新华财经北京12月31日电（胡晨曦） 在BD（商务拓展）出海大单持续超预期等催化下，创新药板块 2025年表现亮眼。尽管近期连续调整，但港股创新药指数（931787.CSI）等创新药代表性指数年内涨幅 仍近70%。个股方面，截至A股12月31日收盘，舒泰神、三生国健、荣昌生物、昭衍新药等个股股价年 内实现翻倍。 展望2026年，业内人士普遍看好在产业政策对真创新、高水平创新的支持下，大量创新药BD将密集落 地。商保实施与集采优化双轮推动下，创新药产业链高景气度有望延续，高价值创新药有望迎来第二增 长曲线。 个股表现抢眼医药企业蜂拥港股 今年以来，二级市场上创新药板块表现十分亮眼。 其中，A股方面，截至12月31日收盘，舒泰神、三生国健、荣昌生物、昭衍新药等个股股价实现翻倍， 其中舒泰神年内股价曾一度暴涨近7倍。港股方面，年初至今，荣昌生物、三生制药涨超300%，信达生 物、翰森制药、诺诚健华、药明合联等多股涨超100%。此外，2025年初至今，港股创新药指数 （931787.CSI）涨约72.5%，其间一度飙升逾100%。A股创新药板块同样大涨，1月10日至9月8日，中证 创新药（931152.CSI）指数累 ...

Group 1 - The core investment theme for the pharmaceutical industry in 2025 is the overseas expansion of innovative drugs, which is expected to yield excess returns compared to the broader pharmaceutical sector and the CSI 300 index [2][21] - The innovative drug index has shown a significant increase, outperforming the pharmaceutical biological index by 37.48 percentage points, with a year-to-date increase of 65.99% [21] - Major transactions in the ADC and dual antibody fields are anticipated to continue, while there is a need to avoid repetitive competition in areas like small nucleic acids and focus on unmet clinical needs [3][4] Group 2 - The report emphasizes the importance of overseas markets for both innovative drugs and medical devices, suggesting that companies should seek growth opportunities beyond domestic market saturation [4][5] - The Chinese pharmaceutical industry is gradually becoming a global innovation center, with significant advancements in dual antibodies and ADCs, while also making strides in emerging fields like small nucleic acids and inhalation formulations [5][6] - The report highlights that the overseas authorization revenue has become a crucial funding source for innovative drug development, with a total upfront payment of $4.551 billion in the first three quarters of 2025 [29][32] Group 3 - The medical device sector is experiencing a shift towards overseas expansion, with a focus on high-value consumables and IVD products, as Chinese companies enhance their market share [7][55] - The export growth of high-value consumables is significant, with a recorded increase of 10.75% in the first half of 2025, particularly in the North American and European markets [57][66] - The report notes that the certification and market establishment processes for high-value consumables are long-term investments, requiring compliance with stringent regulations in the EU and the US [60][61] Group 4 - The recovery of financing in the domestic innovative drug sector has been robust, with a total of 324 financing events amounting to $5.51 billion in the first three quarters of 2025, marking a 67.6% increase year-on-year [70][72] - The CXO industry is experiencing varied recovery rhythms across different segments, with some areas like CDMO seeing order growth due to overseas financing recovery [74]

Investment Rating - The report maintains a "Neutral" rating for the pharmaceutical and biotechnology industry [1]. Core Insights - The focus of the industry is shifting from "Business Development (BD)" to "Clinical Development Partnerships (CDP)" as companies aim to enhance their clinical development capabilities for overseas markets. The report emphasizes the importance of core assets and suggests that the industry is entering a strong alpha phase, with a continued positive fundamental outlook despite uncertainties in international expansion [2][12]. - The pharmaceutical sector has underperformed compared to the broader market, with a year-to-date return of 14.29% against the Shanghai Composite Index's 18.36%, indicating a 2.09 percentage point lag [2][3]. - The current valuation of the pharmaceutical sector is 32.9 times PE based on 2026 earnings forecasts, which represents a 37% premium over the overall A-share market (excluding financials). The TTM valuation stands at 29.1 times PE, below the historical average of 35.0 times PE [2][27]. Summary by Sections Recent Performance - For the week of December 22 to 26, 2025, the Shanghai Composite Index rose by 1.95%, while the pharmaceutical sector declined by 0.18%, ranking 25th among 31 sub-industries. The performance of various pharmaceutical sub-sectors was as follows: chemical pharmaceuticals (0.05%), biological products (-0.10%), medical devices (0.08%), pharmaceutical commerce (-1.66%), traditional Chinese medicine (-0.67%), and medical services (-0.25%) [2][8]. Market Dynamics - The report notes that the pharmaceutical sector's performance has been relatively weak, with a year-to-date return lagging behind the broader market. The report suggests that the recent adjustments in the pharmaceutical sector are seen as healthy and that the underlying logic for innovative drugs and devices remains unchanged [2][3]. Valuation Metrics - The report highlights that the pharmaceutical sector's current valuation is 32.9 times PE based on 2026 earnings forecasts, which is a 37% premium compared to the overall A-share market (excluding financials). The TTM valuation is 29.1 times PE, which is below the historical average of 35.0 times PE [2][27]. Key Companies and Developments - The report identifies key companies to watch, including Sanofi, Innovent Biologics, and others, indicating their significance in the ongoing developments within the industry [2][35].

Core Insights - Suzhou Zelgen Biopharmaceutical Co., Ltd. has announced a strategic collaboration and licensing agreement with AbbVie for the global development and commercialization of its core product ZG006 (Alveltamig) [1] - AbbVie will obtain exclusive rights for ZG006 outside Greater China, while Zelgen retains all rights within Greater China [1] Financial Terms - Zelgen will receive an upfront payment of $100 million, with potential milestone payments up to $1.235 billion and tiered royalties [2] - The total potential amount from this collaboration could reach $1.235 billion (approximately 8.9 billion RMB), with the upfront payment already confirmed [2] - Royalties will be structured on a tiered basis, ranging from high single digits to mid-double digits based on net sales outside Greater China [2] Product Overview - ZG006 is a novel trispecific T-cell engager targeting DLL3 protein, currently in late-stage clinical development for small cell lung cancer and other DLL3-expressing malignancies [3] - The drug has received significant attention from regulatory agencies in both China and the U.S. due to the high malignancy of small cell lung cancer and limited existing treatment options [3] Strategic Significance - This collaboration represents a key implementation of Zelgen's strategy of "parallel independent research and open collaboration" [4] - By leveraging AbbVie's global clinical development and commercialization network, the international market expansion of ZG006 will be significantly accelerated [4] - The partnership also highlights the growing competitiveness of Chinese innovative pharmaceutical companies on the global stage [4]

Group 1 - The core investment theme for the pharmaceutical sector in 2026 is the innovation drug industry chain, with a clear trend towards international business development and accelerated commercialization of domestic products [2][3]. - The CXO sector is experiencing continuous improvement in performance and orders, supported by favorable financing conditions that benefit the industry's upward trajectory [3]. - The medical device sector is focusing on two main lines: international expansion and innovation [3]. Group 2 - The latest trends in medical insurance show a decline in total expenditure for the first ten months of 2025, amounting to 1,903.6 billion yuan, a year-on-year decrease of 1% [5][7]. - The total income of the medical insurance fund for the same period reached 2,352 billion yuan, with a year-on-year growth of 2%, indicating a slowdown in income growth [7][11]. - The number of medical insurance beneficiaries and hospitalization cases continues to grow, with 6.07 billion total beneficiaries in 2024, a year-on-year increase of 18% [11]. Group 3 - The average medical insurance cost per visit decreased in 2024, with the average cost for employees at 629 yuan (down 10%) and for residents at 351 yuan (down 12%) [15]. - The average hospitalization cost also saw a decline, with employees averaging 11,707 yuan (down 3.8%) and residents at 7,408 yuan (down 3.5%) [15]. Group 4 - The Chinese pharmaceutical industry is witnessing a significant increase in license-out transactions, with over 100 deals completed in 2025, totaling more than 110 billion USD [21][32]. - The number of license-out transactions involving upfront payments exceeding 100 million USD has also risen, indicating a growing interest from global pharmaceutical companies in Chinese innovations [21][32]. - The ADC (Antibody-Drug Conjugate) market is expanding rapidly, with a projected market size exceeding 16 billion USD in 2025, driven by several successful product launches [38]. Group 5 - The Chinese government is actively supporting the innovation drug sector through various policies aimed at enhancing accessibility and encouraging high-quality innovation [16][18]. - The proportion of medical insurance spending on innovative drugs is steadily increasing, with 149 innovative drugs included in the insurance coverage over the past seven years [90][94]. - The average price reduction for innovative drugs during negotiations with the national medical insurance has been around 60%, with some drugs seeing reductions as high as 94% [88][94].

RE FOTI 202 2025年，生物医药正迎来历史性跨越，无论是国内获 批上市的创新药数量再创新高，还是中国创新药对外授权 总金额突破1000亿美元,其背后离不开政策制定者的顶层 设计、产业从业者的深耕细作,以及普通大众的坚定信 心。这份比金子更珍贵的精神财富,共同铸就了改写国人 健康答案的关键瞬间。 每经记者 | 林姿辰 陈星 定调 政府工作报告再提"创新药" 品 阿尔茨海默病新药开出中国 首方 直销 三生制药与辉瑞授权交易额高 达60.5亿美元 中国侵入式脑机接口进入临床 试验阶段 甜气 创新药龙头百济神州首次实现 扭亏为盈 创新药临床申请审批开"2倍速" ←←弹幕：定调了！这是给创新药打了信心"强心剂"。 2025年的中国医药行业步履铿锵、亮点纷呈，而作为行业发展的核心引擎，生物医药正迎来属于自己的历史性跨越。截至12月7日，今年国内获批上市的 创新药数量达到69个，较去年全年的48个实现大幅跃升，创新研发成果呈现井喷之势。 在创新药市场，今年另一大核心关键词非BD（商务拓展）莫属。 医药魔方发布的《2025Q1—Q3医药交易趋势分析》显示，2025年前三季度，中国医药领域对外授权交易总金额已达92 ...

| 6、高盛认为中国 AI 模型与美国顶尖模型的差距已缩窄至 3-6 个月。此外研报认为 | | --- | | 字节跳动豆包手机助手等 AI 助手的推出，可能预示着移动应用流量格局的根本性 | | 改变。预计中国头部云服务商 2026 年资本开支将进一步攀升至 5000 亿元。 | | 7、字节跳动初步计划的 2026 年资本支出达 1600 亿元人民币，较今年的 1500 亿元 | | 有所增长。投资重点将集中在 AI 基础设施建设上，其中约一半资金将用于采购先 | | 进芯片以开发 AI 模型和应用。 | | 8、国际半导体产业协会（SEMI）日前发布报告显示，2025 年全球原始设备制造商 | | （OEM）的半导体制造设备总销售额预计达 1330 亿美元，同比增长 13.7%，创历史 | | 新高。预计 2026 年和 2027 年分别达到 1450 亿美元和 1560 亿美元。 | | 9、全国机器人租赁生态峰会暨"擎天租"平台发布会在上海举行。会上，智元机 | | 器人发布机器人租赁平台"擎天租"，标志着具身智能行业将向生态化、服务化的 | | 租赁模式深度演进。 | | 10、GGII（高工产 ...

不过，谈及市场周期，沙利文大中华区合伙人兼董事总经理毛化在接受21世纪经济报道专访时，以"分 化与修复并存"概括当下态势。 "中国创新药行业已逐步走出底部，进入修复与分化并存的新阶段。"毛化指出，尽管当下医药市场有所 回暖，但周期是否"彻底结束"仍需理性看待。 近一年来，中国药企在国际舞台上频频亮相，国际社会对中国制药业的发展关注度持续攀升。 过去一年，中国生物科技企业的股价涨幅远超美国同类企业，这一切无不表明，全球生物医药创新长达 一个世纪的"西方主导"格局正悄然改变。 这一判断的背景是：2025年以来，创新药出海交易数据屡创新高，但资本寒冬的印记仍深，市场"冷热 不均"的特征十分显著。 一方面，融资层面寒意未消。数据显示，2025年上半年中国创新药公司完成134起融资，数量为近10年 同期最低；一级市场公开交易笔数与总金额呈逐月下降趋势。另一方面，海外授权交易热潮涌动，商业 拓展（BD）交易空前活跃，成为替代融资的"造血"生命线。 2026年的医药市场究竟会呈现怎样的态势？ 拐点、重塑 2025年以来，创新药出海加快、一级市场融资回暖、海外基石投资者重返港股IPO，行业投融资活跃度 显著提升。当被问及市场 ...

近一年来，中国药企在国际舞台上频频亮相，国际社会对中国制药业的发展关注度持续攀升。 一方面，融资层面寒意未消。数据显示，2025年上半年中国创新药公司完成134起融资，数量为近10年同期最低；一级市场公开交易笔数与总 金额呈逐月下降趋势。另一方面，海外授权交易热潮涌动，商业拓展（BD）交易空前活跃，成为替代融资的"造血"生命线。 2026年的医药市场究竟会呈现怎样的态势？ 毛化。资料图 过去一年，中国生物科技企业的股价涨幅远超美国同类企业，这一切无不表明，全球生物医药创新长达一个世纪的"西方主导"格局正悄然改 变。 不过，谈及市场周期，沙利文大中华区合伙人兼董事总经理毛化在接受21世纪经济报道专访时，以"分化与修复并存"概括当下态势。 "中国创新药行业已逐步走出底部，进入修复与分化并存的新阶段。"毛化指出，尽管当下医药市场有所回暖，但周期是否"彻底结束"仍需理性 看待。 这一判断的背景是：2025年以来，创新药出海交易数据屡创新高，但资本寒冬的印记仍深，市场"冷热不均"的特征十分显著。 拐点、重塑 2025年以来，创新药出海加快、一级市场融资回暖、海外基石投资者重返港股IPO，行业投融资活跃度显著提升。当被问 ...

每日经济新闻 注：如提及个股仅供参考，不代表投资建议。指数/基金短期涨跌幅及历史表现仅供分析参考，不预示 未来表现。市场观点随市场环境变化而变动，不构成任何投资建议或承诺。文中提及指数仅供参考，不 构成任何投资建议，也不构成对基金业绩的预测和保证。如需购买相关基金产品，请选择与风险等级相 匹配的产品。基金有风险，投资需谨慎。 中泰证券指出，创新药出海从"叙事"进入兑现阶段，2025年License out总金额超1200亿美元。政策端全 链条支持创新药，首次增设商保目录，与医保形成"双轨制"支付格局。医疗器械领域政策扰动逐步出 清，高值耗材和医疗设备率先走出拐点，国产化率持续提升，其中医疗设备国产化率已突破87%。体外 诊断和低值耗材有望在2026年边际改善。原料药板块处于周期底部，多数品种价格筑底，伴随"专利悬 崖"到来，仿制药及配套API增量空间可期。消费医疗领域，中药、生物制品等内需板块有望逐步走出 低谷。AI+医疗领域政策密集发布，脑机接口被列为"十五五"重点产业，非侵入式产品商业化进程加 速。 创业板医药ETF国泰（159377）跟踪的是创医药指数（399275），单日涨跌幅达20%，该指数聚焦于创 ...