本次会议是否有否决议案：无 证券代码：600276 证券简称：恒瑞医药 公告编号：临 2025-143 一、 会议召开和出席情况 江苏恒瑞医药股份有限公司 2025年第一次临时股东会决议公告 (一)股东会召开的时间：2025 年 9 月 16 日 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 重要内容提示： | 1、出席会议的股东和代理人人数 | 4,505 | | --- | --- | | 股股东人数 其中：A | 4,504 | | 境外上市外资股股东人数（H 股） | 1 | | 2、出席会议的股东所持有表决权的股份总数（股） | 3,068,160,282 | | 其中：A 股股东持有股份总数 | 2,900,683,191 | | 境外上市外资股股东持有股份总数（H 股） | 167,477,091 | | 3、出席会议的股东所持有表决权股份数占公司有表决权股 | | | 份总数的比例（%） | 46.2869 | | 其中：A 股股东持股占股份总数的比例（%） | 43.7603 | | 境外上市外资股股东持股 ...

www.grandall.com.cn 中国江苏省南京市汉中门大街 309 号 B 座 5、7-8 层（210036） 5、7-8F/Block B, 309# Hanzhongmen Street, Nanjing, China Tel: 86-25-89660900 Fax: 86-25-89660966 国浩律师（南京）事务所 关于 江苏恒瑞医药股份有限公司 2025 年第一次临时股东会的 法律意见书 致：江苏恒瑞医药股份有限公司 根据《中华人民共和国公司法》（以下简称"《公司法》"）、《中华人民 共和国证券法》（以下简称"《证券法》"）、《上市公司股东会规则》（以下 简称"《股东会规则》"）、《上海证券交易所上市公司自律监管指引第 1 号— —规范运作》(以下简称"《监管指引第 1 号》")及《江苏恒瑞医药股份有限公 司章程》（以下简称"《公司章程》"）的规定，国浩律师（南京）事务所（以 下简称"本所"）接受江苏恒瑞医药股份有限公司（以下简称"公司"）的委托， 指派刘向明律师、张秋子律师（以下简称"本所律师"）出席公司 2025 年第一次 临时股东会（以下简称"本次股东会"或"本次会议"），对本次股东 ...

恒瑞医药（600276）(600276.SH)公告，公司子公司苏州盛迪亚生物医药有限公司、上海盛迪医药有限 公司收到国家药品监督管理局核准签发关于注射用SHR-1826、阿得贝利单抗注射液、贝伐珠单抗注射 液的《药物临床试验批准通知书》，将于近期开展临床试验，具体为：注射用SHR-1826联合其他抗肿 瘤治疗在实体瘤患者中的安全性、耐受性和有效性的多中心、开放的ⅠB/Ⅱ期临床研究。 ...

每经AI快讯，9月16日，恒瑞医药（600276）(600276.SH)公告称，子公司苏州盛迪亚生物医药有限公 司、上海盛迪医药有限公司收到国家药监局核准签发关于注射用SHR-1826、阿得贝利单抗注射液、贝 伐珠单抗注射液的《药物临床试验批准通知书》，将于近期开展临床试验。注射用SHR-1826是一款以 c-MET为靶点的抗体偶联药物，阿得贝利单抗注射液是公司自主研发的人源化抗PD-L1单克隆抗体，贝 伐珠单抗注射液是一种人源化抗VEGF单克隆抗体。 ...

恒瑞医药公告，子公司苏州盛迪亚生物医药有限公司和上海盛迪医药有限公司收到国家药监局核准签发 的关于注射用SHR-1826、阿得贝利单抗注射液、贝伐珠单抗注射液的《药物临床试验批准通知书》。 这些药物将于近期开展临床试验。注射用SHR-1826是针对c-MET靶点的抗体偶联药物，阿得贝利单抗 注射液为人源化抗PD-L1单克隆抗体，贝伐珠单抗注射液为抗VEGF单克隆抗体。相关项目累计研发投 入分别为约8809万元、9.39亿元和3.49亿元。药品需完成临床试验并通过审批后才能生产上市。 ...

智通财经APP讯，恒瑞医药(600276.SH)公告，公司子公司苏州盛迪亚生物医药有限公司、上海盛迪医 药有限公司收到国家药品监督管理局核准签发关于注射用SHR-1826、阿得贝利单抗注射液、贝伐珠单 抗注射液的《药物临床试验批准通知书》，将于近期开展临床试验，具体为：注射用SHR-1826联合其 他抗肿瘤治疗在实体瘤患者中的安全性、耐受性和有效性的多中心、开放的ⅠB/Ⅱ期临床研究。 ...

Investment Rating - The report indicates a positive outlook for the atopic dermatitis (AD) market, highlighting significant unmet medical needs and potential for new therapies, particularly in small molecules and biologics [4][10][12]. Core Insights - Atopic dermatitis is a chronic, recurrent inflammatory skin disease characterized by severe itching, affecting approximately 600-700 million patients globally, with around 67 million in China, indicating a substantial unmet demand for effective treatments [1][18][20]. - Recent advancements in small molecules and biologics have marked a new phase in AD treatment, with several new products entering the market, although the number remains limited [1][10][32]. - JAK inhibitors have shown excellent efficacy but come with safety concerns, while TYK2 inhibitors are emerging as a promising new option due to their selective action and potentially better safety profile [2][11][12]. - Biologics targeting IL-4Rα and IL-13 have demonstrated significant efficacy in improving skin lesions, with IL-31 showing strong itch relief capabilities [3][12][13]. - The development of dual/multi-target antibodies is seen as a new strategy to enhance treatment efficacy by combining the advantages of different targets [4][13][21]. Summary by Sections Investment Highlights - The AD market has immense potential, with a pressing need for effective therapies [4][10]. - The patient population is large, with over 600 million affected globally, necessitating urgent treatment options [1][18]. Disease Characteristics - AD is characterized by chronic inflammation and severe itching, significantly impacting patients' daily lives [1][14]. - The disease burden is heavy, with a complex pathogenesis involving multiple factors, primarily driven by Th2-type inflammation [21][24]. Current Treatment Landscape - Traditional therapies have safety concerns, leading to a shift towards biologics and small molecules [32][35]. - JAK inhibitors are the most approved class of drugs for AD, but they carry black box warnings due to safety issues [11][12]. - Emerging therapies, particularly TYK2 inhibitors, show promise for better safety and efficacy [2][11]. Biologics and Emerging Therapies - Currently approved biologics include IL-4Rα, IL-13, TSLP, and IL-31, with ongoing research into additional targets [3][12][13]. - Dual/multi-target antibodies are being explored to improve treatment outcomes and extend dosing intervals [4][13][21]. Market Potential - The report emphasizes the significant market potential for AD treatments, with projected growth driven by increasing patient numbers and the introduction of innovative therapies [4][10][20].

Core Viewpoint - The Shanghai Stock Exchange 50 Index (SSE 50) has become a core target in value investing due to its precise selection of quality constituent stocks and scientific industry allocation, providing a robust underlying support for returns amidst market volatility [1][2]. Group 1: Constituent Stock Quality - The top ten constituent stocks of the SSE 50 form a "leader matrix" covering multiple core sectors, representing the pricing power and profit resilience of China's core economic assets [1]. - Key sectors include food and beverage, finance, public utilities, resources, and pharmaceuticals, with leading companies establishing strong competitive moats [1][2]. - For instance, Kweichow Moutai, with a weight of 10.55% and a market capitalization exceeding 1.8 trillion, leverages brand scarcity and rigid consumption scenarios to maintain high profitability across economic cycles [1][4]. Group 2: Industry Allocation Advantages - The SSE 50 exhibits a strategic positioning in core sectors, emphasizing "economic foundation + consumption upgrade," which provides a comparative advantage over the CSI 300 and CSI 500 indices [2][7]. - In the financial sector, the SSE 50's allocation is significant, with a combined weight of 36.4% in banking and non-banking financial sectors, substantially higher than the CSI 300's 26.2% and CSI 500's 9.5% [7][8]. - Leading banks like Industrial and Commercial Bank of China and China Merchants Bank are noted for their superior asset quality management and interest margin control, contributing to a "double boost" effect on performance during economic recovery [7][8]. Group 3: Consumer Sector Focus - The food and beverage sector holds a weight of 13.6% in the SSE 50, significantly surpassing the CSI 300's 8.1% and CSI 500's 1.8%, focusing on high-end consumer leaders like Kweichow Moutai [8][9]. - The current TTM price-to-earnings ratio for the food and beverage index is 21.76, indicating it is at a historically low relative valuation, which, combined with a recovering consumption trend, suggests potential for valuation recovery [8][9]. - The food and beverage sector is positioned as a "stabilizer" for the SSE 50, with expectations for steady earnings growth and reasonable valuation recovery, contributing to ongoing cash flow and valuation elasticity [9].

Core Insights - The Chinese innovative drug sector has become a hot area in the capital market this year, driven by the real demand for high-quality innovative drugs from domestic patients, which is seen as the core driver for industry recovery [1] Group 1: Market Performance - In the first half of this year, 21 innovative drug companies listed on A-shares achieved a revenue of 28.69 billion yuan, a year-on-year increase of approximately 42%, while 32 innovative drug companies listed on H-shares reported a revenue of 42.13 billion yuan, a year-on-year increase of about 10% [2] - Leading companies have shown particularly strong performance, with Heng Rui Medicine's innovative drug sales revenue reaching 7.57 billion yuan, a year-on-year increase of approximately 14.5% [2] - Innovative drugs from Bai Jie Shen Zhou, such as Bai Yue Ze and Bai Ze An, reported sales of 1.192 billion yuan and 2.643 billion yuan respectively, with year-on-year growth rates of 36.5% and 20.6% [2] Group 2: Policy and Market Dynamics - The Chinese innovative drug market is entering a dual development cycle with domestic medical insurance and overseas markets, leading to a gradual path to profitability for companies [2] - Since its establishment in 2018, the National Medical Insurance Bureau has included 149 innovative drugs in the medical insurance catalog through seven rounds of adjustments, significantly optimizing the clinical medication structure [3] - By May 2025, the medical insurance fund is expected to pay a cumulative 410 billion yuan for negotiated drugs, driving related drug sales to exceed 600 billion yuan [3] Group 3: Future Outlook - The innovative drug market in China is projected to reach a scale of 162 billion yuan by 2024, with medical insurance payments accounting for approximately 43.8% [4] - The commercial success of innovative drugs is seen as a starting point for higher-level research and development, with many companies increasing their R&D investments despite revenue growth [4] - China currently holds a 30% share in global drug research and development, with 1,775 first-in-class drug pipelines, representing 19% of the global total [4]

| 表格序號 | 大股東/董事/最高行政人員名 作出披露的 買入 / 費出或涉及的 每股的平均價 | | | | | 持有權益的股份數目 佔已發行的 有關事件的日期 相 | | --- | --- | --- | --- | --- | --- | --- | | | 보 | 開示 | 股份數目 | | | ( 請參閱上述 * 註 有投票權股 (日 / 月 / 年) 材 | | | | | | | | 월 份百分比 | | | | | | | | ( % ) | | CS20250915E00060 | GIC Private Limited | 1101(L) | | 2.519.000(L) | HKD 81.9747 | 50.534.200(L) 19.57(L)11/09/2025 | 追加内容 本文作者可以追加内容哦 ! 格隆汇9月16日丨根据联交所最新权益披露资料显示，2025年9月11日，恒瑞医药(01276.HK)获GIC Private Limited在场内以每股均价81.9747港元增持251.9万 股，涉资约2.06亿港元。 增持后，GIC Private Limited最新持股数目为 ...