香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其 準確性或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部份內容 而產生或因依賴該等內容而引致的任何損失承擔任何責任。 聯邦制藥國際控股有限公司（「本公司」）董事會（「董事會」）謹此公佈，董事會將 於二零二五年八月二十八日（星期四）舉行會議，其中包括考慮及批准本公司及其附屬 公司截至二零二五年六月三十日止六個月的中期業績，及宣派中期股息（如有）。 承董事會命 聯邦制藥國際控股有限公司 公司秘書 梁永康 香港，二零二五年八月十四日 於本公告日期，董事會成員包括執行董事蔡海山先生、梁永康先生、蔡紹哲女士、方煜 平先生、鄒鮮紅女士及朱蘇燕女士；以及獨立非執行董事張品文先生、宋敏教授及傅秋 實博士。 The United Laboratories International Holdings Limited 聯邦制藥國際控股有限公司 (於開曼群島成立之有限公司) (股份代號: 3933) 董事會召開日期 ...

Group 1 - The Hang Seng Hong Kong Stock Connect Innovative Drug Selection Index (HSSCPB) increased by 0.02%, with notable stock performances including Jingtai Holdings (02228) up 7.38% and Fosun Pharma (02196) up 6.00% [3] - The Hong Kong Innovative Drug Selection ETF (520690) rose by 0.52%, reaching a latest price of 0.97 yuan, with a trading volume of 240.45 million yuan and a turnover rate of 0.62% [3] - Jingtai Holdings announced an expected comprehensive income of no less than 500 million yuan for the six months ending June 30, 2025, representing an increase of at least 387% compared to the same period in 2024 [3] Group 2 - The Hong Kong Innovative Drug Selection ETF reached a new high in scale at 385 million yuan and a new high in shares at 399 million [4] - The ETF has seen continuous net inflows over the past three days, with a maximum single-day net inflow of 22.93 million yuan, totaling 42.28 million yuan [4] - The ETF's management fee is 0.50% and the custody fee is 0.10%, which are among the lowest in comparable funds [5] Group 3 - The HSSCPB index aims to reflect the performance of Hong Kong-listed companies involved in innovative drug research, development, and production [5] - The top ten weighted stocks in the HSSCPB index account for 78.05% of the total index weight, including companies like BeiGene (06160) and WuXi Biologics (02269) [5]

致：香港交易及結算所有限公司 股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年7月31日 狀態: 重新提交 公司名稱: 聯邦制藥國際控股有限公司 II. 已發行股份及/或庫存股份變動 呈交日期: 2025年8月8日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 03933 | 說明 | | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 3,800,000,000 | HKD | | 0.01 | HKD | | 38,000,000 | | 增加 / 減少 (-) | | | | | | | HKD | | | | 本月底結存 | | | 3,800,000,000 | HKD | | 0.01 | HKD | | 3 ...

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年7月31日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 聯邦制藥國際控股有限公司 呈交日期: 2025年8月5日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 (註1) | | 是 | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 03933 | 說明 | | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 3,800,000,000 | HKD | | 0.01 | HKD | | 38,000,000 | | 增加 / 減少 (-) | | | | | | | HKD | | | | 本月底結存 | | | 3,800,000,000 | HKD | | 0.01 | HKD | | 38,000,000 | 本月底法定/註冊 ...

Core Viewpoint - UBT251, the first high-value licensed three-target weight loss drug in China, is expected to achieve significant clinical progress and market potential in the coming years [2] Group 1: UBT251 Development and Market Potential - UBT251 has initiated four clinical trials in China, with key advancements anticipated for overweight/obesity indications by the second half of 2025 and potential market approval by 2028 [2] - The competitive landscape for three-target drugs is favorable, with UBT251 being the second in clinical progress domestically [2] - Clinical data shows UBT251 demonstrating superior weight loss effects compared to Eli Lilly's Retatrutide, with a 15.1% average weight reduction at the highest dose after 12 weeks [2] - The global market for GLP-1 drugs is projected to reach approximately $51.8 billion in 2024, indicating a growing opportunity for UBT251 [2] - UBT251 is expected to achieve a conservative domestic sales peak of 7.7 billion yuan and an overseas peak of $6 billion, with risk-adjusted sales estimates of 3.8 billion yuan and $3 billion respectively [2] Group 2: Antibiotics and Insulin Business - The company has a comprehensive supply chain in antibiotics, from upstream intermediates to finished products, positioning it as a leading global player in penicillin [3] - The demand for penicillin formulations is expected to drive steady growth in the upstream intermediate/raw material market, benefiting leading manufacturers [3] - In the insulin sector, the company has secured A-class selections in the second round of insulin procurement, with a 52.5% year-on-year increase in procurement volume [4] - The company has a full product line in the diabetes and weight loss sectors, including various generations of insulin and GLP-1 receptor agonists, enhancing its market position [4] Group 3: Investment Outlook - The company is rated as a "Buy-A" with a target price of 20.71 HKD, reflecting confidence in its innovative drug pipeline and expected revenue growth [4] - Projected revenue growth rates for 2025 to 2027 are 0.89%, -3.65%, and 7.25% respectively, with net profit estimates of 2.86 billion, 2.32 billion, and 2.48 billion yuan [4]

Investment Rating - The report assigns a "Buy-A" investment rating to the company with a 6-month target price of HKD 20.71 [4][7]. Core Insights - The report highlights the overseas licensing of UBT251 as a demonstration of the company's R&D capabilities, with an innovative drug pipeline expected to yield results [2][3]. - UBT251 is the first three-target weight loss drug authorized to a multinational corporation (MNC) in China, with significant clinical progress anticipated by 2025 and potential market peaks in both domestic and overseas sales [3][4]. - The company has a robust antibiotic and insulin segment, with a comprehensive supply chain from upstream intermediates to finished products, and is expanding into animal health, which is expected to drive new growth [4][6]. Summary by Sections 1. Company Overview - The company has established itself as a leader in the penicillin industry, with a fully integrated supply chain from intermediates to finished products, and is expanding into new therapeutic areas such as autoimmune diseases and metabolism [13][14]. - Historical performance shows a strong revenue growth trajectory, with a CAGR of 11.55% from 2005 to 2023, although recent performance has been impacted by production adjustments and increased R&D investments [25][29]. 2. UBT251 Development - UBT251 has commenced multiple clinical trials in China, with significant milestones expected in the coming years, including potential market approval by 2028 [3][37]. - The competitive landscape for three-target weight loss drugs is favorable, with UBT251 currently positioned second in clinical progress among domestic competitors [39][40]. 3. Antibiotic and Insulin Segments - The antibiotic market is expected to grow steadily, driven by the rigid demand for penicillin formulations, while the insulin segment has shown resilience with a significant increase in procurement volumes [4][6]. - The company has successfully navigated the challenges posed by antibiotic procurement policies, maintaining a competitive edge in the market [4][6]. 4. Financial Projections - Revenue growth is projected at 0.89% for 2025, with net profits expected to reach approximately CNY 2.86 billion [7][8]. - The report anticipates a peak sales potential of CNY 7.7 billion domestically and USD 6 billion overseas for UBT251, assuming a 50% success rate for market entry [3][4].

Investment Rating - The report maintains a positive outlook on the pharmaceutical and biotechnology industry, emphasizing the transition from "Made in China" to "Created in China" for innovative drugs [10]. Core Insights - The report highlights that domestic innovative drugs are gaining global competitiveness and are currently in the first and second stages of international expansion, primarily through licensing agreements and partnerships [10][12]. - The report identifies key areas of focus for investment, including PD-(L)1 plus, ADCs, and GLP-1 drugs, which are expected to drive future growth and business development (BD) opportunities [10][51]. Summary by Sections Section 1: Transition from "Manufacturing" to "Innovation" - The policy reforms initiated in 2015 have stimulated a shift from generic to innovative drug development in China, with significant increases in R&D investment since 2018 [19][21]. - The number of First-in-Class (FIC) drugs developed in China has risen from 9 in 2015 to 120 in 2024, indicating a substantial increase in innovation [25][26]. Section 2: Continued BD Opportunities - PD-(L)1 plus is identified as a cornerstone for next-generation cancer treatments, with significant demand and potential for new products [51]. - The report notes that ADCs are transitioning towards more differentiated targets, focusing on unmet clinical needs, with promising candidates like PD-L1, DLL3, and EGFR [51]. - The GLP-1 market is experiencing rapid growth, with a focus on multi-target, oral, combination, and long-acting formulations [51]. Section 3: Investment Recommendations - For PD-(L)1 plus, companies such as Kangfang Biotech, Shansheng Pharmaceutical, and Junshi Biosciences are recommended for investment due to their strong pipelines [5]. - In the ADC space, companies like Fuhong Hanlin and Zai Lab are highlighted for their potential in addressing unmet clinical needs [5]. - In the GLP-1 sector, firms such as Borui Pharmaceutical and Zai Lab are noted for their promising developments [5].

Core Insights - The report highlights the strong performance of Celestica, which raised its annual revenue guidance to $11.55 billion, up from the previous $10.85 billion, driven by robust demand from major clients [12][13] - The AI PCB industry is experiencing a significant expansion due to high demand for advanced AI servers, leading to increased capital expenditures and a tight supply chain for PCB equipment [16][17] - The antibiotic sector, particularly for the company Federated Pharmaceuticals, is stable with a growing market for diabetes and animal health products, projecting net profits of 2.839 billion, 2.452 billion, and 2.705 billion for 2025-2027 [29][30] Total Research - As of July 29, 2025, the 10-year government bond yield is at 1.75%, up 11 basis points from the June low of 1.64% [3] - Historical patterns indicate that bond yields can reverse in either a V-shape or W-shape, with the latter often leading to a more significant upward movement [4][5] - The report anticipates that the 10-year government bond yield could rise to a target range of 1.9% to 2.2% in the second half of 2025, driven by economic recovery and inflation normalization [10] Industry Analysis - The communication sector is seeing increased demand for light modules and liquid cooling solutions, as indicated by Celestica's performance [12] - The PCB industry is entering a phase of intensive expansion, with several manufacturers announcing new projects to meet the rising demand for high-end products [17][18] - AI's impact on PCB performance is pushing for upgrades in materials and manufacturing processes, with a focus on higher layer counts and advanced techniques [19][20] Company-Specific Insights - Celestica's second-quarter revenue reached $2.89 billion, a 21% year-over-year increase, with a notable 82% growth in its hardware platform solutions segment [12] - The company is benefiting from strong demand from its top clients, which account for a significant portion of its revenue [12] - The report emphasizes the potential for significant growth in the PCB equipment market due to ongoing expansions and technological upgrades [16][18]

Core Viewpoint - The company is positioned as a leader in the antibiotic industry, with a diversified business model that includes intermediates, active pharmaceutical ingredients (APIs), and formulations, which is expected to drive a new growth cycle through business synergies [1] Group 1: Business Overview - The company has developed a comprehensive business structure encompassing intermediates (6APA, G potassium salt), APIs (Amoxicillin, Ampicillin), and formulations (animal health, insulin, generic formulations) [1] - The company is expected to see resilient growth in its core business driven by the removal of capacity constraints in animal health, increased coverage from insulin contract renewals, and the market launch of hard-to-copy biosimilars [1][2] - The stable cash flow from core businesses is anticipated to support ongoing innovation and transformation efforts, potentially leading to a new performance growth cycle [1] Group 2: Innovation and Clinical Development - The company successfully partnered with Novo Nordisk for its innovative product UBT251, a self-developed GLP/GIP/GCG tri-target drug, which has shown promising results in clinical trials [2] - UBT251 has completed Phase Ib clinical trials in overweight/obese patients, demonstrating a weight loss of 15.1% in the highest dosage group over 12 weeks [2] - The company has initiated Phase II clinical trials for UBT251 in China, with expectations for domestic approval by 2028, and has a pipeline of other products in the metabolic and autoimmune fields [2] Group 3: Revenue Projections - The company's formulation business is projected to achieve a CAGR of 8.0% from 2024 to 2027, driven by the establishment of new production bases and the introduction of new products [3] - The animal health business is expected to benefit from new production bases in Henan and Zhuhai, while insulin products are anticipated to see significant growth due to contract renewals and new product approvals [3] - The intermediate and API segments are forecasted to experience a CAGR of -7.0% from 2024 to 2027, with price stabilization expected in the medium to long term due to oligopolistic market conditions [3] Group 4: Financial Outlook - The company is projected to achieve net profits of 2.78 billion, 2.13 billion, and 2.27 billion yuan from 2025 to 2027, with year-on-year growth rates of 4.5%, -23.4%, and 6.9% respectively [4] - Corresponding PE multiples are expected to be 10, 13, and 12 times for the same period, with an initial recommendation of "buy" [4]

Investment Rating - The report gives a "Buy" rating for the company, with a target price of 16.16 HKD [6]. Core Insights - The company is positioned as a leader in the antibiotic industry, with a diversified business model that includes intermediates, active pharmaceutical ingredients, and formulations, which is expected to drive a new growth cycle [1][10]. - The innovative pipeline is showing promising results, particularly with UBT251, which has successfully partnered with a global leader in diabetes treatment, Novo Nordisk, indicating strong potential for future revenue [2][23]. - The company is expected to achieve a compound annual growth rate (CAGR) of 8.0% in its formulation business from 2024 to 2027, driven by various factors including the expansion of its animal health business and the approval of new insulin products [3][4]. Summary by Sections 1. Antibiotic Industry Leadership - The company has over 30 years of experience in the pharmaceutical industry, starting with antibiotic formulations and expanding into a fully integrated business model covering intermediates, active ingredients, and formulations [10]. - The company has established a strong cash flow from its core business, which supports its innovative transformation strategy [1][14]. 2. Innovative Pipeline - UBT251, a self-developed GLP-1/GIP/GCG three-target drug, has shown significant weight loss results in clinical trials, with a 15.1% reduction in weight over 12 weeks in the highest dosage group [22][40]. - The partnership with Novo Nordisk includes a potential total income of up to 2 billion USD, with an upfront payment of 200 million USD and milestone payments [23][24]. 3. Formulation Business - The formulation business is expected to grow steadily, with a projected CAGR of 8.0% from 2024 to 2027, supported by the expansion of animal health production and new insulin product approvals [3][4]. - The company’s insulin products have achieved significant market presence, with a 52.5% growth rate in basic volume [3]. 4. Intermediates and Active Pharmaceutical Ingredients - The intermediates and active pharmaceutical ingredients business is expected to see a CAGR of -7.0% from 2024 to 2027, primarily due to price fluctuations in key products [3]. - Despite short-term price declines, the long-term outlook remains stable due to a consolidated market structure [3]. 5. Financial Forecast - The company is projected to achieve net profits of 2.78 billion, 2.13 billion, and 2.27 billion RMB from 2025 to 2027, with corresponding growth rates of 4.5%, -23.4%, and 6.9% [4][5].