Core Viewpoint - HengRui Medicine has entered into a licensing agreement with Merck to develop and commercialize the HRS-5346 project, a significant move in the pharmaceutical industry targeting Lp(a) as a cardiovascular risk factor [1][2]. Group 1: Licensing Agreement Details - The agreement allows Merck exclusive rights to develop, produce, and commercialize HRS-5346 outside Greater China, with an upfront payment of $200 million and potential milestone payments of up to $1.77 billion, plus sales royalties [1]. - The agreement is expected to take effect in the second quarter, but the approval and milestone payment timelines for HRS-5346 remain uncertain [1]. Group 2: Lp(a) and Cardiovascular Disease - Elevated Lp(a) is an independent risk factor for atherosclerotic cardiovascular disease (ASCVD), affecting approximately 1.4 billion people globally, with traditional medications showing limited efficacy in lowering Lp(a) levels [2][3]. - Current treatments, including statins and PCSK9 inhibitors, have limited impact on Lp(a), necessitating the development of targeted therapies [2][3]. Group 3: HRS-5346 and Market Potential - HRS-5346 works by blocking the covalent binding of apolipoprotein(a) with low-density lipoprotein (LDL), significantly reducing Lp(a) levels and improving atherosclerosis risk [3]. - As an oral small molecule drug, HRS-5346 offers better patient compliance and has the potential to become a market breakthrough [3]. Group 4: Industry Trends and Competitors - The development of Lp(a) inhibitors signifies a shift in cardiovascular treatment from broad lipid-lowering strategies to precision-targeted therapies, with several companies, including Novartis and Eli Lilly, advancing their own Lp(a) targeting drugs [4]. - Other domestic companies such as Jingxin Pharmaceutical, Xinlitai, WuXi AppTec, and Shiyao Group are also exploring this target, currently in preclinical stages [4].

港股概念追踪|恒瑞医药与默沙东达成许可协议 港股 创新药"含金量"普遍提升（附概念股） 恒瑞医药公告，公司与默沙东达成协议，将脂蛋白（a）[Lp（a）]口服小分子项目（包括名为HRS-5346 的先导化合物）有偿许可给默沙东，默沙东将获得HRS-5346在大中华地区以外全球范围内开发、生产 和商业化的独家权利。 根据协议，恒瑞授予默沙东在全球范围内（大中华地区除外）开发、生产和商业化HRS-5346的独家权 利。 默沙东将向恒瑞支付2亿美元首付款，恒瑞有资格获得与开发、监管和商业化相关的里程碑付款，最高 可达17.7亿美元。 根据HRS-5346在大中华地区以外的销售情况，默沙东还将向恒瑞支付相应的销售提成。 智通财经APP获悉，自2023年底以来，跨国药企与本土创新药企之间的商务拓展（BD）合作持续升 温，今年更是涌现出多个引人瞩目的合作项目。 今年年初，DeepSeek引爆全球市场，在生物医药领域的创新也颇受华尔街市场关注。 如此也使得，一众跨国药企瞄准研发生产之际，也有不少跨国药企选择探索释放数据、技术和人工智能 的潜力，积极探索与中国本土生物技术公司的合作与伙伴关系，加速数字化布局，寻求新的突破及市场 ...

Core Insights - Heng Rui Medicine has entered into a significant licensing agreement with Merck for its oral small molecule project targeting lipoprotein(a), with an upfront payment of $200 million and potential milestone payments up to $1.77 billion [3][4] - The Hong Kong Stock Connect Innovation Drug ETF (159570) has seen substantial inflows, with net subscriptions exceeding 240 million yuan and a total of over 800 million yuan in the last 60 days, indicating strong investor interest in innovative drug companies [4][6] - The trend of Chinese innovative drug companies expanding overseas is accelerating, with at least 262 license-out transactions expected from 2020 to 2024, totaling over $150 billion [4][5] Company Developments - Heng Rui Medicine's licensing deal with Merck includes exclusive rights for global development, production, and commercialization outside Greater China for the drug HRS-5346 [3][4] - Other companies like United Pharmaceuticals and Innovent Biologics have also secured significant licensing agreements, indicating a broader trend in the industry [3][5] - The recent performance of stocks within the Hong Kong Stock Connect Innovation Drug ETF shows a mixed picture, with notable gains from companies like 3SBio and declines from companies like Yunnan Baiyao [3][4] Market Trends - The Hong Kong Stock Connect Innovation Drug ETF has reached a new high in shares, reflecting a doubling in size over the past month, driven by increased investor confidence [4][6] - The overall market for innovative drugs is expected to benefit from AI advancements, improved financing conditions, and potential fiscal support, which could enhance profit margins for these companies [4][6] - The ETF's composition highlights a strong focus on leading companies in the innovative drug sector, with over 68% of its weight in the top ten holdings [6][7]

Group 1 - The core viewpoint is that the increase in risk appetite is a significant support for the market trend this year, with A50ETF Huabao (159596) seeing a notable rise in its major holding, Heng Rui Pharmaceutical, which increased by 3.7% [1] - The A-share market showed a collective rebound with the Shanghai Composite Index up by 0.18%, the Shenzhen Component Index up by 0.36%, and the ChiNext Index also up by 0.36% [1] - The trading volume in the market reached 746.3 billion yuan, a decrease of 55.3 billion yuan compared to the previous day, with over 4,000 stocks rising [1] Group 2 - Huatai Securities suggests that with the recent catalytic window for pan-technology assets closing, investors are looking for sectors with potential support, particularly in the pan-consumption industry [2] - The report highlights that consumption promotion is a key policy focus for 2025, with specific measures being rolled out, indicating a clearer approach [2] - The analysis indicates that the fundamentals of the pan-consumption sector are showing signs of improvement, supported by stable employment, expanded social security spending, and a bottoming out of housing prices [2] Group 3 - Ping An Securities emphasizes that the increase in risk appetite is crucial for the market this year, suggesting that besides the technology sector, investors should also consider structurally favorable opportunities in lower-valued consumption sectors [2] - Specific sectors recommended for attention include the home appliance industry, benefiting from substantial subsidies, and the consumer electronics industry, which is expected to gain from AI integration [2] - The report notes that while the liquor industry is facing downward revisions in profit expectations, its PE valuation is currently below the historical 20% percentile, presenting potential short-term trading opportunities [2] Group 4 - Investors can consider A50ETF Huabao (159596) and its associated off-market funds (Class A 021216/Class C 021217) for investment positioning [3]

或受此影响，3月26日开盘，恒瑞医药股价小幅上涨，随后稍有回落，截至发稿涨超3%，总市值为2953 亿元。 恒瑞医药方面表示，借助默沙东在心血管领域的领先地位（其抗血小板药物氯吡格雷年销售额超50亿美 元）及覆盖120国的销售网络，可加速实现创新价值转化，同时还能规避海外高昂的研发投入和法规风 险。 实际上，恒瑞医药一直在通过海外授权，来完成其出海战略。粗略统计，恒瑞医药已有13项创新药实现 海外授权。值得一提的是，2024年5月，恒瑞医药将具有自主知识产权的GLP-1类创新药HRS-7535、 HRS9531、HRS-4729许可给美国Kailera公司。彼时，首付款加里程碑付款累计高达约60亿美元，并且 还取得美国Kailera公司19.9%的股权。 加速出海的背后，是恒瑞医药在研发方面的大力投入。2024年前三季度业绩报告显示，其研发费用达 45.49亿元，同比增长22.1%。目前，恒瑞医药已在全球布局 14 个研发中心，组建了超 5500 人的全球研 发团队；在中国获批上市的有19款新分子实体药物（1类创新药）和4款其他创新药（2类新药）。 加速出海，恒瑞医药与默沙东签下19.7亿美元大单 3月25日 ...

2025年以来，内地推进赴港上市的A股上市公司已有21家， 其中包括万亿市值的宁德时代（300750.SZ），千亿市值的海天味业（603288.SH）、恒 瑞医药（600276.SH）、三一重工（600031.SH）等。 这一数据远超去年同期。2024年前三个月，明确推进赴港上市且处于实质性进展的A股上市公司较少，有康乐卫士、迈威生物等。 具体来说，宁德时代是全球知名的新能源创新科技公司，已递交招股书。 赴港上市主要是为了进一步推进公司全球化战略布局，其港股 IPO 募集资金用 于推进匈牙利项目等。 海天味业是千亿市值的调味品行业龙头企业， 在推进赴港上市事宜以拓展国际市场，提升品牌的国际影响力。 恒瑞医药是千亿市值的医药生物领域巨头， 拟赴港上市以加强国际业务布局，提升公司在全球医药市场的竞争力。 晶澳科技是全球光伏一体化组件龙头之一， 2025年2月21日晚间公告计划发行境外上市外资股（H 股）股票并申请在香港联交所主板挂牌上市，旨在进一 步推动公司全球化发展战略。 三一重工是千亿市值的工程机械行业龙头企业， 2025年2月18日晚间公告称正在筹划境外发行股份（H 股）并在香港联合交易所有限公司上市事项， ...

Core Viewpoint - HengRui Medicine has entered into an exclusive licensing agreement with Merck for its Lp(a) oral small molecule project, HRS-5346, with a total transaction value of $1.97 billion [1]. Group 1: Licensing Agreement Details - The agreement grants Merck exclusive rights to develop, manufacture, and commercialize HRS-5346 outside Greater China, with HengRui receiving an upfront payment of $200 million [1]. - HengRui is also eligible for up to $1.77 billion in milestone payments related to development, regulatory, and commercialization, along with sales royalties based on net sales if the product is approved [1]. Group 2: Clinical Background and Market Potential - HRS-5346 is currently undergoing Phase II clinical trials in China and targets elevated Lp(a) levels, which affect over 1.4 billion people globally and are an independent risk factor for atherosclerotic cardiovascular diseases [1]. - Targeting Lp(a) represents a significant breakthrough in the prevention and treatment of cardiovascular diseases [1]. Group 3: Strategic Implications for HengRui - This marks HengRui's first strategic collaboration with a major multinational company, enhancing its internationalization efforts [3]. - The transaction is expected to close in the second quarter of 2025, contingent upon regulatory approvals and customary conditions [3][4]. - HengRui's recent licensing activities have accelerated since the appointment of its Chief Strategy Officer in January 2023, indicating a shift towards more aggressive business development strategies [2].

恒瑞与默沙东签合作单：心血管疾病小分子药物，2亿美元首付款 3月25日晚间，江苏恒瑞医药股份有限公司（恒瑞医药，600276）公告称，与默沙东达成协议，将恒瑞的脂蛋白（a）（以下简称"Lp(a)"）口服小分 子项目（包括名为HRS-5346的先导化合物）有偿许可给默沙东。默沙东将获得HRS-5346在大中华地区以外的全球范围内开发、生产和商业化的独 家权利。 这份合作协议预计生效时间为2025年第二季度。由此，恒瑞将获得2亿美元的首付款，还有资格获得与开发、监管和商业化相关的里程碑付款，最 高可达17.7亿美元。此外，根据HRS-5346在大中华地区以外的销售情况，默沙东将向恒瑞支付相应的销售提成。按此计算，恒瑞医药未来可获得的 收入近20亿美元。 恒瑞医药 视觉中国 资料图 虽然PD-1肿瘤药出海美国一波三折，但恒瑞医药通过授权交易"借船出海"的步伐还在继续。 默沙东方面表示，HRS-5346将有力拓展并完善公司在心血管、代谢疾病领域的研发管线。在与恒瑞医药合作之前，2024年底，默沙东还通过与翰 森制药合作获得一款在研的口服小分子GLP-1受体激动剂，此次合作潜在最高总金额超过20亿美元，其中包括1.12 ...

"心血管疾病在全球存在巨大未满足的临床需求。我们很高兴与心血管领域全球领军企业默沙东达成战略合作，让恒瑞的心血管创新药服务于全球患 者。"恒瑞医药执行副总裁、首席战略官江宁军表示，"相信默沙东卓越的临床研发实力和全球化布局，将加速推动HRS-5346的研发进程。" "血液中Lp（a）升高是动脉粥样硬化性心血管疾病的明确风险因素，影响全球多达五分之一的成年人。"默沙东研究实验室总裁Dean Y.Li博士表 示，"HRS-5346是一种在研的口服小分子Lp（a）抑制剂，将有力拓展并完善我们在心血管、代谢疾病领域的研发管线。" 需要注意的是，该交易的交割取决于能否获得美国《哈特-斯科特-罗迪诺反托拉斯改进法》项下的批准，以及能否满足其他惯常条件。该交易预计于 2025年第二季度完成交割。 19.7亿美元！恒瑞医药出海大消息 创新药龙头恒瑞医药又有出海大动作。 恒瑞医药3月25日晚公告，公司与美国医药巨头默沙东达成协议，将恒瑞的脂蛋白（a）[Lp（a）]口服小分子项目（包括名为HRS-5346的先导化合 物）有偿许可给默沙东，默沙东将获得HRS-5346在大中华区以外的全球范围内开发、生产和商业化的独家权利。 恒瑞医 ...

Group 1: China Telecom Performance - China Telecom reported a net profit of RMB 33.01 billion for 2024, representing a year-on-year growth of 8.4% [3] - The company's total revenue for 2024 was RMB 529.4 billion, an increase of 3.1% compared to the previous year [3] - Service revenue reached RMB 482 billion, up 3.7% year-on-year, while EBITDA was RMB 140.8 billion, growing by 2.9% [3] - The board proposed a cash dividend distribution of 72% of the net profit, with a final dividend of RMB 0.0927 per share [3] Group 2: Rongsheng Development Debt Restructuring - Rongsheng Development announced plans to restructure its debt to mitigate financial risks and promote healthy development [3] - The company aims to implement a debt-for-equity swap by leveraging its quality assets, including stakes in light-asset subsidiaries [3] - The restructuring will address both financial and operational debts, with a focus on enhancing light-asset operational capabilities [3] Group 3: Dual杰 Electric Major Contract - Dual杰 Electric signed two significant contracts with a total value of RMB 1.555 billion, accounting for approximately 44.35% of its audited revenue for 2023 [4] - The contracts involve the procurement of 35kV box substations and the EPC general contracting for a 3 million kW photovoltaic base project [4] - The execution of these contracts is expected to positively impact the company's future operating performance [4] Group 4: Heng Rui Pharmaceutical Licensing Agreement - Heng Rui Pharmaceutical entered into a licensing agreement with Merck for its Lp(a) oral small molecule project, including the lead compound HRS-5346 [4] - The agreement includes an upfront payment of USD 200 million and potential milestone payments up to USD 1.77 billion, along with sales royalties based on performance outside Greater China [4] - This deal is anticipated to expand the overseas market for HRS-5346 and enhance the company's innovative brand and international performance [4] Group 5: Hongbao Li Project Update - Hongbao Li's epoxy propylene comprehensive technology renovation project is expected to enter trial production by the end of 2025 [5] - The project has received necessary approvals and completed various design and construction phases, with equipment procurement underway [6] Group 6: Yongding Co. Clarification - Yongding Co. clarified that it does not directly manufacture controllable nuclear fusion devices but provides materials for the winding of magnetic coils [7] - The production of high-temperature superconducting tapes is limited, with expected revenue contribution of less than 1% to the overall income in 2024 [7]