Core Viewpoint - Princeton University's research team has developed an innovative "curved wave" system capable of transmitting ultra-high frequency signals rapidly and stably, addressing the challenges posed by the increasing demand for data and the Internet of Things [1][2]. Group 1: Technology and Innovation - The new system utilizes a neural network to dynamically shape the transmission path of wireless signals, allowing them to bypass obstacles and maintain stable, high-speed communication [1]. - The technology focuses on the sub-terahertz frequency band, which has the potential to transmit ten times the data volume of current wireless systems, making it crucial for high-bandwidth applications such as virtual reality and fully autonomous vehicles [1]. - Traditional methods rely on external reflectors to navigate around obstacles, which are often unreliable or difficult to deploy in real-world scenarios [2]. Group 2: Methodology - The research team employs a special radio wave technology known as "Airy beams," which can propagate along curved trajectories rather than in straight lines, enabling effective transmission in non-line-of-sight conditions [2]. - A neural network is introduced to select and optimize the best curved path in real-time, similar to how professional basketball players make shooting decisions based on experience rather than complex calculations [2]. - A high-fidelity simulator was developed to allow the neural network to learn efficiently in a virtual environment, adapting to various obstacle layouts and dynamic changes [2]. Group 3: Future Implications - This work addresses a long-standing challenge in high-frequency wireless communication within dynamic environments, paving the way for future transmitters to intelligently navigate complex settings [2]. - The advancements in this technology are expected to support ultra-fast and highly reliable wireless connections for applications that are currently difficult to realize, such as immersive virtual reality and fully autonomous transportation [2].

Core Viewpoint - Recent advancements in gene editing technology, particularly through pioneering editing techniques, show promise in treating severe neurological diseases, although significant technical and funding challenges remain to be addressed [1][4]. Group 1: Breakthroughs in Gene Editing - Harvard University and Jackson Laboratory successfully utilized pioneering editing technology to correct pathogenic gene mutations in a mouse model of Alternating Hemiplegia of Childhood (AHC), achieving an 85% mutation correction rate [2]. - The treatment led to significant improvements in the mice's brain function, reducing seizure frequency and doubling their lifespan, alongside enhancements in motor and cognitive abilities [2]. - A separate team, led by Professor Qiu Zilong, demonstrated the ability to reverse behavioral abnormalities in MEF2C mutation mice using base editing technology, which is crucial for addressing epilepsy and developmental disorders in children [2][3]. Group 2: Safety and Feasibility - The precision of gene editing technology allows for targeted correction of pathogenic mutations, making it an ideal treatment for neurodevelopmental disorders and autism in children [3]. - The pioneering editing technique requires only a single brain injection for treatment, with minimal off-target effects, confirming its safety and feasibility [3]. - The technology has shown the capability to simultaneously correct five mutations, indicating its broad applicability [3]. Group 3: Challenges Ahead - Despite promising results in mouse models, significant hurdles remain before gene editing can benefit human patients, including the need for advanced delivery systems to target brain cells effectively [4]. - The use of adeno-associated virus 9 (AAV9) as a delivery vehicle poses risks of severe immune reactions at high doses, necessitating the development of improved viral vectors and exploration of non-viral delivery methods [4]. - The biotechnology sector is currently facing a funding crisis, which complicates the lengthy and complex development processes for gene therapies, potentially deterring investors [5].

Core Insights - The Baocai Energy Storage Station, China's first large-scale lithium-sodium hybrid energy storage facility, has achieved a cumulative charge and discharge volume of over 100 million kilowatt-hours, significantly supporting the integration of renewable energy into the power grid [1][2] Group 1: Project Overview - The Baocai Energy Storage Station, located in Yunnan, covers an area of approximately 50 acres and has a capacity of 200 megawatts/400 megawatt-hours, featuring 52 independent energy storage systems [1] - Since its commissioning in May, the station has recorded a total charge and discharge volume of 103 million kilowatt-hours and has been activated 272 times, maintaining a high-frequency operation of "two charges and two discharges" daily [1] Group 2: Technological Innovations - The Baocai Energy Storage Station serves as a pilot demonstration project for new energy storage technologies, achieving the world's first applications of various systems, including the "global first set of network-type sodium-ion energy storage systems" and the "world's largest single high-voltage direct-connected network-type energy storage system" [1] - The station utilizes five differentiated network-type energy storage technology routes, promoting the transition of new energy storage technologies from pilot demonstrations to mature applications [1] Group 3: Operational Impact - The station has enhanced the power grid's capacity to manage fluctuations, equivalent to the effect of 400,000 household air conditioners operating simultaneously, thereby stabilizing the integration of renewable energy from over 30 wind and solar power plants [1] - With Yunnan's installed renewable energy capacity exceeding 68 million kilowatts and a penetration rate nearing 70%, the Baocai Energy Storage Station plays a crucial role in supporting the high proportion of renewable energy in the power system [2]

Core Insights - Anhui Wanrui Cold Electric Technology Co., Ltd. has developed a low-temperature refining and neon removal device that achieved helium purity of 99.99997% (6N9 grade) at a natural gas helium extraction project site in Yan'an, Shaanxi [1] - This device is the first of its kind in China to extract ultra-pure helium from natural gas, marking a significant breakthrough in the low-abundance natural gas helium extraction field [1] - Helium is a non-renewable strategic resource essential in various fields such as large scientific installations, advanced medical applications, and aerospace, often referred to as the "blood of industry" [1] Technology and Process - The research team has pioneered a new "combined method" helium extraction process that integrates four stages: hydrogen removal, membrane separation, pressure swing adsorption, and low-temperature refining [1] - The process begins with catalytic hydrogen removal to enrich helium, followed by membrane separation and pressure swing adsorption to eliminate nitrogen, methane, and other impurities, and concludes with a 30K deep low-temperature refining process to remove neon impurities [1] Operational Capacity - The device can operate continuously for 24 hours without downtime, with an annual extraction capacity of 400,000 cubic meters of high-purity helium [2]

据了解，白鹤滩水电站安全监测自动化系统各项指标均满足并优于规范要求，获得了验收专家的一致认 可。该系统不仅为白鹤滩水电站的安全运行提供了智能化保障，更为世界巨型水电水利工程的安全监测 自动化提供了中国方案和"白鹤滩智慧"。 记者从三峡集团获悉，近日，国家能源局大坝安全监察中心组织权威专家组，对白鹤滩水电站安全监测 自动化系统进行实用化验收并一致通过。这标志着这套堪称"超级安全大脑"的系统正式全面投入运行， 为这座国之重器配备了全天候、智能化的"中枢神经"。 白鹤滩水电站安全监测自动化系统规模创下全球水电站之最，共接入11287台（套）监测设备。这些遍 布大坝、地下厂房、工程边坡等关键部位的"神经末梢"，通过自动化数据采集，实时捕捉变形、渗流、 应力应变和温度等关键信息，经由专用网络传输至信息系统平台，实现全流程的智能处理、分析评价与 自动预警。 未来，白鹤滩水电站将以这套"超级安全大脑"为核心，加快数字孪生、人工智能等新一代信息技术与大 坝安全管理的融合创新，不断提升水电站本质安全水平，为保障国家能源安全和推动水电行业高质量发 展贡献更大力量。（何亮） 责任编辑：于彤彤 ...

Core Viewpoint - The event in Wuhan on August 18 celebrated the eighth Chinese Physician's Day and showcased the first batch of 112 core medical technologies, aiming to create a quality platform for medical technology innovation [1][2]. Group 1: Medical Technology Highlights - A total of 112 core medical technologies were released, categorized into three levels: 32 "Leading Technologies," 40 "Pioneering Technologies," and 40 "Fundamental Technologies" [1]. - "Leading Technologies" include world-first innovations such as the "Chen's pancreatic-intestinal anastomosis" technique and the "micro life pump" providing the lightest artificial heart globally [1]. - "Pioneering Technologies" feature advancements like a corneal transplantation technique that can treat three patients with one donated cornea and a "bionic multi-organ chip" technology that can replace human drug testing [1]. - "Fundamental Technologies" focus on widely applicable techniques, such as a "super minimally invasive" technique for immediate stone removal and a technique for acute ischemic stroke intervention that can be taught to clinicians through short-term training [1]. Group 2: Support Measures and Competitive Edge - The Wuhan Municipal Health Commission plans to implement support measures in platform construction, insurance policies, professional title promotions, funding, and publicity to enhance the impact of these technologies [1]. - The evaluation of core medical technologies highlights Wuhan's competitive edge in various fields, particularly in hepatobiliary and gastrointestinal diseases, gynecological tumors, organ transplantation, cardiovascular diseases, and urological diseases [2]. - The application of cutting-edge technologies such as brain-computer interfaces, artificial intelligence, stem cell therapy, and biomaterials in Wuhan demonstrates significant breakthrough potential [2].

Core Insights - A research team led by Fudan University and Seoul National University has developed a potential precision treatment strategy for hereditary hearing loss, recently published in the journal Nature Communications [1][2] - Hearing impairment is one of the most common sensory disorders, affecting approximately 430 million people globally, which is about 5% of the world's population [1] - The study identified MPZL2 gene mutations as a common cause of hereditary mild to moderate sensorineural hearing loss (SNHL) in East Asian populations, with specific mutations showing a founder effect [1] Group 1 - The research involved a systematic etiological analysis of 1,437 unrelated hereditary hearing loss families, identifying pathogenic genes in 155 patients, with 24 cases linked to MPZL2 mutations, accounting for 15.5% [1] - Among the identified cases, 23 patients carried at least one c.220C>T allele mutation, representing a high prevalence of 95.8%, suggesting it may be a founder mutation in East Asia [1] Group 2 - The team created a humanized mouse model that replicated the auditory phenotype of human patients with MPZL2 gene mutations [2] - A novel adenine base editor system with enhanced flexibility was developed, successfully correcting the abnormal expression of the MPZL2 gene, leading to significant hearing recovery in the mouse model for at least 20 weeks without noticeable off-target effects [2] - This research not only offers a potential treatment strategy for hereditary hearing loss but also expands the application of single-base editing technology in genetic diseases [2]

在肿瘤免疫与代谢干预相结合的探索中，仲雷团队首次创立了"代谢干预联合免疫激活的双金属炸 弹"新策略。针对免疫治疗在部分患者中应答率低的瓶颈现象，他们采用一步法技术手段，合成了具有 双金属成分的纳米材料。该材料深入肿瘤组织后可快速释放金属离子，阻断癌细胞能量代谢通路，使其 失去生长能力；同时释放信号分子，触发免疫系统识别并攻击残余肿瘤细胞。小鼠实验中，该策略的肿 瘤抑制率超过90%，且再次接种肿瘤细胞后，小鼠体内仍可维持长效免疫记忆，无肿瘤复发出现。 专家评论称，仲雷团队的这些研究成果构建了由局部精准杀伤到全身免疫激活的多层次纳米抗肿瘤 体系，为今后肿瘤精准诊疗和个体化管理提供了新思路、新方法。 仲雷团队长期聚焦纳米材料在抗肿瘤领域的应用研究。在光热—化学协同治疗领域，针对传统光热 治疗能量利用不足、肿瘤残留易复发等难题，团队设计出一种基于过渡金属二维碳氮化物的新型材料， 兼具光热与催化活性。在近红外光照射下，这种材料能够温和升温至肿瘤细胞的耐受极限，同时催化肿 瘤微环境中的过氧化氢分解生成大量具有强氧化作用的活性氧，达到物理与化学双重杀伤肿瘤细胞的效 果。动物实验结果显示，利用该材料小鼠肿瘤体积两周内缩小超过 ...

Core Findings - A large-scale exome sequencing study conducted by Cardiff University identified 8 new risk genes associated with schizophrenia, providing important insights into the neurobiological mechanisms of the disease and potential pathways for future drug development [1] Genetic Analysis - The research analyzed genetic data from 28,898 patients, 103,041 healthy controls, and 3,444 affected families, focusing on rare protein-coding gene mutations unique to the patient population [1] - Significant associations were found with the genes STAG1 and ZNF136, while moderate associations were noted with SLC6A1, KLC1, PCLO, ZMYND11, BSCL2, and CGREF1 [1] Mechanisms of Schizophrenia - SLC6A1 and KLC1 were identified as the first genes linked to schizophrenia solely through missense mutations, indicating that disruptions in GABA neurotransmitter communication and abnormal DNA spatial organization may be critical pathogenic mechanisms [1] - The study also revealed genetic commonalities between schizophrenia and other neurodevelopmental disorders, suggesting that these genes are key pieces in understanding the complex genetic network of schizophrenia [1]

研究还发现了一个引人注目的现象：当培养温度从常规的37℃降至34℃（接近睾丸生理温度）时， 无论是源自男性还是女性iPSC的细胞，进入减数分裂的效率均显著提高。这一结果挑战了低温仅有利 于精子生成的传统认知，为未来构建人工卵巢微环境提供了重要线索。 此次团队另辟蹊径，完全绕过PGC阶段，直接激活减数分裂程序。他们通过基因工程改造干细胞， 使其一旦启动减数分裂便发出荧光信号，便于实时监测。随后，他们又系统筛选了多种基因组合，并结 合两种小分子化合物，显著提升了减数分裂的诱导效率。 经过对超过64万个细胞的高通量测试，团队鉴定出3个关键调控基因：BOLL、MEIOC和HOXB5。 令人意外的是，HOXB5此前并未被明确关联到减数分裂过程里，而此次发现揭示了其潜在的重要作 用。 实验结果显示，在优化条件下，细胞可在约12天内完成减数分裂的前两个阶段——细线期和偶线 期。到第15天，部分细胞进入粗线期，实现遗传物质交换。这是人类细胞在体外首次被明确诱导进入这 一核心生殖过程。 科技日报北京8月18日电 （记者张梦然）一项由美国哈佛大学Wyss研究所与哈佛医学院联合开展的 突破性研究，首次在体外引导人类诱导多能干细胞（ ...