Summary of Key Points Core Viewpoint - On August 11, southbound funds recorded a transaction volume of 115.814 billion HKD, with a net inflow of approximately 0.038 billion HKD, indicating mixed investor sentiment in the Hong Kong market [1]. Group 1: Major Net Buy and Sell Activities - Significant net buying was observed in Xiaomi Group-W (01810.HK) with 5.62 billion HKD, Kangfang Biotech (09926.HK) with 3.06 billion HKD, and Dongfang Zhenxuan (01797.HK) with 1.88 billion HKD [1]. - Major net selling was noted in XPeng Inc. (09868.HK) with 66.496 billion HKD, Innovent Biologics (01801.HK) with 52.789 billion HKD, and Tencent Holdings (00700.HK) with 33.983 billion HKD [1]. Group 2: Individual Stock Performance - Xiaomi Group-W experienced a decline of 0.88% with net buying of 3.70 billion HKD from the Shanghai-Hong Kong Stock Connect and 1.92 billion HKD from the Shenzhen-Hong Kong Stock Connect [1]. - Kangfang Biotech saw a slight increase of 0.25% with a net inflow of 3.06 billion HKD from the Shenzhen-Hong Kong Stock Connect [1]. - Dongfang Zhenxuan rose by 3.32%, with net buying of 2.01 billion HKD from the Shanghai-Hong Kong Stock Connect and a net sell of 131.974 million HKD from the Shenzhen-Hong Kong Stock Connect [1]. - Crystal Tech Holdings (02228.HK) increased by 4.78% with net buying of 1.17 billion HKD from the Shanghai-Hong Kong Stock Connect [2]. - CSPC Pharmaceutical Group (01093.HK) rose by 0.97% with a net inflow of 386.093 million HKD from the Shenzhen-Hong Kong Stock Connect [3]. - Hua Hong Semiconductor (01347.HK) fell by 3.68% with net buying of 360.177 million HKD from the Shanghai-Hong Kong Stock Connect [4]. - XPeng Inc. increased by 5.36% but faced significant net selling of 39.574 billion HKD from the Shanghai-Hong Kong Stock Connect and 26.922 billion HKD from the Shenzhen-Hong Kong Stock Connect [5]. - Innovent Biologics declined by 1.42% with net selling of 30.133 billion HKD from the Shanghai-Hong Kong Stock Connect and 22.656 billion HKD from the Shenzhen-Hong Kong Stock Connect [6]. - Tencent Holdings remained stable with no change in price, but had net buying of 925.043 million HKD from the Shanghai-Hong Kong Stock Connect and net selling of 43.233 billion HKD from the Shenzhen-Hong Kong Stock Connect [6]. - Meituan-W (03690.HK) decreased by 1.32% with net selling of 37.107 billion HKD from the Shanghai-Hong Kong Stock Connect and net buying of 1.06 billion HKD from the Shenzhen-Hong Kong Stock Connect [6].

Core Viewpoint - The article emphasizes the importance of weight management as a national strategy in China, highlighting the need for collaborative efforts across various sectors to address obesity and promote scientific weight loss solutions [10][12][24]. Group 1: Conference Overview - The "2025 Weight Management Industry Conference" was held in Suzhou, gathering over 800 participants from government, medical, research, and retail sectors to discuss the new positioning of weight loss in the Healthy China strategy [2]. - Keynote speeches were delivered by prominent figures, including government officials and industry leaders, focusing on innovative solutions and the construction of a weight loss ecosystem [2][6]. Group 2: Obesity Statistics and Health Impact - According to the "World Obesity Map 2025," over 50% of Chinese adults are overweight or obese, with projections indicating that the population affected will reach 515 million by 2030 [10]. - Obesity is not only a health issue but also a significant social burden, with metabolic syndromes linked to obesity causing economic losses exceeding 100 billion yuan annually [10]. Group 3: Innovative Solutions in Weight Management - The conference announced the launch of the first GLP-1 dual-target weight loss drug, "Masitide," which has shown an average weight loss of 18.6% over 48 weeks and an 80% reduction in liver fat content [6][12]. - The drug's clinical research was published in the New England Journal of Medicine, marking a significant milestone for China's drug development capabilities [12]. Group 4: Collaborative Ecosystem Development - The article discusses the need for a comprehensive weight management system that includes screening, diagnosis, intervention, and management, moving from fragmented attempts to standardized practices [13][14]. - A declaration was signed by leading organizations to support the national weight management initiative, aiming to enhance the weight loss ecosystem and contribute to the Healthy China 2030 strategy [24]. Group 5: Educational Initiatives - A weight loss science book titled "Doctors Teach You Scientific Weight Loss" was published, involving contributions from 88 experts to improve public understanding of obesity and weight management [7][21]. - The conference highlighted the importance of integrating medical, retail, and educational resources to create a holistic approach to weight management [9][19].

Core Viewpoint - The stock price of Innovent Biologics (01801) experienced a decline of 5.37% on August 11, trading at 86.35 CNY per share with a transaction volume of 999.3 million CNY [1] Company Overview - Innovent Biologics focuses on the research, development, production, and sales of innovative drugs targeting major diseases such as tumors, autoimmune diseases, metabolic disorders, and ophthalmology [1] - The company has successfully launched 10 products, with 4 products currently under review and 4 new drug molecules in Phase III or pivotal clinical studies. Additionally, 18 new drug candidates are in clinical research [1] Financial Performance - As of the 2024 annual report, Innovent Biologics reported total revenue of 9.422 billion CNY and a net profit of -94.631 million CNY [1] - The company's patient assistance program has benefited over 170,000 patients, with a total drug donation value of 3.4 billion CNY [1] Upcoming Events - Innovent Biologics is scheduled to disclose its interim report for the fiscal year 2025 on August 27 [1]

Core Viewpoint - The investment value of innovative drugs is not a short-term pulse but a long-term industrial dividend, with optimal solutions for sharing this dividend through index tools in golden tracks [1] Group 1: Performance of Innovative Drug Indices - Since July, the National Index for Hong Kong Stock Connect Innovative Drugs and the China Securities Innovative Drug Industry Index have reached new highs, with year-to-date increases of 106.7% and 32.3% respectively as of July 31 [2] - The impressive performance of these indices reflects a decade-long transformation of China's innovative drug industry from "follower" to "leader" [2] - Recent inflows into ETFs tracking innovative drug indices have been significant, with a net inflow of 4.26 billion yuan from August 4 to August 8 and over 16 billion yuan since June [2] Group 2: Index Adjustments and Sensitivity - The recent upgrade of the Hong Kong Stock Innovative Drug Index aims to enhance its focus by excluding CXO companies and increasing adjustment frequency from semi-annual to quarterly, effective August 12 [3][4] - This adjustment allows the index to better capture the core drivers of the innovative drug industry, focusing on pharmaceutical companies that lead drug development and hold key patents [3] - The increased adjustment frequency enhances the index's sensitivity, enabling it to quickly identify emerging growth companies in a rapidly evolving market [4] Group 3: Policy Support for Innovative Drugs - The innovative drug industry has received significant policy support this year, with the State Council's 2025 strategic goal to create a globally competitive innovation ecosystem [5] - Multiple regulatory bodies have introduced supportive measures, including optimizing review processes and reopening IPO channels for unprofitable companies [6] - The 2024 medical insurance fund expenditure on innovative drugs is projected to be 3.9 times that of 2020, with an annual growth rate of 40% [7] Group 4: Market Dynamics and Future Outlook - By the end of 2024, China is expected to have 3,575 original innovative drugs in clinical trials, surpassing the U.S. and becoming the global leader [7] - The proportion of first-in-class (FIC) drugs has increased from less than 10% in 2015 to 24% in 2024, indicating a significant enhancement in original innovation capabilities [7] - The innovative drug market in China currently accounts for less than 10% of the total pharmaceutical market, indicating substantial growth potential compared to over 20% in other G20 countries [9] Group 5: Investment Opportunities in Innovative Drugs - The China Securities Innovative Drug Industry Index has shown a year-to-date increase of 32.3%, with significant upside potential remaining [8] - The long-term growth of the innovative drug market is supported by an aging population and increasing demand for treatments for chronic diseases and rare diseases [8] - Investing in ETFs that track the innovative drug sector provides a way to mitigate risks associated with individual stock investments while capitalizing on overall industry growth [9]

Investment Rating - The report maintains an investment rating of "Outperform" with a target price set for leading stocks [3][4]. Core Insights - The innovative drug sector is experiencing fluctuations, but several catalysts are anticipated, including academic conferences, business development achievements, and negotiations for medical insurance [2]. - The National Medical Insurance Administration has updated the data on innovative drugs included in the medical insurance directory, showing rapid hospital admissions for several newly included domestic innovative drugs [2][22]. Summary by Sections Weekly New Drug Market Review - From August 4 to August 10, 2025, the top five companies in the new drug sector by stock price increase were: Beihai Kangcheng (+73.1%), Jiahe Biotech (+39.0%), Gilead Sciences (+30.3%), Heyu Biotech (+21.1%), and Hengrui Medicine (+15.3%). The top five companies with the largest declines were: Hutchison China MediTech (-13.8%), Frontier Biotech (-13.4%), Yifang Biotech (-11.7%), Haichuang Pharma (-9.9%), and Maiwei Biotech (-9.2%) [1][16]. Recommended Stocks to Watch - The report suggests focusing on potential overseas licensing opportunities for significant products, including differentiated GLP-1 assets from companies like Zhongsheng Pharma, Kangyuan Pharma, and Gilead Sciences. Additionally, upgraded PD-1 products from Kangfang Biotech and others are highlighted [2][22]. Key Analysis of the New Drug Industry - The report notes that several innovative drugs newly included in the medical insurance directory are rapidly entering hospitals, with notable growth in hospital admissions for drugs such as Zaiqiang Pharma's recombinant thrombin and Hengrui Medicine's Tazemetostat [2][22][23]. New Drug Approval and Acceptance Status - This week, three new drug applications were approved, including Adalimumab injection from Wuhan Biological Products Research Institute, Dulaglutide injection from Shandong Boan Biotech, and Evinacumab injection from Xi'an Janssen [28][29]. Additionally, four new drug applications were accepted, including Trastuzumab injection from Amgen and others [28][30]. Clinical Application Approval and Acceptance Status - A total of 55 new drug clinical applications were approved this week, while 31 new drug clinical applications were accepted [10][31].

Investment Rating - The report maintains an "Overweight" rating for the pharmaceutical and biotechnology sector, indicating a positive outlook for investment opportunities in this industry [5]. Core Insights - The report highlights the ongoing competition in the weight loss drug sector, particularly focusing on the technological advancements and the performance of various companies in this space [14][20]. - It emphasizes the strong performance of innovative drugs, particularly in the context of the pharmaceutical market's overall trends, which remain robust despite some short-term fluctuations [3][16]. - The report outlines a strategic focus on innovative drugs and new technologies, including brain-computer interfaces and AI in medicine, as key areas for investment moving forward [17][18]. Summary by Sections 1. Industry Performance - The pharmaceutical index decreased by 0.84% during the week of August 4-8, underperforming compared to the CSI 300 and ChiNext indices [14]. - The market showed signs of recovery after a previous downturn, with innovative drugs experiencing some volatility but still presenting structural opportunities, particularly in weight loss medications [2][15]. 2. Weight Loss Drug Sector - The report discusses the shift from single-target GLP-1 drugs to multi-target approaches, highlighting the potential of drugs like Retatrutide, which showed a weight reduction of 24.2% in clinical trials [20][25]. - Emerging multi-functional targets such as FGF21 are gaining attention, with companies like GSK making significant investments in this area [22][31]. - The report notes the importance of oral formulations and long-acting drugs to improve patient compliance and market penetration [33][34]. 3. Investment Strategies - The report suggests focusing on overseas large pharmaceutical companies and small to mid-cap technology revolutions as primary investment themes [17][18]. - Specific companies highlighted for investment include Innovent Biologics, BeiGene, and others in the innovative drug space [18][19]. - The report also emphasizes the importance of new technologies, including AI in pharmaceuticals and brain-computer interfaces, as critical areas for future growth [8][9]. 4. Future Outlook - The report maintains an optimistic view for the pharmaceutical sector through 2025, with a focus on innovative drugs and new technologies [17]. - It identifies key themes for investment, including innovative drugs, new technologies, and the restructuring of supply chains [17][18].

Investment Rating - The investment rating for the pharmaceutical industry is "Positive" (maintained) [4] Core Views - The report emphasizes the potential opportunities in the autoimmune dual-antibody sector amidst the ongoing trend of international expansion. It highlights the increasing interest from multinational corporations (MNCs) in Chinese innovative drugs, particularly in the context of patent cliffs faced by leading MNCs [3][8] - The report suggests that the pharmaceutical sector is poised for growth in 2025, driven by several factors including the successful transition from traditional to innovative growth drivers, the increasing capabilities of Chinese companies in international markets, and the rising demand due to an aging population [4][47] Summary by Sections Market Performance - From August 4 to August 8, the pharmaceutical index declined by 0.84%, underperforming the CSI 300 index by 2.07%. Notable gainers included Nanmo Biology (+42.48%), Haichen Pharmaceutical (+41.29%), and Sino Medical (+39.52%). Conversely, Nanxin Pharmaceutical (-18.5%) and Qizheng Tibetan Medicine (-16.11%) were among the largest decliners [5][24] BD Opportunities - The report notes a surge in BD (business development) transactions, particularly in the autoimmune sector, with a total of over 100 license-out transactions in China from January 1 to August 7, 2025, amounting to $840.5 billion. The focus of these transactions has been primarily on oncology and metabolic fields, with a notable lack of activity in the autoimmune sector [9][8] Investment Recommendations - The report recommends focusing on innovative drugs and medical devices, particularly those with low valuations and potential for marginal improvement. Key companies to watch include Heng Rui Pharmaceutical, Keren Pharmaceutical, and Innovent Biologics [4][49] - It also highlights the importance of the aging population and the increasing demand for chronic disease treatments, suggesting that companies like Kunming Pharmaceutical and Yuyue Medical could benefit from this trend [48][47] Valuation Insights - As of August 8, 2025, the overall PE valuation for the pharmaceutical sector stands at 38.77X, indicating that the sector is still at a relatively low historical valuation compared to other sectors [36][47] Future Outlook - The report anticipates a rebound in the pharmaceutical sector in 2025, driven by innovative drugs and the ongoing internationalization of Chinese pharmaceutical companies. It emphasizes the need to focus on sectors with structural growth potential, such as innovative drugs, medical devices, and the aging population market [47][48]

Group 1 - On August 8, several stocks including Hutchison Whampoa, Nanjing Panda Electronics, Oriental Selection, Fubo Group, Zai Ding Pharmaceutical, and Huitongda Network made their debut on the Hong Kong Stock Connect active trading list for the first time in a month [1][2] - The total trading volume of active stocks on August 8 reached 33.757 billion HKD, accounting for 27.32% of the total trading amount on that day, with a net buying amount of 1.614 billion HKD [1] - Among the active stocks, SMIC had the highest trading volume at 11.074 billion HKD, followed by Alibaba and Xiaomi with trading amounts of 3.887 billion HKD and 3.800 billion HKD respectively [1] Group 2 - Hutchison Whampoa had a trading volume of 0.958 billion HKD with a net selling of 0.158 billion HKD, closing down 15.99% [2] - Nanjing Panda Electronics recorded a trading volume of 1.075 billion HKD with a net selling of 0.025 billion HKD, closing down 10.40% [2] - Oriental Selection had a trading volume of 1.024 billion HKD with a net buying of 0.056 billion HKD, closing up 12.32% [2] - Fubo Group had a trading volume of 0.747 billion HKD with a net buying of 0.031 billion HKD, closing up 18.36% [2] - Zai Ding Pharmaceutical had a trading volume of 0.768 billion HKD with a net buying of 0.217 billion HKD, closing down 10.47% [2] - Huitongda Network had a trading volume of 1.758 billion HKD with a net buying of 0.076 billion HKD, closing up 26.90% [2]

Core Viewpoint - The company reported a total product revenue exceeding 5.2 billion yuan in the first half of 2025, representing a year-on-year growth of 35% [1][3]. Revenue Growth - In Q2 2025, the total product revenue surpassed 2.7 billion yuan, showing a year-on-year increase of 30% and a quarter-on-quarter growth of 12.5% [1][3]. - The growth was primarily driven by the oncology segment and the comprehensive product line, with stable growth from main products and an increasing revenue share from new products [3][5]. Profitability Status - The company did not disclose whether it achieved profitability, nor did it provide information on Non-IFRS profit or Non-IFRS EBITDA [3][5]. - In 2024, the Non-IFRS profit and Non-IFRS EBITDA were reported at 332 million yuan and 412 million yuan, respectively, both turning positive for the first time, although the net profit remained negative [5][8]. Product Pipeline - The product pipeline is divided into oncology and comprehensive categories, with oncology being the main revenue source as of 2024 [8][10]. - The company launched five new approved drugs in 2024, including three targeted therapies for lung cancer and the world's first non-covalent BTK inhibitor for blood cancers [9][10]. Future Growth Potential - The company plans to raise 4.3 billion HKD for research and development, focusing on key pipelines like IBI-363 and IBI-343, which have received breakthrough therapy designations [10][15]. - The comprehensive pipeline, particularly the recently approved weight management drug, is crucial for the company's performance in the next two to three years [10][15]. Market Competition - The domestic GLP-1 drug market is becoming increasingly competitive, with 21 GLP-1 drugs already available for various indications as of July 2025 [11][14]. - The CFO indicated that the company will leverage both traditional and online retail channels for the commercialization of its products [14][15]. Long-term Goals - The company aims to achieve a product revenue target of 20 billion yuan by 2027 and plans to have five pipelines enter global multi-center phase III clinical trials by 2030 [15].

Core Insights - On August 8, 2025, SMIC (00981), Alibaba-W (09988), and Xiaomi Group-W (01810) were the top three companies by trading volume in the Southbound Stock Connect, with trading amounts of 6.668 billion, 2.541 billion, and 2.286 billion respectively [1] - In the Southbound Stock Connect for Shenzhen, SMIC (00981), Xiaomi Group-W (01810), and Alibaba-W (09988) also ranked as the top three, with trading amounts of 4.406 billion, 1.514 billion, and 1.346 billion respectively [1] Southbound Stock Connect (Shanghai) - Top active companies by trading volume: - SMIC (00981): 6.668 billion with a net buy of 0.213 billion - Alibaba-W (09988): 2.541 billion with a net buy of 0.398 billion - Xiaomi Group-W (01810): 2.286 billion with a net buy of 0.547 billion - Tencent Holdings (00700): 1.916 billion with a net buy of 0.424 billion - Huizhou Network (09878): 1.758 billion with a net buy of 0.0758 billion - Hua Hong Semiconductor (01347): 1.125 billion with a net sell of 0.336 billion - Nanjing Panda Electronics (00553): 1.075 billion with a net sell of 0.0252 billion - CSPC Pharmaceutical Group (01093): 1.075 billion with a net sell of 0.133 billion - Dongfang Zhenxuan (01797): 1.024 billion with a net buy of 0.0556 billion - Jing Tai Holdings (02228): 0.956 billion with a net buy of 0.0446 billion [1] Southbound Stock Connect (Shenzhen) - Top active companies by trading volume: - SMIC (00981): 4.406 billion with a net sell of 0.639 billion - Xiaomi Group-W (01810): 1.514 billion with a net sell of 0.0745 billion - Alibaba-W (09988): 1.346 billion with a net buy of 0.333 billion - Tencent Holdings (00700): 1.214 billion with a net sell of 0.319 billion - Hutchison China MediTech (00013): 0.958 billion with a net sell of 0.158 billion - CanSino Biologics (09926): 0.893 billion with a net buy of 0.0202 billion - Zai Lab (09688): 0.768 billion with a net buy of 0.0217 billion - Innovent Biologics (01801): 0.759 billion with a net buy of 0.0745 billion - Fufeng Group (03738): 0.747 billion with a net buy of 0.0315 billion - Tracker Fund of Hong Kong (02800): 0.729 billion with a net buy of 0.0684 billion [1]