Group 1 - Pfizer has accelerated the development of SSGJ-707 (PF-4404) with plans to initiate at least 7 clinical trials, including two global Phase III trials starting in December targeting 1L sq-/nsq-NSCLC and metastatic colorectal cancer [1] - The company aims to expand SSGJ-707 into over 10 new indications and more than 10 new combination therapies by the end of 2026, including evaluating its use with Pfizer's extensive ADC product portfolio [1] - Pfizer has identified over 500 clinical centers across more than 25 countries for the development of PF-4404 and has completed domestic production in the U.S. to ensure efficient development and compliance with global registration requirements [1] Group 2 - The company plans to spin off its consumer pharmaceutical business, Mandi International, for a listing on the Hong Kong Stock Exchange, which will allow it to focus on prescription and innovative drugs [2] - The spin-off is expected to generate short-term investment returns and support the commercialization of new products after the separation [2] - The target price for the stock has been raised to 39.5 HKD due to strong clinical data and partner support, reflecting increased confidence in the global development of SSGJ-707 [2]

Core Insights - The focus in the PD-(L)1/VEGF bispecific antibody market has shifted from business development amounts to development efficiency and indication differentiation [1] - The competition is intensifying as multiple PD-(L)1/VEGF bispecific antibodies are entering Phase III clinical trials, emphasizing the importance of research speed and strategic indication planning [1] Domestic Indication Layout - The PD-(L)1/VEGF bispecific antibody market in China is characterized by rapid development and strategic positioning, with 康方生物/Summit’s Ivonescimab leading the way [2] - Ivonescimab has received approval for two indications in China, with projected sales of approximately 9 billion CNY in 2024 and 7.2 billion CNY in the first half of 2025, and a forecasted total sales exceeding 15 billion CNY in 2025 [2][3] Clinical Development and Market Potential - The first indication for Ivonescimab was approved in May 2024 for treating advanced non-squamous non-small cell lung cancer (nsq-NSCLC) after progression on EGFR-TKI therapy [3] - The second indication was approved in April 2025 for first-line treatment of PD-L1 positive (TPS≥1%) EGFR mutation negative and ALK negative advanced NSCLC [3] - The third indication for Ivonescimab is under review for first-line treatment of advanced squamous NSCLC [3] - The potential of the advanced lung cancer market is significant, with non-small cell lung cancer accounting for approximately 85% of all lung cancer cases [3] Competitive Landscape - The competitive landscape includes other key players such as BioNTech/BMS with PM8002 and Pfizer with SSGJ-707, both of which are also in late-stage clinical trials [5][6] - PM8002 is focusing on triple-negative breast cancer (TNBC) and small cell lung cancer (SCLC), while SSGJ-707 has initiated a head-to-head comparison with Keytruda for treating PD-L1 positive NSCLC [6][8] Global Market Dynamics - The global PD-(L)1/VEGF bispecific antibody market is dominated by three main players: 康方生物/Summit, BioNTech/BMS, and Pfizer, all of which are conducting Phase III clinical trials [8] - The strategies of these companies vary, with 康方生物 focusing on building a strong clinical barrier in the lung cancer market, BioNTech/BMS creating differentiation in TNBC and SCLC, and Pfizer leveraging its ADC advantages in colorectal cancer [18]

Core Viewpoint - The report from CMB International raises the target price for Sihuan Pharmaceutical (01530) to HKD 39.5, maintaining a "Buy" rating and highlighting it as a key industry recommendation [1] Group 1: Clinical Data and Development - Strong clinical data, unwavering support from partners, and extensive R&D experience have increased confidence in the global development success of the 707 project [1] - The overseas development of the 707 project is progressing rapidly [1] Group 2: Business Spin-off - Sihuan Pharmaceutical plans to spin off its consumer pharmaceutical business, Mandi International, for a listing in Hong Kong, through a distribution of shares and a global offering of new shares [1] - After the spin-off, Sihuan Pharmaceutical will no longer hold any equity in Mandi International, which currently holds 87.16% [1] - The spin-off is expected to bring short-term investment returns and allow the company to focus on prescription and innovative drugs, with the raised funds supporting the commercialization of self-developed innovative products [1]

Core Insights - The Hong Kong Innovative Drug ETF (159567) closed with a gain of 0.23% on November 27, with a trading volume of 1.149 billion yuan [1] - The fund was established on January 3, 2024, with an annual management fee of 0.50% and a custody fee of 0.10% [1] - As of November 26, 2024, the fund's shares totaled 9.88 billion, with a total size of 8.495 billion yuan, reflecting a significant increase in both shares and size compared to the previous year [1] Fund Performance - The fund's share count increased by 2398.89% and its size increased by 2148.37% from 3.95 million shares and 378 million yuan on December 31, 2024 [1] - Over the last 20 trading days, the cumulative trading amount reached 31.987 billion yuan, with an average daily trading amount of 1.599 billion yuan [1] - Since the beginning of the year, the cumulative trading amount has been 263.006 billion yuan, with an average daily trading amount of 1.201 billion yuan over 219 trading days [1] Fund Management - The current fund manager is Ma Jun, who has managed the fund since its inception, achieving a return of 68.86% during the management period [2] - The top holdings of the fund include companies such as BeiGene, CanSino Biologics, Innovent Biologics, and China National Pharmaceutical Group, with significant percentages of the portfolio allocated to these stocks [2] - The largest holding is BeiGene, accounting for 10.62% of the portfolio, followed closely by CanSino Biologics at 10.55% and Innovent Biologics at 10.21% [2]

Investment Rating - The report assigns a "Buy" rating to the company, with a target price raised to HKD 39.50, indicating a potential upside of 25.1% from the current price of HKD 31.58 [2][11]. Core Insights - The report highlights the rapid advancement of the overseas development of SSGJ-707, with Pfizer planning to initiate at least seven clinical trials soon, including two global Phase III trials targeting first-line squamous and non-squamous non-small cell lung cancer (NSCLC) and metastatic colorectal cancer [6]. - The company plans to spin off its consumer pharmaceutical business, Mandi International, to focus on its core prescription and innovative drug sectors, which is expected to generate short-term investment returns and support the development of innovative products [6]. - The report expresses increased confidence in the global development potential of SSGJ-707 due to strong clinical data and support from partners, leading to an adjustment in long-term milestone payment forecasts [6]. Financial Overview - Revenue projections for the company are as follows: RMB 7,816 million in 2023, RMB 9,108 million in 2024, and a significant increase to RMB 17,470 million in 2025, followed by a decline to RMB 12,821 million in 2026 and RMB 12,018 million in 2027, reflecting a growth rate of 91.8% in 2025 [5][14]. - Net profit is expected to rise sharply to RMB 8,057 million in 2025, with a corresponding earnings per share (EPS) of RMB 3.34, before declining in subsequent years [5][14]. - The company’s market capitalization is reported at approximately HKD 75.55 billion, with a year-to-date price change of 419.41% [4]. Valuation Model - The discounted cash flow (DCF) model estimates the equity value at approximately RMB 87.35 billion, translating to a per-share value of HKD 39.50, based on a weighted average cost of capital (WACC) of 9.4% [10][11].

Group 1 - The core viewpoint of the report is that the spin-off of Mandi International from 3SBio is beneficial for both parties, allowing 3SBio to focus on innovative drug development while Mandi concentrates on consumer healthcare products [1] - The spin-off will enhance Mandi's image among customers, suppliers, and potential partners, improving its position for business negotiations and attracting more business [1][2] - Mandi International is recognized as a leading consumer pharmaceutical company in China, with a strong focus on skin health and weight management solutions [2] Group 2 - Mandi has established a leading position in the hair health sector within the skin health industry, with its flagship Minoxidil-based hair loss treatment products ranking first in the Chinese market for ten consecutive years [2] - Revenue projections for Mandi International from 2022 to 2024 are 982 million, 1.228 billion, and 1.455 billion yuan, respectively, with a CAGR of 21.7% [3] - Mandi's gross profit margins are expected to improve from 80.3% in 2022 to 82.7% in 2024, while net profit margins are projected to be 20.5%, 27.8%, and 26.8% for the same years [3]

Group 1 - The core viewpoint of the report is that the spin-off of Mandi International from 3SBio is beneficial for both companies, allowing 3SBio to focus on innovative drug development while Mandi specializes in consumer healthcare products [1] - The spin-off will enhance Mandi's image among customers, suppliers, and potential partners, improving its position for business negotiations and attracting more business [1] - The financial flexibility of both companies will increase, supporting sustainable growth through stable cash flow [1] Group 2 - Mandi International is recognized as a leading consumer pharmaceutical company in China, focusing on skin health and weight management solutions [2] - Mandi has established a leadership position in the hair health sector, with its flagship Minoxidil-based hair loss treatment products ranking first in the Chinese market for ten consecutive years, holding approximately 57% and 71% market shares in 2024 for hair loss and Minoxidil markets respectively [2] - The company is actively expanding into broader skin health and weight management areas to meet the growing consumer demand in China's rapidly developing consumer healthcare market [2] Group 3 - Mandi International has shown stable and rapid revenue growth from 2022 to 2024, with revenues of 982 million, 1.228 billion, and 1.455 billion yuan respectively, resulting in a CAGR of 21.7% [3] - The gross margins for the same period are projected to be 80.3%, 82.0%, and 82.7% [3] - Net profits are expected to increase from 202 million to 341 million and then to 390 million yuan, with net profit margins of 20.5%, 27.8%, and 26.8% respectively [3]

Core Viewpoint - Guosen Securities maintains an "outperform" rating for 3SBio (01530), highlighting the rapid global clinical development of its core products and robust performance growth, particularly following the successful licensing of 707 [1] Group 1: Clinical Development - 3SBio presented Phase 2 clinical data for 707 in combination with chemotherapy for 1L NSCLC at the STIC conference, showing good efficacy and safety in both sqNSCLC and nsqNSCLC, supporting further Phase 3 studies [1] - Pfizer discussed the global clinical strategy for 707, focusing on two key Phase 3 trials for NSCLC 1L and mCRC 1L, with plans to initiate five additional studies soon [1] Group 2: Financial Projections - Guosen Securities raised its profit forecast for 3SBio, expecting net profit attributable to shareholders to reach 9.955 billion, 2.875 billion, and 3.212 billion yuan for 2025-2027, up from previous estimates of 2.38 billion, 2.71 billion, and 3.07 billion yuan [1] Group 3: Future Development Plans - Pfizer's second wave of development plans aims to add 10 new indications and over 10 novel combination therapies by the end of 2026, targeting to replace existing standard treatments with 707 [1] - The strategy includes exploring combinations with ADCs and developing non-chemotherapy options, expanding applications to early treatment scenarios [1]

Core Viewpoint - Guosen Securities maintains an "outperform" rating for 3SBio (01530), highlighting the rapid global clinical development of its core products and robust performance growth, particularly following the successful licensing of 707. The profit forecast for 2025-2027 has been raised, with expected net profits of 9.955 billion, 2.875 billion, and 3.212 billion yuan respectively, up from previous estimates of 2.38 billion, 2.71 billion, and 3.07 billion yuan [1]. Group 1 - 3SBio presented clinical phase II data for 707 in combination with chemotherapy for 1L NSCLC at the STIC conference, demonstrating good efficacy and safety in both sqNSCLC and nsqNSCLC, supporting the continuation of phase III trials [1]. - Pfizer discussed the global clinical strategy for 707, focusing on two key phase III trials for NSCLC1L and mCRC1L, with plans to initiate five additional studies soon, including phase 2/3 for ES-SCLC1L and phase 1/2 for various other indications [1]. - Pfizer's second wave of development plans aims to add 10 new indications and over 10 novel combination regimens by the end of 2026, targeting the replacement of existing standard treatments with 707 as a new cornerstone therapy [1].

格隆汇11月27日丨根据联交所最新权益披露资料显示，2025年11月21日，三生制药(01530.HK)获汇添富基金管理股份有限公司在场内以每股均价29.8174港 元增持116.2万股，涉资约3464.78万港元。 增持后，汇添富基金管理股份有限公司最新持股数目为146,132,500股，持股比例由5.96%上升至6.01%。 | 表格序號 | 大股東/董事/最高行政人員名稱 作出披露的 買入 / 費出或涉及的股 每股的平均價 | | | | 持有權益的股份數目 佔已發行的 有關事 | | --- | --- | --- | --- | --- | --- | | | 原因 | 份敷目 | | | (請參閱上述*註解) 有投票權股 (日 / 月 | | | | | | | 份百分比 | | | | | | | ( % ) | | CS20251126E00005 | 汇添富基金管理股份有限公司 1101(L) | | 1.162.000(L) | HKD 29.8174 | 146.132.500(L) 6.01(L)21/11/2 | | 股份代號: | 01530 | | --- | --- | | 上 ...