Core Insights - The report emphasizes the importance of proactive discovery in the financial market rather than merely relaying information [1] Domestic Financial Market - The Shanghai Composite Index closed at 3402.66, with a slight increase of 0.01% [3] - The Shenzhen Component Index closed at 10234.33, showing a decrease of 0.11% [3] - The ChiNext Index closed at 2067.15, reflecting an increase of 0.26% [3] - The Hang Seng Futures Index closed at 31013.11, with a decline of 1.2% [3] Macro News Summary - The central bank and foreign exchange bureau are increasing financial support for cross-strait integration development [5] - The Ministry of Industry and Information Technology supports automotive companies in adhering to a payment term of no more than 60 days [5] - The National Development and Reform Commission emphasizes the coordination of economic reforms with education, technology, and talent [5] Industry Latest Developments - A solid-state battery conference is scheduled for next week, indicating the industry is on the verge of mass production, with related stocks including Honggong Technology and Guoxuan High-Tech [6] - The biomanufacturing sector is receiving policy support for the establishment of pilot platforms, with related stocks including Huaxi Biological and Chuaning Biological [6] - The stablecoin market is experiencing rapid growth, with increasing activity in cross-border payment applications, related stocks include Newland and Dongxin Peace [6] Company Focus - Xidian Co., Ltd. is the first domestic company to achieve industrial application of 12-inch wafer probe stations [7] - Antarctic Light is currently the only LCD backlight module supplier certified by Nintendo, maintaining a stable position in the Switch 2 backlight module supply [7] - Jin Modern has adapted its low-code development platform to the DeepSeek large model [7] - Lanshi Heavy Industry's wholly-owned subsidiary plans to acquire 100% equity of Qingdao Equipment for 99.9821 million yuan, enhancing its nuclear equipment manufacturing capabilities [7] Market Review and Outlook - On June 12, the market opened slightly lower and exhibited a fluctuating pattern, with the Shanghai Composite Index briefly falling below 3400 points before recovering [8] - The total trading volume in the Shanghai and Shenzhen markets reached 1.27 trillion yuan, an increase of 16.3 billion yuan from the previous trading day [8] - Sectors with notable gains included precious metals, beauty care, jewelry, diversified finance, and cultural media, while shipping ports, liquor, electronic chemicals, and coal sectors faced declines [8] - The report indicates a cautious outlook for the market, with a potential for further consolidation, while maintaining a bullish medium-term perspective [8]

Core Viewpoint - The article discusses the establishment of pilot testing platforms for biomanufacturing, focusing on key product areas such as food additives, biopharmaceuticals, cosmetics, chemicals, energy, and enzyme preparations, with a goal to support innovation and commercialization in the industry [1][2]. Group 1: Pilot Testing Platforms - The Ministry of Industry and Information Technology and the National Development and Reform Commission aim to cultivate over 20 pilot testing platforms by 2027, serving more than 200 enterprises and incubating over 400 products [1]. - The initiative emphasizes market-driven and demand-led approaches, encouraging national laboratories and innovation platforms to develop pilot testing capabilities [1][2]. - The platforms will focus on addressing the shortcomings and pain points in the pilot testing phase of biomanufacturing, particularly in the development of new raw materials such as lignocellulosic and one-carbon compounds [2]. Group 2: Guidelines and Events - The article includes attachments such as the "Biomanufacturing Pilot Testing Capability Construction Platform Cultivation Guidelines (2025 Edition)" and an application form for the platform [3]. - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) is scheduled for August 20-22 in Jinan, Shandong, aiming to discuss trends in biomanufacturing and promote technology transfer and commercialization [4].

Core Viewpoint - The Ministry of Industry and Information Technology and the National Development and Reform Commission have initiated a program to cultivate pilot-scale biomanufacturing capabilities, focusing on addressing gaps and pain points in the biomanufacturing sector [1] Group 1: Biomanufacturing Focus Areas - The initiative aims to develop pilot platforms for key product areas including food and additives, biopharmaceuticals, cosmetics, chemicals, energy, and enzyme preparations, promoting collaborative innovation across the industry chain [1] - Emphasis is placed on cultivating pilot platforms for new raw material development, particularly in lignocellulosic materials and one-carbon compounds (such as carbon monoxide and methanol) [1] - The program will also focus on establishing pilot platforms for plant chassis cells, which utilize genetically modified plant cells (such as tobacco, rice, and Taxus cells) to address emerging field gaps in biomanufacturing [1]

Core Viewpoint - Shanghai aims to enhance its pilot testing service supply in key industries by establishing around 20 municipal pilot testing platforms by 2027, with a goal of creating 3 national-level platforms [1] Group 1: Pilot Testing Platforms - The implementation plan includes building comprehensive, specialized, and distinctive pilot testing platforms in key industrial sectors [1] - The focus will be on industries such as integrated circuits, large aircraft, gas turbines, and industrial mother machines to improve testing and validation service capabilities [1] Group 2: Software and AI Development - The plan emphasizes accelerating the construction of pilot testing platforms for foundational software, industrial software, and artificial intelligence, including model training and evaluation [1] Group 3: New Materials and Biomanufacturing - There will be efforts to promote the conversion of technological achievements into process packages and complete equipment in fields like new materials and biomanufacturing [1] - The development of contract research outsourcing models will be encouraged [1] Group 4: Future Industry Integration - The initiative aims to facilitate the integration of production, education, research, and application in future industries, shortening the pilot testing maturation cycle and addressing gaps from engineering to industrialization [1]

Group 1 - The core viewpoint of the article emphasizes the characteristics of industrial transfer in China, highlighting the shift from labor-intensive to capital and technology-intensive industries, particularly in the central and western regions [1] - The article notes that the transfer of industries is effectively driving industrial upgrades and value chain elevation, with significant movements in sectors such as steel, non-ferrous metals, petrochemicals, food processing, and new energy [1] - The importance and urgency of promoting industrial transfer are underscored, as it relates to enhancing the resilience and security of supply chains, building a modern industrial system, and constructing a new development pattern [1] Group 2 - Inner Mongolia is identified as a region with significant resource advantages, including abundant wind and solar energy, rich coal resources, and leading rare earth reserves, which can facilitate a new landscape for industrial transfer [2] - The region's agricultural strength is highlighted, with Inner Mongolia being one of the main grain-producing areas in China, and key industrial chains in dairy, meat, and other sectors exceeding a total output value of 700 billion yuan [2] - The development of the bio-manufacturing industry in Inner Mongolia is noted, focusing on a modern industrial structure that includes biopharmaceuticals and traditional Mongolian medicine [2] Group 3 - The article suggests that Inner Mongolia should actively integrate into national strategies, leveraging its development logic and industrial foundation to clarify key directions for industrial transfer [3] - It emphasizes the need to strengthen border advantages, promote trade-logistics-industry coordination, and enhance port construction and cross-border cooperation [3] - The article calls for improvements in infrastructure, including parks and new infrastructure, to enhance capacity for industrial transfer and create a favorable business environment [3]

Group 1: Policy Release - The report includes three domestic policies related to the bio-based industry [7][18]. - Key projects in the policies focus on carbon reduction and include initiatives for biodegradable polyester rubber, high-performance bio-based materials, and sustainable aviation fuel [8][19]. Group 2: Industry Dynamics - The report highlights two domestic developments in the bio-based chemicals sector, including a project for lactic acid production and the establishment of a new company for food additives [9][20]. - A total of 13 domestic developments in the bio-manufacturing sector are reported, including strategic collaborations and new project announcements [20][21]. Group 3: Capital Events - Several financing events in the bio-based sector are noted, with companies raising millions in funding for various bio-manufacturing projects [11][22]. - Notable investments include over 100 million yuan for recombinant collagen and nearly 100 million yuan for bioactive ingredients [22]. Group 4: Scientific Research Progress - Significant breakthroughs in scientific research related to bio-based materials and manufacturing are reported, including advancements in bioremediation and the synthesis of high-order carbohydrates [12][23]. - Research highlights include the development of engineered bacteria for pollutant degradation and innovative methods for synthesizing sugars from low-carbon molecules [23]. Group 5: Upcoming Events - The fourth Synthetic Biology and Green Bio-Manufacturing Conference is scheduled for August 20-22, 2025, in Jinan, Shandong, focusing on industry trends and technological innovations [25][26].

Core Viewpoint - The article emphasizes the transformative potential of synthetic biology in addressing sustainability challenges in traditional agricultural protein production, particularly through the development of microbial protein from non-grain raw materials [1][2]. Group 1: Technological Innovations - The research team has made significant breakthroughs in the use of methanol as a renewable C1 compound, enhancing the efficiency of converting methanol into single-cell protein through metabolic engineering and genomic perturbation [2]. - Innovations in gas-phase non-grain microbial protein production include the construction of a light-dark energy adapter in E. coli, enabling light-driven CO2 assimilation [2]. - The team has developed a machine learning model to decode the composition of degrading enzyme systems based on the structural characteristics of lignocellulose, facilitating the production of microbial protein from agricultural waste [2]. Group 2: Economic and Environmental Impact - The innovative conversion models not only enhance the economic value of agricultural waste but also pave the way for the industrial-scale biosynthesis of microbial protein from these resources, achieving a dual benefit of resource utilization [2]. - The research highlights the integration of synthetic biology and interdisciplinary innovation as a driving force for sustainable protein production, contributing to food security and carbon neutrality goals [6]. Group 3: Future Research Directions - Future research will focus on the super-evolutionary design of chassis cells, the closed-loop integration of negative carbon manufacturing systems, and the construction of AI-driven intelligent bio-manufacturing platforms [6].

团队前期的工作围绕甲醇作为一种可再生的 C1 化合物以及与二氧化碳氢化合成技术的重大突破，通过碳氮协同耦合代谢工程与基因组扰动等多重策 略，有效提升天然甲基营养菌中甲醇向单细胞蛋白的定向转化效率，进而突破工业菌株性能极限，为利用甲醇作为碳源生物制造微生物蛋白大规模工业 化生产提供了关键技术支持；在气态非粮生物制造微生物蛋白方面，通过构建大肠杆菌中的光 - 暗反应能量适配器，实现光驱动 CO 2 同化的全细胞 催化过程；通过电催化 - 生物耦合技术，可将电化学还原 CO 2 生成的甲酸盐与微生物同化模块精准对接，为气态非粮原料的转化技术开辟了负碳生 物制造微生物蛋白的新维度；在固态非粮原料生物合成微生物蛋白技术方面，该团队通过机器学习模型，基于木质纤维素结构特性破译出降解酶系组成 的新算法，进而摆脱复杂性底物结构 - 多样性酶系构效关系的实验先验，精准定制了多种地源性木质纤维素来源的微生物蛋白，达到地源性农业废弃 物资源利用与微生物蛋白生物合成"一草双收"效果。这些创新转化模式不仅提升了农业废弃物资源化利用经济价值，更开辟了农业废弃物规模化生物 合成微生物蛋白的工业化新路径。 以下文章来源于中国科学院天津工业生 ...

建设内容：在本公司"微元合成绿色生物制造二期项目"车间内，建设"微元合成绿色生物制造二期健 康糖项目"，利用现有发酵、公用工程和检验等设备，新增膜分离、离交、浓缩、结晶、分离干燥等 设备， 项目建成后， 柔性生产阿洛酮糖和甘露糖醇（食品级）， 年产量共计2000吨 。 阿洛酮糖 作为一种新型低倍甜味剂，具备多种生理功效，如抑制人体对糖类的吸收、降血糖、抗氧 化等，是蔗糖的理想替代品。 甘露糖醇 则广泛应用于医药、食品、化工等领域，作为甜味剂、保湿 剂、赋形剂等。 2、在建项目 "微元合成绿色生物制造二期项目"，项目运用生物提取技术，以一水合葡萄糖、柠檬酸、磷酸二氢 钾、硫酸钾等组分组成的培养液为基本原料，利用菌体进行发酵得到产物胆红素后进行纯化提取，从 而制出胆红素产品。目前项目正在建设过程中，建成后年生产胆红素5吨。 3、微元合成 【SynBioCon】 获悉，近日，关于 微元合成生物技术（秦皇岛）有限公司 微元合成绿色生物制造 二期健康糖项目在相关网站批复前公示。 1、项目基本情况 项目名称：微元合成绿色生物制造二期健康糖项目 建设单位：微元合成生物技术（秦皇岛）有限公司 项目投资：4000万元 微元合成 ...

Core Insights - The 10th Bio-based Conference and Exhibition was held in Shanghai from May 26-27, 2025, focusing on AI-enabled innovation in new materials and applications in bio-based materials [1][3][19] - The conference featured discussions on the development trends of the bio-manufacturing industry in China, highlighting its potential as a global bio-manufacturing center [3] - Various experts presented on the integration of AI in chemical new materials research and production, emphasizing the challenges and opportunities in this field [7][16] Group 1: Industry Trends and Insights - YiKai Capital's partner shared insights on the definition and market size of the global and Chinese bio-manufacturing industry, along with development trends and capital market reviews for 2024 and 2025 [3] - The Shanghai Academy of Science's researcher discussed a dual-driven molecular pre-training model that significantly improved reaction selectivity by five times and designed new biodegradable polymer materials [5] - The roundtable discussions included perspectives from investment institutions and scientific experts on how AI can enhance the efficiency of bio-based material research and development [9][15] Group 2: AI Applications in Material Science - The market director of Magnesium Technology presented on the application of AI in the research and production of chemical new materials, addressing the challenges faced in implementing these technologies [7] - A report on high-resolution atomic imaging analysis using deep learning highlighted the limitations of traditional models and introduced a new framework for analyzing structural diversity [11] - The application of AI in polymer material design was discussed, showcasing recent advancements and case studies in composite materials and organic photovoltaic materials [13]