Market Overview - The medical services sector increased by 1.03% on December 25, with Baihua Medicine leading the gains [1] - The Shanghai Composite Index closed at 3959.62, up 0.47%, while the Shenzhen Component Index closed at 13531.41, up 0.33% [1] Top Gainers in Medical Services - Baihua Medicine (600721) closed at 11.56, up 6.54% with a trading volume of 396,400 shares and a transaction value of 449 million [1] - Zhaoyan New Drug (603127) closed at 37.38, up 4.24% with a trading volume of 254,500 shares and a transaction value of 266.56 million [1] - Aoyang Health (002172) closed at 4.18, up 3.98% with a trading volume of 330,500 shares and a transaction value of 137 million [1] Top Losers in Medical Services - Yinos (688710) closed at 44.60, down 1.87% with a trading volume of 16,000 shares and a transaction value of 71.19 million [2] - Baiao Saitou (688796) closed at 51.80, down 1.52% with a trading volume of 35,500 shares and a transaction value of 184 million [2] - Yangguang Nuohuo (688621) closed at 68.01, down 1.29% with a trading volume of 32,700 shares and a transaction value of 223 million [2] Capital Flow Analysis - The medical services sector experienced a net outflow of 148 million from institutional investors and 126 million from retail investors, while retail investors saw a net inflow of 275 million [2] - Zhaoyan New Drug had a net inflow of 164 million from institutional investors, while Baihua Medicine saw a net inflow of 45.83 million [3] - The overall capital flow indicates a mixed sentiment among different investor categories within the medical services sector [3]

Investment Rating - The report maintains an "Overweight" rating for the industry [5] Core Insights - The pharmaceutical sector is experiencing a phase of oscillation and differentiation, with a recommendation to seize thematic rotation and bottom adjustment opportunities, particularly in the innovative drug supply chain and AI+ sectors [6][13] - The long-term growth driver for the pharmaceutical sector is technological innovation, with key focuses on "continuation of policy benefits," "breakthroughs in frontier technologies," and "international BD transactions" [6][13] - The report highlights the potential of new generation CTLA-4 therapies that address toxicity issues, thereby unlocking market potential [7] Summary by Sections Industry Overview - The pharmaceutical industry comprises 499 listed companies with a total market value of 71,291.29 billion [2] - The industry is currently valued at 25.8 times PE based on 2025 earnings forecasts, with a premium of 10.2% over the overall A-share market [22] Market Dynamics - The report notes a 14.49% return for the pharmaceutical sector since the beginning of 2025, underperforming the CSI 300 index by 1.60 percentage points [19] - Recent market movements show a decline in the pharmaceutical sector, with specific segments like pharmaceutical commerce and medical devices showing positive growth [19][6] Key Recommendations - Focus on companies involved in innovative drug development and AI applications, such as 恒瑞医药 (Hengrui Medicine), 中国生物制药 (China National Pharmaceutical Group), and 康方生物 (Kangfang Biopharma) [6][13] - The report emphasizes the importance of addressing clinical pain points and enhancing safety in new generation immuno-oncology drugs [7] Notable Companies - The report recommends several companies for investment, including 康方生物 (Kangfang Biopharma), 药明合联 (WuXi AppTec), and 泰格医药 (Tigermed) [7][30] - It highlights the performance of specific stocks, noting that the average decline for 中泰医药 (Zhongtai Medicine) was 2.51% this month, while it outperformed the industry by 0.68% this week [29][30]

Investment Rating - The investment rating for the pharmaceutical and biotechnology industry is "Positive" [2] Core Insights - The report highlights a recovery trend in the pharmaceutical market, driven by the passage of the revised Biological Safety Act in the U.S., which is expected to improve valuations and performance in the CXO sector [3][10] - The report emphasizes the potential for growth in the AI and healthcare sectors, particularly with the recent upgrade of Ant Group's AI health application, which has seen significant user engagement [3][10] - The upcoming JPM Healthcare Conference is anticipated to be a major catalyst for innovation in the pharmaceutical sector, with over 8,000 participants expected [3][10] Summary by Sections Market Performance - The pharmaceutical and biotechnology sector's weekly return was -0.14%, ranking 22nd among 31 primary sub-industry indices, while the pharmaceutical commercial sector had the highest weekly return of 4.94% [3][10] - Over the past month, the sector's return was -2.50%, ranking 19th, with the pharmaceutical commercial sector again leading with a return of 4.68% [3][10] Policy Dynamics - On December 17, 2025, the National Health Commission released an action plan to enhance elderly care services, aiming to improve the care system by 2027 [3][10] - The National Medical Products Administration published guidelines for clinical trial institutions to enhance regulatory oversight [3][10] CXO and Life Sciences - Recommended leading CXO companies include WuXi AppTec, WuXi Biologics, and others, while domestic clinical CRO leaders such as Tigermed and others are also highlighted [3][10] - The life sciences upstream supply chain includes companies like BGI and others [3][10] AI + Healthcare - Key companies in AI healthcare models include Zhiyun Health and others, while AI imaging and diagnostics sectors also have notable players [4][10] High-end Medical Devices - Companies benefiting from the recovery in hospital procurement include Mindray and others, while domestic demand for consumer medical devices is gradually recovering [4][10] Innovative Drugs - Focus areas include small nucleic acids, ADCs, and dual/multi-antibody therapies, with recommended companies in each category [4][10]

Investment Rating - The industry investment rating is "Overweight" [1] Core Views - The biopharmaceutical investment and financing environment has shown significant recovery since the second half of 2025, with a total financing amount of USD 30.32 billion from July to November 2025, representing a year-on-year increase of 30.90% [4] - The number of new drug IND applications stabilized in 2025, with approximately 1,897 applications from January to November, reflecting a year-on-year growth of about 7.91% [4] - The demand for CRO services has shown a clear turning point, and the report continues to recommend opportunities in the innovative drug industry chain (CXO + research services) for 2026 [4] Summary by Sections Industry Performance - The biopharmaceutical sector experienced a decline of 0.14% in the third week of December 2025, outperforming the CSI 300 index by 0.14 percentage points, ranking 22nd among 31 sub-industries [7][14] - The offline pharmacy sector saw the highest increase, rising by 5.59%, while the chemical preparation sector had the largest decline at 2.1% [18][22] Investment Opportunities - The report highlights the strong performance of leading CXO and research service companies, with many exceeding earnings expectations. Companies like WuXi AppTec and Tigermed have raised their earnings guidance for 2025 [5] - The report recommends a valuation switch opportunity for leading CXO and research service companies, given the continuous improvement in demand [5] Clinical Research Organizations (CRO) - There has been a notable improvement in orders for preclinical and clinical CROs, with expectations for significant improvements in financial statements for 2026 [6] - The report anticipates that the market demand will continue to focus on leading companies as the capacity of clinical CROs is expected to be streamlined [6] Monthly and Weekly Recommendations - The report recommends a monthly investment portfolio including companies such as Sanofi, Innovent Biologics, and others, focusing on innovative drug opportunities and valuation switch [8]

Group 1 - The core viewpoint of the news is that Tigermed has experienced fluctuations in its stock price, with a recent increase of 2.03% and a total market capitalization of 44.196 billion yuan [1] - As of September 30, 2025, Tigermed reported a revenue of 5.026 billion yuan, a year-on-year decrease of 0.82%, while the net profit attributable to shareholders increased by 25.45% to 1.02 billion yuan [2] - The company has distributed a total of 2.458 billion yuan in dividends since its A-share listing, with 1.154 billion yuan distributed in the last three years [3] Group 2 - Tigermed operates in the medical and biological sector, specifically in medical research outsourcing, and is involved in various concept sectors including CRO, medical devices, and internet healthcare [2] - The company has seen a decrease in the number of shareholders, with 48,400 shareholders as of September 30, 2025, a reduction of 6.01% from the previous period [2] - The top shareholders include Hong Kong Central Clearing Limited and several ETFs, with notable changes in their holdings compared to the previous period [3]

12月15日的指数调整打破了CXO行业的平静，泰格医药被调出了深证100成分股。 作为深市核心龙头的代名词，深证100的成分股调整也向来被视为市场地位的"试金石"。而泰格医药的 离场，也恰逢其在当下普涨行情中成为了少数股价逆市下跌的企业。 炒股就看金麒麟分析师研报，权威，专业，及时，全面，助您挖掘潜力主题机会！ 来源：环球老虎财经app 12月15日，曾经的CXO龙头泰格医药被深圳100指数除名，终结了6年的指数生涯。反常的是，其前三 季度净利润20.88%的增长似乎并没能留住市场资金，2025年以来公募机构持续撤离。这业绩向好却资 金出逃的背后，到底发生了什么？ 事实上，早在泰格医药被指数剔除之前，高管与公募基金就早早的开始离场，公司市值也从1784亿高点 跌至500亿梯队，市值蒸发超千亿。而公司2025年前三季度净利润同比上涨20.88%的表现，似乎并未阻 止这一切的发生。 泰格医药 被挪出指数 12月15日，泰格医药正式被调出深证100成分股，结束了其长达6年的指数生涯。 作为中国资本市场的重要风向标，深证100汇聚了深市规模大、流动性好、盈利能力强的核心企业，包 括但不限于宁德时代、中际旭创、美的集团 ...

Investment Rating - The report maintains an "Outperform" rating for several companies in the innovative drug and medical device industry, including Jiangsu Heng Rui Medicine, Hansoh Pharmaceutical Group, 3SBio, Sichuan Kelun Pharmaceutical, and Jiangsu Nhwa Pharmaceutical [5][6][25]. Core Insights - The report emphasizes the high prosperity in innovative drugs and continues to recommend companies with innovative pipelines that are entering a volume increase phase, maintaining "Outperform" ratings for various Biopharma/Biotech companies [5][25]. - The National Healthcare Security Administration announced the 2025 insurance drug list, which added 114 drugs, including 50 innovative drugs, further validating insurance support for innovation and indicating promising domestic demand [26][27]. Summary by Sections 1. Continuous Recommendation of Innovative Drugs and Industry Chain - The report highlights the ongoing recommendation of innovative drugs and the industry chain, with a focus on companies expected to see a revaluation due to their innovative pipelines [5][25]. - Specific companies mentioned include WuXi AppTec, WuXi XDC Cayman, Hangzhou Tigermed Consulting, and leading medical equipment companies like Beijing Chunlizhengda Medical Instruments and Lepu Medical, all rated "Outperform" [5][25]. 2. Performance of A-Shares Pharmaceutical Sector - In the second week of December 2025, the A-Shares pharmaceutical sector underperformed the market, with the SW Pharma and Biotech index falling by 1.0% compared to a 0.3% decline in the SHCOMP [8][27]. - The report notes that the premium level of the pharmaceutical sector relative to all A-Shares is at a normal level, with a current relative premium rate of 69.8% [16][27]. 3. Performance of Hong Kong and U.S. Pharmaceutical Sectors - The Hong Kong stock pharmaceutical sector underperformed the market, with the Hang Seng Healthcare index falling by 2.3%, while the U.S. stock pharmaceutical sector outperformed, with the S&P 500 Healthcare Select Sector Index rising by 0.4% [28][27].

Investment Rating - The report maintains an "Overweight" rating for the innovative pharmaceutical and medical device industry chain [3][5][6]. Core Insights - The report emphasizes the continuous recommendation of innovative drugs and medical devices, highlighting the high growth potential in the innovative pharmaceutical sector. It maintains "Overweight" ratings for companies such as Heng Rui Medicine, Hansoh Pharmaceutical, and others, indicating a potential for value re-evaluation [3][5]. - The report notes that the National Medical Insurance Administration has officially announced the 2025 medical insurance drug catalog, which includes 114 new drugs, 50 of which are first-class innovative drugs. This adjustment is seen as a validation of the support for innovation in the healthcare sector [3][5]. - The A-share pharmaceutical sector underperformed the broader market in the second week of December 2025, with the SW Pharmaceutical Biotechnology index declining by 1.0% compared to a 0.3% drop in the Shanghai Composite Index [7][18]. Summary by Sections Section 1: Continuous Recommendation of Innovative Drugs and Medical Devices - The report highlights the sustained recommendation of innovative drugs and medical devices, with a focus on companies that are expected to see performance growth and value re-evaluation [5][6]. Section 2: A-share Pharmaceutical Sector Performance - In the second week of December 2025, the A-share pharmaceutical sector's performance was weaker than the overall market, ranking 16th among the primary industries [7][18]. Section 3: Hong Kong and US Market Performance - The report indicates that the Hong Kong pharmaceutical sector also underperformed, while the US pharmaceutical sector showed stronger performance compared to the broader market [18].

Summary of China Clinical CRO Expert Call Industry Overview - **Industry**: Clinical Contract Research Organizations (CROs) in China - **Key Company**: Tigermed Core Insights 1. **2026 Outlook**: The expert predicts a better outlook for 2026 for the Chinese CRO industry, with expectations of less fierce price competition and increased overseas pharmaceutical and biotech trials due to cost and speed advantages [1][2][3] 2. **Price Recovery**: Smaller CROs are struggling, leading to industry prices being 30-40% lower than in 2022. Leaders like Tigermed are expected to recover first, with a gradual price increase anticipated in 2026 [2][3] 3. **Client Demand**: Demand from multinational corporations (MNCs) and large domestic pharmaceutical companies remains resilient, with increasing demand from domestic biotech firms. A pickup in client demand was noted starting in July 2025 [3][4] 4. **FDA Concerns**: Despite concerns raised by the US FDA regarding the quality of Phase 3 trial data from China, the expert believes that Chinese data meets global standards, adhering to ICH guidelines [4][5] 5. **Global Attraction**: China is becoming a preferred location for overseas biotech companies to conduct clinical trials, particularly Phase I trials, due to its cost and operational speed advantages compared to the US, Europe, and Australia [5][7] 6. **AI Integration**: The integration of AI in clinical trials is expected to enhance efficiency by improving trial design, accelerating patient matching, and assisting with medical writing and translation [8] Additional Insights 1. **Global Expansion of Chinese CROs**: The expert suggests that Chinese CROs can expand globally through partnerships, acquisitions, and attracting overseas clients for early-phase trials in China [9] 2. **Cost Comparisons**: The expert highlighted significant cost advantages for conducting trials in China, with Phase I trials costing substantially less than in the US and Europe, and even higher disparities for certain conditions like ophthalmic diseases [7] 3. **Valuation of Tigermed**: The target price for Tigermed is set at Rmb67 based on an NPV-based SOTP valuation, with contributions from clinical trial solutions, laboratory services, and investment income [10][12] 4. **Risks**: Potential risks affecting Tigermed's share price include weaker-than-expected client orders, intense market competition, and margin pressures due to overseas expansion and AI investments [11][13] This summary encapsulates the key points discussed during the expert call, providing insights into the current state and future outlook of the Chinese CRO industry, particularly focusing on Tigermed.

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內 容 概 不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不對因本公告全部或任何部分內容而產生或因倚賴該等內容而引致的 任 何 損 失 承 擔 任 何 責 任。 HANGZHOU TIGERMED CONSULTING CO., LTD. 杭州泰格醫藥科技股份有限公司 （於 中 華 人 民 共 和 國 註 冊 成 立 的 股 份 有 限 公 司） （股 份 代 號：3347） 海外監管公告 本 公 告 乃 杭 州 泰 格 醫 藥 科 技 股 份 有 限 公 司（「本公司」）根 據 香 港 聯 合 交 易 所有限公司證券上市規則第13.10B條 而 作 出。 茲 載 列 本 公 司 於 深 圳 證 券 交 易 所 網 站 刊 登 公 告 如 下，僅 供 參 閱。 承董事會命 杭州泰格醫藥科技股份有限公司 於 本 公 告 日 期，執 行 董 事 為 葉 小 平 博 士、曹 曉 春 女 士、吳 灝 先 生 及 聞 增 玉 先 生；獨 立 非 執 行 董 事 為 廖 啟 宇 先 生、袁 華 剛 先 生 ...