A股创新药板块午后再度异动，万邦德、哈三联午后封板，丽珠集团、健康元、金石亚药跟涨。 ...

Group 1 - The innovative drug sector remains active, with companies such as Wanbangde (002082) and Hasanlian (002900) seeing significant market activity in the afternoon session [1] - Other companies like Lizhu Group (000513), Jiankangyuan (600380), and Jinshiyao (300434) are also experiencing upward movement in their stock prices [1] - There is a notable influx of dark pool capital into these stocks, indicating potential investor interest and market dynamics [1]

Core Viewpoint - The acquisition of Verona Pharma by Merck for $10 billion highlights the significant value in the respiratory field, while Health元 has already established a comprehensive strategic layout that surpasses Verona in several key innovative directions [1][15][17]. Group 1: COPD Market Insights - COPD, known as the "silent killer," ranks among the top three causes of death globally [2]. - The disease is characterized by its slow progression and limited treatment options, leading to persistent symptoms in nearly half of the patients [3][5]. - Traditional treatments have not effectively controlled symptoms, necessitating a shift in focus towards chronic local inflammation rather than solely bronchial dilation [6][4]. Group 2: Health元's Strategic Innovations - Health元 is pursuing three innovative solutions for COPD: 1. An inhaled PDE4 inhibitor, aligning with Verona's approach to enhance safety and anti-inflammatory effects [7]. 2. A globally unique oral PREP inhibitor, which is currently in Phase II clinical trials [9][10]. 3. A new generation of inhaled corticosteroids (ICS) that optimizes structure and delivery to address traditional issues of efficacy and side effects [11][12]. - This multi-faceted strategy positions Health元 as a leader in the COPD innovation matrix, combining global uniqueness, cutting-edge mechanisms, and deep innovation in traditional areas [13][14]. Group 3: Market Positioning and Future Outlook - Health元's strategic foresight in recognizing the respiratory market as a future growth area has led to a robust pipeline of 12 drugs targeting various pathways, including TSLP, IL-4, PREP, PDE4, and β inhibitors [14]. - The recent acquisition by Merck signals a clear market trend towards respiratory innovation, particularly products that combine PDE mechanisms, inhalation delivery, and anti-inflammatory capabilities [15]. - Health元's proactive approach has transitioned it from a follower to a leader in the respiratory sector, positioning it well for future opportunities [16][17].

Core Points - The company announced a cash dividend of 0.20 RMB per share for its A shares, totaling approximately 365.89 million RMB to be distributed to shareholders [1][2] - The dividend distribution plan was approved at the annual general meeting held on June 6, 2025 [1] - Key dates for the dividend distribution include the record date on July 17, 2025, and the ex-dividend date on July 18, 2025 [1][2] Dividend Distribution Details - The total number of shares for the dividend calculation is 1,829,453,386 [2] - The cash dividend will be distributed through China Securities Depository and Clearing Corporation Limited, Shanghai Branch, to shareholders registered by the record date [2] - Shareholders who have not completed designated transactions will have their dividends held by the clearing company until the transactions are completed [2] Taxation Information - For individual shareholders and securities investment funds, no personal income tax will be withheld at the time of dividend distribution [3] - The tax implications vary based on the holding period of the shares, with different tax rates applicable [3] - For qualified foreign institutional investors (QFII), a 10% withholding tax will be applied, resulting in a net dividend of 0.18 RMB per share [5][6] - Hong Kong investors through the Stock Connect will also face a 10% withholding tax, with similar provisions for tax treaty benefits [6][7] - Other institutional investors will not have taxes withheld by the company, and they are responsible for their own tax obligations [8]

●相关日期 | 股份类别 | 股权登记日 | 最后交易日 | 除权（息）日 | 现金红利发放日 | | --- | --- | --- | --- | --- | | Ａ股 | 2025/7/17 | － | 2025/7/18 | 2025/7/18 | 健康元药业集团股份有限公司2024年年度权益分派实施公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者 重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 重要内容提示： ●每股分配比例 A 股每股现金红利0.20元 健康元药业集团 2024 年年度权益分派实施公告 证券代码：600380 证券简称：健康元 公告编号：临 2025-053 ●差异化分红送转： 否 一、通过分配方案的股东大会届次和日期 本次利润分配方案经健康元药业集团股份有限公司（以下简称：本公司）2025 年 6 月 6 日的2024年年度股东大会审议通过。 二、分配方案 3、分配方案： 本次利润分配以方案实施前的公司总股本1,829,453,386股为基数，每股派发现金 红利0.20元（含税），共计派发现金红利365,890,677.20元。 三、相关日 ...

Policy Developments - The Ministry of Finance announced measures regarding government procurement of medical devices imported from the EU, stating that for medical devices with a procurement budget of over 45 million yuan, EU companies (excluding EU-funded enterprises in China) must be excluded from participation if imported products are required [2] Drug and Device Approvals - Weikang Pharmaceutical's Anruini capsules have been submitted for market approval, intended for adult and adolescent patients with solid tumors carrying NTRK fusion genes [3] - AstraZeneca's Imfinzi (Durvalumab) has been approved in the EU for use in muscle-invasive bladder cancer (MIBC) as a neoadjuvant treatment in combination with Gemcitabine and Cisplatin, followed by monotherapy after radical cystectomy [4] Capital Markets - Micot completed a D-round financing exceeding 100 million yuan, led by Zhejiang Merchants Venture Capital, with funds aimed at core pipeline development and the establishment of a formulation industrialization base [5] - Opcon Vision announced plans to use 334 million yuan to acquire 75% of Jiangsu Shangyue Qicheng Hospital Management Co., with part of the funds originally allocated for community optical service terminal construction [6] Industry Developments - Tengsheng Bo Pharmaceutical has reached a BD licensing agreement with Health Yuan for BRII-693, with Health Yuan responsible for its development and commercialization in Greater China [8] - Sunshine Nuohong signed a technical development cooperation contract with Shanghai Lekuang Huilin Pharmaceutical Technology for the STC007 project, with a total milestone payment of 200 million yuan [7] Public Sentiment Alerts - Nengte Technology adjusted the listing price for the 100% equity transfer of its subsidiary, Ankang Shenqian Mining Co., to 114 million yuan, a 15% decrease from the previous listing price [9] Shareholder Actions - Ever Union (H.K.) Limited, a shareholder of Mindray Medical, plans to reduce its stake by up to 5 million shares, representing approximately 0.41% of the company's total share capital [10][11]

Policy Developments - The Ministry of Finance announced measures regarding the procurement of medical devices imported from the EU, stating that for procurement budgets over 45 million yuan, EU companies (excluding EU-funded enterprises in China) must be excluded if import products are required [1] Drug and Device Approvals - Weikang Pharmaceutical's Anruini capsules have been submitted for market approval, targeting adult and adolescent patients with specific solid tumors carrying NTRK fusion genes [2] - AstraZeneca's Imfinzi (Durvalumab) has received EU approval for use in muscle-invasive bladder cancer (MIBC) as an adjuvant treatment following radical cystectomy [3] Capital Market Activities - Micot announced the completion of over 100 million yuan in Series D financing, led by Zhejiang Merchants Venture Capital, with funds aimed at core pipeline development and the establishment of a formulation industrialization base [4] - Opcon Vision plans to use 334 million yuan to acquire 75% of Shanyang Qicheng Hospital Management Co., with part of the funds redirected from a community eye care service project [5] Industry Developments - Tengsheng Bo Pharmaceutical has reached a BD licensing agreement with Health元 for BRII-693, with Health元 responsible for development and commercialization in Greater China [7][8] - Nengte Technology has adjusted the listing price for the sale of its subsidiary, Ankang Shenqian Mining Co., to 114 million yuan, a 15% decrease from the previous listing price [9] - Ever Union, a shareholder of Mindray Medical, plans to reduce its stake by up to 0.41% through various legal means [10]

Group 1 - Lin Yanglin, the chairman of Xinlicheng, has been placed under detention and is under investigation, which may impact investor confidence despite the company stating the matter is unrelated to its operations [1] - Weiming Pharmaceutical's stock will be suspended for one day due to its trial progress not meeting expectations and its subsidiary's inability to resume normal operations within three months, affecting performance expectations [2] - Tengsheng Bo Pharmaceutical has signed a licensing agreement with Health Yuan Group for the exclusive rights to research, develop, and commercialize BRII-693 in China, providing cash flow and enhancing market expectations [3] Group 2 - China Resources Double Crane announced a cash dividend of 3.71 yuan per 10 shares despite a decline in revenue and net profit, indicating strong cash flow and commitment to shareholders [4] - InnoTech's subsidiary has obtained long-term product certification for a flu detection kit, which is expected to enhance market competitiveness and potentially increase revenue [5]

Core Viewpoint - The collaboration between Tengsheng Bo Pharmaceutical and Health元 Group focuses on the exclusive licensing and commercialization of BRII-693 in Greater China, addressing the urgent need for new antibiotics in the face of rising antibiotic resistance [1] Company Summary - Tengsheng Bo Pharmaceutical's subsidiary, Brii Biosciences, has signed a technology transfer agreement with Health元 Group for the development and commercialization of BRII-693 in Greater China [1] - Health元 Group will be responsible for the development, regulatory approval, and commercialization of BRII-693 in the specified regions [1] - The agreement includes an upfront payment and additional milestone payments based on the achievement of specific development and commercialization milestones, along with a sales revenue sharing arrangement [1] Industry Summary - The increasing threat of antibiotic resistance in Greater China highlights the urgent need for new hospital antibiotics, making the development of BRII-693 particularly timely [1] - The collaboration is expected to leverage Health元 Group's proven capabilities in the production and commercialization of hospital antibiotics, enhancing the prospects for BRII-693 [1] - The project is anticipated to address significant unmet clinical needs, with potential to become a Best-in-Class drug based on its therapeutic potential and pharmacological characteristics [1]

点击注册小程序 查看完整报告 保健品和OTC产品快速发展，驱动板块收入快速增长 24年健康元（不含丽珠集团、丽珠单抗）保健食品及OTC板块实现营业收入6.97亿元，同比增长约 53.91%。保健食品与OTC板块利用小红书、抖音、微信等新媒体内容渠道，通过达人推荐、健康科普、达 人直播带货等方式创作优质的内容触达用户，传递品牌理念，驱动品牌全渠道的销售增长。我们预计 25~26年板块发展势头良好，收入有望维持较快增速。 研发有序投入，创新转型可期 在创新药领域，公司正逐步推进"机制创新+多适应症覆盖"战略，向"抗感染+呼吸+镇痛"等多元协同方向 发展。其中：1）抗流感新药TG-1000已报产，预计2025年下半年获批上市，该新药具有较长的有效治疗 期；2）在高壁垒复杂制剂方面，沙美特罗替卡松吸入粉雾剂、丙酸氟替卡松雾化吸入用混悬液获得注册 批件，均实现国内首仿。3）在前沿靶点布局方面，TSLP单抗与IL-4R单抗均已进入Ⅱ期临床研究阶段。 在创新药加速向机制升级、适应症精准拓展演进的趋势下，公司在其呼吸系统疾病治疗主线之外，开始布 局多元化创新领域，Nav1.8作为外周神经系统疼痛信号传导的重要钠通道，具有机制 ...