Investment Rating - The report maintains an "Outperform" rating for the pharmaceutical sector, specifically for innovative drugs, CXO, domestic replacement of innovative devices, and consumer healthcare recovery [1][3]. Core Insights - The report emphasizes the continuous recommendation of innovative drugs, maintaining "Outperform" ratings for companies such as Jiangsu Heng Rui Medicine, Huadong Medicine, Hansoh Pharmaceutical Group, Betta Pharmaceuticals, Shenzhen Salubris Pharmaceuticals, Sichuan Kelun Pharmaceutical, Remegen, PATEO, and CSPC Pharmaceutical Group [7][28]. - The report highlights the successful progress of Jiangsu Heng Rui Medicine's Hong Kong listing, which is expected to catalyze the innovative drug market. In 2024, innovative drug sales reached RMB 13.89 billion, a 31% year-on-year increase, accounting for nearly half of the company's total revenue [3][28]. - The report notes that the pharmaceutical sector underperformed the market in the first week of May 2025, with the Shanghai Composite Index rising by 1.9% while the SW Pharma Bio index increased by only 1.0% [10][28]. - The report identifies the best-performing subsectors within the pharmaceutical industry, including medical equipment (+1.7%), traditional Chinese medicine (+1.5%), and biologics (+1.1%) [16][28]. - The report indicates that the premium of the pharmaceutical sector over the A-shares market is currently at a normal level, with a relative premium rate of 79.18% as of May 9, 2025 [20][28]. Summary by Sections Section 1: Continuous Recommendation of Innovative Drugs, CXO, Domestic Replacement of Devices, and Consumer Healthcare Recovery - The report continues to recommend innovative drugs with an "Outperform" rating for several key companies, including Jiangsu Heng Rui Medicine, Huadong Medicine, Hansoh Pharmaceutical Group, and others [7][28]. Section 2: Performance of the Pharmaceutical Sector in Early May 2025 - The pharmaceutical sector's performance was weaker than the overall market, with specific subsectors showing varying degrees of growth [10][28].

简历显示：赵伟先生:中国,硕士研究生。历任葛兰素史克(上海)医药研发有限公司药物化学部助理研究 员、广发证券股份有限公司投资自营部医药研究员、招商基金管理有限公司研究部医药组组长及招商基 金管理有限公司国际业务部基金经理助理。现任农银汇理基金管理有限公司基金经理。2019年11月8日 至2021年3月5日担任农银汇理中小盘混合型证券投资基金基金经理。2020年1月13日至2021年3月5日担 任农银汇理行业成长混合型证券投资基金基金经理。2020年1月21日至2021年3月5日任职农银汇理创新 医疗混合型证券投资基金基金经理。2017年6月20日至2021年3月5日担任农银汇理医疗保健主题股票型 证券投资基金基金经理。曾任农银汇理中国优势灵活配置混合型证券投资基金基金经理。2021年03月加 入富国基金管理有限公司,2021年7月6日起担任富国精准医疗灵活配置混合型证券投资基金基金经理。 2024年04月23日起担任富国科创板两年定期开放混合型证券投资基金基金经理。 金融界2025年5月12日消息，富国精准医疗混合A(005176) 最新净值2.6542元，下跌3.50%。该基金近1个 月收益率-2.01%， ...

Investment Rating - The investment rating for the biopharmaceutical industry is "Positive" (maintained) [2] Core Insights - The report highlights the aggressive nature of small cell lung cancer (SCLC), with extensive stage SCLC accounting for approximately 75% of cases, which often rely on systemic treatment and have a poor prognosis [6][21] - The first-line treatment for extensive stage SCLC primarily involves PD-1/PD-L1 immunotherapy combined with doublet chemotherapy, while there are limited approved drugs for later-line treatments, indicating a significant unmet clinical need [24][30] - The report identifies three key areas of focus for research and development in the SCLC field: Antibody-Drug Conjugates (ADC), DLL3 T-cell engagers (TCE), and next-generation immune-oncology (IO) therapies [30][34] Summary by Sections 1. SCLC Overview - SCLC accounts for about 15%-20% of all lung cancer cases, with a high incidence of early metastasis [18][19] - The majority of SCLC cases are extensive stage, which has a poor prognosis and relies heavily on systemic therapies [21][22] 2. Treatment Landscape - The standard treatment for extensive stage SCLC has been established as a combination of chemotherapy and PD-1/PD-L1 immunotherapy, but the overall prognosis remains poor [24][25] - The NCCN and CSCO guidelines recommend various treatment options, including the recent inclusion of Tarlatamab as a preferred second-line treatment [28][29] 3. Research and Development Focus - ADCs are rapidly advancing in the SCLC field, targeting multiple hot spots such as B7-H3, DLL3, and TROP-2, with no ADC products currently approved for SCLC [37][38] - DLL3 TCEs, particularly Tarlatamab, have shown promising early data and are expected to reshape the treatment landscape for SCLC [30][31] - Next-generation IO therapies are being developed to challenge the current PD-L1 standard in first-line SCLC treatment [8][36] 4. Investment Recommendations - The report suggests that companies with strong pipelines in the SCLC space, such as Zai Lab, Zai Lab-U, Innovent Biologics, and others, are likely to benefit from the anticipated growth in the market as new data emerges [9]

Group 1 - The core viewpoint of the news highlights the significant performance of the STAR Market Index and its constituent stocks, with notable increases in stock prices for companies like Aerospace South Lake and China Post Technology [2][3] - The STAR Market Index ETF, Huaxia, has seen a recent increase of 0.85%, with a latest price of 0.95 yuan, and a trading volume of 49.9287 million yuan [2] - The ETF has achieved a scale of 2.898 billion yuan, ranking 2nd among comparable funds, and has experienced a substantial increase in shares by 2.168 billion, leading in growth among similar funds [3] Group 2 - Huawei's launch of the "Hongmeng Computer" marks a significant breakthrough for domestic operating systems in the PC sector, reflecting China's push for technological self-reliance [2] - The article published by Renmin Daily emphasizes the importance of maintaining control over the development of AI large models, aligning with the current trend of promoting domestic technology [2] - Guotai Junan Securities notes that the support for domestic software and AI is expected to increase, aiding China's technological advancement on a global scale [2]

Summary of the Conference Call Industry Focus - The report focuses on the pharmaceutical industry, specifically highlighting innovative drugs and contract research organizations (CXO) Core Insights and Arguments - Continuous recommendation of innovative drugs with positive growth outlook, including: - 恒瑞医药 (Hengrui Medicine) - 华东医药 (East China Pharmaceutical) - 翰森制药 (Hansoh Pharmaceutical) - 贝达药业 (Betta Pharmaceuticals) - 信立泰 (Sinopharm) - 科伦药业 (Kelun Pharmaceutical) - 百利天恒 (Baili Tianheng) - 荣昌生物 (Rongchang Biopharmaceutical) - 科伦博泰生物 (Kelun Biotech) - 石药集团 (Shijiazhuang Pharmaceutical Group) [1][1][1] - Recommendation of CXOs showing signs of profit growth turning points, including: - 药明生物 (WuXi Biologics) - 药明康德 (WuXi AppTec) [1][1] - Positive outlook on domestic replacement of innovative medical devices, specifically: - 惠泰医疗 (Huitai Medical) [1] - Anticipation of recovery in consumer healthcare, particularly: - 爱尔眼科 (Aier Eye Hospital) [1] Other Important Points - The report emphasizes the ongoing trend of recommending companies that are positioned well within the pharmaceutical sector, particularly those that are expected to benefit from market dynamics and growth opportunities - The focus on innovative drugs and CXOs indicates a strategic approach to capitalize on emerging trends in the healthcare market - The mention of domestic replacements in medical devices suggests a shift towards local production and innovation, which could impact market competition and supply chains - The recovery in consumer healthcare points to potential growth areas as the market stabilizes post-pandemic

A股创新药概念集体回调，迈威生物跌超10%，百济神州、信立泰双双跌超8%，益方生物、舒泰神、热 景生物、百利天恒、诺诚健华等跌幅靠前。 ...

早盘 创新药概念集体回调， 迈威生物跌超10%， 百济神州、 信立泰双双跌超8%， 益方生物、 舒泰 神、 热景生物、 百利天恒、 诺诚健华等跌幅靠前。 ...

Investment Rating - The report rates the pharmaceutical industry as "Outperform" [1] - Sub-industry ratings include "Add" for pharmaceutical manufacturing and pharmaceutical services [1] Core Insights - The report is optimistic about innovative drugs, CXO, and strong consumer performance in Q1 2025 [5][27] - In April 2025, the pharmaceutical sector performed similarly to the market, with the SHCOMP index down 1.7% and SW Pharma Bio down 2.1%, ranking 11th among Shenwan primary industries [9][28] - The premium of the pharmaceutical sector over all A-Shares is currently at a normal level of 81.01% [18][28] Summary by Sections 1. Focus on Innovative Drugs and CXO - Key A-share stocks recommended include Jiangsu Heng Rui Medicine, Betta Pharmaceuticals, Shenzhen Salubris Pharmaceuticals, Sichuan Kelun Pharmaceutical, Remegen, Huadong Medicine, WuXi AppTec, APT Medical, and AIER EYE HOSPITAL GROUP [5][27] - H-share top picks include Wuxi Biologics Cayman, PATEO, Innovent Biologics, and Zai Lab, with beneficiaries being CSPC Pharmaceutical Group, Gushengtang, and Angelalign [27] 2. April 2025 Pharmaceutical Sector Performance - The pharmaceutical sector's performance was on par with the market, with notable sub-sectors being chemical preparations (+2.8%), pharmaceutical commerce (+1.5%), and chemical raw materials (+0.7%) [12][28] - Top gainers included Apichope Pharmaceutical (+56.2%), Qianjiang Yongan Pharmaceutical (+55.9%), and Kexing Biopharm Co., Ltd. (+55.2%), while top losers were Hainan Poly Pharm (-71.9%), Landfar Bio-Medicine Co., Ltd (-40.0%), and Jiangsu Wuzhong Industrial (-39.5%) [17][28] 3. Performance Disparities in 2024 and Q1 2025 - In 2024, the pharmaceutical sector's overall revenue fell by 1.5% YoY, and net profit decreased by 12.5% YoY, with medical consumables, chemical preparations, and blood products showing positive growth [22][28] - In Q1 2025, the sector's revenue fell by 6.1% YoY, and net profit fell by 9.7% YoY, with medical R&D outsourcing, consumables, and hospitals performing well [22][28] 4. Profitability Metrics - The gross profit margin (GPM) for the pharmaceutical sector fell by 0.5pp YoY in 2024, while the net profit margin (NPM) fell by 0.8pp YoY [24][28] - In Q1 2025, GPM decreased by 1.6pp YoY, and NPM decreased by 0.4pp YoY, with medical R&D outsourcing showing improvements in both GPM and NPM [24][28]

Core Viewpoint - The Sci-Tech Innovation Board (STAR Market) continues to play a crucial role in supporting technological innovation in China amid a complex economic environment in 2024, focusing on high-quality development in key industries such as integrated circuits, artificial intelligence, innovative pharmaceuticals, and advanced manufacturing [1] Group 1: Company Performance - In 2024, STAR Market companies achieved a total operating revenue of 1,422.17 billion yuan, a year-on-year increase of 0.24%, with nearly 70% of companies reporting revenue growth [2] - The net profit for the year reached 47.52 billion yuan, with 50% of companies experiencing profit growth, and 32 companies turning losses into profits [2] - Private enterprises, which account for over 80% of STAR Market companies, showed resilience and vitality, with 154 companies doubling their revenue post-listing and 70 companies achieving doubled or turned profitable net income [2] Group 2: Innovation and R&D - STAR Market companies increased their R&D investment, with total R&D expenditure reaching 168.08 billion yuan in 2024, exceeding net profit by 2.5 times, and a year-on-year growth of 6.4% [7] - The median R&D intensity among STAR Market companies was 12.6%, leading all A-share sectors, with 107 companies maintaining an R&D intensity above 20% for three consecutive years [7] - A total of 20 companies listed under the fifth set of standards have made significant progress, with 18 achieving core product launches and 16 companies reporting revenues exceeding 100 million yuan [3] Group 3: Market Reforms and Financing - Recent capital market reforms, including the "STAR Market Eight Articles" and "Merger and Acquisition Six Articles," have enhanced the adaptability and inclusiveness of the STAR Market, facilitating high-quality industrial integration [4] - The STAR Market has seen 100 new industry mergers and acquisitions since June 2024, with disclosed transaction amounts exceeding 24.7 billion yuan [4] - Eight companies have disclosed refinancing plans under the new "light asset, high R&D investment" criteria, with a total financing scale exceeding 17.5 billion yuan [5] Group 4: International Expansion and Competitiveness - Over 80% of STAR Market companies focus on core products aimed at import substitution and self-control, with over 380 companies achieving international advanced levels in their products or technologies [8] - In 2024, STAR Market companies reported total overseas revenue of 430.36 billion yuan, a year-on-year increase of 6.1%, with 173 companies experiencing over 30% growth in overseas revenue [8] - High-margin products are increasingly penetrating global markets, with the median gross margin for overseas sales reaching 40.8% [8]

Investment Rating - The investment rating for the company is "Buy" (maintained) [1] Core Views - The company is increasing its R&D investment and has initiated its first overseas registration clinical trial for its core product BL-B01D1 [7] - The company reported a significant decline in revenue and profit for Q1 2025, primarily due to the absence of large intellectual property licensing income that was recognized in the same period last year [7] - BL-B01D1 has over 40 ongoing clinical studies, with several in Phase III trials, indicating strong potential for becoming a standard treatment for various cancers [7] - The company forecasts revenues of 2.018 billion for 2025, with growth expected in subsequent years, reflecting the potential of its innovative products [7] Financial Summary - Total revenue for 2023 is projected at 561.87 million, with a significant increase to 5,822.72 million in 2024, followed by a decrease to 2,018 million in 2025 [1] - The net profit attributable to the parent company is expected to be a loss of 780.50 million in 2023, with a recovery to a profit of 3,707.51 million in 2024, followed by further losses in the subsequent years [1] - The latest diluted EPS is projected to be (1.95) in 2023, improving to 9.25 in 2024, but declining again in the following years [1]