Core Insights - A new gene editing technology based on reverse transcriptase has been developed, allowing for more precise and efficient repair of multiple pathogenic mutations in mammalian cells, laying a significant foundation for broad-spectrum gene therapies [1][2] Group 1: Technology Development - The new technology can simultaneously correct various pathogenic mutations in mammalian cells and has successfully cured mutations causing scoliosis in zebrafish embryos, marking the first use of reverse transcriptase technology for precise mutation repair in vertebrates [1] - Existing gene editing technologies typically target one or two specific mutations, limiting effective treatment options for many patients; the new technology can replace entire defective regions with healthy DNA segments, akin to "patching" genes, thus offering hope for more patients [1] Group 2: Efficiency and Application - The new technology has increased editing efficiency from 1.5% to approximately 30% in mammalian cells, significantly improving the success rate of gene editing [2] - The technology utilizes an RNA delivery system encapsulated in lipid nanoparticles, effectively overcoming challenges associated with the delivery phase of traditional gene editors [2] - The research team is currently developing a gene therapy for cystic fibrosis, a disease known to have over a thousand pathogenic mutations, with the new technology potentially benefiting a broader patient population by directly replacing entire defective regions [2]

Core Insights - LLZTO (Lithium Lanthanum Zirconium Oxide) is identified as a key material for solid-state batteries, maintaining exceptionally low temperatures during operation, making it an ideal candidate for next-generation rechargeable batteries [1][2] - A recent study from the University of California, Riverside, published in the journal PRX Energy, reveals the reasons behind LLZTO's low thermal conductivity, which is crucial for developing safer and higher energy density lithium batteries [1] Group 1 - LLZTO is a ceramic material that serves as a solid electrolyte, providing higher energy density while significantly reducing the risks of overheating and fire [1] - The thermal conductivity of LLZTO is measured at only 1.59 W/m·K, approximately 1/250th that of copper, indicating that low thermal conductivity is an inherent property of the material [1] - The research utilized floating zone method to grow LLZTO single crystals, which reflect the intrinsic properties of the material [1] Group 2 - The study found that the presence of numerous optical phonon modes in LLZTO leads to interactions that scatter the primary heat-conducting acoustic phonons, thereby hindering thermal conduction [2] - Understanding how LLZTO naturally impedes heat flow is essential for managing internal temperature changes in solid-state batteries and preventing safety risks [2] - This discovery offers new insights into atomic-level thermal regulation, aiding in predicting internal temperature distribution and improving thermal management for safer, higher-performance batteries [2]

包括法国国家健康与医学研究院科学家在内的团队此次开发出一种新型超声探头，首次在活体动物模型 中对多个重要器官进行了四维血流成像，其空间分辨率达到小于100微米水平，足以清晰捕捉最细微血 管中的血流变化。 研究显示，该探头不仅能显示出器官整体的血管网络，还能准确量化血流动态。例如在肝脏中，由于其 独特的血流结构，可明确区分动脉、门静脉和肝静脉三大血流系统，为理解复杂器官的灌注机制提供了 全新工具。 团队成员表示，这项技术的独特之处在于，能够在亚百微米尺度上对整个大器官的血管系统进行四维成 像。无论是成像范围还是分辨率，都是以往无法实现的。 目前，该技术正进入临床测试阶段，团队正致力于推动该设备在人体中的应用。由于探头可连接至小型 便携式装置，未来有望直接融入临床诊疗流程。 法国科学家开发出一种全新超声成像技术，首次在四个维度（三维空间+时间）对活体心脏、肾脏和肝 脏等大器官中，从大血管到最细微血管的微循环和完整血流动态，实现了全面、高精度可视化。这一突 破为研究和诊断血液循环相关疾病提供了前所未有的视角，将为循环系统疾病的精准医疗带来深远影 响，研究发表于最新一期《自然·通讯》。 血液微循环是维系生命的关键系统 ...

Core Insights - Lithography technology is a key driver for the continuous miniaturization of integrated circuit chip manufacturing processes [1] - A research team led by Professor Peng Hailin from Peking University has utilized cryo-electron tomography to analyze the microscopic three-dimensional structure and entanglement behavior of photoresist molecules in a liquid phase, leading to a significant reduction in lithography defects [1] - The findings were published in the journal Nature Communications, highlighting the importance of this research in advancing semiconductor manufacturing [1] Summary by Sections - **Lithography Process**: The development of photoresist is crucial for the lithography process, where the developer dissolves the exposed areas of the photoresist to accurately transfer circuit patterns onto silicon wafers [1] - **Challenges in the Industry**: The microscopic behavior of photoresist in the developer has been a "black box," limiting process optimization to trial and error, which has been a bottleneck for improving yield in advanced processes below 7nm [1] - **Innovative Techniques**: The research team introduced cryo-electron tomography to the semiconductor field, achieving a three-dimensional "panoramic photo" with a resolution better than 5nm, overcoming traditional observational limitations [1] - **Implications for Semiconductor Manufacturing**: Understanding the structure and microscopic behavior of polymers in liquid can enhance defect control and yield improvement in critical processes such as lithography, etching, and wet cleaning [1]

Core Insights - Shandong Energy Group and Huawei jointly launched the Yunding Fuxi Chemical Model and six mature application scenarios at the 21st China International Coal Mining Technology Exchange Conference, aiming to provide scalable intelligent transformation paths for the energy industry [1][4] Group 1: Model and Applications - The Yunding Fuxi Chemical Model was developed over two years by Yunding Technology, integrating chemical process mechanisms, expert experience, and equipment and quality data [4] - The model features capabilities such as intelligent optimization of gasification coal blending, methanol distillation process, low-temperature methanol washing, AI comprehensive analysis and early warning, intelligent monitoring of belt conveyors, and intelligent inspection of sulfur recovery [4] - Six innovative outcomes were introduced, covering mining production, network support, collaborative management, platform empowerment, and non-coal mining sectors [4] Group 2: Strategic Collaboration - Since the strategic partnership began in 2021, Shandong Energy Group and Huawei have established several innovative platforms, including a 5G smart mining laboratory and an intelligent mining testing center [5] - The collaboration has expanded from coal to chemical and high-end manufacturing sectors, injecting new momentum into traditional energy industries [5] - The successful release of these results signifies the validation of a "factory-style" development model that integrates AI large models and industrial internet technologies with industry knowledge [5] Group 3: Industry Impact - The China Coal Industry Association highlighted the collaboration as a benchmark for digital transformation in the industry, emphasizing the importance of key technology breakthroughs and disruptive innovation [4] - Yunding Technology has developed over 220 AI application scenarios, covering nearly 100 units, creating a replicable and promotable industry intelligent solution [5] - The new Fuxi model aims to empower the entire process of production operations, safety management, and process optimization in the chemical industry [5]

Core Insights - The average carbon footprint factor for electricity in China for 2024 is 0.5777 kg CO2 equivalent per kWh, a decrease of 6.9% from 0.6205 kg CO2 equivalent per kWh in 2023, reflecting the progress in the clean and low-carbon transformation of the power industry [1][2] Group 1: Carbon Footprint Data - The 2024 carbon footprint factors include data for coal, gas, hydro, nuclear, wind, solar, thermal, and biomass power generation, as well as transmission and distribution, totaling 11 carbon footprint factors [1] - The quantification work for 2024 has significantly increased the number of case samples, with the number of participating enterprises nearly doubling compared to last year, enhancing the representativeness of the data [1] Group 2: Clean Energy Growth - The decline in the average carbon footprint factor is primarily attributed to the rapid growth of clean energy generation, with wind, solar, and hydro power generation increasing by 12.5%, 43.6%, and 10.9% respectively compared to the previous year [2] - The Ministry of Ecology and Environment plans to continue regular assessments of the carbon footprint factors, aiming to expand the coverage and improve the scientific accuracy and representativeness of the data [2]

Core Insights - The successful delivery of domestically developed enriched boric acid to the Guangdong Lufeng Nuclear Power Unit 5 marks a significant breakthrough in the localization of key nuclear materials in China [1][5] - This achievement follows the small-scale demonstration applications at Yangjiang Nuclear Power Unit 3 and Fangchenggang Nuclear Power Unit 4 in November 2024, indicating progress in the supply chain for enriched boric acid [1][5] Industry Summary - Enriched boric acid, produced by isotope separation technology, increases the abundance of boron-10 from less than 20% in natural sources to over 96%, playing a crucial role in controlling the chain reaction in pressurized water reactor cores [4] - The production process of enriched boric acid is complex and has stringent quality standards, leading to a historical reliance on imports, which raised supply chain security concerns as nuclear power construction expanded [4] - Since 2022, the Suzhou Thermal Engineering Research Institute has led a project to develop domestic production of enriched boric acid, overcoming challenges such as high energy consumption and waste generation through innovative separation and recycling techniques [4] - The new production methods have improved isotope separation efficiency by over 20%, reduced impurity content by more than 50%, and achieved a product quality that meets international advanced standards [4] Company Summary - The large-scale delivery of enriched boric acid signifies China's capability to ensure stable supply, reliable quality, and reasonable pricing in the enriched boric acid industry, thereby strengthening the supply chain security for nuclear power development [5]

Core Insights - The AG600 amphibious aircraft successfully completed its first water collection and water dropping exercise in a wild environment at Songhua Lake, Jilin Province, marking a significant operational milestone for the aircraft [1] - The exercise tested the full system of the AG600, demonstrating its capabilities in firefighting and emergency response [1][2] - The AG600 can carry out water collection and dropping tasks, with a total water dropping capacity of 120 tons over an area exceeding 40,000 square meters [1] Summary by Sections - **Operational Achievement** - The AG600 aircraft took off from Changbai Mountain Airport and flew approximately 190 kilometers to Songhua Lake for the exercise, marking its first operation outside the designated test base [1] - This exercise serves as a comprehensive test of the aircraft's systems and operational readiness [1] - **Regulatory Development** - The first technical specification for large amphibious water collection sites, titled "AG600 Series Aircraft Water Collection Site Requirements," will be published in September 2025, filling a gap in standards both domestically and internationally [2] - The Jilin Provincial Emergency Management Department is organizing site selection for water collection in accordance with these new standards [2] - **Future Prospects** - Three AG600 aircraft have completed production testing and are expected to be delivered within the year [2] - The AG600 "Kunlong" aims to expand its operational footprint and work alongside ground firefighting forces to create a comprehensive forest safety protection network [2]

Core Insights - The interstellar object 3I/ATLAS has sparked significant interest in both the scientific community and the public due to its unique characteristics and the ongoing debate about its origins [1][2][4] Group 1: Characteristics of 3I/ATLAS - 3I/ATLAS was first detected by NASA's ATLAS system, traveling at an astonishing speed of approximately 210,000 kilometers per hour, and is classified as a comet due to its faint coma and short tail [2] - The estimated diameter of 3I/ATLAS is between 10 to 20 kilometers, making it comparable in size to Manhattan, and its mass is at least 3.3 billion tons, significantly larger than previous interstellar visitors [2] - It is noted for its high activity, releasing about 180 kilograms of dust per second, which is more than double that of the previous interstellar comet 2I/Borisov [2][3] Group 2: Chemical Composition and Observations - Observations have detected glowing nickel vapor in the comet's coma, indicating complex chemical processes at play, with nickel potentially existing in molecular forms rather than through traditional high-temperature vaporization [3] - The chemical composition of 3I/ATLAS is complex, with high levels of carbon dioxide detected, alongside water ice and carbon monoxide, suggesting a variety of frozen materials are being heated [3] Group 3: Scientific Community's Response - The scientific community largely dismisses the theory proposed by Avi Loeb that 3I/ATLAS could be an alien spacecraft, emphasizing that the evidence supports it being a natural celestial body consistent with known comet characteristics [4][5] - NASA has confirmed that 3I/ATLAS poses no threat to Earth and is closely monitoring its trajectory and behavior as it approaches perihelion [5][6]

Core Insights - LLZTO (Lithium Lanthanum Zirconium Oxide) is identified as a key material for solid-state batteries, maintaining exceptionally low temperatures during operation, making it an ideal candidate for next-generation rechargeable batteries [1][2] - A recent study from the University of California, Riverside, published in the journal PRX Energy, reveals the reasons behind LLZTO's low thermal conductivity, which is crucial for developing safer and higher energy density lithium batteries [1] Group 1 - LLZTO is a ceramic material that serves as a solid electrolyte, providing higher energy density while significantly reducing the risks of overheating and fire [1] - The thermal conductivity of LLZTO is measured at only 1.59 W/m·K, approximately 1/250th that of copper, indicating that low thermal conductivity is an inherent property of the material [1] - The research utilized floating zone method to grow LLZTO single crystals, which reflect the intrinsic properties of the material [1] Group 2 - The study found that the presence of numerous optical phonon modes in LLZTO leads to interactions that scatter the primary heat-conducting acoustic phonons, thereby hindering thermal conduction [2] - LLZTO exhibits significant "anharmonicity," which relates to the degree of deviation of atomic vibrations from ideal states, associated with the movement of mobile ions within the material [2] - Understanding how LLZTO naturally impedes heat flow is essential for managing internal temperature variations in solid-state batteries, thereby enhancing safety and performance [2]