Core Viewpoint - The article discusses the advancements and applications of artificial intelligence (AI) in the field of biomanufacturing, highlighting various case studies and innovations presented at the SynBioCon 2025 conference [1][44]. Group 1: AI Empowerment in Biomanufacturing - The conference featured a series of activities promoting typical application cases of AI in biomanufacturing, including forums on AI-driven innovations [1][3]. - Shanghai Zhiyu Biotechnology introduced the "ZCloud Biocomputing Platform" and "ZBot Experimental Verification Platform," achieving the production of vanillin through enzyme methods at a scale of hundreds of tons [6]. - Baidu Biotechnology has emerged as a global leader in foundational models for life sciences, showcasing their xTrimoDNA and xTrimoProtein models and applications [7]. Group 2: Innovative Technologies and Applications - Dibil Biotechnology developed an intelligent dynamic and optimization system for microbial culture, enabling real-time prediction of intracellular metabolic flux [10]. - The roundtable discussion emphasized the importance of technology empowerment, scenario innovation, and ecological collaboration to drive high-quality industrial development [13]. - A high-throughput protein engineering platform was established, leading to the discovery of a new gene editing tool with a 40% efficiency increase and the identification of two new industrial enzymes with over ten times the catalytic activity of competitors [16]. Group 3: Future Food and Agriculture - The conference included discussions on the rapid growth of the global functional sugar market and the challenges in obtaining new functional sugars due to unclear biosynthesis pathways [28]. - The research center of Yili Group focused on developing a self-controlled probiotic R&D technology system tailored to the gut microbiome characteristics of the Chinese population [30]. - The report from Henglu Biotechnology highlighted the development of human milk oligosaccharides and their potential applications, with a focus on safety assessments for production strains [32]. Group 4: Industry Trends and Innovations - The article mentions the establishment of China's first enzymatic production line for vitamin A palmitate by Xinhai Biotechnology, which has entered into strategic cooperation for product development [33]. - The report from Zhejiang University discussed the development and application of biotechnology in fine chemical production [34]. - The potential of microalgae as a sustainable food source was emphasized, showcasing advancements in microalgae protein cultivation and its nutritional benefits [43].

Core Insights - The article discusses the completion and operational readiness of Hubei Weiqi's green intelligent manufacturing project for producing 30,000 tons of biodegradable PHA materials annually, with the first phase achieving a production capacity of 10,000 tons [1][2][3] Project Overview - Project Name: Annual production of 30,000 tons of synthetic biological PHA biodegradable materials green intelligent manufacturing project (Phase I) [3] - Construction Unit: Hubei Weiqi Biotechnology Co., Ltd. [3] - Location: Yichang City, Xiaoting District, within the Anqi Biotechnology Park [3] - Nature of Construction: New construction [3] - Total Investment for Phase I: 34 million yuan [3] - Project Area: Approximately 200.86 acres with a total building area of about 34,516 square meters [3] Production Details - Phase I includes the construction of a production facility for 10,000 tons of PHA, along with supporting facilities such as drying workshops and fermentation and extraction workshops [1] - The products produced in Phase I include PHB and P34HB, with a production ratio of approximately 1:2 for PHB and 3,4-HB [1] - Finished products are packaged in various sizes, including 20 kg, 40 kg, 600 kg, and ton bags for sale [1] Environmental Compliance - The project has completed trial operations and has met the designed production capacity, with all environmental protection facilities for wastewater, waste gas, and noise having been tested and functioning properly [2]

Core Viewpoint - The article highlights the transformative potential of synthetic biology in traditional industries, particularly in agriculture, through a strategic partnership between GELEXIMCO Group, Vietnam National University of Agriculture, and Senrise Biotechnology [1][10]. Group 1: Market Overview - The global synthetic biology market is projected to reach $16 billion by 2024, with an annual growth rate of 27% over the past five years [1]. - Vietnam's agricultural market is substantial, with an estimated total output value of around $50 billion in 2024, showing a rising demand for green agricultural bioproducts [4]. Group 2: Strategic Partnership - The collaboration aims to develop and mass-produce synthetic biological products such as ginsenoside, jasmonate, and astaxanthin, focusing on sustainable agricultural practices [1][4]. - This partnership is expected to enhance cooperation between China and Vietnam in cutting-edge biotechnology, injecting new momentum into the green transformation of agriculture in ASEAN [1][10]. Group 3: Company Profiles - GELEXIMCO Group is a significant player in Vietnam's economy, with annual revenues exceeding 200 trillion VND and total assets reaching 800 trillion VND, aiming to establish a competitive synthetic biology platform [6]. - Vietnam National University of Agriculture is a leading institution in agricultural education and research, providing expertise and local insights for the partnership [7]. - Senrise Biotechnology has developed over 70 patents and utilizes AI algorithms and automated platforms for efficient production, focusing on high-yield chassis cells and precision fermentation [8]. Group 4: Societal Impact - The collaboration is expected to significantly contribute to Vietnam's agricultural green transformation and high-quality development by promoting environmentally friendly agricultural practices [10]. - The project will foster talent development in synthetic biology and modern agriculture, establishing a collaborative innovation platform between academia and industry [10].

Core Insights - The Fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) was held in Ningbo, featuring over 60 experts and executives sharing more than 40 presentations on various topics related to bio-manufacturing and green chemistry [2][4]. Group 1: Conference Overview - The conference included four main sessions: macro forum on bio-manufacturing, green chemistry and new materials, AI applications in bio-manufacturing, and future food & agriculture [2]. - Additional activities included a youth forum, high-level discussions on bio-manufacturing, and a closed-door seminar on the "2025 AI Empowering Bio-Manufacturing Industry Innovation Development Blue Book" [2]. Group 2: Keynote Highlights - Zhang Xian'en, Dean of the Synthetic Biology Institute at Shenzhen University, emphasized the rapid development of synthetic biology over the past decade, highlighting AI's role in overcoming the complexity of biological systems [10][11]. - Chen Luoping, Director of the Electronic Information Research Institute, noted that AI in bio-manufacturing presents opportunities for significant advancements, particularly in enzyme design and strain construction, despite existing challenges such as data scarcity and algorithm limitations [12][13]. Group 3: Technological Innovations - Chen Haibin, Vice President of Ningbo Enzyme Bioengineering Co., discussed the company's transition from technological innovation to product innovation, achieving industrial-scale production of small organic acids and bio-based nylon [15]. - Feng Yan, a professor at Shanghai Jiao Tong University, presented breakthroughs in enzyme molecular design and gene editing, which enhance the bio-synthesis of high-value compounds [19]. Group 4: Green Chemistry and New Materials - Wang Dan from Chongqing University addressed the bottlenecks in bio-synthesis of polyamide materials and shared advancements in developing key monomers for industrial applications [23]. - Li Zhen, co-founder of Suzhou Polygen Biotech, highlighted the company's use of straw as a raw material for producing bio-based succinic acid at a scale that is cost-competitive with petrochemical products [28]. Group 5: Industry Collaboration and Future Directions - The conference featured a signing ceremony for a joint laboratory between Shenzhen University and Ningbo Enzyme Bioengineering Co., aimed at fostering collaboration in synthetic biology research [6]. - The high-level discussions focused on the future trends of bio-manufacturing, technological innovation, and industry chain collaboration, aiming for high-quality development in the synthetic biology sector [56].

Core Viewpoint - The establishment of the "Shenzhen University-Ningbo Enzyme Bioengineering Co., Ltd. Joint Laboratory for Computational Protein" marks a significant collaboration aimed at advancing AI-driven synthetic biology research and its industrial applications in pharmaceuticals, energy, and agriculture [1][4][6]. Group 1: Joint Laboratory Focus - The joint laboratory will focus on AI-driven synthetic biology research, emphasizing protein design and optimization, high-performance industrial enzyme development, and the application of these technologies in various industries [4][5]. - Key research directions include computational protein design, computer simulation and intelligent optimization of biosynthetic pathways, and talent cultivation in AI-integrated enzyme engineering [5][6]. Group 2: Industry Impact - The introduction of AI technology is expected to revolutionize traditional research methods in protein design, metabolic engineering, and biosynthesis, aiming to create a programmable and scalable intelligent bio-manufacturing platform [6]. - The collaboration is seen as a model for industry-academia cooperation, leveraging the research strengths of Shenzhen University and the industrial capabilities of Ningbo Enzyme Bioengineering to promote practical applications of synthetic biology [6][7]. Group 3: Company Background - Shenzhen University, established as a new research-oriented institution in 2024, focuses on foundational and cutting-edge scientific research and the cultivation of innovative talents [6][7]. - Ningbo Enzyme Bioengineering Co., Ltd. is a leading synthetic biology company in China, possessing proprietary technologies in protein design and enzyme engineering, with capabilities spanning from laboratory research to industrial production [7]. Group 4: Future Prospects - The collaboration signifies a new phase in AI-driven bio-manufacturing, contributing to the high-quality development of China's bio-economy [8].

Group 1 - The meeting, hosted by Dr. Zhang Lisheng, CEO of DT New Materials, gathered government representatives, research institution leaders, corporate executives, and investment experts to discuss the development trends of biomanufacturing during the 14th Five-Year Plan, technology innovation implementation, and industry chain collaboration [2][5] - Wuhan, as a central city in China, has a strong industrial foundation and innovation ecosystem, with over 92 universities and 1.35 million students, producing more than 300,000 graduates annually who stay for employment and entrepreneurship [4] - The city has gathered over 20 academicians in the biomanufacturing field and has several national-level innovation platforms, showcasing cutting-edge achievements such as "algal imaging" and "rice blood production" [4] Group 2 - The Qing Shan District is focusing on building a modern industrial system and upgrading traditional industries while promoting emerging sectors like hydrogen energy, new materials, and biomedicine [7] - The district has the only new materials industrial park in Wuhan, covering an area of 5.05 square kilometers, and is planning to create a "bio-based materials innovation island" to support synthetic biology enterprises [7] - The East Lake High-tech Zone, known as Optics Valley, has a planned area of 30 square kilometers and an annual industrial revenue exceeding 200 billion yuan, housing over 4,200 companies and 484 high-tech enterprises [9] Group 3 - During the thematic discussion, representatives from 18 companies emphasized the importance of technology innovation, supply chain resilience, and ecological value chains in the biomanufacturing sector [11] - The president of Ningbo Enzyme Science highlighted the critical nature of the pilot testing phase in the long industrial chain of synthetic biology products [13] - The founder of Wuhan Ruijia Kang called for closer integration between biomanufacturing and the chemical industry, urging the government to lead the establishment of an industry chain collaborative ecosystem [13] Group 4 - The meeting served as an efficient platform for synthetic biology enterprises and local governments to connect, showcasing Wuhan's strategic determination and attractiveness in the biomanufacturing field [14] - Wuhan aims to accelerate the gathering of new productive forces in synthetic biology through an open policy environment, a complete industrial ecosystem, and high-quality service guarantees [14]

Core Viewpoint - The article discusses the collaboration between the Ministry of Industry and Information Technology and the National Health Commission to promote innovative biomanufacturing technologies in the food processing sector, aiming to enhance the industrialization and marketization of research outcomes [2][3]. Group 1: Policy and Application Directions - The initiative focuses on collecting innovative biomanufacturing technology applications in areas such as food raw materials, food additives, and food and beverage processing [3]. - The application directions should align with the goal of building a diversified food supply system and have significant promotional value for industry development [3][4]. - Relevant products must be domestically developed, have completed small-scale pilot production or be in large-scale production, and demonstrate safety through research or prior approvals in other regions [4]. Group 2: Submission and Evaluation Process - Entities eligible for recommendation include registered companies, universities, research institutions, and industry associations with good biomanufacturing capabilities and no major safety or environmental incidents in the past three years [5]. - Recommended units must submit a detailed application form along with supporting materials by September 15, 2025, to the Ministry of Industry and Information Technology [6][7]. - The Ministry will organize experts to evaluate the submissions and identify key application directions that are strategically significant, technologically advanced, and have broad application prospects [8]. Group 3: SynBioCon 2025 Conference - The fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22, 2025, in Ningbo, Zhejiang, focusing on AI and biomanufacturing, green chemicals and new materials, future food, and future agriculture [9][10]. - The conference will include various activities such as a youth forum, high-level discussions, and a closed-door seminar on AI-enabled biomanufacturing innovation [9][10]. - The event aims to explore the development trends and growth points of biomanufacturing during the 14th Five-Year Plan period [22].

Core Viewpoint - The fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will focus on four main directions: AI + Bio-Manufacturing, Green Chemistry and New Materials, Future Food, and Future Agriculture [2]. Group 1: Conference Overview - The conference will take place from August 20-22 at the Sheraton Hotel in Donggang, Ningbo, Zhejiang [2][3]. - Various activities will be held concurrently, including a Youth Forum on Bio-Manufacturing, a high-level discussion on the bio-manufacturing industry, and a closed-door seminar for the "2025 AI Empowering Bio-Manufacturing Industry Innovation Development Blue Book" [2][12]. Group 2: Event Schedule - Registration will occur on August 20 from 12:00 to 20:00 and on August 21 from 8:50 to 12:00, where attendees will receive conference materials [7]. - The opening ceremony and macro forum for the bio-manufacturing industry will be held on August 21, followed by specialized forums on green chemistry and AI applications in bio-manufacturing [10][19]. Group 3: Supporting Organizations - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. and supported by various institutions, including Peking University Ningbo Institute of Ocean Medicine and the Ningbo Enzyme Science Bioengineering Co., Ltd. [4][5]. - Strategic media partners and numerous experts from various universities and companies will also participate [5][12]. Group 4: Accommodation and Transportation - Attendees can enjoy special rates at the conference hotel, with prices starting at 400 RMB per night for a standard room [9]. - Transportation options from Ningbo Lishe International Airport and Ningbo Railway Station to the hotel are available, with estimated travel times and costs provided [8]. Group 5: Weather Forecast - The weather forecast for the conference days indicates mostly sunny to partly cloudy conditions, with temperatures ranging from 27°C to 38°C [8]. Group 6: Key Topics and Innovations - The conference will feature discussions on innovative topics such as the synthesis of bio-based carboxylic acids, the application of enzyme molecular engineering, and the design of humanized "4D" collagen proteins [14][38]. - Presentations will also cover advancements in the production of functional sugars, microalgae-based selenium proteins, and the biomanufacturing of natural terpenoids [37][38].

Core Viewpoint - The article highlights the participation of Huo Tong Instruments at the SynBioCon 2025, emphasizing its leadership in high-end reaction kettle and customized reaction synthesis equipment in China [2][21]. Company Overview - Huo Tong Instruments is headquartered in Shanghai, China, with branches in Hefei, Beijing, Guangzhou, and Taiyuan. The company possesses multiple technical patents and has extensive experience in providing complete solutions from design to manufacturing [5]. - The company integrates research and development, production, and sales, supported by a team of experienced technical personnel and professional after-sales service [5]. Product Summary - **100L Polylactic Acid Reaction Device**: A continuous flow reaction device characterized by continuous feeding, reaction, and discharging, offering high mass and heat transfer efficiency, stability, and safety [6]. - **Resin Synthesis Device**: Features dual gas inlets, high-quality flow meters for accurate measurement, and a deep-cooling reaction kettle with a design temperature of -120°C, along with a user-friendly touchscreen control system [9]. - **Esterification and Polycondensation Reaction Device**: Customizable according to client needs, including high vacuum and high-temperature discharge capabilities [11]. - **Dynamic Tubular Reactor**: Designed for high shear dispersion with a dual heat exchange structure, offering a design pressure of 0-2 MPa and temperature range of -15 to 200°C [14]. - **Intelligent Continuous Flow Platform**: A self-developed system centered around micro-reactors, capable of an annual production capacity of approximately 50 tons [17]. Event Details - The SynBioCon 2025 will take place from August 20-22, 2025, in Ningbo, Zhejiang, focusing on AI and bio-manufacturing, green chemistry, new materials, future food, and agriculture [21]. - The event will include various activities such as a youth forum, high-level discussions, and a closed-door seminar on the "2025 AI Empowering Bio-Manufacturing Industry Innovation Development Blue Book" [21][22][23].

Core Viewpoint - The fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will focus on four main directions: AI + Bio-Manufacturing, Green Chemistry and New Materials, Future Food, and Future Agriculture, taking place from August 20-22 in Ningbo, Zhejiang [2]. Group 1: Conference Overview - The conference will include various activities such as a Youth Forum on Bio-Manufacturing, a high-level discussion on the bio-manufacturing industry, and a closed-door seminar for the "2025 AI Empowering Bio-Manufacturing Industry Innovation Development Blue Book" [2]. - The event will be held at the Sheraton Hotel in Donggang, Ningbo, with registration starting on August 20 from 12:00 to 20:00 [7][8]. Group 2: Supporting Organizations - The conference is organized by Ningbo Detai Zhongyan Information Technology Co., Ltd. and supported by several institutions including Peking University Ningbo Institute of Ocean Medicine and the Ningbo Enzyme Bioengineering Co., Ltd. [4][5]. Group 3: Agenda Highlights - The agenda includes a macro forum on the bio-manufacturing industry, thematic forums on green chemistry and new materials, and AI applications in bio-manufacturing [11][20]. - Notable sessions will cover topics such as the design of microbial cell factories and the synthesis of bio-based materials [25][27]. Group 4: Weather and Transportation - The weather forecast for the conference days indicates high temperatures ranging from 36°C to 38°C, with potential for thunderstorms on August 22 [9]. - Transportation options from Ningbo Lishe International Airport and Ningbo Railway Station to the hotel are provided, including estimated costs and travel times [8]. Group 5: Accommodation - Special rates are available for conference attendees at the Sheraton Hotel and nearby hotels, with prices starting from 320 RMB per night [9].