本文源自：金融界 作者：行情君 百济神州有限公司是一家全球性、商业阶段的生物科技公司，专注于研究、开发、生产以及商业化创新 型药物，主要产品百悦泽（（BRUKINSA），BTK抑制剂）、百泽安（抗PD-1单抗）、帕米帕利。 最新一期业绩显示，2024年年报，公司实现营业收入272.14亿元，同比56.19%；净利润-4978287000.0 元，同比25.87%，销售毛利率84.44%。 序号股票简称PE(TTM)PE(静)市净率总市值(元)8百济神州-67.20-67.2013.843345.35亿行业平均 57.2745.109.66181.27亿行业中值38.9936.382.8172.21亿1优宁维-1970.71245.081.2124.87亿2万泰生 物-1148.16780.856.79829.54亿3仁度生物-149.24-196.671.6815.36亿4诺思兰德-116.73-105.0214.6747.45亿 5通化东宝-97.37-337.862.22144.34亿6诺诚健华-81.88-81.885.36360.80亿7双鹭药业-68.61-90.991.2067.39 亿9康希诺- ...

Financial Performance - Total revenues for Q1 2025 increased by 48.6% to $1.117 billion compared to $751.7 million in Q1 2024[94] - BRUKINSA global sales rose by 62.1% to $791.7 million, with U.S. sales growing by 60.2% to $563.2 million[95] - TEVIMBRA revenue increased by 17.8% to $171.2 million in Q1 2025 compared to $145.3 million in the prior-year period[96] - The company achieved GAAP profitability in Q1 2025, marking a significant turnaround from a net loss of $251.2 million in Q1 2024[92] - GAAP net income improved to $1.3 million in Q1 2025, compared to a loss of $251.2 million in the prior-year period[107] - Adjusted earnings per share (basic) for Q1 2025 was $0.10, compared to a loss of $0.11 in Q1 2024[108] Expenses and Costs - Operating expenses rose by 6.0% to $941.2 million, with R&D expenses increasing by 4.6% to $481.9 million[93] - Selling, general and administrative expenses increased by $31.9 million, or 7.5%, to $459.3 million for Q1 2025, primarily due to global commercial expansion efforts[103] - Selling, general and administrative expenses as a percentage of product sales decreased to 41.4% in Q1 2025 from 57.2% in the prior-year period[103] - Research and development expense increased by $21.2 million, or 4.6%, to $481.9 million for Q1 2025 from $460.6 million in Q1 2024[98] - External research and development expenses rose by $19.4 million, or 11.3%, to $190.8 million in Q1 2025, driven by advancing preclinical and early clinical programs[100] Cash and Debt Management - Cash, cash equivalents, and restricted cash totaled $2.53 billion as of March 31, 2025, down from $2.64 billion at the end of 2024[110] - Total debt decreased to $923.6 million as of March 31, 2025, from $1.02 billion at the end of 2024, with $97.1 million paid down in Q1 2025[110] - The company expects to repay approximately $763.5 million of loans in the next 12 months, with refinancing dependent on prevailing interest rates and credit spreads[116] - As of March 31, 2025, total debt obligations due in the next twelve months are $763.5 million, with long-term debt obligations at $160.2 million[123] - The company had $461.6 million in cash remaining related to the STAR Offering proceeds as of March 31, 2025[111] Revenue Sources - Collaboration revenue increased by 84.8% to $8.7 million in Q1 2025, driven by agreements with Novartis and Amgen[96] Operational Highlights - Gross margin on global product sales improved to 85.1% in Q1 2025, up from 83.3% in the same period last year[97] - Cash provided by operating activities improved by $352.7 million in Q1 2025 compared to Q1 2024, driven by significantly improved revenue and a $325.6 million increase in gross margin[113] - Net cash used in investing activities decreased to $121.9 million in Q1 2025 from $209.8 million in Q1 2024, primarily due to reduced capital expenditures[114] - Financing activities used $33.8 million in cash in Q1 2025, a significant decrease from $162.3 million provided in Q1 2024, mainly due to a net reduction in short-term debt borrowings[115] Strategic Initiatives - The company plans to host an Investor R&D Day on June 26, 2025, to discuss advancements in its late-stage pipelines[92] - The company secured shareholder approval to rename itself to BeOne Medicines Ltd. and to redomicile to Switzerland[92] Legal and Regulatory Developments - The U.S. Patent and Trademark Office invalidated all claims of Pharmacyclics LLC's U.S. Patent No. 11,672,803, benefiting the company's competitive position[89] Foreign Exchange Impact - The RMB appreciated approximately 0.6% against the U.S. dollar in Q1 2025, while it depreciated approximately 2.8% in the year ended December 31, 2024[132] - A hypothetical 10% appreciation in the U.S. dollar against the RMB would have resulted in an increase in foreign exchange loss of approximately $14.8 million as of March 31, 2025[133]

Financial Performance - Total revenue for Q1 2025 reached $1.12 billion, a 49% increase from $751.65 million in Q1 2024[8] - Product revenue for Q1 2025 was $1.11 billion, up 48% from $746.92 million in the same period last year[8] - GAAP operating profit for Q1 2025 was $11.1 million, a significant improvement from a loss of $261.35 million in Q1 2024, marking a 104% change[8] - Adjusted operating profit for Q1 2025 was $139.36 million, compared to a loss of $147.34 million in the previous year, representing a 195% increase[8] - The company achieved its first GAAP quarterly profit in Q1 2025, with a GAAP net profit of $1.27 million, compared to a loss of $251.15 million in Q1 2024[8] - The company reported a net profit of $0.00 per share in Q1 2025, an improvement from a loss of $0.19 per share in the same period last year[14] - The net profit for Q1 2025 was $1,270,000, a turnaround from a net loss of $251,150,000 in Q1 2024[32] Sales and Market Performance - Global sales of Brukinsa (Zebutinib) amounted to $792 million, reflecting a 62% year-over-year growth[7] - The U.S. remained the largest market, contributing $563 million in product revenue for Q1 2025, up from $351 million in the same quarter last year[9] - Baiyueze® sales in the U.S. reached $563 million in Q1 2025, a 60% increase year-over-year, primarily due to increased demand in CLL indications[13] - Baiyueze® is now approved in 75 markets globally, with recent expansions in Japan, Europe, and Brazil[17] Expenses and Costs - R&D expenses for Q1 2025 were $481.9 million, a 5% increase from $460.6 million in Q1 2024; adjusted R&D expenses rose 4% to $421.2 million[11] - SG&A expenses in Q1 2025 were $459.3 million, up 7% from $427.4 million in Q1 2024, with SG&A expenses accounting for 41% of product revenue, down from 57% year-over-year[12] - Operating expenses totaled $941,175,000 in Q1 2025, compared to $888,065,000 in Q1 2024, marking an increase of approximately 6%[32] Cash Flow and Assets - Cash and cash equivalents as of March 31, 2025, were $2,530,591,000, a slight decrease from $2,638,747,000 as of December 31, 2024[33] - Total assets amounted to $5,841,526,000 as of March 31, 2025, down from $5,920,910,000 at the end of 2024[33] - Net cash provided by operating activities was $44,082 thousand in Q1 2025, a significant improvement from a net cash used of $308,572 thousand in Q1 2024[34] - Cash used in investing activities was $121,941 thousand in Q1 2025, compared to $209,831 thousand in Q1 2024[34] Future Plans and Developments - The company plans to hold an investor R&D day on June 26, 2025, to discuss advancements in its late-stage hematologic and solid tumor pipeline[7] - The company expects to report proof of concept data in various projects related to antibody-drug conjugates, multispecific antibodies, and targeted protein degradation throughout the year[7] - The company expects to complete mid-term analysis for the Phase 3 MANGROVE trial for MCL treatment in the second half of 2025[23] - The company plans to submit a global accelerated approval application for Sotoclar in R/R MCL following data readout from a Phase 2 trial anticipated in late 2025[26] - Baiyueze® tablet formulation is anticipated to receive FDA and EU approval in the second half of 2025[23] Corporate Changes - The company has received shareholder approval to adopt a new English name, BeOne Medicines Ltd., and relocate its registered office to Switzerland[7] - The company has received shareholder approval to change its name to BeOne Medicines Ltd. and relocate its registered office to Switzerland, expected to be completed later this year[26]

Financial Reporting - BeiGene, Ltd. filed its 2024 Annual Report with the STAR Market of the Shanghai Stock Exchange on April 28, 2025[5]. - The STAR Annual Report includes financial information for the year ended December 31, 2024, prepared in accordance with PRC GAAP[6]. - Financial information prepared under U.S. GAAP is also included, highlighting differences between PRC GAAP and U.S. GAAP[6]. - The financial information in the report is intended to be furnished and not deemed "filed" under the Exchange Act[8]. Key Financial Metrics - The report contains details on gross profit margin ratio and research and development expenses allocated by key products[6]. Public Availability - The STAR Annual Report is publicly available in Chinese on the Shanghai Stock Exchange's website[7]. Strategic Insights - The report does not include any new product launches or market expansion strategies[5][6]. - No specific performance guidance or future outlook was provided in the current report[5][6]. - The report does not mention any mergers or acquisitions during the reporting period[5][6]. Signatory Information - The filing was signed by Chan Lee, Senior Vice President and General Counsel of BeiGene, Ltd.[16].

Macro Strategy - The focus of monetary policy adjustments, including "reserve requirement ratio cuts" and "interest rate cuts," is to stabilize economic growth and enhance domestic demand, expectations, and confidence [1] - The analysis of Trump's 2.0 policy indicates a combination of continuity from the 1.0 policy and a new political cycle, with tariffs and fiscal policies being the main sources of expectation differences [1] Overseas Market Overview - The overseas market data during the May Day holiday showed resilience in the US economy, with core GDP and non-farm payrolls exceeding expectations, leading to a delay in interest rate cut expectations to July [2] - The upcoming FOMC meeting is expected to maintain interest rates, with a CPI forecast of 2.4% providing conditions for potential rate cuts [2] Fixed Income Market - In the week of April 28 to May 2, seven green bonds were issued, totaling approximately 8.475 billion yuan, a decrease of 27.725 billion yuan from the previous week [4] - The secondary capital bonds issued during the same period totaled 50 billion yuan, with a trading volume of approximately 104.9 billion yuan, down 31.3 billion yuan from the previous week [5] Company Performance Insights - The company "老百姓" reported a revenue of 22.358 billion yuan in 2024, a decrease of 0.36% year-on-year, with a net profit of 519 million yuan, down 44.13% [8] - "同享科技" adjusted its profit forecast due to intense competition, expecting net profits of 33 million yuan, 52 million yuan, and 68 million yuan for 2025-2027, reflecting a year-on-year decline of 22% in 2025 [9] - "海南机场" is expected to benefit from the development of Hainan Free Trade Port, with revised net profit forecasts of 680 million yuan and 1.02 billion yuan for 2025 and 2026, respectively [9] - "益丰药房" achieved a revenue of 24.062 billion yuan in 2024, an increase of 6.53%, with a net profit of 1.529 billion yuan, up 8.26% [10] - "九安医疗" reported a revenue of 2.59 billion yuan in 2024, a decrease of 19.77%, but a net profit increase of 33.3% to 1.67 billion yuan [15] Industry Trends - The report on "科润智控" indicates a significant increase in transformer demand, with net profit forecasts for 2025-2027 adjusted to 84 million yuan, 123 million yuan, and 168 million yuan, reflecting a year-on-year growth of 97% in 2025 [17] - "海吉亚医疗" is expected to stabilize after a low point in 2024, with revised net profit forecasts of 666 million yuan and 782 million yuan for 2025 and 2026, respectively [18] - "中国电建" is projected to have net profits of 12.5 billion yuan and 13.2 billion yuan for 2025 and 2026, respectively, benefiting from infrastructure investments [20] - "中国中铁" reported a revenue decline in traditional infrastructure but saw growth in overseas orders, with net profit forecasts adjusted to 28 billion yuan for 2025 [22] - "微软" continues to show strong performance in cloud business, with net profit forecasts of 99.1 billion dollars for FY2025 [23]

港股创新药板块盘初下挫，百济神州跌超6%，荣昌生物跌超5%，信达生物、药明生物、君实生物纷纷 下挫。 ...

Group 1 - The core viewpoint of the article highlights the performance of the CSI Hong Kong-Shanghai Biotech Theme Index, which opened high and is currently at 1195.47 points, reflecting a recent decline of 2.95% over the past month but an increase of 13.55% over the last three months and 13.14% year-to-date [1][2] - The index comprises 50 listed companies involved in biopharmaceuticals, pharmaceuticals, and biotech services from the mainland and Hong Kong markets, serving as a benchmark for the overall performance of biotech-themed securities [1][2] - The top ten weighted companies in the index include: Hengrui Medicine (13.31%), BeiGene (10.94%), WuXi AppTec (8.63%), Mindray Medical (7.77%), WuXi Biologics (5.11%), Innovent Biologics (4.73%), CanSino Biologics (3.38%), CSPC Pharmaceutical Group (2.73%), China National Pharmaceutical Group (2.41%), and Shanghai RAAS Blood Products (1.82%) [1][2] Group 2 - The index's holdings are distributed across different market exchanges, with the Hong Kong Stock Exchange accounting for 41.35%, Shanghai Stock Exchange for 36.05%, and Shenzhen Stock Exchange for 22.61% [1][2] - In terms of industry composition, biopharmaceuticals represent 42.86%, chemical drugs 25.82%, pharmaceutical and biotech services 21.73%, and medical devices 9.59% [2] - The index samples are adjusted biannually, with adjustments occurring on the next trading day following the second Friday of June and December each year, ensuring that the weight factors are updated accordingly [2]

文/飞云 截至2025年4月30日，A股5411家上市公司中，共有5071家公司在2024年年度报告中披露了具体的研发费 用，其中研发费用过亿的有2012家。研发费用前五名分别为：比亚迪、中国建筑、中国移动、中国中铁、 中国交建。科创板、创业板公司研发费用最多的分别是百济神州、宁德时代。本文根据同花顺提供的最新 数据，整理统计了A股研发费用前100名、科创板和创业板研发费用的前30名，具体如下： 一、A股2024年研发费用前100名 研发费用最高的100家公司研发费用合计76995146.25万元，中位数为365510.85万元，平均数为769951.46万 元。比亚迪以5319474.50万元的研发费用位列2024年A股上市公司研发投入榜首。 | 序号 | 股票代码 | 股票简称 | 研发费用(万元) | | --- | --- | --- | --- | | | | | 2024/12/31 | | 1 | 002594.SZ | 比亚迪 | 5319474.50 | | 2 | 601668.SH | 中国建筑 | 4545933.90 | | 3 | 600941.SH | 中国移动 | 281630 ...

证券研究报告 | 行业周报 2025 年 05 月 06 日 医药 本周医药板块上涨 0.49%，百济神州 BCL-2 抑制剂申报上市 | 股票 | 股票 | 投资 | EPS（元） | | PE | | | --- | --- | --- | --- | --- | --- | --- | | 代码 | 名称 | 评级 | 2025E | 2026E | 2025E | 2026E | | 002755.SZ | 奥赛康 | 买入 | 0.2 | 0.28 | 93.95 | 67.11 | | 01952.HK | 云顶新耀 | 买入 | -0.94 | 0.58 | - | - | | 600079.SH | 人福医药 | 增持 | 1.59 | 1.86 | 13.13 | 11.22 | | 688192.SH | 迪哲医药 | 增持 | -1.33 | -0.08 | -43.54 | -723.88 | | 688315.SH | 诺禾致源 | 买入 | 0.53 | 0.62 | 26.53 | 22.68 | | 688321.SH | 微芯生物 | 增持 | 0.05 | 0.23 | 3 ...

买入（维持） | [Table_EPS] 盈利预测与估值 | 2023A | 2024A | 2025E | 2026E | 2027E | | --- | --- | --- | --- | --- | --- | | 营业总收入（百万元） | 17,423 | 27,214 | 35,855 | 43,743 | 53,367 | | 同比（%） | 82.13 | 56.19 | 31.75 | 22.00 | 22.00 | | 归母净利润（百万元） | (6,715.86) | (4,978.29) | 403.50 | 3,592.88 | 6,748.76 | | 同比（%） | 50.77 | 25.87 | 108.11 | 790.43 | 87.84 | | EPS-最新摊薄（元/股） | (4.79) | (3.55) | 0.29 | 2.56 | 4.82 | | P/E（现价&最新摊薄） | - | - | 857.32 | 96.28 | 51.26 | [Table_Tag] [Table_Summary] 投资要点 证券研究报告·公司点评报告·生物制品 百济神州-U（688 ...