Core Viewpoint - The document outlines the management measures for the shares held by directors and senior management of Wuxi AppTec Co., Ltd., emphasizing compliance with relevant laws and regulations to maintain market order and transparency in share transactions [1][2]. Summary by Sections General Principles - The management measures are established to strengthen the oversight of shares held by directors and senior management, ensuring adherence to the Company Law, Securities Law, and various regulatory guidelines [1]. - The measures apply to all shares held by directors and senior management, including those held in multiple accounts [2]. Trading Prohibitions and Restrictions - Directors and senior management are prohibited from transferring shares under specific circumstances, such as within one year of the company's stock listing or within six months after leaving the company [5]. - There are also restrictions on trading during certain periods, such as before the announcement of annual or quarterly reports [6][7]. Information Reporting and Disclosure - Directors and senior management must report their shareholdings and any changes to the board secretary promptly, ensuring accurate and timely disclosures [5][6]. - Any share reduction plans must be reported in advance, detailing the number of shares, method, and reasons for the reduction [6][10]. Violations and Responsibilities - The company can impose penalties on directors and senior management for violations of these measures, including financial penalties and potential legal action [11][12]. - The board secretary is responsible for managing and monitoring the shareholding data of directors and senior management [10][12]. Additional Provisions - Shareholders holding more than 5% of the company's shares are also subject to similar reporting and trading restrictions [11]. - The measures will take effect upon approval by the board and will supersede previous regulations [12].

Core Points - The document outlines the rules for the Nomination Committee of Wuxi AppTec Co., Ltd., focusing on the selection and appointment of directors and senior management [2][5][11] Group 1: General Provisions - The Nomination Committee is established to regulate the selection of directors and senior management, optimize the board composition, and improve corporate governance [2] - The committee is responsible for proposing candidates, conditions, standards, and procedures for the selection of directors and senior management [2][5] Group 2: Composition of the Committee - The Nomination Committee consists of three directors, with independent directors making up the majority and at least one director of a different gender [4] - The committee members are nominated by the chairman, a majority of independent directors, or one-third of all directors, and elected by the board [4] Group 3: Responsibilities and Authority - The main responsibilities include reviewing the board's structure and composition annually, proposing changes to align with corporate strategy, and evaluating the performance of the board [5][6] - The committee is tasked with assessing the independence of independent directors and providing recommendations for the appointment or dismissal of senior management [6][7] Group 4: Decision-Making Procedures - The committee can establish a working group to assist in the preparation of proposals and gather relevant information on candidates [4][14] - The selection process for directors and senior management involves extensive research and consideration of candidates' qualifications, experiences, and diversity [15] Group 5: Meeting Rules - Meetings require the presence of at least two-thirds of the committee members and decisions are made by a majority vote [18] - Meeting records must be maintained, including details of attendees, resolutions, and any independent directors' opinions [10][20] Group 6: Miscellaneous Provisions - The rules take effect upon approval by the board and replace any previous regulations [27] - Any unresolved matters will be governed by relevant laws, regulations, and the company's articles of association [11][29]

Core Points - The internal audit system of Wuxi WuXi AppTec Co., Ltd. aims to enhance and standardize internal audit work, protect investors' rights, and improve audit quality [1][2] - The internal audit is an independent and objective evaluation of the effectiveness of internal controls and risk management, as well as the legality, compliance, authenticity, and completeness of financial information and business activities [1][2] - The internal audit institution is responsible to the board of directors and must report directly to the audit committee when significant issues are discovered [3][5] Group 1: General Principles - The internal audit system is based on national laws and regulations, as well as the company's articles of association [1][2] - The objectives of internal control include ensuring legal compliance in management, asset security, and the authenticity of financial reporting [2] - The internal audit institution must operate independently and is not subordinate to the finance department [3][4] Group 2: Audit Committee and Personnel - The audit committee is established under the board of directors and consists of non-executive directors, with a majority being independent directors [6][7] - The company must appoint a dedicated internal audit manager responsible for managing internal audit activities [4][6] - Internal audit personnel must possess the necessary professional capabilities and undergo continuous education to enhance their skills [4][5] Group 3: Responsibilities and Authority - The audit committee guides and supervises the internal audit institution, reviews annual audit plans, and coordinates with external audit units [5][6] - The internal audit institution is responsible for auditing the legality, compliance, authenticity, and completeness of financial and economic activities [5][6] - The internal audit institution has the authority to request relevant documents, attend meetings, and investigate issues related to audit matters [7][8] Group 4: Audit Scope and Procedures - The internal audit covers financial audits, internal control audits, special audits, and management audits [8][9] - The internal audit institution evaluates the effectiveness of internal controls related to financial reporting and information disclosure [9][10] - The audit process includes verifying financial records, conducting interviews, and preparing audit work papers [10][11] Group 5: Reporting and Follow-up - After completing the audit, the internal audit department must submit an audit report, which the audited unit can respond to within five days [11][12] - The internal audit institution is responsible for monitoring the implementation of corrective measures for identified internal control deficiencies [12][13] - The internal audit institution must prepare an annual internal audit report for the audit committee [5][12]

Core Viewpoint - The document outlines the rules and regulations governing the Audit Committee of Wuxi AppTec Co., Ltd., emphasizing the importance of effective oversight, internal control, and accurate financial reporting. Group 1: General Provisions - The Audit Committee is established to enhance the efficiency of the Board and ensure effective supervision of the company according to various legal and regulatory frameworks [1][2] - The committee is responsible for communication and evaluation of internal and external audits, reviewing financial information, and supervising major decision-making matters [1][2] Group 2: Composition of the Committee - The Audit Committee consists of three non-executive directors, with a majority being independent directors, including at least one accounting professional [2][3] - Members must possess the necessary expertise and experience to fulfill their responsibilities effectively [3] Group 3: Responsibilities and Authority - The committee is tasked with reviewing financial reports, supervising internal and external audits, and ensuring compliance with legal and regulatory requirements [4][5] - It has the authority to recommend the hiring or dismissal of external auditors and evaluate their performance [4][5] Group 4: Decision-Making Procedures - The committee must meet at least quarterly and can convene special meetings as needed, with decisions requiring a majority vote [8][9] - Meeting records must be maintained, including attendance and decisions made [10][11] Group 5: Information Disclosure - The company is required to disclose the Audit Committee's annual performance and any significant issues identified during its oversight [11][12] - Any recommendations made by the committee that are not adopted by the Board must be disclosed along with the reasons [12]

Core Points - The document outlines the rules for the board of directors of Wuxi AppTec Co., Ltd., aiming to standardize the decision-making process and enhance the board's operational efficiency [1][2][3] Group 1: General Provisions - The rules are established to ensure compliance with various laws and regulations, including the Company Law and Securities Law of the People's Republic of China [1] - The board consists of eleven directors, including five independent directors, to ensure a diverse and professional composition [2] Group 2: Board Authority and Responsibilities - The board has the authority to convene shareholder meetings, execute resolutions, and make significant decisions regarding the company's operational plans and investment strategies [2][3] - The board is responsible for formulating profit distribution plans, capital changes, and major acquisitions, as well as managing internal structures and appointing senior management [2][3] Group 3: Meeting Procedures - The board must hold at least four regular meetings annually, with provisions for temporary meetings under specific circumstances [9][10] - Meeting notifications must be sent out in advance, with specific requirements for both regular and temporary meetings [21][22] Group 4: Voting and Decision-Making - Decisions require a majority vote from the attending directors, with specific rules for handling conflicts of interest and ensuring independent directors' involvement [30][31][32] - The board must maintain transparency and confidentiality regarding meeting resolutions and decisions [38][39] Group 5: Documentation and Record-Keeping - The board secretary is responsible for maintaining accurate records of meetings, including minutes and resolutions, which must be preserved for at least ten years [40][44] - The rules stipulate that any amendments or conflicts with existing regulations must be addressed promptly [46][47]

Core Points - The document outlines the rules for the shareholders' meeting of Wuxi AppTec Co., Ltd, emphasizing the legal framework and responsibilities of the board and shareholders [1][2][3] Group 1: General Provisions - The rules are established to clarify the responsibilities and powers of the shareholders' meeting, ensuring fair and effective exercise of rights by shareholders [1] - The rules are legally binding for the company, shareholders, directors, and senior management upon their effective date [1][2] Group 2: Meeting Organization - The company must strictly adhere to legal and regulatory requirements when convening shareholders' meetings, ensuring shareholders can exercise their rights [2][3] - The shareholders' meeting is categorized into annual and extraordinary meetings, with the annual meeting required to be held within six months after the end of the previous fiscal year [2][3] Group 3: Meeting Procedures - The board of directors is responsible for convening the shareholders' meeting within specified timeframes and must provide written feedback on requests for extraordinary meetings [4][5] - If the board fails to convene a meeting, the audit committee or shareholders holding over 10% of shares can initiate the meeting [5][6] Group 4: Proposals and Notifications - Proposals for the shareholders' meeting must comply with legal and regulatory requirements and be submitted in writing [8][9] - Notifications for annual meetings must be sent 20 working days in advance, while notifications for extraordinary meetings must be sent 10 to 15 working days prior [9][10] Group 5: Voting and Resolutions - Resolutions can be classified as ordinary or special, with ordinary resolutions requiring a simple majority and special resolutions requiring two-thirds approval [17][18] - The voting process must be transparent, with results announced immediately after voting [26][62] Group 6: Meeting Records - The company must maintain accurate records of the shareholders' meetings, including attendance, proposals, and voting results, for a minimum of ten years [31][78] - Any resolutions that violate laws or regulations are deemed invalid [79]

Report Industry Investment Rating - Not provided in the given content Core Viewpoints of the Report - ETFs are becoming a "super hub" connecting the market and investors, and their development is a major trend. Analyzing the penetration of ETF holdings and trading helps understand the interaction between ETFs and corresponding stocks [1]. - The impact of ETFs on the equity market can be divided into four quadrants based on ETF持仓占比 and ETF成交占比, which reflect the holding and trading influence of ETFs on stocks respectively [2][10]. - ETFs show strong configuration and trading willingness in traditional industries such as banking, coal, and non - bank finance. Market preference may be shifting towards low - valuation, high - dividend sectors [2][3]. Summary by Relevant Catalogs I. ETF's Influence Mechanism on the Equity Market - The influence of ETFs on the equity market is divided into four scenarios according to the low/high of ETF持仓占比 and ETF成交占比: weak influence, stable ballast, high - active trader, and strong influence [2]. II. Industry Perspective - ETFs are actively traded and have a high持仓占比 in traditional industries like banking, coal, and non - bank finance. In August, the banking sector had a 20.55%成交占比 and 10.48%持仓占比; the coal sector had a 16.81%成交占比 and 11.11%持仓占比; the non - bank finance sector had an 11.60%成交占比 and 11.76%持仓占比 [2]. - From July to August, the trading activity and持仓占比 of ETFs in cyclical industries such as coal, banking, and petroleum and petrochemicals increased significantly, while those in technology - growth sectors like electronics and computers decreased, possibly due to market style switching [3]. III. Individual Stock Perspective - Among the top 30 stocks in terms of ETF持仓, ETFs have a high degree of pricing power as the ETF持仓占 their free - float market value exceeds 10%, and stock price fluctuations are highly correlated with ETF redemptions and position adjustments [11]. - The stocks with high ETF持仓 are concentrated in industries, mainly in the semiconductor industry chain, followed by the pharmaceutical and biological industry, and also include some new energy, artificial intelligence, and software stocks [12]. - The market capitalization of stocks heavily held by ETFs varies widely, covering large - cap giants and medium - sized growth companies. These stocks are mostly leading companies in niche industries and are favored by ETFs, especially those from the Science and Technology Innovation Board [13].

Group 1 - The company held its 25th meeting of the 3rd Board of Directors on September 2, 2025, with all 11 directors present, chaired by Ge Li [1] - The Board approved the proposal to cancel the Supervisory Board, change the registered capital, and amend the Articles of Association, which will take effect upon the approval of the shareholders' meeting [1][2] - The Board also approved the revision of several corporate governance systems, with unanimous support from all directors [2][3] Group 2 - The Board authorized the investment department to dispose of listed shares, with a total transaction amount not exceeding 15% of the latest audited net assets attributable to the parent company's shareholders, valid for 12 months [4][5] - The Board approved a framework agreement for daily related party transactions, with specific voting results showing 8 votes in favor and 3 abstentions from related directors [6] - The Board agreed to the equity transfer between wholly-owned subsidiaries and authorized management to handle all related matters [6][7] Group 3 - The Board proposed to hold the second extraordinary general meeting of shareholders in 2025, with the chairman or authorized personnel responsible for the announcement and related arrangements [7]

Core Viewpoint - WuXi AppTec (603259.SH) has signed a framework agreement with WuXi XDC Cayman Inc. to increase the transaction amount for the year 2025 and establish a new three-year service agreement [1] Group 1: Transaction Details - The expected transaction amount for 2025 has been raised from 168 million yuan to 200 million yuan [1] - Projected transaction amounts for the years 2026, 2027, and 2028 are set at 300 million yuan, 400 million yuan, and 400 million yuan respectively [1] Group 2: Related Party Transactions - The CFO of the company, Shi Ming, serves as a director of XDC Cayman, making this transaction a related party transaction [1] - The company asserts that the transaction is in line with normal business operations and is established under general business terms, adhering to market pricing principles [1]

無錫藥明康德新藥開發股份有限公司 WuXi AppTec Co., Ltd.* （於中華人民共和國註冊成立的股份有限公司） 股份代碼：2359 2025 中期報 告 無錫藥明康德新藥開發股份有限公司 WuXi AppTec Co., Ltd.* (A joint stock company incorporated in the People's Republic of China with limited liability) Stock Code : 2359 2025 INTERIM REPORT C M Y CM MY CY CMY K ai175642881316_WuXi AppTec IR2025 Cover V03A 15mm OP.pdf 1 29/8/2025 上午8:53 目錄 | 公司資料 | 2 | | --- | --- | | 財務摘要 | 5 | | 管理層討論與分析 | 6 | | 法定披露 | 37 | | 簡明綜合財務報表的審閱報告 | 67 | | 簡明綜合損益及其他全面收益表 | 68 | | 簡明綜合財務狀況表 | 71 | | 簡明綜合權益變動表 | 74 | | ...