Core Viewpoint - The article discusses the significant decline in sales of the collagen product "可复美胶原棒2.0" from 巨子生物 (Juzi Biological) due to quality concerns raised by external parties, leading to a 60% to 70% drop in orders for individual distributors like 李吉 [1][5][11]. Group 1: Sales Performance and Market Impact - Sales of 可复美胶原棒2.0 have plummeted, with 李吉 reporting that he could sell 200 boxes a day before the controversy, but now only a few boxes per week [1][5][11]. - The product's sales during the critical "6·18" shopping festival saw a decline, marking the first drop in rankings for 可复美 in three years [7][19]. - The overall GMV for 可复美 during "6·18" was significantly lower than in previous years, with sales post-May 24 contributing only 29.2% of the total [18][19]. Group 2: Company Background and Financials - 巨子生物's revenue from 可复美 in 2024 is projected to be 45.4 billion yuan, accounting for 82% of the company's total revenue [3]. - The company has maintained a strong growth trajectory, with a compound annual growth rate of 52.8% in revenue from 2022 to 2024 [23]. - Despite the recent challenges, the management has stated that they will maintain their performance targets for 2025 [8][22]. Group 3: Market Reactions and Future Outlook - The controversy has led to a reduction in the number of influencers promoting 可复美, with a 32% decrease in the number of key opinion leaders during "6·18" compared to previous years [16]. - 李吉 and other distributors are currently in a wait-and-see mode, monitoring the situation and considering diversifying their product offerings [29]. - 巨子生物's stock has experienced volatility, with significant share buybacks by its major shareholder following the price drop [29][30].

Core Viewpoint - The article discusses the significant decline in sales of the skincare product "可复美胶原棒2.0" (Kefumei Collagen Stick 2.0) due to quality concerns raised by external parties, leading to a broader impact on the parent company, 巨子生物控股有限公司 (Juzi Biotech) [2][3][4]. Sales Performance - Sales of the Kefumei Collagen Stick 2.0 have dropped by 60% to 70% compared to April 2023, severely affecting individual distributors like 李吉 (Li Ji) [3][5]. - The product's price has fallen from 178 yuan to 150 yuan per box, resulting in losses for distributors who had previously stocked up at higher prices [5][11]. - The company's performance during the "6·18" sales event saw a decline in rankings and sales, marking the first time in three years that it did not disclose sales data for this period [4][9][10]. Market Impact - The controversy began with a report from a beauty influencer questioning the collagen content in the product, which led to a significant drop in consumer trust and sales [5][6]. - The number of influencers promoting the product decreased by 32% during the "6·18" period compared to the previous year, indicating a shift in marketing dynamics [7][9]. Company Response - 巨子生物 acknowledged the limitations of its quality standards and testing methods in a public statement, indicating a need for improvement [6][10]. - Despite the challenges, the company maintains its revenue targets for 2025 and expresses confidence in recovering from the losses incurred during the sales event [4][10]. Financial Overview - 巨子生物 reported a compound annual growth rate of 52.8% in revenue from 2022 to 2024, with a net profit growth rate of 43.5% [10][12]. - The company’s stock price has seen fluctuations, dropping nearly 40% since May 24, but showed a slight recovery following announcements of share buybacks by its major shareholder [13][14].

Core Viewpoint - The article discusses the recent controversy surrounding Juzhi Biotechnology (巨子生物) and its admission of limitations in quality standards and testing methods, which has raised further questions about the integrity of its products and the broader implications for the industry [2][4][10]. Group 1: Company Response and Market Impact - Juzhi Biotechnology acknowledged its limitations in quality standards and testing methods, marking a significant shift from its previous defensive stance against accusations regarding its collagen products [4][10]. - Following the controversy, Juzhi's stock price fell from 87.1 HKD to 53.9 HKD, resulting in a market capitalization loss of over 330 billion HKD [10]. - The company's internal investor meeting indicated confidence in recovering from short-term impacts, despite the ongoing public skepticism [4][11]. Group 2: Industry Context and Competition - The controversy highlights a broader "ingredient war" between Juzhi Biotechnology and Huaxi Biotechnology (华熙生物), with both companies competing in the collagen and hyaluronic acid markets [14][15]. - Huaxi Biotechnology, a leader in the hyaluronic acid market, has criticized Juzhi's claims about collagen superiority, emphasizing the lack of scientific basis for such assertions [15][16]. - The article suggests that the current lack of unified testing standards in the collagen industry poses challenges for quality control and consumer trust [17][19]. Group 3: Consumer Trust and Market Dynamics - The incident has led to a decline in consumer trust, particularly among core users who prioritize ingredient efficacy, which could have long-term repercussions for Juzhi's brand reputation [12][13]. - The article notes a shift in consumer behavior towards more informed purchasing decisions, moving from concept-driven marketing to a focus on ingredient transparency and scientific validation [23][24]. - The controversy may catalyze regulatory changes and industry standards, potentially leading to a market reshuffle where companies lacking core R&D capabilities may struggle to survive [22][24].

Industry Overview - The medical beauty injection products mainly include hyaluronic acid, collagen, regenerative materials, and botulinum toxin, with hyaluronic acid and collagen being classified as medical devices, while botulinum toxin is categorized as a toxic medical drug [1][2][5] Industry Chain Analysis - The upstream of the medical beauty injection materials includes raw materials and equipment manufacturing, while the midstream focuses on product research and manufacturing, and the downstream consists of sales channels such as public hospitals and private chains [2][5] Industry Development History - The Chinese medical beauty injection materials market has evolved from reliance on imports to self-innovation, with significant milestones including the approval of the first domestic hyaluronic acid filler in 2009 and the emergence of domestic leaders like Huaxi Biological, Aimeike, and Haohai Biological by 2015 [6][8] Industry Policy Background - Regulatory measures have been strengthened since 2019, with guidelines issued for the clinical trial of hyaluronic acid products and stricter management of medical beauty injection materials to enhance product quality and safety [9][11][12] Current Industry Status - The market size of China's medical beauty injection materials is projected to reach approximately 34.6 billion yuan in 2024, reflecting a year-on-year growth of 28.6% and a CAGR of 31.3% from 2021 to 2024 [14][16] Market Structure - Hyaluronic acid and botulinum toxin dominate the market, with hyaluronic acid accounting for about 36% and botulinum toxin for about 29% of the total market share [17][19] Competitive Landscape - Major competitors in the hyaluronic acid market include Huaxi Biological, Aimeike, and Haohai Biological, while the botulinum toxin market is primarily represented by Lanzhou Biological, which is currently the only domestic company with approved products [23][25] Future Industry Outlook - The medical beauty injection materials market is expected to reach 93.7 billion yuan by 2030, driven by technological advancements, compliance, and the rise of male consumers [28][30] Industry Development Trends - Key trends include the long-lasting and precise application of materials, the rise of intelligent and customized solutions, and increased regulatory scrutiny leading to higher approval thresholds for injection materials [32]

Core Viewpoint - The ongoing debate between two major companies regarding the restructuring of collagen detection methods highlights the industry's need for standardized testing protocols and the challenges posed by varying product quality in the market [1][4][6]. Group 1: Company Actions and Statements - Huaxi Biological published an article asserting the need for industry standards based on testing results, revealing that their product "Runbaiyan" was tested for collagen content using advanced HPLC-HRMS technology, yielding a result of 0.60 mg/g (0.06%) for type III collagen [2][3]. - Huaxi Biological emphasized that their testing method effectively eliminates matrix interference and ensures accurate detection of recombinant collagen, addressing concerns about the reliability of their results [2][3]. - Juzhi Biological acknowledged the limitations of their existing quality standards and testing methods, stating the need for continuous optimization to meet industry advancements and consumer expectations [5][6]. Group 2: Industry Implications - The debate over collagen measurement methods has been ongoing since May, with Huaxi Biological criticizing misleading conclusions from industry reports and calling for a unified testing standard [4][6]. - Juzhi Biological has committed to collaborating with research institutions to enhance detection methods and to gradually disclose key technical parameters and quality control data to foster industry development and transparency [5]. - The lack of a unified detection method has been described as a strategy to evade scrutiny, highlighting the industry's regulatory challenges and the necessity for verifiable solutions [6].

Investment Rating - The report rates the cosmetics and medical beauty industry as "Positive" [2][3] Core Viewpoints - The cosmetics retail sales growth for January to May 2025 is 4.1%, an increase of 2 percentage points compared to the same period last year, indicating a steady recovery in demand [3] - The performance of leading brands remains strong, with double-digit growth, supported by the theme of self-care in new consumption trends, leading to a positive outlook for the first half of 2025 [3] - The 618 shopping festival saw strong performances from domestic brands, with notable rankings on platforms like Tmall and Douyin [3] Summary by Sections Cosmetics Industry Outlook - The report anticipates significant revenue and net profit growth for major companies in Q2 and H1 2025, with specific forecasts: - Up Beauty Co. is expected to see a revenue increase of 16% and a net profit increase of 25% [3] - Marubi is projected to grow revenue by 22% and net profit by 28% in Q2 2025 [3] - Proya is expected to achieve a revenue growth of 10% and net profit growth of 15% in Q2 2025 [3] Key Companies Performance - Notable companies and their expected performance include: - Mao Geping is projected to have a revenue increase of 38% and net profit increase of 35% in H1 2025 [3] - Ruibin is expected to see a revenue increase of 15% and net profit increase of 15% in Q2 2025 [3] - Huaxi Biological is expected to maintain stable performance with a 0% revenue growth and a 10% net profit increase in Q2 2025 [3] Investment Recommendations - The report recommends focusing on companies with strong brand matrices and comprehensive product layouts, such as Up Beauty Co., Marubi, and Proya, which are expected to benefit from the live e-commerce traffic [3] - It also highlights the importance of niche market players like Ruibin and Mao Geping, who are positioned to capitalize on the rise of personal care and domestic beauty trends [3] - For the medical beauty sector, the report suggests focusing on companies with high R&D barriers and strong profitability, recommending companies like Aimeike and Langzi [3] E-commerce and Other Segments - The report suggests monitoring e-commerce companies like Ruibin, which is expected to see significant growth in revenue and net profit [3] - In the maternal and infant sector, Kid King is projected to exceed market expectations with a revenue increase of 10% and a net profit increase of 70% in Q2 2025 [3]

Core Viewpoint - The article discusses the ongoing dispute between Huaxi Biological and Juzhi Biological regarding the measurement and standards of recombinant collagen products, emphasizing the importance of scientific validation and the need for reliable testing methods [1][5][7]. Group 1: Huaxi Biological's Position - Huaxi Biological published an article asserting that claims without scientific testing are pseudoscience, specifically targeting the lack of unified testing methods for recombinant collagen [1][7]. - The company argues that if the actual content of recombinant collagen cannot be accurately measured, then claims about its presence or efficacy become unverifiable, thus lacking scientific credibility [7][8]. - Huaxi Biological emphasizes the need for collaborative efforts to explore the limitations of current testing methods and to develop more precise standards, rather than evading verification [7][8]. Group 2: Juzhi Biological's Response - Juzhi Biological acknowledged the limitations of its existing quality standards and testing methods in a statement, indicating a need for continuous optimization to meet industry advancements [5][6]. - The company defended its testing methods by referencing national standards, claiming that the methods used by critics were not validated and therefore produced inaccurate results [6][8]. Group 3: The Role of "Big Mouth Doctor" - The influencer "Big Mouth Doctor" (Hao Yu) has been involved in the dispute, previously criticizing Juzhi Biological for alleged false claims regarding recombinant collagen content [1][6]. - Despite being silenced on social media, "Big Mouth Doctor" published an article aligning with Huaxi Biological's views on the standards of scientific validation, quoting philosophers on the nature of science [9][12]. - There are speculations about a potential conflict of interest between "Big Mouth Doctor" and Huaxi Biological due to their financial connections, suggesting that the dispute may have underlying commercial motivations [12].

Core Insights - The article discusses a significant commercial battle in the beauty industry, particularly focusing on the competition between two major players, Huaxi Biological and Juzhi Biological, over the standards of recombinant collagen products [3][4][8] - The conflict highlights deeper issues within the biotechnology sector, such as the lack of research and development (R&D) investment and the prevalence of concept marketing over scientific validation [9][13][20] Group 1: Industry Competition - The battle over recombinant collagen standards has been ongoing for over a month, revealing a struggle for market share and consumer trust in the beauty sector [3][4] - The conflict was ignited by a report from beauty blogger "Big Mouth Doctor" questioning the amino acid content in Juzhi Biological's product, leading to public scrutiny [4][6] - Juzhi Biological's stock price fell by 37.12% from its peak on May 20 to June 23, resulting in a market value loss of 33.2 billion HKD, while Huaxi Biological's stock saw a slight increase of approximately 1.9% during the same period [8] Group 2: Research and Development Shortcomings - Juzhi Biological admitted to the limitations of its current testing methods, indicating a lack of adequate R&D investment, which was only 1.9% of its revenue in 2024, down from 2.1% in 2023 [9][10] - In contrast, Huaxi Biological and Jinbo Biological had R&D expense ratios of 8.68% and 10.89% respectively, showcasing a significant disparity in investment in innovation [9] - The article emphasizes the need for Juzhi Biological to enhance its R&D efforts to avoid future crises and to better respond to market challenges [10][13] Group 3: Industry Standards and Consumer Trust - The absence of national standards for recombinant collagen testing has led to confusion among consumers, as different companies use varying testing methods, resulting in inconsistent product quality [6][15] - The article argues that the reliance on concept marketing rather than scientific validation is unsustainable and can lead to significant reputational damage for companies [16][20] - The ongoing battle serves as a wake-up call for the industry to prioritize scientific rigor and consumer trust over short-term marketing gains [17][21]

Short Selling Ratios - Great Wall Motor-R (82333) and JD Health-R (86618) have the highest short selling ratios at 100.00% [1][2] - BYD Company-R (81211) follows with a short selling ratio of 86.11% [1][2] Short Selling Amounts - Xiaomi Group-W (01810) leads in short selling amount with 1.733 billion [2] - Meituan-W (03690) and Alibaba-SW (09988) follow with 901 million and 803 million respectively [1][2] Deviation Values - JD Health-R (86618) has the highest deviation value at 48.31% [1][2] - SF Holding (N23067) and Xiaomi Group-W (01810) also show significant deviation values of 47.35% and 36.04% respectively [1][2]

Core Viewpoint - Juzi Holding, the controlling shareholder of Juzi Bio, has shown confidence in the company's future by purchasing additional shares, indicating a positive outlook on the company's performance and potential growth [1] Summary by Relevant Sections - **Share Purchase Details** - Juzi Holding has acquired 1,056,600 shares of Juzi Bio since the announcement of the buyback plan on June 9, 2025, with a total investment of approximately 53.5 million HKD [1] - **Ownership Structure** - Following the share purchase, Juzi Holding now holds a total of 582 million shares, representing 54.36% of the company's total issued shares [1] - **Future Plans** - Juzi Holding may consider further increasing its stake depending on market conditions and regulatory requirements [1]