Group 1: Shuoshi Biotech - Shuoshi Biotech reported a significant decline in net profit for the first half of 2025, with a net profit of 3.99 million yuan, down 86.35% year-on-year [1] - The company’s non-recurring net profit was -28.05 million yuan, a staggering decrease of 1219.78% year-on-year [1] - Eight senior executives voluntarily reduced their salaries by 5% to 50% to demonstrate solidarity during challenging times, indicating a need for innovation and market expansion to find new profit growth points [1] Group 2: BeiGene - BeiGene announced that the European Commission has approved its PD-1 monoclonal antibody, Tislelizumab, for use in neoadjuvant therapy for adult patients with resectable non-small cell lung cancer (NSCLC) at high risk of recurrence [2] - This approval marks a significant step for the internationalization of domestic PD-1 therapies, benefiting patients in Europe [2] Group 3: Shenzhou Cell - Shenzhou Cell reported a revenue of 972 million yuan for the first half of 2025, a decrease of 25.5% year-on-year, with a net profit of -33.77 million yuan, down 126.87% [3] - The second quarter saw a revenue of 452 million yuan, a decline of 34.66% year-on-year, and a net profit of -97.54 million yuan, down 289.37% [3] - Despite the revenue and profit decline, the company is actively advancing its R&D pipeline and exploring international markets [3] Group 4: Sali Medical - Sali Medical reported a revenue of approximately 584 million yuan for the first half of 2025, a decrease of 40.2% year-on-year, with a net loss of approximately 56.12 million yuan [4] - The company’s revenue and gross profit declined due to the transfer of some subsidiaries and challenges in its transformation, compounded by slow accounts receivable collection and difficulties in business renewals [4] - The company needs to accelerate its transformation efforts to improve performance [4]

Group 1 - Shuoshi Biotech reported a significant decline in net profit for the first half of 2025, with a net profit of 3.99 million yuan, down 86.35% year-on-year, and a non-recurring net profit of -28.05 million yuan, down 1219.78% year-on-year [1] - Eight senior executives, including the honorary chairman and the chairman, voluntarily reduced their salaries by 5% to 50%, demonstrating a commitment to overcoming current challenges [1] - The company faces pressure from industry-wide price reductions and tax rate adjustments, leading to a decline in gross margin, necessitating a focus on innovation and market expansion for future growth [1] Group 2 - BeiGene announced that the European Commission has approved its PD-1 monoclonal antibody, Tislelizumab, for use in neoadjuvant therapy for adult patients with resectable non-small cell lung cancer (NSCLC) at high risk of recurrence [2] - This approval marks a significant step for the internationalization of domestic PD-1 therapies, benefiting patients in Europe [2] Group 3 - Shenzhou Cell reported a revenue of 972 million yuan for the first half of 2025, a decrease of 25.5% year-on-year, with a net profit of -33.77 million yuan, down 126.87% year-on-year [3] - The second quarter saw a revenue of 452 million yuan, down 34.66% year-on-year, and a net profit of -97.54 million yuan, down 289.37% year-on-year [3] - Despite the revenue decline, the company is actively advancing its R&D pipeline and exploring international markets, indicating potential for future growth [3] Group 4 - Sali Medical reported a revenue of approximately 584 million yuan for the first half of 2025, a decrease of 40.2% year-on-year, with a net loss of approximately 56.12 million yuan [4] - The company experienced a significant increase in net loss compared to the previous year, where the net loss was approximately 477,000 yuan [4] - Challenges include slow accounts receivable collection and difficulties in business renewals, necessitating a faster transformation to improve performance [4]

百济神州2025年中期业绩分析：盈利转机下的增长逻辑与挑战并存核心要点财务表现：营收增长强劲： 总收...百济神州2025年中期业绩分析：盈利转机下的增长逻辑与挑战并存 核心要点 财务表现： 营收增长强劲：总收入24.33亿美元，同比增长44.7%；产品收入24.11亿美元，同比增长44.5% 扭亏为盈：净利润9,560万美元，去年同期净亏损3.72亿美元，实现历史性盈利转机 现金储备充裕：现金及现金等价物27.56亿美元，较年初增长1.29亿美元 毛利率持续改善：毛利率从去年同期84.3%提升至86.4% 核心业务进展： 百悦泽持续领跑：收入17.42亿美元，占产品收入72%，同比增长54.7% 美国市场表现突出：收入12.49亿美元，同比增长50.1%，首次超越中国市场成为最大单一市场 合作收入增长：安进特许权使用费收入1,455万美元，显著高于去年同期84万美元 费用控制成效显著：经营费用增长12.2%至20.04亿美元，远低于收入增速 发展战略： 全球化布局深化：完成注册地迁至瑞士，启用新英文名称"BeOne Medicines Ltd." 产能建设投入：霍普韦尔工厂等基础设施持续推进，资本承诺6,2 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因依賴 該等內容而引致的任何損失承擔任何責任。 BeOne Medicines Ltd. 百濟神州有限公司 （根據瑞士法律註冊成立的公司） （股份代號：06160） 截至2025年6月30日止六個月 中期業績公告 百濟神州有限公司連同其子公司（「本公司」或「百濟神州」或「我們」）謹此公佈本 公司截至2025年6月30日止六個月（「報告期」）的未經審核簡明綜合業績連同2024 年相應期間的比較數字，其乃根據美國公認會計原則（「美國公認會計原則」或 「GAAP」）編製並由本公司董事會（「董事會」）審計委員會（「審計委員會」）審閱。 財務摘要 1 • 截至2025年6月30日止六個月的收入合計較截至2024年6月30日止六個月增 加約751.8百萬美元或約44.7%至約2,432.6百萬美元。產品收入較截至2024 年6月30日止六個月增加約742.5百萬美元或約44.5%至約2,410.6百萬美元。 • 截至2025年6月30日止六個月的經營費用合計較截至 ...

Group 1: Financial Performance - The company reported a total revenue increase of approximately $751.8 million or about 44.7% to approximately $2,432.6 million for the six months ending June 30, 2025 [1] - Product revenue increased by approximately $742.5 million or about 44.5% to approximately $2,410.6 million during the same period [1] - The net profit for the period was approximately $95.6 million, a significant recovery from a net loss of approximately $371.6 million for the six months ending June 30, 2024 [1] Group 2: Research and Development Expenses - Research and development expenses increased by $91.7 million (or 10.0%) from $915.1 million in the previous year to $1,006.8 million for the six months ending June 30, 2025 [1] - Internal R&D expenses grew by $21.5 million (or 3.7%) to $606.5 million, primarily due to the expansion of global R&D facilities and an increase in clinical and preclinical candidates [1] Group 3: Gross Profit and Margin - Gross profit from product sales increased to $2,081.0 million, up from $1,405.0 million in the same period last year, driven by the increase in product revenue [2] - The gross margin improved from 84.2% in the previous year to 86.3% for the six months ending June 30, 2025, attributed to a higher sales proportion of Baiyueze compared to other products [2] Group 4: Sales Performance of Baiyueze - Global sales of Baiyueze reached $1,741.5 million, a growth of 54.7% compared to the same period last year [3] - U.S. sales of Baiyueze totaled $1,246.9 million, a 50.1% increase from $830.8 million, driven by robust demand across all indications and moderate net pricing benefits [3] - European sales of Baiyueze amounted to $266.4 million, a year-on-year increase of 79.7%, benefiting from market share growth in major European markets [3]

Core Insights - The company reported a total revenue of 2.433 billion RMB for the six months ending June 30, 2025, representing a year-on-year increase of 44.73% [1] - Gross profit reached 2.103 billion USD, up 48.33% compared to the previous year [1] - The net profit was 95.59 million USD, a turnaround from a net loss of 372 million USD in the same period last year, with basic earnings per share of 0.07 USD [1] Revenue Breakdown - The increase in total revenue was primarily driven by sales growth of the company's self-developed products, Baiyueze and Trelatuzumab, as well as an increase in sales from licensed products, mainly from Amgen [1] - Product revenue net increased by 44.5% to 2.4106 billion USD, compared to 1.6681 billion USD in the same period last year, largely due to significant sales growth of Baiyueze in the US and Europe [1] - Baiyueze's global sales reached 1.7415 billion USD, a 54.7% increase year-on-year, with US sales totaling 1.2469 billion USD, up 50.1% from 830.8 million USD last year [2] Market Position - Baiyueze continues to maintain a leading market share among new patients in the BTK inhibitor class, supported by robust demand across all indications and moderate gains from net pricing [2]

Group 1 - The core viewpoint of the articles highlights the significant financial performance of BeiGene, with a total revenue of 2.433 billion RMB for the six months ending June 30, 2025, representing a year-on-year increase of 44.73% [1] - Gross profit reached 2.103 billion USD, an increase of 48.33% compared to the previous year [1] - The net profit for the period was 95.59 million USD, a turnaround from a net loss of 372 million USD in the same period last year, with basic earnings per share of 0.07 USD [1] Group 2 - The increase in total revenue is primarily attributed to the sales growth of the company's self-developed products, including Baiyueze® and Tislelizumab, as well as the sales of licensed products, mainly from Amgen [1] - For the six months ending June 30, 2025, product revenue net increased by 44.5% to 2.4106 billion USD, up from 1.6681 billion USD in the same period last year [1] - Baiyueze® global sales reached 1.7415 billion USD, a 54.7% increase year-on-year, with U.S. sales totaling 1.2469 billion USD, up 50.1% from 830.8 million USD in the previous year [2] Group 3 - The robust growth in Baiyueze® sales is attributed to strong demand across all indications and moderate gains from net pricing [2] - Baiyueze® continues to maintain a leading market share among new patients in the BTK inhibitor class due to its differentiated and best-in-class clinical characteristics [2]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因依賴 該等內容而引致的任何損失承擔任何責任。 BeOne Medicines Ltd. 百濟神州有限公司 （根據瑞士法律註冊成立的公司） （股份代號：06160） 截至2025年6月30日止六個月 中期業績公告 百濟神州有限公司連同其子公司（「本公司」或「百濟神州」或「我們」）謹此公佈本 公司截至2025年6月30日止六個月（「報告期」）的未經審核簡明綜合業績連同2024 年相應期間的比較數字，其乃根據美國公認會計原則（「美國公認會計原則」或 「GAAP」）編製並由本公司董事會（「董事會」）審計委員會（「審計委員會」）審閱。 財務摘要 1 • 截至2025年6月30日止六個月的收入合計較截至2024年6月30日止六個月增 加約751.8百萬美元或約44.7%至約2,432.6百萬美元。產品收入較截至2024 年6月30日止六個月增加約742.5百萬美元或約44.5%至約2,410.6百萬美元。 • 截至2025年6月30日止六個月的經營費用合計較截至 ...

Core Viewpoint - BeiGene, a leading innovative drug company, has entered the innovative drug business development (BD) wave by selling a portion of the royalty rights for a cancer drug for up to $950 million, marking a significant transaction in the Chinese innovative drug sector [1] Group 1: Transaction Details - BeiGene announced the sale of royalty rights for a cancer drug, receiving an upfront payment of $885 million, which accounts for 36% of its revenue for the first half of the year [1] - The drug, Talazoparib, is set to launch in the U.S. in May 2024 for small cell lung cancer treatment, with the overseas sales managed by Amgen [2] - Royalty Pharma, the buyer, expects a return on investment of 10%-15% from this transaction, with total sales of Talazoparib projected to reach $19.6 billion from 2025 to 2035 [3] Group 2: Market Impact and Analysis - The transaction is significant as it is BeiGene's first drug rights sale in four years and introduces a new BD model in the Chinese innovative drug industry, focusing solely on royalty rights [1][5] - Despite the substantial upfront payment, BeiGene's stock did not rise post-announcement, contrasting with other companies that saw stock increases following similar transactions [6] - Analysts suggest that the transaction may not create long-term value for BeiGene, as it resembles a debt financing rather than a value-generating deal [6] Group 3: Financial Position and Future Outlook - BeiGene's CFO emphasized the importance of a robust balance sheet, stating that the transaction enhances operational and strategic flexibility [7] - The company has over 30 drug candidates in its pipeline, with more than 10 in Phase III clinical trials, necessitating significant R&D investment [7] - As of June 30, 2025, BeiGene had approximately $2.8 billion in cash, down $170 million year-over-year, with liabilities around $2.5 billion [7]

今年8月，百济神州(06160)在释出一份扭亏为盈并超出市场预期的半年报后，又迎来一份重磅BD。 智通财经APP观察到，8月25日盘后，百济神州发布公告，宣布与Royalty Pharma签订《特许权使用费购 买协议》。根据协议，Royalty Pharma将支付8.85亿美元首付款，获得百济神州/安进旗下DLL3/CD3双 抗Tarlatamab (DLL3/CD3，商品名: Imdelltra)在中国以外地区特许权使用费的大部分权利。 Imdelltra即塔拉妥单抗，是百济神州与安进公司合作开发的一款DLL3靶点产品。 近年来DLL3靶点赛道热度飙升，其是Notch信号通路的一个关键蛋白，在正常组织中低表达，但能在特 定癌种尤其是SCLC和其他神经内分泌肿瘤中显著过度表达，由此被认为是SCLC和其它神经内分泌肿 瘤治疗的潜力靶点。智通财经APP了解到，最近一年来，全球范围内涉及DLL3靶点的在研管线数量急 剧飙升，已突破60款。然而目前获批上市的DLL3靶向药仅一款，即此次百济神州BD交易的主角—— Imdelltra。 协议还约定，百济神州在明年8月25日前还有权行使卖出选择权，向Royalty Pha ...