Core Viewpoint - The source of dietary fat significantly influences anti-tumor immunity in obese individuals, with animal fats impairing immune response and promoting tumor growth, while plant fats do not have this negative effect [5][7][9]. Group 1: Research Findings - A study published in Nature Metabolism indicates that high-fat diets based on animal fats (lard, beef tallow, or butter) weaken anti-tumor immunity in obese mice and accelerate tumor growth [5][7]. - In contrast, high-fat diets based on plant oils (coconut oil, palm oil, or olive oil) do not exhibit this detrimental effect, with palm oil even enhancing anti-tumor immunity and slowing tumor growth in obese mice [5][7][9]. - The research highlights that the metabolic byproducts of animal fats, particularly long-chain acylcarnitines, strongly inhibit NK and CTL cells, leading to impaired immune function [9]. Group 2: Implications for Cancer Treatment - The findings suggest that dietary modifications, such as replacing animal fats with plant oils, could be beneficial for obese cancer patients undergoing treatment, potentially lowering their cancer risk [5][6][9]. - The study emphasizes the importance of dietary fat composition in maintaining a healthy immune system and improving treatment outcomes for obese individuals with cancer [9].

Core Viewpoint - The article reflects on the life and philosophy of the late writer Cai Lan, emphasizing his carefree and hedonistic approach to life, which includes enjoying food, drink, and the beauty of the world around him [2][86]. Group 1: Life Philosophy - Cai Lan believed in living life to the fullest, stating that "living day by day" is essential, and he embraced a carefree attitude towards aging and life's uncertainties [15][62]. - He expressed that physical pain can be managed, but emotional pain is self-inflicted, advocating for a mindset that avoids dwelling on sorrow [11][12]. - His approach to life included a focus on enjoying the present, as he stated, "so beautiful scenery, so beautiful place, if not enjoy now, isn't it a pity!" [13][73]. Group 2: Attitude Towards Relationships - Cai Lan had a unique perspective on relationships, stating he had no regrets about not having children and preferred to enjoy life without attachments [20][21]. - He often discussed love and relationships candidly, suggesting that one should not blindly pursue love at the expense of their own life [55][70]. - His views on societal norms, such as the concept of "leftover women," were progressive, encouraging women to enjoy life without the pressure of marriage [67]. Group 3: Views on Food and Enjoyment - Cai Lan's love for food was profound, equating the enjoyment of food with a respect for life, and he believed in indulging in culinary experiences [76][78]. - He famously stated that "to be a foodie, one must sacrifice a bit of health," highlighting his belief that pleasure in food is paramount [80]. - His culinary philosophy included a willingness to try all kinds of food, even those deemed unhealthy, as long as they brought joy [82][83]. Group 4: Legacy and Influence - Cai Lan was known for his candid and humorous interactions with the public, often sharing wisdom through social media, which resonated with younger generations [48][62]. - His contributions to Hong Kong's cultural landscape, including his role in television and film, established him as a significant figure in the entertainment industry [25][28]. - The article concludes with a reflection on the end of an era with Cai Lan's passing, marking the loss of a literary and cultural icon [86].

Core Viewpoint - The negative impacts of the U.S. tariff policy have exceeded market expectations, causing troubles for the U.S. economy and increasing uncertainty in the global economy, reminiscent of the disastrous effects of the Smoot-Hawley Tariff Act in the 1930s [1][7]. Historical Context - The Smoot-Hawley Tariff Act, initiated in 1929, aimed to protect U.S. agricultural interests by significantly raising tariffs on over 20,000 imported goods, with rates reaching as high as 60% [2][3]. - The act faced strong opposition from academia and business but was signed into law by President Hoover, leading to retaliatory tariffs from other countries and igniting a global trade war [2][3]. Economic Consequences - Following the implementation of the Smoot-Hawley Tariff, U.S. imports from Europe plummeted from $1.334 billion in 1929 to $390 million in 1932, while exports dropped from $2.341 billion to $784 million, resulting in a 67% decrease in trade volume [3]. - The U.S. unemployment rate soared to 25.1% by 1933, and the Dow Jones Industrial Average fell by 89% from its peak in 1929 [3][4]. - The global trade volume and industrial output also suffered, with a 66% decline in global trade and a 33% drop in industrial output by 1934 [3][4]. Modern Implications - The current U.S. tariff policies, initiated under the Trump administration and continued by the Biden administration, have not achieved their intended goals of manufacturing return or trade deficit reduction, instead causing economic damage and loss of credibility [7][8]. - The U.S. agricultural sector faces estimated annual losses exceeding $12 billion due to these tariffs, which are ultimately passed on to consumers, exacerbating inflation risks [7][8]. Global Trade Dynamics - The persistence of high tariffs distorts price signals and hinders global productivity, leading to long-term economic damage [8]. - In today's highly specialized and integrated global economy, the negative impacts of protectionism spread rapidly, disrupting global supply chains and hindering economic growth [8][9].