Core Viewpoint - The company Maiwei Biopharma is facing challenges in achieving significant revenue growth from its products, particularly in the competitive landscape of the domestic innovative drug market, despite having several products approved for commercialization [1][3]. Financial Performance - In 2023 and 2024, the company's revenue was 128 million yuan and 200 million yuan, respectively, with drug sales contributing 42.09 million yuan and 145 million yuan [3]. - The company reported significant R&D expenses of 836 million yuan in 2023 and 783 million yuan in 2024, leading to net losses of 1.053 billion yuan and 1.044 billion yuan for the respective years [3]. - The company's debt situation is concerning, with a cash balance of 1.193 billion yuan and total borrowings of 922 million yuan short-term and 1.12 billion yuan long-term, resulting in an increase in the debt-to-asset ratio from 42.24% to 63.61% [9]. Product Portfolio - Maiwei Biopharma has three products in the commercialization stage: Junmaikang, Mailishu, and Maiweijian, with Junmaikang being a biosimilar to Adalimumab [2]. - Mailishu generated sales of 124 million yuan in 2024, marking a 195.5% increase year-on-year, making it the company's leading product [3]. - The company is struggling with market penetration for Junmaikang, which is the sixth Adalimumab biosimilar in the market, facing challenges due to established competitors and market dynamics [5][7]. Market Dynamics - The innovative drug market in China has seen successful entries from other companies, such as Qilu Pharmaceutical and Fuhong Hanlin, which have achieved significant sales with their biosimilars [4]. - The market for TNF inhibitors, including Adalimumab, is not well established in China, with leading competitors only achieving sales of around 1 billion yuan [5]. - Maiwei Biopharma's sales strategy has shifted to focus on core regions and partnerships due to previous losses and low return rates in certain areas [7]. Future Outlook - The company plans to introduce three new products over the next three years to enhance revenue generation and is considering an IPO in Hong Kong to alleviate cash flow issues [9]. - The pipeline includes promising candidates like 9MW2821, which is in phase 3 clinical trials and has potential for significant market impact if approved [10].

Core Viewpoint - The company received an inquiry letter from the Shanghai Stock Exchange regarding its 2024 annual report, prompting a detailed response about its operational performance and product sales [1][2]. Group 1: Operational Performance - In 2024, the company achieved operating revenue of 200 million yuan, a year-on-year increase of 243.53% [2][19]. - The company has three commercialized products: Junmaikang, Mailishu, and Maiweijian, with varying sales performance and challenges [2][3]. - Junmaikang's sales volume significantly decreased by 66.61%, with 48,821 units shipped in 2024 [2][10]. - Mailishu's sales revenue increased by 195.50%, with a total revenue of 12.44 million yuan in 2024 [3][5]. - Maiweijian achieved a total revenue of 14.46 million yuan in 2024, with a gross margin of 78.47% [4][11]. Group 2: Product Analysis - Junmaikang's sales were impacted by its late market entry and intense competition, leading to a strategic shift in sales approach [6][9]. - Mailishu's cost increased by 1,122.70% compared to the previous year, resulting in a decrease in gross margin by 9.96 percentage points [5][6]. - Maiweijian's market entry was slow, with only 75 hospitals approved by the end of 2024, attributed to its limited indications compared to the original drug [12][14]. Group 3: Market Trends and Strategies - The TNF-α drug market in China grew from 3.5 billion yuan in 2019 to 42.9 billion yuan in 2023, with a compound annual growth rate of 17.5% [6][7]. - The company plans to expand Maiweijian's indications to include SREs, which could enhance its market presence [23][24]. - The company is actively pursuing international collaborations and expanding its product pipeline to enhance revenue streams [25][26]. Group 4: Financial Outlook - The company anticipates gradual revenue growth and a reduction in net losses over the next three years, with a low risk of expanding losses [20][19]. - The company is focusing on improving operational efficiency and expanding its commercialized product offerings to achieve profitability [20][21].

Core Viewpoint - The company, Maiwei (Shanghai) Biotechnology Co., Ltd., reported a significant increase in revenue for 2024, driven by its commercialized products and technical services, while facing challenges in market penetration and competition in the biopharmaceutical sector [3][21]. Financial Performance - In 2024, the company achieved a revenue of 200 million RMB, representing a year-on-year growth of 56.28% [3]. - The revenue breakdown includes 145 million RMB from antibody drugs and 55 million RMB from technical services [3]. - The sales volume of the product Junmaikang decreased by 66.61% year-on-year, with a total shipment of 48,821 units [3][10]. Product Analysis - The company has three commercialized products: Junmaikang, Mailishu, and Maiweijian, with detailed sales revenue, costs, and gross margins provided [3][5]. - Junmaikang's sales revenue for 2024 was 124.37 million RMB, with a gross margin of 6.25% [5]. - Mailishu's sales revenue was 145.94 million RMB, with a gross margin of 86.87% [5]. - Maiweijian's sales revenue reached 145.92 million RMB, with a gross margin of 78.47% [5]. Market Dynamics - The TNF-α drug market in China grew from 3.5 billion RMB in 2019 to 10.1 billion RMB in 2023, with a projected growth to 42.9 billion RMB by 2032 [7]. - The competitive landscape for Junmaikang is challenging, with multiple similar products already in the market, leading to a decline in its sales volume [9][10]. Strategic Adjustments - The company is optimizing its regional operating model to improve efficiency and resource utilization, transitioning from self-operated sales to cooperative sales in underperforming areas [10][21]. - The company plans to expand the indications for Maiweijian to enhance its market competitiveness and sales revenue [25][21]. Research and Development - The company has several products in the pipeline, with multiple candidates entering Phase III clinical trials, expected to launch between 2028 and 2031 [20][21]. - The company is actively pursuing international collaborations and market expansions, particularly in emerging markets [26][27]. Technical Services - The technical service revenue composition includes significant contracts with major clients, contributing to the overall revenue [15][19]. - The company has received substantial payments for milestone achievements in its technical service agreements [15].

证券代码：688062 证券简称：迈威生物 公告编号：2025-024 问题一 关于经营业绩 1 主要客户、服务内容、合同对价、交付进展、收入确认进度及依据、销售回款 情况等。（4）结合营业收入分季度波动情况，说明第四季度营业收入环比增长 超 100%的原因及合理性。（5）结合公司主要在研产品的研发进度、预计上市 时间、预计销售规模等，说明公司是否存在亏损扩大风险，以及公司拟采取的 提高经营质效措施。 关于经营业绩。年报显示，2024 年公司实现营业收入 2.00 亿元，同比增长 56.28%，具体为抗体药物收入 1.45 亿元，技术服务收入 0.55 亿元。药物销售 方面，公司已有君迈康、迈利舒、迈卫健等 3 款产品获批上市，其中君迈康全 年发货 48,821 支，同比下降 66.61%，迈卫健全年发货 12,530 支，累计准入医 院 75 家。请你公司：（1）分产品列示公司三款商业化产品的销售收入、成本、 毛利率，并分析变动情况及原因。（2）结合市场需求、竞争格局、竞品销售情 况、价格成本波动等因素，分别说明君迈康发货量大幅下降、迈卫健医院准入 进度较慢的原因，分析是否符合行业趋势，并补充说明公司拟采取 ...

国泰海通证券股份有限公司 关于迈威（上海）生物科技股份有限公司 2024 年报告的信息披露监管问询函的专项核查意见 上海证券交易所： 根据贵所《关于迈威（上海）生物科技股份有限公司2024年报告的信息披 露监管问询函》（上证科创公函【2025】0064号）（以下简称"《问询函》"） 的要求，国泰海通证券股份有限公司（以下简称"国泰海通"或"保荐机构"） 作为迈威（上海）生物科技股份有限公司（以下简称"公司"）首次公开发行 股票并在科创板上市的保荐机构及持续督导机构，对问询函相关问题进行了审 慎核查，并出具核查意见如下： 本核查意见中若出现总计数尾数与所列数值总和尾数不符的情况，均为四 舍五入所致。本核查意见中所列示的包括但不限于收入、利润及产能规划等数 据的相关测算和预计均不构成业绩承诺或盈利预测。如无特别说明，本核查意 见中使用的简称或名词释义与《迈威（上海）生物科技股份有限公司2024年年 度报告》（以下简称"2024年报"）一致。 问题一 关于经营业绩 关于经营业绩。年报显示，2024 年公司实现营业收入 2.00 亿元，同比增长 56.28%，具体为抗体药物收入 1.45 亿元，技术服务收入 0.55 ...

就上海证券交易所科创板公司管理部 《关于对迈威(上海)生物科技股份有限公司2024年报告的信息披露监管问询函》 中部分涉及财务报表项目问询意见的专项说明 年报显示，2024年公司实现营业收入2.00亿元，同比增长56.28%，具体为抗体药物收入1.45亿元， 技术服务收入0.55亿元。药物销售方面，公司已有君迈康、迈利舒、迈卫健等3款产品获批上市，其中 君迈康全年发货48,821支，同比下降66.61%，迈卫健全年发货12,530支，累计准入医院75家。请你公 司：（1）分产品列示公司三款商业化产品的销售收入、成本、毛利率，并分析变动情况及原因。（2） 结合市场需求、竞争格局、竞品销售情况、价格成本波动等因素，分别说明君迈康发货量大幅下降、 迈卫健医院准入进度较慢的原因，分析是否符合行业趋势，并补充说明公司拟采取的改进措施。（3） 说明公司技术服务收入的具体构成，包括但不限于技术服务收入对应的主要客户、服务内容、合同对 价、交付进展、收入确认进度及依据、销售回款情况等。（4）结合营业收入分季度波动情况，说明第 四季度营业收入环比增长超 100%的原因及合理性。（5）结合公司主要在研产品的研发进度、预计上 市时 ...

A股生物制品板块短线拉升，三生国健涨超10%，诺诚健华、荣昌生物、迈威生物、凯因科技、智翔金 泰等跟涨。 ...

Group 1 - The innovative pharmaceutical ETF (560900) has seen a 0.89% increase, marking a four-day rising streak, with the index tracking the innovative drug industry (931152) up by 0.85% [1] - Notable stock performances include Maiwei Biotech (688062) rising over 9%, Tianshili (600535) up 4.76%, and Baotai (688177) increasing by 4.38% [1] - The innovative pharmaceutical ETF has experienced a significant growth of 4 million shares in the last three months, indicating a recovery in market enthusiasm for the pharmaceutical sector [2] Group 2 - The pharmaceutical and biotechnology sector's Q1 2025 financial reports show stable revenue and profit performance, with notable improvements in certain sub-industries [2] - The market sentiment towards the pharmaceutical sector has shifted positively, ending a continuous downtrend since Q1 2024, driven by a systematic valuation increase in the innovative drug sector [2] - Long-term potential exists in China's biomanufacturing, quantum technology, embodied intelligence, and 6G industries, with significant development opportunities across the entire industrial chain [2] Group 3 - Morgan Asset Management is integrating its "Global Vision Investment Technology" product line to assist investors in seizing investment opportunities in quality technology companies globally [2] - Various actively managed funds focus on emerging industry trends, including the Morgan Emerging Power Fund and the Morgan Smart Connectivity Fund, which targets artificial intelligence opportunities [3] - The Morgan Hang Seng Technology ETF and the Morgan Zhongzheng Innovative Pharmaceutical Industry ETF provide passive investment options for technology and innovative pharmaceutical sectors [3]

Group 1 - The core viewpoint is that the China Securities Regulatory Commission (CSRC) is expediting a comprehensive policy package to deepen reforms in the Sci-Tech Innovation Board and the Growth Enterprise Market, aiming to enhance the scale and proportion of medium to long-term capital entering the market [1] - The People's Bank of China and four other departments are implementing policies to support technological innovation, encouraging financial institutions to expand first-time financing and equipment renewal loans for tech companies [1] - Guoyuan Securities believes that under high global technological barriers, companies on the Sci-Tech Innovation Board are pursuing independent innovation across various sectors, including chip design, biomedicine, high-end equipment, and new energy, positioning themselves as pioneers in the international value chain [1] Group 2 - As of April 30, 2025, the top ten weighted stocks in the Sci-Tech Innovation Board 100 Index account for 25.04% of the index, with companies like Hengxuan Technology and BeiGene among the leaders [2] - The Sci-Tech 100 ETF fund has shown a positive performance, with notable increases in the stock prices of several constituent companies, indicating a favorable market sentiment [1]

Group 1 - The A-share market saw a collective decline on May 16, while the Sci-Tech Innovation Pharmaceutical sector rebounded, with the Sci-Tech Innovation Pharmaceutical ETF (588860) rising by 0.16% [1] - Notable stocks in the sector included Maiwei Biotech-U, which increased by over 5%, along with Shouyao Holdings-U, KQ Biotech, Innotec, CanSino, and Baotai, all of which experienced gains [1] - The Sci-Tech Innovation Pharmaceutical ETF closely tracks the Shanghai Stock Exchange Sci-Tech Innovation Board Biopharmaceutical Index, which selects 50 large-cap companies in biopharmaceuticals and related fields to reflect the overall performance of representative companies in the sector [1] Group 2 - According to CMB International, the optimization of centralized procurement policies in mainland China provides hospitals and enterprises with more flexibility and autonomy, benefiting leading prescription drug companies [2] - The anticipated implementation of favorable policies, such as the 2025H2 medical insurance category, is expected to accelerate industry consolidation, with the sector's valuations remaining at historical lows [2] - The recommendation is to focus on innovative drug targets with high growth potential or clear breakeven timelines after short-term sentiment stabilizes [2]