香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因依賴 該等內容而引致的任何損失承擔任何責任。 BeOne Medicines Ltd. 百濟神州有限公司 （根據瑞士法律註冊成立的公司） （股份代號：06160） 授出受限制股份單位 本公告乃根據上市規則第17.06A、17.06B以及17.06C條作出。於2025年6月30 日，董事會薪酬委員會根據2016期權及激勵計劃的條款向二百一十六名承授人授 出涉及合共43,839股美國存託股份的受限制股份單位。 2016期權及激勵計劃項下的受限制股份單位 於2025年6月30日，董事會薪酬委員會根據2016期權及激勵計劃的條款授予二百 一十六名承授人合共43,839股美國存託股份受限制股份單位。該等受限制股份單 位相當於569,907股股份，約佔本公告之日公司發行股份總數的0.04%。 授出受限制股份單位詳情 受限制股份單位詳情如下： 1 授出日期： 2025年6月30日 承授人數目： 二百一十六名 已授出受限制股份單位涉及 的相關股份數目： 569,90 ...

Group 1: ETF Performance - The liquidity of the Kexin Pharmaceutical ETF managed by Jiashi showed a turnover rate of 5.93% with a transaction volume of 13.27 million yuan [2] - Over the past month, the average daily transaction volume reached 38.52 million yuan, ranking first among comparable funds [2] - In the past week, the Kexin Pharmaceutical ETF saw a significant scale increase of 16.98 million yuan, also ranking first among comparable funds [2] - The ETF's share increased by 15 million shares in the past week, marking a notable growth and leading among comparable funds [2] - In the last three days, the ETF experienced continuous net inflows, with a maximum single-day net inflow of 10.41 million yuan, totaling 18.13 million yuan [2] Group 2: Historical Performance - As of July 2, 2025, the Kexin Pharmaceutical ETF's net value increased by 30.63% over the past year [2] - The highest monthly return since inception was 23.29%, with the longest consecutive monthly gains being five months and the maximum gain during this period being 23.50% [2] - The average return during the months of increase was 7.43%, with a historical one-year profit probability of 73.77% [2] Group 3: Index Composition - As of June 30, 2025, the top ten weighted stocks in the Shanghai Stock Exchange Science and Technology Innovation Board Biopharmaceutical Index accounted for 50.3% of the total index [2] - The top stocks include: - United Imaging Healthcare (8.97% weight, +0.35% change) - BeiGene (7.05% weight, -0.05% change) - Huatai Medical (5.85% weight, -1.19% change) - Aier Eye Hospital (4.91% weight, -0.14% change) - Baillie Gifford (4.77% weight, +1.51% change) - Zai Lab (4.75% weight, +2.29% change) - BGI Genomics (4.17% weight, -0.73% change) - Junshi Biosciences (4.15% weight, +2.18% change) - Aibo Medical (3.33% weight, +0.25% change) - Teva Pharmaceutical (3.25% weight, -0.22% change) [4] Group 4: Policy Support - The National Healthcare Security Administration and the National Health Commission issued measures to support the high-quality development of innovative drugs, focusing on key issues faced by the industry [4] - The measures include 16 specific actions across five areas, aiming to provide comprehensive support for innovative drug research, access, hospital use, and multi-channel payment [4] Group 5: Industry Outlook - According to Industrial Securities, the innovative drug sector's prosperity is expected to be sustainable, with a focus on "innovation + internationalization" as the core direction of the pharmaceutical sector [5] - The sector is benefiting from policy support, enhanced global competitiveness, and the realization of commercial profitability [5] - Investors without stock accounts can access opportunities in the biopharmaceutical sector through the Kexin Pharmaceutical ETF Jiashi linked fund [5]

FF305 翌日披露報表 (股份發行人 ── 已發行股份或庫存股份變動、股份購回及/或在場内出售庫存股份) 表格類別： 股票 狀態： 新提交 公司名稱： 百濟神州有限公司 (根據瑞士法律註冊成立的公司) 呈交日期： 2025年7月2日 如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 | 是 | | | 證券代號 (如上市) | 06160 | 說明 | | | | | | | A. 已發行股份或庫存股份變動 | | | | | | | | | | | 已發行股份（不包括庫存股份）變動 | | | 庫存股份變動 | | | | 事件 | | 已發行股份（不包括庫存股 ...

Investment Rating - The report assigns an "Outperform" rating to multiple companies in the healthcare sector, including JD Health, WuXi AppTec, and Innovent Biologics, among others [1]. Core Insights - The innovative drug revenue for the companies is expected to exceed 10 billion yuan in 2025, with innovative drugs projected to account for over 80% of total revenue [22]. - The oncology pipeline leadership is expanding, with core products like Ameitini expected to reach peak sales of 8 billion yuan [22]. - The ADC (Antibody-Drug Conjugate) market is projected to reach $64.7 billion by 2030, with a CAGR of 30% [17]. Summary by Sections Company Ratings - Companies rated as "Outperform" include JD Health, WuXi AppTec, Innovent Biologics, and BeiGene [1]. - Neutral rating is assigned to China National Pharmaceutical Group [1]. Market Trends - The report highlights a strong performance in the online pharmacy sector, driven by chronic disease drugs and innovative weight-loss medications [34]. - JD Health's revenue growth accelerated to 25.5% YoY in Q1 2025, indicating a robust market position [34]. Pipeline and Product Development - The report emphasizes the importance of ADC technology platforms, with several companies establishing global partnerships valued over $6 billion [22]. - Upcoming catalysts include approvals for various ADC products and significant clinical data releases expected in 2025 [34]. Financial Projections - The innovative drug industry chain is expected to grow by over 15% YoY, with high-margin polypeptide business projected to maintain over 60% growth [29]. - Companies like BeiGene are expected to see peak sales in their hematological oncology segment exceed $8 billion [24].

Market Overview - The main funds in the Shanghai and Shenzhen markets experienced a net outflow of 27.907 billion yuan, with the Sci-Tech Innovation Board seeing a net outflow of 999 million yuan [1] - A total of 255 stocks saw net inflows, while 332 stocks experienced net outflows [1] Sci-Tech Innovation Board Performance - On the Sci-Tech Innovation Board, 284 stocks rose, with two stocks, Frontier Bio and Kaiweite, hitting the daily limit, while 293 stocks fell [1] - Among the stocks with net inflows, Longxin Zhongke led with a net inflow of 155 million yuan, followed by Baijie Shenzhou and Anji Technology with net inflows of 111 million yuan and 102 million yuan, respectively [1] Continuous Fund Flow Analysis - There are 53 stocks that have seen continuous net inflows for more than three trading days, with Zhengfan Technology leading at 12 consecutive days of inflow [2] - Conversely, 100 stocks have experienced continuous net outflows, with Puyuan Information leading at 13 consecutive days of outflow [2] Top Fund Inflows - The top stocks by net inflow include: - Longxin Zhongke: 155.47 million yuan, 8.92% inflow rate, 6.43% increase [2] - Baijie Shenzhou: 111.34 million yuan, 13.10% inflow rate, 3.65% increase [2] - Anji Technology: 101.90 million yuan, 11.29% inflow rate, 5.01% increase [2] Notable Outflows - The stock with the highest net outflow is Hanwujing, with a net outflow of 692 million yuan and a 6.40% decrease [1] - Other significant outflows include Haiguang Information and Hengxuan Technology, with net outflows of 220 million yuan and 163 million yuan, respectively [1]

Core Viewpoint - The former president of Takeda China, Dan Guohong, will join BeiGene on August 18, taking the role of General Manager for Greater China, Central Asia, and South Asia, reporting to BeiGene's President and COO, Wu Xiaobin [1] Group 1 - Dan Guohong's appointment is expected to strengthen BeiGene's leadership in the specified regions [1] - The transition reflects BeiGene's strategy to enhance its operational capabilities in Greater China and surrounding areas [1]

Group 1 - The Shanghai Stock Exchange Sci-Tech Innovation Board Biopharmaceutical Index (000683) increased by 0.93% as of July 1, 2025, with notable gains from stocks such as Rongchang Biopharmaceutical (688331) up 7.21% and Shanghai Yizhong (688091) up 3.61% [1] - Starting July 1, 2025, a new policy mandates that all drug sales must include a verification code for medical insurance reimbursement, with full traceability of drug codes required by January 1, 2026, which is expected to enhance drug circulation regulation and impact the entire pharmaceutical industry chain [1] - The current bull market in innovative drugs is driven by the improvement of China's pharmaceutical innovation capabilities, with a trend towards international collaboration in new drug development expected to enhance profitability and market potential for Chinese pharmaceutical companies [2] Group 2 - As of June 30, 2025, the top ten weighted stocks in the Shanghai Stock Exchange Sci-Tech Innovation Board Biopharmaceutical Index accounted for 50.3% of the index, including companies like United Imaging Healthcare (688271) and BeiGene (688235) [3] - The Sci-Tech Biopharmaceutical ETF closely tracks the performance of the Shanghai Stock Exchange Sci-Tech Innovation Board Biopharmaceutical Index, which includes 50 large-cap companies in various biopharmaceutical sectors [2]

Core Viewpoint - The innovative drug sector in China has experienced significant growth in 2023, exemplifying a narrative of China's rise in the capital market, with the Huatai-PB Hong Kong Innovative Drug ETF increasing by 57.87% year-to-date and numerous stocks doubling in value [1]. Group 1: Market Performance and Trends - Chinese innovative drug companies are entering a "Deepseek" moment, a culmination of two decades of development, as stated by industry analysts [2][10]. - The recent surge in the innovative drug sector is attributed to the performance of leading pharmaceutical companies, driven by increased sales of commercialized innovative drugs and a surge in licensing deals for clinical trial assets [4][10]. - The total amount of licensing deals by Chinese innovative drug companies reached $45.5 billion in the first five months of 2025, surpassing the total for the first half of 2024, indicating a robust growth in international licensing transactions [8]. Group 2: Company Highlights - A notable example is BeiGene, which created China's first billion-dollar blockbuster drug, Zebrutinib, achieving global sales of $1.3 billion in 2023 [6]. - BeiGene is projected to generate $3.8 billion in revenue in 2024, with Zebrutinib contributing $2.6 billion, leading to a reduction in the company's losses [7]. Group 3: Future Outlook - Analysts believe that the innovative drug sector in China is on a long-term upward trajectory, with the industry poised for a growth phase characterized by the approval of new drugs and increased licensing revenue [11][12]. - The next 3-5 years are expected to see accelerated globalization and a shift towards original innovation in the Chinese innovative drug sector, with companies that have strong pipelines and clinical advantages likely to lead the next growth wave [13]. - Despite recent market volatility, the long-term outlook remains positive, with expectations of a return to reasonable valuations as innovative results continue to materialize [16].

Core Viewpoint - The innovative drug sector has shown a sharp upward trend, attracting funds that previously focused on other pharmaceutical segments to increase their positions in innovative drugs [1][3][10]. Group 1: Fund Movements - Several funds have shifted their focus towards innovative drugs, with notable examples including Huafu Health Entertainment, which initially held positions in various pharmaceutical stocks but has now significantly adjusted its portfolio towards innovative drugs [3][4]. - Funds like Yongying Pharmaceutical Health and Shenyin Wanguo Pharmaceutical Pioneer have also shown similar trends, indicating a broader movement within the fund management community towards innovative drugs [4][5]. Group 2: Market Dynamics - There is a notable influx of new innovative drug-themed funds entering the market, alongside existing funds reallocating their investments [2][8]. - Despite the positive sentiment, some institutions have warned of potential overvaluation and market overheating in certain stocks within the innovative drug sector [2][11]. Group 3: Performance Metrics - Data from Wind indicates that on June 17, a fund's estimated net value dropped by 0.75%, while the Hang Seng Hong Kong Stock Connect Innovative Drug Index fell by 4.77%, highlighting the correlation between fund performance and the innovative drug index [4]. - A significant increase in ETF shares related to innovative drugs has been observed, with 17 out of 20 ETFs showing positive growth during a recent market correction [7]. Group 4: Future Outlook - Industry experts believe that the current market dynamics reflect a rational correction of previously overly pessimistic expectations regarding the innovative drug sector, with strong long-term growth potential anticipated [10][11]. - However, challenges remain, including high research and development costs, long timelines, and a low success rate for drug development, which necessitate careful investment strategies [11].

Core Insights - BeiGene is advancing its global leadership in hematology through strong drug development and commercialization capabilities, with over 40 products in clinical development and commercialization stages, expecting 20 milestone advancements in the next 18 months [1][10]. Hematology Leadership - The company has established itself as a leader in hematology, particularly with its BTK inhibitor, Brukinsa (Zebutinib), which has gained significant market share in the U.S. and is approved in 75 global markets, benefiting over 200,000 patients [2][4]. - BeiGene is focusing on the development of next-generation therapies, including the BCL-2 inhibitor Sotorasib and the BTK CDAC BGB-16673, which shows promise in overcoming patient resistance [4][7]. - BGB-16673 has demonstrated an overall response rate (ORR) of 84.8% in R/R CLL indications, and a head-to-head trial against a non-covalent BTK inhibitor has been initiated [4][6]. Innovative Pipeline - Sotorasib is positioned as a next-generation BCL-2 inhibitor with superior efficacy and safety compared to existing treatments, and it is currently undergoing pivotal trials for various indications [7][10]. - The company is also developing a diverse pipeline for solid tumors, focusing on breast, gynecological, lung, and gastrointestinal cancers, with several innovative candidates like the CDK4 inhibitor BGB-43395 and the B7-H4 ADC [11][13][19]. Future Growth Potential - BeiGene plans to submit regulatory applications for Sotorasib globally by the second half of 2025, aiming to solidify its position in the B-cell malignancy treatment landscape [10][19]. - The company is expected to report clinical proof of concept data for over 10 new molecules in the next 6-18 months, including promising candidates in the solid tumor space [25][26]. - Recent analyst reports have given BeiGene a "buy" rating, highlighting its potential for significant growth driven by its innovative pipeline and global market expansion [27].