Ke Ji Ri Bao
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再生医学在脑修复领域迈出关键一步 干细胞移植逆转动物中风损伤
Ke Ji Ri Bao· 2025-09-25 23:54
Core Insights - A breakthrough in regenerative medicine has been achieved by a research team from the University of Zurich, demonstrating the ability to reverse brain damage caused by stroke through stem cell transplantation, promoting neuron regeneration and significantly restoring motor function [1][2] Group 1: Research Findings - One in four adults will experience a stroke in their lifetime, with about half suffering long-term consequences such as paralysis or speech disorders due to irreversible brain cell death caused by hemorrhage or hypoxia [1] - The research utilized human-induced pluripotent stem cell-derived neural stem cells, which can be reprogrammed from ordinary somatic cells and have the ability to differentiate into various neural system cells [1] - In animal models, the team induced permanent brain damage similar to that in humans and transplanted neural stem cells into the damaged area one week post-stroke, tracking changes for five weeks [1][2] Group 2: Regeneration Effects - The transplanted stem cells survived in the damaged brain area, with most differentiating into mature neurons that established functional connections with the host's existing neural network, indicating successful integration into brain operations [1] - The team observed widespread regeneration effects, including the formation of new blood vessels, significant reduction in brain inflammation, and restoration of blood-brain barrier integrity, revealing how transplanted cells activate the brain's "regeneration program" [2] Group 3: Future Applications - Collaboration with Kyoto University ensures that all stem cells are prepared without using animal-derived reagents, laying the groundwork for safe human applications [2] - A critical finding is that transplantation is more effective when performed one week after the stroke, providing a valuable preparation window for clinical treatment [2] - The team is developing a "safety switch" system to minimize potential risks and optimize the technology for human application, allowing for the termination of stem cell proliferation if necessary [2]
中国风电产业:从追风者到全球领航者
Ke Ji Ri Bao· 2025-09-25 23:54
Core Viewpoint - The article highlights the significant advancements and contributions of China's wind power industry, emphasizing its global leadership in installed capacity and technology, while countering misconceptions about its domestic usage of wind energy [1][4]. Group 1: Industry Growth and Achievements - China's wind power industry has experienced a remarkable growth from 340,000 kilowatts in 2000 to 521 million kilowatts in 2024, representing an increase of over 1500 times [2]. - In 2024, China's wind power generation reached approximately 991.6 billion kilowatt-hours, marking a 16% year-on-year growth, with an average utilization rate of 95.9% [2]. - By 2024, China's offshore wind power capacity reached 43.31 million kilowatts, maintaining its position as the global leader for four consecutive years [2]. Group 2: Global Market Impact - In 2024, China accounted for 68.2% of the global new wind power installations, with a total installed capacity of 521 million kilowatts, representing 45.8% of the global total [3]. - Chinese-made wind turbines have been exported to over 40 countries, significantly contributing to global energy transition efforts [3]. Group 3: Future Projections - By 2035, China aims to increase its total installed capacity of wind and solar power to over six times that of 2020, targeting 360 million kilowatts [4]. - The Chinese government is committed to reducing greenhouse gas emissions by 7% to 10% from peak levels across the economy by 2035, with non-fossil energy consumption expected to exceed 30% of total energy consumption [4]. Group 4: Technological Leadership - China is recognized as the largest manufacturer and user of wind power equipment globally, with significant advancements in technology and sustainable development practices [4][5]. - Experts affirm that China's comprehensive approach to sustainable development in wind and solar energy positions it as a global benchmark in the industry [4].
再生医学在脑修复领域迈出关键一步:干细胞移植逆转动物中风损伤
Ke Ji Ri Bao· 2025-09-25 23:09
Core Insights - A breakthrough in regenerative medicine has been achieved by a research team from the University of Zurich, demonstrating the ability to reverse brain damage caused by stroke through stem cell transplantation, promoting neuron regeneration and significantly restoring motor function [1][2] Group 1: Research Findings - The study published in Nature Communications indicates that one in four adults will experience a stroke in their lifetime, with about half suffering from long-term sequelae such as paralysis or speech disorders due to irreversible brain cell death [1] - The research utilized human-induced pluripotent stem cell-derived neural stem cells, which can be reprogrammed from ordinary somatic cells and have the ability to differentiate into various neural system cells [1] - In the experiment, a permanent brain injury similar to that in humans was induced in genetically modified mice, which do not reject transplanted human cells [1] Group 2: Results of Stem Cell Transplantation - The transplanted stem cells successfully survived in the damaged brain area, with most differentiating into mature neurons that established functional connections with the host's existing neural network, indicating integration into the brain's operational system [2] - A broad regeneration effect was observed, including the formation of new blood vessels in the damaged area, a significant reduction in brain inflammation, and restoration of the blood-brain barrier integrity [2] - The collaboration with Kyoto University ensured that all stem cells were prepared without using animal-derived reagents, laying the groundwork for future safe applications in humans [2] Group 3: Clinical Implications - The research highlights a critical one-week window for transplantation post-stroke, suggesting that delayed intervention may yield better outcomes, providing a valuable preparation period for clinical treatment [2][3] - The study opens new clinical prospects by achieving biological repair of structural brain damage rather than merely alleviating symptoms, potentially offering a treatment paradigm for other neurodegenerative diseases such as Parkinson's or spinal cord injuries [3] - Future human trials could significantly alter the landscape of neuro-rehabilitation medicine if the efficacy of this approach is validated [3]
阿尔茨海默病会遗传吗
Ke Ji Ri Bao· 2025-09-25 08:24
Core Insights - The prevalence of Alzheimer's disease among individuals aged 60 and above in China exceeds 5%, and it reaches as high as 30% in those aged 85 and above [1] - Genetic factors play a significant role in Alzheimer's disease, with 5%-10% of cases being hereditary [1] - The presence of pathogenic genes such as APP, PS1, and PS2 indicates a high likelihood (over 95%) of developing Alzheimer's, often at an early age [1] - Risk genes like APOEε4 increase the probability of developing the disease but have a lower chance of being inherited [1] Genetic Testing and Early Detection - It is recommended for children of parents with Alzheimer's to undergo genetic testing to determine the presence of pathogenic or risk genes [2] - Early diagnosis through methods like PET scans and cerebrospinal fluid tests can help in timely intervention with antibody drugs to slow disease progression [2] Prevention Strategies - Prevention of Alzheimer's should begin early in life, emphasizing the importance of good learning habits and cognitive engagement from youth [2] - Building cognitive reserves throughout life is crucial for effectively preventing neurodegenerative diseases [2]
我国液氢制取技术产业化应用获新突破
Ke Ji Ri Bao· 2025-09-25 07:29
Core Insights - China's liquid hydrogen technology has achieved a significant milestone with the demonstration application of a 5 tons/day liquid hydrogen production equipment in a civil liquid hydrogen plant in Fuyang, Anhui, which has operated stably for over 168 hours [1][3]. Group 1: Technology Development - The successful development of the 5 tons/day liquid hydrogen production equipment involved overcoming several core technologies, including large-scale efficient hydrogen liquefaction process design, integrated technology for hydrogen conversion and heat exchange, and high-efficiency heavy-load hydrogen gas turbine expansion technology [3][4]. - The equipment has achieved a liquefaction capacity of 5.27 tons/day, with an energy consumption of 11.8 kilowatt-hours per kilogram of liquid hydrogen produced [4]. Group 2: Industry Impact - This achievement lays a solid foundation for China's first "liquid hydrogen production-storage-transportation" industrial chain demonstration, which is expected to significantly promote the development of hydrogen fuel commercial vehicles, green energy, and aerospace sectors [4]. - The advancements in liquid hydrogen technology will also support the subsequent research and development of larger-scale hydrogen liquefaction devices with capacities of 10 to 30 tons/day [4].
全球首座,验收成功!
Ke Ji Ri Bao· 2025-09-25 06:36
Core Insights - The successful acceptance of the 50 MW/100 MWh digital energy storage demonstration project marks a significant advancement in China's digital energy storage technology, transitioning from research to large-scale engineering application [1] Group 1: Project Overview - The project is the world's first 100 MWh level digital energy storage station, located in Inner Mongolia at the Three Gorges Ulanqab new generation green power station [1] - The project was led by the Three Gorges Research Institute in collaboration with Tsinghua University, consisting of 46 energy storage containers with capacities of 1.075 MW/2.15 MWh [1] Group 2: Technical Components - The project includes three core components: digital energy exchange system, digital energy storage integration system, and energy management and intelligent operation and maintenance platform [1] Group 3: Impact on Energy Sector - The total installed capacity of the Three Gorges Ulanqab new generation green power station is 2 million kW, with an accompanying 550,000 kW of electrochemical energy storage [1] - The project demonstrates an integrated approach of "source, grid, and storage," which can alleviate the flexibility adjustment pressure on the power grid and enhance the region's clean energy consumption level [1]
人类染色体“牵手”之谜揭开,罗伯逊易位融合点首次精确定位
Ke Ji Ri Bao· 2025-09-25 06:18
据《自然》杂志24日报道,美国斯托瓦斯医学研究所团队首次精确定位了人类染色体在形成罗伯逊易位时的融合点。这项研究具有里程碑式的意义,不仅揭 示了这类染色体融合是如何形成并保持稳定的,还指出曾被认为是"垃圾"的重复DNA,可能在基因组组织和进化中发挥核心作用。 人类染色体通常被描绘成两两配对的"整齐队列"。但在大约每800人中,就有一人出现不同寻常的情况,即两条染色体"牵手"融合,形成一种特别的结构, 这就是所谓的罗伯逊易位。这种现象长期以来困扰着科学家。 罗伯逊易位携带者往往并不自知。他们大多健康,但可能会出现不孕或流产的情况。当他们有子女时,孩子罹患唐氏综合征的风险也会升高。 此次,团队利用一种称为"长读长测序"的DNA测序技术,首次获得了完整的罗伯逊易位染色体序列。与传统测序方法不同,长读测序能读取高度重复的 DNA区域,使科学家看清了此前难以解析的"盲区"。团队比较了3条罗伯逊易位染色体与正常染色体,发现它们的断裂点均位于一种称为SST1的重复DNA序 列中。当这些SST1序列在细胞核仁中靠近时,可能发生融合,形成罗伯逊易位染色体。 罗伯逊易位的形成机制是两条染色体的长臂融合,而短臂丢失。这样会留下45 ...
地上“振动模式”竟源于地下“岩浆拔河”
Ke Ji Ri Bao· 2025-09-25 01:25
这一发现对未来自然灾害监测或有重要意义。过去,科学家通常将每个火山视为独立系统,但这项 研究揭示,火山之间可能通过深层岩浆网络相互连接,甚至彼此影响。 圣托里尼和科隆博这对"海底双胞胎",或许只是冰山一角。一些火山活跃区可能也存在类似的机 制。例如,夏威夷、冰岛和堪察加半岛等地的火山,背后或许也有"共享岩浆源"的影子。 这项研究由德国亥姆霍兹协会地球科学中心与基尔海洋中心主导。科学家借助卫星雷达(InSAR) 技术,精确测量了地表的微小隆起。这些数据如同"地球的脉搏",揭示了地下岩浆的流动轨迹。 从2024年7月起,卫星就监测到圣托里尼岛的地表开始缓慢抬升;到2025年初,部分地区已隆起数 厘米。这表明,在地表以下约3.8公里深处,一个巨大的岩浆房正在悄悄"注浆",就像一个缓慢膨胀的 气球。 但真正的转折点出现在今年1月27日。科学家发现,海底的科隆博火山区域突然出现了地面下沉的 迹象。结合地震数据,他们推断:一股岩浆正从科隆博下方约7.6公里深处,向圣托里尼方向迁移。这 就像两个连通的水袋,当一个充水膨胀时,另一个就会缩小。 这是一场岩浆争夺战。当圣托里尼的岩浆房压力升高,它就从共享的岩浆管道中吸走了本可能 ...
科技兴农结满喜人“致富果”
Ke Ji Ri Bao· 2025-09-25 01:25
金秋时节,粮满仓、果满枝,各地丰收节庆典描绘出农业增收喜人画卷。 从实验室到田间地头,从深海牧场到数字云端,2025年中国农民丰收节见证了科技创新如何重塑传 统农业。"建设农业强国,利器在科技。"正如农业农村部副部长张兴旺所言,"我国坚持把农业科技创 新摆在突出位置,加大政策支持力度,狠抓重点任务落实。我国农业科技创新整体水平现在已经进入世 界第一方阵。" 在这片充满希望的田野上,科技创新结满"致富果",书写着乡村振兴新篇章。 种子是农业的"芯片",今年丰收节期间,种业创新成果展示成为重要板块。在四川省农业科学院新 都基地举办的丰收节活动现场,"川蒜3号"蒜薹、"黑亮59"茄子、"旌黑甜糯1号"玉米等院地合作新品种 整齐陈列。 "截至目前,我们的1474个新品种、1124项新技术已扎根新都田间,为农业现代化注入科技动 能。"四川省农业科学院院长牟锦毅介绍,该院自2008年起与新都共建西南最大农业科研实验基地,到 如今已成功培育"川蒜""川薯"等系列品种,建成3700亩"五良融合"智慧示范农场。 数字技术正在深刻改变传统农业的面貌。在今年的丰收节上,智慧农业成果颇为吸睛。在举办上海 主会场活动的金山廊下生态园, ...
新型体外诊断AI产品提高异常细胞检出率
Ke Ji Ri Bao· 2025-09-24 23:57
9月23日,记者获悉,"AI+检验,智启新纪元:血涂片全域分析智能体"成果发布会于近日举办。北京 小蝇科技有限责任公司(以下简称"小蝇科技")携全国首个获批体外诊断领域人工智能三类医疗器械注 册证的创新产品——Cygnus全自动血细胞形态学分析系统(以下简称"Cygnus分析系统")亮相。 当患者白细胞减少时,外周血涂片中细胞密度进一步降低,使用传统显微镜对患者进行血涂片分类时, 费时费力,还容易漏掉有价值的异常细胞。而Cygnus分析系统使用"血膜全域扫描模式",可精准分析外 周血涂片中所有白细胞,大大提高了异常细胞的检出率。在发现异常细胞时,可精准定位外周血涂片中 细胞所在位置,方便镜检人员在显微镜下复核,显著提升样本检测结果的准确性。 "Cygnus分析系统能识别多种异常血细胞,经国家药品监督管理局验证,其准确率≥90%,检测结果不受 检验人员疲劳、经验差异影响,即便样本质量较低也可直接精准分析。"小蝇科技联合创始人伍博深 说,Cygnus分析系统不仅是单纯的技术产品,也已成为区域医疗服务质量提升的"利器"。小蝇科技携 Cygnus分析系统深度参与了北京市海淀区"外周血细胞形态学分析技术科技应用场景项目 ...