Core Insights - The Hong Kong stock market saw a net inflow of 87.19 billion HKD from northbound trading on October 31, with 57.72 billion HKD from the Shanghai Stock Connect and 29.47 billion HKD from the Shenzhen Stock Connect [1] Group 1: Net Inflows and Outflows - The most bought stocks included Xiaomi Group-W (01810), Meituan-W (03690), and Sanofi Pharmaceutical (01530) [1] - The most sold stocks included Tencent (00700), SMIC (00981), and Hua Hong Semiconductor (01347) [1] Group 2: Stock Performance Details - Xiaomi Group-W (01810) had a net inflow of 6.46 billion HKD, supported by optimistic forecasts for its smartphone and electric vehicle businesses [5] - Meituan-W (03690) received a net inflow of 4.64 billion HKD, with news of its international food delivery brand Keeta launching operations in Brazil [5] - Sanofi Pharmaceutical (01530) saw a net inflow of 754.6 million HKD, following the registration of a new cancer treatment in clinical trials [5] Group 3: Notable Sell-offs - Tencent (00700) experienced a net outflow of 12.19 billion HKD, amid increased short-selling activities in the market [7] - SMIC (00981) faced a net outflow of 7.11 billion HKD, as the semiconductor sector reacted to potential changes in AI chip export policies [8] - Hua Hong Semiconductor (01347) had a net outflow of 4.73 billion HKD, reflecting broader trends in the chip industry [8]

Market Overview - The Hong Kong stock market experienced a decline, with the Hang Seng Index falling 1.43% to 25,906.65 points, and the Hang Seng Technology Index dropping 2.37% to 5,908.08 points. The total trading volume for the day was 257.61 billion HKD [1] - For the month, the Hang Seng Index decreased by 3.53%, the Hang Seng China Enterprises Index fell by 4.05%, and the Hang Seng Technology Index saw a decline of 8.62% [1] Blue-Chip Stocks Performance - AIA Group (01299) rose by 3.07% to 75.45 HKD, contributing 37.56 points to the Hang Seng Index. The company reported a 25% year-on-year increase in new business value to 1.476 billion USD for Q3 2025 [2] - Other notable blue-chip stocks included Hansoh Pharmaceutical (03692) up 4.21%, and China Biologic Products (01177) up 2.91%. Conversely, SMIC (00981) fell by 5.3%, and Xinyi Solar (00968) dropped by 5.04% [2] Sector Highlights - The innovative drug sector saw gains, with 3SBio (01530) increasing by 11.27% and Innovent Biologics (01801) rising by 7.81%. The sector is benefiting from the upcoming National Medical Insurance negotiations and a significant increase in licensing deals for innovative drugs [3][4] - AI application stocks also showed positive movement, with Huya Technology (01860) rising by 7.86% and Fourth Paradigm (06682) increasing by 2.76% [4][5] Quarterly Earnings - Several pharmaceutical companies reported strong Q3 earnings, including Heng Rui Medicine with a net profit of 5.751 billion CNY, up 24.5% year-on-year, and Innovent Biologics with over 3.3 billion CNY in total product revenue, reflecting a 40% growth [4][6] - Spring Medical (01858) reported a 109.51% increase in revenue to 268 million CNY for Q3, while China CNR Corporation (01766) saw a 10.62% decline in net profit [6] Notable Stock Movements - Dipei Technology (01384) surged by 15.02% to 113.7 HKD, marking a 300% increase since its IPO, driven by a 118.4% revenue growth in the first half of the year [7] - China Shengmu (01432) rose by 13.11% to 0.345 HKD, following a strategic shareholding increase by Modern Dairy [8] - China Duty Free Group (01880) increased by 5.78% to 66.8 HKD, supported by new policies aimed at boosting consumption through duty-free stores [9] - Huahao Zhongtian Pharmaceutical (02563) fell by 33.93% to 3.35 HKD, following a significant share unlock event [10] - Air China (00753) dropped by 6.55% to 5.71 HKD, with a reported net profit decline of 11.31% in Q3 [11]

Core Viewpoint - The innovative drug sector in Hong Kong and A-shares has seen a significant rally driven by multiple favorable factors, including the introduction of a "commercial insurance innovative drug catalog" in national medical insurance negotiations [1][4]. Market Performance - A-share innovative drug stocks performed actively, with notable gains including: - Sanofi Guojian and Shuyai Shen both hitting the 20% daily limit up - Other stocks like Zhongsheng Pharmaceutical and Lianhuan Pharmaceutical also reaching their daily limits [1][2] - In the Hong Kong market, notable stocks such as Sanofi Pharmaceutical and Xinda Biopharmaceutical saw increases of nearly 12% and 8.49% respectively [2][3]. Policy Support - The introduction of the "commercial insurance innovative drug catalog" aims to alleviate the payment pressure for high-value innovative drugs and provide broader avenues for R&D returns [4]. - The recent guidelines from the Central Committee emphasize support for the development of innovative drugs and medical devices, reinforcing the policy foundation [5]. R&D and Collaborations - Leading companies are making substantial progress in international collaborations, with Sanofi Pharmaceutical registering two global Phase III clinical trials for its dual antibody drug SSGJ-707 [5]. - The innovative drug sector has seen a surge in licensing deals, with a reported 170% year-on-year increase in patent licensing transactions, exceeding $100 billion in 2025 [5]. Financial Performance - Major companies reported strong financial results: - WuXi AppTec's revenue reached 32.86 billion yuan, up 18.6% year-on-year - Hengrui Medicine reported a revenue of 23.188 billion yuan, up 14.85%, with a net profit increase of 24.50% [6]. - Positive macroeconomic signals include the U.S. decision to cancel additional tariffs on Chinese goods, which may benefit international collaborations for innovative drug companies [6]. Future Outlook - Analysts are optimistic about the continued growth of the innovative drug sector, with expectations of sustained policy support and enhanced global competitiveness for Chinese innovative drugs [7]. - The trend of declining interest rates by major central banks is anticipated to further boost the valuation of innovative drugs [7].

Core Viewpoint - The innovative drug sector is experiencing a rise in stock prices despite market conditions, driven by new policies and strong quarterly performances from several pharmaceutical companies [1] Group 1: Stock Performance - Innovent Biologics (01801) saw an increase of 8.12%, reaching HKD 87.25 [1] - Three-Sixty Biopharma (01530) rose by 11.42%, trading at HKD 30.84 [1] - Kelun-Biotech (06990) increased by 6.97%, priced at HKD 451 [1] - Connaissance-B (02162) gained 4.71%, with a price of HKD 60.05 [1] - Hansoh Pharmaceutical (03692) rose by 4.56%, trading at HKD 35.76 [1] Group 2: Policy Changes - The 2025 National Medical Insurance negotiation commenced on October 30, introducing a "commercial insurance innovative drug catalog" mechanism for the first time [1] - This year's negotiations continue the regular adjustment mechanism of the medical insurance catalog [1] Group 3: Market Activity - As of October 21, 2023, there have been 115 licensing agreements for innovative drugs in China, totaling USD 101.24 billion, significantly surpassing the total of USD 51.9 billion for the entire year of 2024 [1] Group 4: Company Performance - Hengrui Medicine reported a net profit of CNY 5.751 billion for the first three quarters, a year-on-year increase of 24.5% [1] - Innovent Biologics achieved total product revenue exceeding CNY 3.3 billion in Q3, maintaining a robust year-on-year growth of approximately 40% [1] Group 5: Industry Outlook - The pharmaceutical industry is showing signs of marginal improvement, with a potential shift in market focus towards high-growth sectors supported by performance [1] - Recommendations include focusing on companies with Q3 performance likely to exceed expectations, as well as sectors such as CXO, upstream life sciences, medical device recovery, and innovative drugs [1]

Group 1 - Pfizer officially launched two global multi-center phase III clinical trials for the PD-1/VEGF dual antibody (code: 707) developed by 3SBio, targeting first-line treatment for non-small cell lung cancer and colorectal cancer, designed as a "head-to-head" challenge against current standard therapies (Keytruda and Bevacizumab) [1] - This event signifies a critical advancement in the model of Chinese innovative drugs going global, shifting from "license-out" to being led and heavily invested in by global multinational corporations (MNCs) for late-stage global development [1] - Pfizer's decision to rapidly advance clinical trials and design them as high-standard "head-to-head" tests serves as a strong endorsement of 3SBio's original innovation capabilities and the potential of the 707 molecule, indicating that the value of Chinese innovative drugs has progressed from "early potential" to being recognized as having "disruptive global market potential" [1] Group 2 - The Guotai Innovation Drug ETF (589720) focuses on innovative drug companies listed on the Sci-Tech Innovation Board, tracking a representative index of 30 high-quality companies, primarily in high-growth biotech, with a 20% limit on price fluctuations to better align with sector volatility [2] - Since the "924 market" rally, the Sci-Tech Innovation Drug Index has outperformed the Hang Seng Hong Kong Stock Connect Innovation Drug Index, with respective gains of 117.04% and 109.62% during the market rebound from September 24, 2024, to September 30, 2025 [2] - The Sci-Tech Innovation Drug Index may help capture the resilience of the Sci-Tech Innovation Board when market risk appetite rebounds [2]

Market Overview - The Hang Seng Index fell by 0.89%, down 232 points, closing at 26,050 points, while the Hang Seng Tech Index dropped by 1.91% [1] - The early trading volume in the Hong Kong stock market reached HKD 142.3 billion [1] Biotechnology Sector - The Hang Seng Biotechnology Index rebounded by 2.16%, with notable gains in several stocks: - InnoCare Pharma (09606) surged by 10.88% - 3SBio (01530) increased by over 10% - Innovent Biologics rose by 6.82% - Kelun-Biotech (06990) gained 5.69% [1] - Fosen Pharmaceuticals (01652) saw a significant increase, with a peak rise of nearly 74% and an early gain of 59.42% following the approval of Enzalutamide soft capsules and the potential selection of Metformin and Empagliflozin for national procurement [1] - Rongchang Biopharma (09995) rose by 6.75%, reporting a 40% year-on-year revenue growth and a significant reduction in losses for the first three quarters [1] Medical Sector - Spring Medical (01858) increased by over 21%, turning a profit of HKD 77.06 million in the third quarter as the company actively expands its international market [2] New Stocks Performance - Newly listed Dipo Technology (01384) continued to rise, gaining 18.97% and doubling its stock price within three days of listing [3] Financial Sector - China Everbright Bank (06818) fell by 5% post-earnings, with both revenue and profit declining in the third quarter, facing pressure from fair value changes [4] Other Notable Stocks - Huahao Zhongtian Pharmaceutical-B (02563) experienced a significant drop of over 37% due to a large unlock of shares after one year of listing [5] - Lion Holdings (02562) plummeted over 24% to a new low, planning to issue convertible bonds to raise approximately HKD 260 million for investments in gold and related products [6] - Air China (00753) dropped over 8%, with a more than 11% decline in net profit for the third quarter, and plans to raise up to HKD 20 billion through A-share placement [7]

Group 1: Hong Kong Stock Market Updates - China Metallurgical Group (01618) saw a decline of over 5%, reporting a revenue of 335.09 billion yuan for the first three quarters, a year-on-year decrease of 18.79%, and a net profit of 3.97 billion yuan, down 41.88% [1] - Fosen Pharmaceutical (01652) surged nearly 74% after announcing that its subsidiary received approval for the "Enzalutamide Soft Capsule" from the National Medical Products Administration of China [1] - Sanhua Intelligent Control (02050) increased over 3%, with a revenue of 24.03 billion yuan for the first three quarters, a year-on-year growth of 16.86%, and a net profit of 3.24 billion yuan, up 40.85% [1] - Rongchang Biopharmaceutical (09995) rose over 5%, reporting a revenue of approximately 1.72 billion yuan, a year-on-year increase of 42.27%, and a net loss of about 551 million yuan, narrowing by 48.6% [1] - New Special Energy (01799) fell nearly 8%, with a revenue of 11.66 billion yuan and a net loss of 526 million yuan for the first three quarters [1] Group 2: Additional Hong Kong Stock Market Updates - Chuny Medical (01858) increased over 10%, reporting a revenue of 756 million yuan, a year-on-year growth of 48.75%, and a net profit of 192 million yuan, up 213.21% [2] - Innovent Biologics (01801) rose over 4%, achieving total product revenue exceeding 3.3 billion yuan in Q3, maintaining a strong year-on-year growth of about 40% [2] - Longpan Technology (02465) increased over 6%, with a revenue of approximately 5.83 billion yuan, a year-on-year growth of 2.91%, and a net loss of about 110 million yuan, narrowing by 63.53% [2] - 3SBio (01530) saw an early morning increase of nearly 7%, following a significant deal with Pfizer worth up to $12.5 billion [2] - China CNR Corporation (01766) fell over 8%, reporting a revenue of approximately 183.87 billion yuan, a year-on-year increase of 20.49%, and a net profit of about 9.96 billion yuan, up 37.53% [2] Group 3: US Stock Market Updates - Carvana (CVNA.US) dropped over 13%, reporting a Q3 revenue growth of 54.5% to $5.65 billion, exceeding analyst expectations [3] - Alphabet (GOOGL.US) rose nearly 2%, with Q3 revenue surpassing $100 billion, driven by strong AI demand boosting cloud business [3] - Meta Platforms (META.US) fell over 11%, reporting Q3 revenue of $51.2 billion, a 26% year-on-year increase, but net profit significantly below expectations due to a one-time tax expense [4] - Bitcoin-related stocks experienced declines, with Strategy (MSTR.US) down nearly 7% and Coinbase (COIN.US) down over 5% [4] - eBay (EBAY.US) plummeted 15%, marking its largest drop in over 20 years despite exceeding sales expectations [4] Group 4: Additional US Stock Market Updates - Comcast (CMCSA.US) fell 4%, losing 104,000 broadband users in Q3, marking the tenth consecutive quarter of user decline [5] - CoreWeave (CRWV.US) dropped over 6% after shareholders rejected a proposed acquisition [5] - Roblox (RBLX.US) fell over 15%, reporting Q3 revenue of $1.4 billion, a 48% year-on-year increase, but widening net losses [5] - Moderna (MRNA.US) rose over 13%, reportedly in talks for a large-scale acquisition with a major pharmaceutical company [6] - Altria (MO.US) fell over 7%, reporting adjusted EPS of $1.45, in line with market consensus, but net revenue declined by 1.7% [6]

Group 1 - The core viewpoint of the news highlights the strong performance of the Hong Kong Stock Connect Innovative Drug ETF (520880), which has seen significant capital inflow and a notable increase in trading volume, indicating investor confidence in the innovative drug sector [1][3]. - The innovative drug sector is benefiting from favorable policy developments, including the introduction of a dual-track adjustment model for basic medical insurance and commercial insurance, which is expected to alleviate payment pressures for high-value innovative drugs [3]. - The "14th Five-Year Plan" emphasizes support for the development of innovative drugs and medical devices, focusing on major diseases and new technology platforms, suggesting a long-term growth potential for companies in these areas [3]. Group 2 - The Hong Kong Stock Connect Innovative Drug ETF (520880) passively tracks the Hang Seng Hong Kong Stock Connect Innovative Drug Select Index, which exclusively invests in innovative drug R&D companies, with over 70% of its holdings in large-cap innovative drug leaders [4][5]. - As of the end of September, the Hang Seng Hong Kong Stock Connect Innovative Drug Select Index has shown a year-to-date increase of 108.14%, outperforming other innovative drug indices [5][6]. - The ETF has a total fund size of 1.806 billion and has maintained the highest liquidity among similar indices, with an average daily trading volume of 493 million since its inception [6].

值得关注的是，近期有资金持续逢跌吸纳便宜筹码。数据显示，昨日港股通创新药ETF（520880）创3 个月新低，当日获4861万元净申购。近10日维度，520880累计吸金超2.6亿元。 10月31日，港股通创新药板块终于反弹！100%创新药研发标的——港股通创新药ETF（520880）高开 后直线冲高3.17%，实时成交超2.6亿元！所覆盖的37家创新药研发类公司30股飘红，三生制药飙涨超 8%居首，映恩生物-B涨超7%，信达生物反弹5%。 消息面上，10月30日，辉瑞在Clinicaltrials.gov网站上注册了PD-1/VEGF双抗PF-08634404（SSGJ-707） 的两项全球三期临床试验。今年5月，辉瑞以"12.50亿美元预付款+48亿美元里程碑付款+双位数百分比 的销售分成"引进三生制药的PD-1/VEGF双抗。中邮证券发布研报称，707有望成为全球肿瘤治疗重磅 基石品种。 | 分时 多日 1分 5分 · | | | | | | | F9 盘前盘后 露加 九50 面托 工具 (0 (2) > | | | 港股通创新药ETF ① | | 520880 | | --- | --- | --- ...

Core Viewpoint - The stock of 3SBio surged over 10% to HKD 30.5 following Pfizer's registration of two global Phase III clinical trials for the PD-1/VEGF dual antibody PF-08634404 (SSGJ-707) on Clinicaltrials.gov [1] Group 1: Clinical Trials - Pfizer registered two Phase III clinical trials for PF-08634404, targeting advanced non-small cell lung cancer (NSCLC) and metastatic colorectal cancer [1] - The NSCLC trial aims to enroll 1,500 patients and is expected to complete preliminary results by February 2029, focusing on progression-free survival (PFS) and overall survival (OS) as primary endpoints [1] - The colorectal cancer trial plans to enroll 800 patients, with preliminary results expected by March 2030, comparing against bevacizumab plus chemotherapy, also using OS and PFS as primary endpoints [1] Group 2: Financial Aspects - In May 2025, Pfizer will pay 3SBio a total of USD 1.25 billion upfront, with an additional USD 4.8 billion in milestone payments and a double-digit percentage of sales for the PD-1/VEGF dual antibody [1]