing substantial stock price increases, particularly Huahao Zhongtian Pharmaceutical, which saw its stock price double in just three trading days [1][2][3] - Huahao Zhongtian Pharmaceutical has emerged as a standout performer, with a stock price increase of 55% on July 3 and a total increase of 95% by July 4, driven by its focus on developing innovative cancer drugs [2][3] - Other notable companies in the innovative drug sector include Rongchang Biopharmaceutical, which rose approximately 15% after licensing global development rights for a drug for $4.23 billion, and Basestone Pharmaceuticals, which saw a stock price increase of over 13% after disclosing new drug candidates [3][6] Group 2 - The first half of 2025 is expected to witness a wave of new listings in the Hong Kong biopharmaceutical market, with 10 companies successfully listing, most of which are innovative drug firms [4][5] - Newly listed innovative drug companies have shown impressive performance, with Yingen Biopharmaceutical's stock price soaring by 193.23% since its April 15 listing, and Yaojie Ankang's stock price increasing by 158.17% since its June 23 listing [5] - Analysts are optimistic about the future of the innovative drug sector, citing supportive policies and improvements in the sector's fundamentals as key factors driving the current market momentum [6][7]

Group 1 - The core viewpoint of the news highlights a significant rise in the innovative drug sector, with the Hang Seng Biotechnology ETF (513280) increasing by 3.5% and showing net inflows for 3 out of the last 5 days, making it the only ETF in its index with positive growth in shares this year [1][3] - The A-share innovative drug sector also saw gains, with the Biopharmaceutical ETF (159839) rising by 1.72% [1] - Notable stock performances include Kangfang Biotech rising over 14%, and other companies like Innovent Biologics and CSPC Pharmaceutical Group also showing significant increases [3] Group 2 - Kangfang Biotech announced the completion of the first patient enrollment in the Phase Ia clinical study for its dual-target ADC drug AK146D1, which targets Trop2 and Nectin4 for treating advanced solid tumors [3][4] - AK146D1 is the first dual-target ADC drug to enter clinical stages for Kangfang Biotech, having received approvals from the FDA, TGA, and the National Medical Products Administration for clinical trials [4] - The drug aims to enhance efficacy and reduce resistance and toxicity by targeting both Trop2 and Nectin4, which are promising tumor targets [4] Group 3 - New policies have been introduced to support the development of innovative drugs, including measures from the National Healthcare Security Administration and the National Health Commission aimed at enhancing the quality of innovative drug development [4][5] - The introduction of a commercial health insurance directory for innovative drugs is expected to expand market opportunities and incentivize pharmaceutical companies to increase R&D efforts [5][6] - The measures include optimizing drug directory access policies and promoting the global market development of innovative drugs [5] Group 4 - The Hang Seng Biotechnology ETF (513280) is noted for its high proportion of innovative drugs and is the only ETF in its category to have net inflows this year, with a year-to-date share change of 11.40% [7] - The ETF is also recognized for having the lowest management fees among Hong Kong pharmaceutical ETFs, making it an attractive option for investors [7] - The Biopharmaceutical ETF (159839) focuses on leading companies in the sector, emphasizing a higher concentration and potential for growth [7]

Group 1 - Akeso, Inc. has successfully enrolled the first patient in its Phase Ia clinical trial for AK146D1, a bispecific Antibody-Drug Conjugate (ADC) targeting Trop2 and Nectin4, marking its first bispecific ADC to enter clinical trials [1] - AK146D1 has received approvals from the U.S. FDA, Australia's TGA, and China's NMPA to begin clinical trials, indicating strong regulatory support for the product [1] - Akeso is the only company globally with two approved cancer immunotherapy bispecific antibodies, cadonilimab and ivonescimab, establishing a strong leadership advantage in the IO+ADC space [2] Group 2 - ADC therapeutics are a key component of Akeso's "IO+ADC" 2.0 strategy, which aims to reshape the global treatment landscape and set new standards for cancer care [3] - The company emphasizes the potential of innovative bispecific ADCs like AK146D1 to unlock global clinical opportunities and enhance cancer therapies [4] - Trop2 and Nectin4 are ideal targets for ADC therapy due to their high expression in various tumor types and low expression in normal tissues, which may improve treatment efficacy [4][5] Group 3 - AK146D1 is the first bispecific ADC targeting both Trop2 and Nectin4, with preclinical studies showing strong anti-tumor activity and favorable safety profiles [5] - The development of AK146D1 holds significant potential for improving treatment outcomes for cancer patients, highlighting Akeso's commitment to advancing cancer therapies [5]

Investment Rating - The report maintains an "Outperform" rating for the company [2][11]. Core Insights - The company reported a revenue of RMB 2.13 billion in 2024, a decrease of 53.1%, primarily due to a reduction in licensing revenue, while commercial sales revenue increased by 24.9% to RMB 2.00 billion [3][16]. - The company has effectively managed costs, with a significant decline in expense ratios, leading to a narrowed operating net loss of RMB 660 million, down 16.7% year-over-year [4][18]. - The clinical pipeline is advancing steadily, with key programs such as Cadonilimab and Ivonescimab making progress in various clinical trials [5][19]. Financial Performance - Revenue projections for 2025-2027 are RMB 3.41 billion, RMB 5.45 billion, and RMB 7.31 billion, reflecting year-over-year growth of 60% and 34% in subsequent years [11][34]. - The company is expected to turn a profit in 2025, achieving a net profit of RMB 50 million [11][34]. - The gross profit margin is projected to remain high, with estimates of 92.3% in 2025 and 92.9% in 2027 [15]. Clinical Pipeline Progress - Cadonilimab is involved in multiple clinical trials, including adjuvant treatment for hepatocellular carcinoma and combination therapies for non-small cell lung cancer [5][19]. - Ivonescimab is also progressing in various trials, including first-line treatments for biliary tract cancer and head and neck squamous cell carcinoma [20][23]. - The company has several NDA/sNDA approvals expected in 2025, which could significantly impact revenue and market position [9][25]. Cost Management - The company has demonstrated excellent cost management, with R&D expenses decreasing by 5.3% due to the transition of certain clinical research services to in-house execution [4][18]. - Selling expenses grew at a lower rate than commercial sales revenue, resulting in a decline in the selling expense ratio by 5.5 percentage points [4][18]. Valuation - The target price has been adjusted to HKD 96.6 per share based on a DCF model, reflecting a WACC of 10.0% and a perpetual growth rate of 3.0% [11][34].

Investment Rating - The report maintains a "BUY" rating for Akeso, indicating a potential return of over 15% over the next 12 months [15]. Core Insights - Akeso's FY24 results showed strong cost controls despite a revenue shortfall, with total revenue of RMB2.1 billion, including RMB2.0 billion from product sales, representing a 25% YoY increase [8]. - The company is expected to see product sales surge by 60% YoY to RMB3.3 billion in FY25, driven by the inclusion of AK104 and AK112 in the National Reimbursement Drug List (NRDL) [8]. - AK112 is positioned as a next-generation immuno-oncology (IO) therapy, with pivotal clinical data demonstrating a meaningful progression-free survival (PFS) benefit in a Phase 3 trial against Keytruda for first-line PD-L1-positive non-small cell lung cancer (NSCLC) [8]. - The report highlights ongoing clinical trials for AK112 in various cancer types, including triple-negative breast cancer (TNBC) and pancreatic cancer, indicating a broad first-line strategy [8]. - The target price for Akeso has been raised from HK$58.97 to HK$102.61, reflecting increased sales projections for AK112 [8]. Financial Summary - For FY23A, Akeso reported revenue of RMB4,526 million, with a YoY growth of 440.3%, followed by a projected revenue of RMB2,124 million for FY24A, reflecting a decline of 53.1% [2]. - The net profit for FY23A was RMB2,028.3 million, with a projected net loss of RMB501 million for FY24A [2]. - R&D expenses are projected to be RMB1,306 million for FY25E, increasing to RMB1,937 million by FY27E [2]. - The company held a cash balance of RMB7.3 billion at the end of FY24, sufficient to support ongoing R&D and future commercial expansion [8]. Share Performance - Akeso's current market capitalization is HK$77,191.5 million, with a current price of HK$86.00 and a target price indicating a 19.3% upside [3]. - The stock has shown strong performance, with a 1-month absolute return of 17.9% and a 3-month return of 41.7% [5]. Valuation - The DCF valuation estimates the equity value at RMB 85,652 million, translating to a DCF per share of RMB 95.43 or HK$ 102.61 [9]. - The report includes a sensitivity analysis indicating how changes in the weighted average cost of capital (WACC) and terminal growth rate affect the target price [10].