A 股代码：688235 A 股简称：百济神州 公告编号：2025-20 港股代码：06160 港股简称：百济神州 美股代码：ONC 百济神州有限公司 关于公司涉及诉讼的进展公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 重要内容提示： 一、本次诉讼的基本情况及最新进展 2023 年 6 月 13 日，Pharmacyclics LLC 公司（作为申诉方，以下简称 "Pharmacyclics"）在美国特拉华州地方法院对百济神州有限公司（以下简称 1 案件所处的诉讼阶段：原告已提出申诉。 公司所处的当事人地位：本次诉讼的被申诉方。 是否会对公司损益产生负面影响：鉴于本次诉讼的最终判决结果尚不确 定，目前无法预计对公司本期及期后损益的影响，最终实际影响以法院 生效判决为准；公司对百悦泽®的知识产权有充分的信心，并将继续研 发更有效、更安全的创新型肿瘤治疗方案；本次诉讼目前未对百悦泽® 在美国的研发和销售产生不利影响，且预计不会对公司的生产经营产生 重大不利影响；敬请投资者注意投资风险。 类似诉讼可能周期较长，提请广大投 ...

FF305 | 第一章節 | | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 | 是 | | | | 證券代號 (如上市) | 06160 | 說明 | | | | | | | | A. 已發行股份或庫存股份變動 | | | | | | | | | | | | | 已發行股份（不包括庫存股份）變動 | | 庫存股份變動 | | | | | 事件 | | 已發行股份（不包括庫存股份）數 目 | | 佔有關事件前的現有已發 行股份（不包括庫存股 份）數目百分比 (註3) | 庫存股份數目 | 每股發行/出售價 (註4) | | 已發行股份總數 | | 於下列日期開始時的結存(註1) | 2025年4月26日 | | 1,285,869,157 | | 0 | | | 1,285,869,157 | | 1). 就根據股份計劃授予參與人（發行人的董事除外）的股份獎勵或期權 | | | 102,869 | 0.007 % | USD | | ...

Investment Rating - The investment rating for the company is "Buy" [6] Core Insights - The company reported a revenue of 27.214 billion yuan for 2024, an increase of 56.19% year-on-year, and a net loss of 4.978 billion yuan, which is a reduction of 1.738 billion yuan compared to the previous year [1] - The growth in product revenue is primarily attributed to the sales of self-developed products Baiyueze® (Zebutinib capsules) and Baizean® (Tislelizumab injection), as well as sales growth from Amgen authorized products [2] - The company is actively expanding in overseas markets, with Baiyueze® having been approved in over 70 markets globally, treating more than 180,000 patients [3] - The company has a robust pipeline with several innovative products, including Sonrotoclax, which is undergoing multiple potential registration trials, and BGB-16673, a BTK degrader that has received FDA fast track designation [4][5] Financial Summary - The company forecasts revenues of 34.938 billion yuan, 42.048 billion yuan, and 48.165 billion yuan for 2025, 2026, and 2027 respectively, representing year-on-year growth rates of 28%, 20%, and 15% [9] - The projected net profit for 2025 is 410 million yuan, with significant growth expected in subsequent years, reaching 3.567 billion yuan in 2026 and 6.291 billion yuan in 2027 [11] - The earnings per share (EPS) are expected to be 0.29 yuan for 2025, 2.55 yuan for 2026, and 4.49 yuan for 2027, indicating a strong recovery and growth trajectory [11] Market Performance - The company's stock closed at 246.91 yuan, with a 52-week high of 258.0 yuan and a low of 111.22 yuan [6] - The total market capitalization is approximately 345.788 billion yuan [6]

Investment Rating - The report maintains a positive investment rating for the pharmaceutical industry, focusing on innovation and growth opportunities in various segments [4]. Core Insights - The pharmaceutical sector is experiencing a comprehensive recovery, with a focus on innovative drug development, particularly in oncology, autoimmune diseases, GLP-1, stem cell therapy, and gene therapy [1][2]. - The report highlights the importance of domestic innovation in pharmaceuticals, with significant attention on the upcoming AACR and ASCO conferences, where numerous Chinese companies are expected to present their research [2][13]. - The report emphasizes the potential for growth in the CXO sector due to recovering domestic demand and stable overseas demand, suggesting a valuation recovery for leading companies [8]. - The report identifies key companies to watch, including 恒瑞医药, 百济神州, and others across various segments such as innovative drugs, medical devices, and IVD [3]. Summary by Sections Innovative Drugs - The report notes the approval of 康方依沃西单抗 for first-line treatment of PD-L1 positive NSCLC, showing a 22.3% reduction in mortality risk [2]. - It highlights the upcoming AACR conference with over 120 Chinese pharmaceutical companies presenting nearly 300 new drug research results [13]. CXO Sector - The CXO sector is expected to benefit from supportive policies and a reduction in geopolitical risks, leading to a potential valuation uplift [8]. Traditional Chinese Medicine - The report suggests monitoring companies related to pediatric medications, such as 济川药业 and 葵花药业, due to their relevance to fertility subsidies [2]. Blood Products - The report emphasizes the growth potential in the immunoglobulin market over the next 3-5 years, driven by increased demand and pricing improvements [2][25]. Vaccines - The vaccine sector is under pressure, but there are opportunities in HPV vaccines and other high-value products [27]. Upstream Supply Chain - The report recommends focusing on companies with strong brand recognition and overseas growth potential in the chemical and biological reagent sectors [30]. IVD Sector - The report indicates that the IVD industry is poised for growth due to the implementation of centralized procurement policies and increasing domestic demand [33]. Medical Devices - The report highlights the potential for growth in the CGM market, particularly with the FDA approval of related products [38]. Medical Services - The report suggests focusing on eye and dental medical service companies, anticipating a boost from consumer stimulus policies [44]. Offline Pharmacies - The report notes that the pharmacy sector is stabilizing, with a recommendation to focus on companies with strong supply chain capabilities [46]. Raw Materials - The report discusses the importance of quality and cost management in the raw materials sector, suggesting a focus on companies with strong product capabilities [50]. Innovative Devices - The report emphasizes the potential for AI applications in medical devices, particularly in surgical navigation and pathology screening [53]. Instrumentation - The report anticipates a recovery in the scientific instrumentation sector, driven by increased domestic demand and new product launches [57].

FANGDA PARTNERS http://www.fangdalaw.com 中国上海市石门一路 288 号 电子邮件 E-mail: email@fangdalaw.com 兴业太古汇香港兴业中心二座 24 楼 电 话 Tel.: +86-21-2208 1166 邮政编码：200041 传 真 Fax.: +86-21-5298 5599 24/F, HKRI Centre Two HKRI Taikoo Hui 288 Shi Men Yi Road Shanghai, PRC 200041 上海市方达律师事务所 关于百济神州有限公司（BeiGene, Ltd.） 2025 年第一次临时股东大会（股东特别大会）的 法律意见书 致：百济神州有限公司（BeiGene, Ltd.） 上海市方达律师事务所（以下简称"本所"）是具有中华人民共和国境内法律执 业资格的律师事务所。根据相关法律顾问协议，本所指派律师出席百济神州有限公 司（BeiGene, Ltd.）（以下简称"百济神州"或"公司"）2025 年第一次临时股东大会 （股东特别大会）（以下简称"本次股东大会"），并就本次股东大会的召集和召开程 序、参 ...

本公司董事会及全体董事保证公告内容不存在任何虚假记载、误导性陈述或 者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 重要内容提示： 本次会议是否有被否决议案：无 一、 会议召开和出席情况 （一） 股东大会召开的时间：2025 年 4 月 28 日 | A | 股代码：688235 | 股简称：百济神州 A | 公告编号：2025-019 | | --- | --- | --- | --- | | 港股代码：06160 | | 港股简称：百济神州 | | | 美股代码：ONC | | | | 百济神州有限公司 2025 年第一次临时股东大会（股东特别大会） 决议公告 （二） 股东大会召开的地点：Mourant Governance Services (Cayman) Limited 的 办公室，位于 94 Solaris Avenue, Camana Bay, Grand Cayman KY1-1108, 开曼群岛 （三） 出席会议的普通股股东、特别表决权股东、恢复表决权的优先股股东及 其持有表决权数量的情况： | 1、出席会议的股东和代理人人数 | 305 | | --- | --- | | ...

Investment Rating - The report maintains a positive investment rating for the pharmaceutical industry, highlighting a recovery and focus on innovation [4]. Core Views - The pharmaceutical sector is experiencing a sustained recovery in fundamentals, supported by favorable policies, with a focus on innovative drug growth, particularly in areas such as oncology, autoimmune diseases, GLP-1, stem cell therapy, and gene therapy [1][2]. - The report emphasizes the importance of domestic pharmaceutical substitution and the growth of medical consumption, especially in aesthetic medicine [1]. Summary by Sections Innovative Drugs - The AACR conference is ongoing, with significant participation from over 120 Chinese pharmaceutical companies presenting nearly 300 new drug research results [11]. - Key approvals include the domestic approval of 康方依沃西单抗 for PD-L1 positive NSCLC and the FDA approval of 派安普利单抗 for nasopharyngeal carcinoma [2][72]. CXO Sector - The CXO sector is expected to see valuation recovery due to supportive policies for innovative drug development and a reduction in geopolitical risks [6]. Traditional Chinese Medicine - The SW secondary index for traditional Chinese medicine has underperformed compared to the broader market, indicating challenges in this segment [19]. Blood Products - The report highlights the increasing demand for immunoglobulin products and the potential for price improvements in the blood products sector, particularly for companies like 天坛生物 and 派林生物 [23]. Vaccines - The vaccine sector is facing challenges due to low birth rates, but there is potential for growth in HPV vaccines and other areas [25]. Upstream Supply Chain - The report suggests focusing on companies with strong brand and operational capabilities in the chemical and biological reagent sectors [28]. IVD (In Vitro Diagnostics) - The IVD industry is expected to benefit from the implementation of centralized procurement policies, which may accelerate domestic substitution [31]. Medical Devices - The report recommends attention to the CGM market, particularly products from 三诺生物, as they align with the growth of GLP-1 drugs [36]. Medical Services - The report suggests focusing on eye and dental medical service companies, anticipating a boost from consumer stimulus policies [43]. Offline Pharmacies - The offline pharmacy sector is stabilizing, with a recommendation to focus on companies with strong supply chain capabilities [45]. Raw Materials - The report emphasizes the importance of quality and cost management in the raw materials sector, suggesting a focus on companies like 华海药业 and 海正药业 [49]. Innovative Instruments - The report highlights the potential for AI applications in the medical device sector, particularly in surgical navigation and pathology screening [52]. Instrument Equipment - The scientific instrument sector is expected to recover as demand improves, with a focus on companies enhancing their market presence through new product launches [57]. Low-value Consumables - The report notes a potential recovery in the low-value consumables sector, particularly for companies like 采纳股份 and 美好医疗 [60].

百济神州有限公司 关于安永华明会计师事务所（特殊普通合伙）履职情况的 评估报告 百济神州有限公司（以下简称"公司"）聘请安永华明会计师事务所（特殊普通 合伙）（以下简称"安永华明"）作为对公司 2024 年度根据中国企业会计准则编制 的财务报表及相关内部控制的有效性（以下简称"A 股财务报表和内部控制"）出具 审计报告的会计师事务所。 根据财政部、国务院国有资产监督管理委员会、中国证券监督管理委员会颁布 的《国有企业、上市公司选聘会计师事务所管理办法》，公司对安永华明在 2024 年 度的审计工作的履职情况进行了评估。具体情况如下： 一、会计师事务所的情况 1、资质条件 安永华明于 1992 年 9 月成立，2012 年 8 月完成本土化转制，从一家中外合作 的有限责任制事务所转制为特殊普通合伙制事务所。安永华明总部设在北京，注册 地址为北京市东城区东长安街 1 号东方广场安永大楼 17 层 01-12 室。截至 2024 年 末拥有合伙人 251 人，首席合伙人为毛鞍宁先生。安永华明拥有财政部颁发的会计 师事务所执业资格，于美国公共公司会计监督委员会（US PCAOB）注册，是中国 首批获得证券期货相关业务 ...

A 股代码：688235 A 股简称：百济神州 公告编号：2025-018 港股代码：06160 港股简称：百济神州 美股代码：ONC 百济神州有限公司 2024年年度募集资金存放与实际使用情况的专项报告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 一、募集资金基本情况 （一）实际募集资金金额及资金到账情况 经中国证券监督管理委员会于 2021 年 11 月 16 日出具的《关于同意百济神 州有限公司首次公开发行股票注册的批复》（证监许可[2021]3568 号）批准，百 济神州有限公司（以下简称"公司"）首次公开发行人民币普通股（A 股）股票（以 下简称"本次发行"）115,055,260 股，每股发行价格为人民币 192.60 元，募集资 金总额为人民币 2,215,964.31 万元；扣除发行费用后的募集资金净额为人民币 2,163,015.49 万元。上述募集资金已于 2021 年 12 月 8 日全部到位，安永华明会 计师事务所（特殊普通合伙）对公司本次发行的募集资金到位情况进行了审验， 并于 2021 年 ...

百济神州有限公司 审计委员会监督安永华明会计师事务所（特殊普通合伙）的履 职情况报告 百济神州有限公司（以下简称"公司"）聘请安永华明会计师事务所（特殊普通 合伙）（以下简称"安永华明"）作为对公司 2024 年度根据中国企业会计准则编制 的财务报表和相关内部控制（以下简称"A 股财务报表和内部控制"）出具审计报告 的会计师事务所。 根据财政部、国务院国有资产监督管理委员会、中国证券监督管理委员会颁布 的《国有企业、上市公司选聘会计师事务所管理办法》，公司审计委员会切实对安永 华明在 2024 年度的审计工作情况履行了监督职责。具体情况如下： 一、对2024年A股财务报表和内部控制出具审计报告的会计师事务所的基本情 况 安永华明于 1992 年 9 月成立，2012 年 8 月完成本土化转制，从一家中外合作 的有限责任制事务所转制为特殊普通合伙制事务所。安永华明总部设在北京，注册 地址为北京市东城区东长安街 1 号东方广场安永大楼 17 层 01-12 室。截至 2024 年 末拥有合伙人 251 人，首席合伙人为毛鞍宁先生。安永华明拥有财政部颁发的会计 师事务所执业资格，于美国公共公司会计监督委员会（US ...