Group 1 - The core point of the article highlights the recent trading activity of Mindray Medical, which saw a decline of 1.51% in its stock price, closing at 192.16 yuan [1] - A significant block trade occurred on January 27, with a total volume of 41,800 shares and a transaction value of 8.0415 million yuan, indicating a premium rate of 0.11% [1] - Over the past three months, Mindray Medical has recorded 13 block trades, with a cumulative transaction value of 172 million yuan [1] Group 2 - In the last five trading days, the stock has experienced a cumulative decline of 2.46%, with a net outflow of 232 million yuan from major funds [1]

Group 1 - The core transaction of Mindray Medical on January 27 involved a block trade of 41,800 shares, amounting to 8.0415 million yuan, with a transaction price of 192.38 yuan, reflecting a premium of 0.11% over the closing price of the day [2][3] - In the last three months, Mindray Medical has recorded a total of 13 block trades, with a cumulative transaction amount of 172 million yuan [2] - The closing price of Mindray Medical on the day of the transaction was 192.16 yuan, showing a decline of 1.51%, with a daily turnover rate of 0.79% and a total trading volume of 1.848 billion yuan [2] Group 2 - The latest margin financing balance for Mindray Medical is 4.137 billion yuan, which has increased by 154 million yuan over the past five days, representing a growth rate of 3.87% [3] - Mindray Medical was established on January 25, 1999, with a registered capital of 12.1244 billion yuan [3]

| 交易日期 | 证券代码 | 证券简称 | 成交价格 (元) | 成交量 (万股/万份) | 成交金额 买方营业部 (万元) | 卖方营业部 | | --- | --- | --- | --- | --- | --- | --- | | 2026-01-27 | 300760 | 迈瑞医疗 | 192.38 | 4.18 | 804.15 光大证券股份有限 | 光大证券股份有限 | | | | | | | 公司宁波柳汀街证 | 公司宁波柳汀街证 | | | | | | | 券营业部 | 券营业部 | 1月27日，迈瑞医疗大宗交易成交4.18万股，成交额804.15万元，占当日总成交额的0.43%，成交价 192.38元，较市场收盘价192.16元溢价0.11%。 ...

Investment Rating - The report maintains an "Outperform" rating for the pharmaceutical industry [1] Core Insights - The overall and weighted holdings of public funds in the pharmaceutical sector reached a new low since 2018 in Q4 2025, with the pharmaceutical heavy holdings accounting for 8.0% of all public funds, down 1.7 percentage points quarter-on-quarter [2][9] - The total scale of pharmaceutical funds in Q4 2025 was 394.6 billion yuan, a decrease of 9.2% from the previous quarter, with active pharmaceutical funds at 177.7 billion yuan, down 14% [20] - The proportion of passive pharmaceutical funds has increased significantly from 18% in Q1 2018 to 55% in Q4 2025, indicating a shift towards passive investment strategies in the sector [20] Fund Holdings Analysis - In Q4 2025, the pharmaceutical sector saw a decrease in active fund holdings, with active pharmaceutical funds accounting for 33% of the total pharmaceutical heavy holdings, up 2 percentage points, while non-pharmaceutical active funds accounted for 26%, down 5.1 percentage points [3][13] - The top five holdings by market value in public funds included Heng Rui Medicine (31.7 billion), WuXi AppTec (29.6 billion), and Innovent Biologics (16.6 billion) [6] - The top three increases in active fund holdings were for Tigermed (1.7 billion), Yimeng Biologics (1.4 billion), and CSPC Pharmaceutical Group (1.3 billion) [6] Sector-Specific Trends - The report highlights a shift in fund holdings towards innovative drugs and CXO services, while traditional Chinese medicine and high-value consumables are underweighted [6] - The report notes that the proportion of holdings in traditional Chinese medicine and biotech has increased, while holdings in BioPharma and CXO have decreased significantly [6][28] - The overall market value of holdings in the Bio-Tech sector reached 7.25% in Q4 2025, marking the highest level since Q1 2018, with active pharmaceutical funds holding 4.9% [28]

消息面上，2026年1月，印度西孟加拉邦及周边地区再次出现疫情，已有死亡病例，近百名密切接触者被隔离。近期，中国科学院武汉病毒 研究所肖庚富/张磊砢研究员团队、单超研究员团队联合上海药物研究所、旺山旺水生物医药股份有限公司胡天文博士在国际期刊Emerging Microbes & Infections上发表了题为"The oral nucleoside drug VV116 is a promising candidate for treating Nipah virus infection"的重要研究成果， 证实口服核苷类药物VV116对尼帕病毒具有显著的抗病毒活性，为这一高致死性新发传染病的防治带来新希望。该成果首次证实VV116对尼 帕病毒的治疗潜力，不仅可作为医护人员、实验室工作者等高危人群的预防性用药，更可为应对当下和未来的尼帕病毒疫情提供了一个现成 的药物选择。 医药ETF（159929）标的指数热门成分股多数飘绿：沃森生物、智飞生物跌超6%，以岭药业跌超5%，恒瑞医药、迈瑞医疗跌超1%。上涨方 面，三生国健大涨超10%，君实生物-U涨超9%。 消息面上，1月26日，三生国健发布2025年年度业绩 ...

证券日报网讯1月26日，迈瑞医疗（300760）在互动平台回答投资者提问时表示，当今数字化转型已成 为企业发展的核心驱动力。借助数字力量，迈瑞的业务链管理从供应商端至客户端，各环节均实现了协 同合作，更好地保障了产品生产、交付、服务的质量，为迈瑞医疗在全球市场的稳健发展筑牢根基。通 过数字化建设，公司实现了供应链业务全链路运营支撑，可更好地支持经营分析、现金流管理、运营结 果分析、预算管理、以及合规与风险管理流程的运转。公司的供应链驾驶舱整合了各个环节的数据，打 破信息孤岛，确保产品从物料供应到交付的每一环节都符合法规和质量要求。2024年，公司重点强化了 总部与各生产基地的数字化建设、以及海外工厂和仓库的系统对接。针对国内生产基地，新建砀山生产 基地实现了数字供应链系统基础生产业务的全覆盖，并完成了与南京生产基地的系统联通，实现多基地 的生产协同。武汉生产基地数字化系统也已完成并投入运行，支持高值医用耗材业务。在海外，公司启 动了欧洲生产基地数字化系统的本土化建设，打通了国内仓储与欧洲外仓系统，实现高效对接，强化了 区域成品交付能力。凭借坚实的信息化基础，公司继续扩大信息化系统覆盖的范围和深度，建设数字化 ...

Group 1 - The core viewpoint is that innovative drugs are expected to show significant excess returns in 2025, driven by continuous BD overseas expansion, excellent clinical data, and policy support [1] - The CXO sector is anticipated to experience substantial growth due to the recovery in demand and improved investment environment in the global pharmaceutical industry [1] - The report emphasizes the importance of focusing on new technologies, particularly bispecific antibodies, small nucleic acid drugs, AI healthcare, and brain-computer interface innovations [3] Group 2 - Domestic supply and demand are relatively stable, with national health expenditure showing a year-on-year growth of 4.7% from January to November 2025, marking a positive turnaround after two years of decline [2] - The medical insurance fund's income and expenditure growth rates continue to decline, with total income of 2.63 trillion yuan (+2.9%) and expenditure of 2.11 trillion yuan (+0.5%) from January to November [2] - The report suggests that the commercialization of new drug forms is entering a critical phase, with significant clinical data supporting the application of B-cell depletion therapies in autoimmune diseases [3] Group 3 - Investment recommendations include focusing on innovative overseas expansion and new technology directions, with suggested stocks such as Mindray Medical, WuXi AppTec, and others [4] - The report highlights the potential for explosive growth in the global market for brain-computer interfaces, supported by policy incentives and technological breakthroughs [3]

截至2026年1月27日 10:12，中证医药及医疗器械创新指数(931484)成分股方面涨跌互现，三生国健领涨 8.29%，大博医疗上涨6.58%，特宝生物上涨2.64%；神州细胞领跌。医疗创新ETF(516820)最新报价0.36 元。 国信证券指出，2025年创新药板块呈现显著超额收益，核心驱动力来自BD出海密集落地、临床数据持 续超预期及政策端支持；展望2026年，具备全球竞争力、差异化创新能力及已实现高质量授权的创新药 企业仍具长期配置价值。荣昌生物PD-1/VEGF双抗RC148获艾伯维6.5亿美元首付款、最高达49.5亿美元 的重磅授权交易，进一步验证中国ADC平台型企业的国际商业化能力。 医疗创新ETF紧密跟踪中证医药及医疗器械创新指数，中证医药及医疗器械创新指数从医药卫生行业的 上市公司中，选取30只盈利能力较好且具备一定成长性和研发创新能力的上市公司证券作为指数样本， 以反映兼具盈利性与成长性的医药及医疗器械上市公司证券的整体表现。 数据显示，截至2025年12月31日，中证医药及医疗器械创新指数(931484)前十大权重股分别为药明康 德、恒瑞医药、迈瑞医疗、爱尔眼科、片仔癀、新和成、华 ...

Investment Rating - The report maintains an "Outperform" rating for the pharmaceutical and biotechnology sector [5] Core Views - The pharmaceutical sector underperformed the overall market, with a 0.39% decline in the biopharmaceutical sector compared to a 1.17% increase in the overall A-share market [32] - The TTM price-to-earnings ratio for the pharmaceutical sector is 38.51x, which is at the 84.35 percentile of the historical valuation over the past five years [32][37] Summary by Sections Market Performance - The overall A-share market increased by 1.17%, while the Shanghai and Shenzhen 300 index decreased by 0.62%. The biopharmaceutical sector saw a decline of 0.39% [32] - Among sub-sectors, chemical pharmaceuticals fell by 1.11%, while medical services dropped by 2.17%. Conversely, medical commercial and traditional Chinese medicine sectors saw increases of 4.26% and 0.89%, respectively [32] Fund Holdings Analysis - As of Q4 2025, the net asset value of pharmaceutical funds reached 358.4 billion, a decrease of 9.0% from the previous quarter [11] - The proportion of pharmaceutical holdings in all funds was 7.97%, down by 1.71 percentage points [16] - The largest sub-sectors by holdings were chemical preparations (37.5%) and other biological products (20.8%) [19] Key Company Earnings Forecasts and Investment Ratings - Major companies such as Mindray Medical (237 billion market cap, outperform rating), WuXi AppTec (293.6 billion market cap, outperform rating), and Aier Eye Hospital (105.4 billion market cap, outperform rating) are highlighted for their strong earnings forecasts [4] - The report lists several companies with outperform ratings, including New Industry, Huatai Medical, and others, with projected earnings growth over the next few years [4] Investment Strategy - The report emphasizes the importance of the CXO sector and recommends focusing on investment opportunities within this area due to its competitive advantages [41] - It also suggests continued recommendations for innovative drugs and the associated industry chain, with a specific investment portfolio for January 2026 including companies like Mindray Medical and WuXi AppTec [42][43]

Core Insights - The report emphasizes the importance of innovation in the pharmaceutical and biotechnology industry, particularly focusing on the overseas expansion of innovative drugs and the adoption of new technologies [1][4]. - The investment rating for the sector is maintained at "outperform the market" [2]. Group 1: Market Overview and Trends - The overseas market for innovative drugs and the CXO industry is expected to perform exceptionally well in 2025, driven by continuous business development (BD) activities, strong clinical data, and supportive policies [4]. - The domestic supply and demand remain stable, with a shift in payment systems favoring innovation. National health expenditure increased by 4.7% year-on-year in the first 11 months of 2025, marking a recovery after two years of decline [4]. - The report highlights the significant growth potential in new drug forms such as dual antibodies and small nucleic acid drugs, as well as innovations in AI healthcare and brain-machine interfaces [4]. Group 2: Investment Recommendations - The report recommends focusing on companies with global competitiveness and differentiated innovation capabilities, as well as domestic CXO leaders with high barriers in cost control, technology accumulation, and production capacity [4]. - Recommended stocks include Mindray Medical, WuXi AppTec, Kelaiying, Aier Eye Hospital, and several others, with specific mention of H-shares like Kelun-Bio and CanSino Biologics [4][5]. Group 3: Financial Performance and Projections - The report provides a detailed strategy portfolio for 2026, listing companies along with their projected net profits and price-to-earnings (PE) ratios, indicating a generally positive outlook for the sector [5]. - The pharmaceutical sector's overall performance in 2025 was strong, with significant gains in sub-sectors such as medical services and chemical pharmaceuticals, driven by BD collaborations and clinical data releases [12][23]. Group 4: Fund Holdings and Market Sentiment - As of Q4 2025, the net asset value of pharmaceutical funds decreased by 9.0%, with a notable shift where passive funds surpassed active funds for the first time since 2019 [25][32]. - The report indicates a decline in the proportion of pharmaceutical holdings in both active and non-pharmaceutical funds, with a concentration in chemical preparations and other biological products [32][40].